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Article: N-Terminal Pro-B Type Natriuretic Peptide as a Predictive Biomarker of Bronchopulmonary Dysplasia or Death Due to Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Meta-Analysis.

Rodolaki, Kalliopi / Pergialiotis, Vasilios / Sapantzoglou, Ioakeim / Theodora, Marianna / Antsaklis, Panagiotis / Pappa, Kalliopi / Daskalakis, Georgios / Papapanagiotou, Aggeliki

Journal of personalized medicine

2023 Volume 13, Issue 9

Abstract: Background: Emerging evidence suggests the clinical utility of N terminal pro B type ...

Abstract	Background: Emerging evidence suggests the clinical utility of N terminal pro B type natriuretic peptide (NT-proBNP) in multiple cardiac and pulmonary abnormalities both in adult and pediatric populations. To date, however, there is no consensus regarding its efficacy for the prediction and severity of bronchopulmonary dysplasia in premature neonates. The objective of the present meta-analysis was to determine differences in NT-proBNP among neonates that develop BPD or die from BPD and to evaluate if there is relative information on the diagnostic accuracy of the method. Methods: We conducted a systematic search according to the PRISMA guidelines and looked into Medline (1966-2023), Scopus (2004-2023), Clinicaltrials.gov (2008-2023), EMBASE (1980-2023), Cochrane Central Register of Controlled Trials CENTRAL (1999-2022) and Google Scholar (2004-2023) together with the reference lists from included studies. The potential risk of bias encountered in our study was evaluated using the QUADAS -2 tool. Finally, a total of 9 studies met the eligibility criteria, comprising 1319 newborns, from which 397 developed BPD and 922 were unaffected controls. Results: The results retrieved from our meta-analysis showed that newborns suffering from BPD had notably elevated NT-proBNP levels after birth when compared with healthy neonates (SMD 2.57, 95% CI 0.41, 4.72). The summary effect of the AUC meta-analysis showed that NT-proBNP was very accurate in detecting neonates at risk of developing severe BPD or dying from the disease (AUC -0.16, 95% CI -0.23, -0.08). No studies reported data relevant to the sensitivity and/or specificity of the method in diagnosing BPD. Conclusion: Serum NT-proBNP levels represent a potential future biomarker with great diagnostic validity for the prediction of BPD complicating preterm deliveries. The limited amount of studies included and the significant variations in cutoff values and timing of measurement still restrict the application of NT-proBNP as an established clinical biomarker for BPD. The design of larger prospective studies will provide a more representative number of participants and will address the discrepancies in existing literature.
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13091287
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Article ; Online: Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee.

Rossini, P M / Burke, D / Chen, R / Cohen, L G / Daskalakis, Z / Di Iorio, R / Di Lazzaro, V / Ferreri, F / Fitzgerald, P B / George, M S / Hallett, M / Lefaucheur, J P / Langguth, B / Matsumoto, H / Miniussi, C / Nitsche, M A / Pascual-Leone, A / Paulus, W / Rossi, S /

Rothwell, J C / Siebner, H R / Ugawa, Y / Walsh, V / Ziemann, U

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2015 Volume 126, Issue 6, Page(s) 1071–1107

Abstract: These guidelines provide an up-date of previous IFCN report on "Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application" (Rossini et al., 1994). A new ... ...

Abstract	These guidelines provide an up-date of previous IFCN report on "Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application" (Rossini et al., 1994). A new Committee, composed of international experts, some of whom were in the panel of the 1994 "Report", was selected to produce a current state-of-the-art review of non-invasive stimulation both for clinical application and research in neuroscience. Since 1994, the international scientific community has seen a rapid increase in non-invasive brain stimulation in studying cognition, brain-behavior relationship and pathophysiology of various neurologic and psychiatric disorders. New paradigms of stimulation and new techniques have been developed. Furthermore, a large number of studies and clinical trials have demonstrated potential therapeutic applications of non-invasive brain stimulation, especially for TMS. Recent guidelines can be found in the literature covering specific aspects of non-invasive brain stimulation, such as safety (Rossi et al., 2009), methodology (Groppa et al., 2012) and therapeutic applications (Lefaucheur et al., 2014). This up-dated review covers theoretical, physiological and practical aspects of non-invasive stimulation of brain, spinal cord, nerve roots and peripheral nerves in the light of more updated knowledge, and include some recent extensions and developments.
MeSH term(s)	Advisory Committees ; Animals ; Brain/physiology ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Cognition Disorders/therapy ; Deep Brain Stimulation/methods ; Humans ; Mental Disorders/diagnosis ; Mental Disorders/physiopathology ; Mental Disorders/therapy ; Peripheral Nerves/physiology ; Research Report ; Spinal Cord/physiology ; Transcranial Magnetic Stimulation/methods
Language	English
Publishing date	2015-02-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2015.02.001
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Article ; Online: Impact of fine-needle aspiration cytology in thyroidectomy extent and associated surgical morbidity in thyroid cancer.

Lind, Patrik / Nordenström, Erik / Johansson, Lars / Wallin, Göran / Daskalakis, Kosmas

Langenbeck's archives of surgery

2024 Volume 409, Issue 1, Page(s) 68

Abstract: ... Methods: A Swedish nationwide cohort of patients having surgery for TC (n = 2519) from the Scandinavian ... often encountered in LTT (n = 314, 33.3%) than TT (n = 63, 4.6%), whereas FNACs suspicion for malignancy ... and/or malignancy were overrepresented in TT (n = 963, 69.4%). Completion thyroidectomies were ...

Abstract	Purpose: To assess the impact of fine-needle aspiration cytology (FNAC) in the extent of surgery in patients with thyroid cancer (TC) and the associated surgical morbidity in primary and completion setting. Methods: A Swedish nationwide cohort of patients having surgery for TC (n = 2519) from the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal surgery between 2004 and 2013 was obtained. Data was validated through scrutinizing FNAC and histology reports. Results: Among the 2519 cases operated for TC, the diagnosis was substantiated and validated through the histology report in 2332 cases (92.6%). Among these, 1679 patients (72%) were female, and the median age at TC diagnosis was 52.3 years (range 18-94.6). Less than total thyroidectomy (LTT) was undertaken in 944 whereas total thyroidectomy (TT) in 1388 cases. The intermediate FNAC categories of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/ FLUS), as well as suspicion for follicular neoplasm (SFN) lesions were more often encountered in LTT (n = 314, 33.3%) than TT (n = 63, 4.6%), whereas FNACs suspicion for malignancy and/or malignancy were overrepresented in TT (n = 963, 69.4%). Completion thyroidectomies were undertaken in 553 patients out of 944 that initially had LTT. In 201 cases with cancer lesions > 1 cm, other than FTC (Follicular TC)/ HTC (Hürthle cell TC) subjected to primary LTT, inadequate procedures were undertaken in 81 due to absent, Bethesda I or II FNAC categories, preoperatively. Complications at completion of surgery in this particular setting were 0.5% for RLN palsy (n = 1) and 1% (n = 2) for hypoparathyroidism 6 months postoperatively. The overall postoperative complication rate was higher in primary TT vs. LTT for RLN palsy (4.8% [n = 67] vs. 2.4% [n = 23]; p = 0.003) and permanent hypoparathyroidism (6.8% [n = 95] vs. 0.8% [n = 8]; p < 0.0001). Conclusions: FNAC results appear to affect surgical planning in TC as intermediate FNAC categories lead more often to LTT. Overall, inadequate procedures necessitating completion surgery are encountered in up to 15% of TC patients subjected to LTT due to absent, inconclusive, or misleading FNAC, preoperatively. However, completion of thyroidectomy in this setting did not yield significant surgical morbidity. Primary LTT is a safer primary approach compared to TT in respect of RLN palsy and permanent hypoparathyroidism complication rates; therefore, primary TT should probably be reserved for lesions > 1 cm or even larger with suspicion for malignancy or malignant FNAC.
MeSH term(s)	Humans ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Male ; Thyroidectomy/adverse effects ; Biopsy, Fine-Needle/methods ; Retrospective Studies ; Thyroid Neoplasms/pathology ; Adenocarcinoma, Follicular/pathology ; Morbidity ; Paralysis/surgery ; Hypoparathyroidism ; Thyroid Nodule/surgery
Language	English
Publishing date	2024-02-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-024-03258-3
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Article ; Online: Lessons From the Mpox Response.

Daskalakis, Demetre / Romanik, Nikki / Jha, Ashish K

JAMA

2023 Volume 331, Issue 5, Page(s) 387–388

Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2023.27868
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Article ; Online: Harnessing laser technology to create stable metal halide perovskite-rGO conjugates as promising electrodes for Zn-ion capacitors.

Kostopoulou, Athanasia / Vernardou, Dimitra / Livakas, Nikolaos / Brintakis, Konstantinos / Daskalakis, Stylianos / Stratakis, Emmanuel

Nanoscale

2024 Volume 16, Issue 13, Page(s) 6455–6463

Abstract: We report that the direct conjugation of metal halide perovskite nanocrystals on rGO sheets can provide high performance and stable electrodes for Zn-ion capacitors. It is the first time that metal halide nanocrystals have been used to enhance the energy ...

Abstract	We report that the direct conjugation of metal halide perovskite nanocrystals on rGO sheets can provide high performance and stable electrodes for Zn-ion capacitors. It is the first time that metal halide nanocrystals have been used to enhance the energy storage of 2D materials in capacitors by introducing an additional pseudocapacitance mechanism. In particular, we present a simple, rapid and room temperature laser-induced method to anchor CsPbBr
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr05552c
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Conference proceedings ; Online: An unsupervised machine learning-based methodology to study the seasonal dispersal pathways of short-lived pollutants from Major Population Centers

Poulidis, A. / Daskalakis, N. / Kanakidou, M. / Vrekoussis, M.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: The rapid increase in human population since 1900 has occurred along with a rapid increase in urbanization - the process of migration from rural into urban areas. The fossil fuel combustion-based emissions affecting areas with high population densities ... ...

Abstract	The rapid increase in human population since 1900 has occurred along with a rapid increase in urbanization - the process of migration from rural into urban areas. The fossil fuel combustion-based emissions affecting areas with high population densities induce a significant health risk for local populations. Protection of human health requires better knowledge of local and regional impacts of urban pollution dispersal. This study addresses the issue of short-lived pollutant transport (e.g. NOx) by constructing a methodology to study the seasonality of common dispersal pathways from Major Population Centers (MPCs); initially applied to 5 MPCs in south America during 2018. For each city, ERA5 reanalysis data were used to drive the FLEXPART emission transport model to simulate the dispersal of near-surface emissions. Simulations are performed for a total of 8 hours from release in the early morning and in the evening, to capture the effects of commuting. A total of 100,000 trajectories per release time per city were analyzed to create representative average trajectories. The k-means clustering algorithm was then applied to categorize the emissions per MPC. Clustering for each MPC led to a robust grouping of trajectories that were seen to reflect climatological and topographic phenomena during the simulation period and exhibit strong seasonality. This finding supports potential applicability of the proposed methodology for a global analysis of MPC emissions.
Subject code	910
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
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Article ; Online: Evaluating the use of electroconvulsive therapy in low-middle income countries: A narrative review.

Daskalakis, Anastasios A / Paric, Angela / Ravindran, Nisha / Ravindran, Arun

Asian journal of psychiatry

2023 Volume 91, Page(s) 103856

Abstract: Background: Electroconvulsive therapy (ECT) is a well-accepted intervention for treatment-resistant, serious mental illnesses. Its acceptability, efficacy, and tolerability are well documented in high-income settings, but less so in lower- and middle- ... ...

Abstract	Background: Electroconvulsive therapy (ECT) is a well-accepted intervention for treatment-resistant, serious mental illnesses. Its acceptability, efficacy, and tolerability are well documented in high-income settings, but less so in lower- and middle-income countries (LMICs). This report is a narrative review of ECT practice in the latter setting. Methods: A literature search was conducted using Medline and PubMed. Initial results yielded 81 publications in English. Following the screening, 19 papers were included to evaluate the information on ECT practice and perceptions. Results: Reports from LMICs on efficacy, tolerability, and perceptions of ECT were relatively sparse. In general, they confirm its use mostly for treatment-resistant major mental illnesses (i.e., depression, schizophrenia, bipolar disorder). Both modified and unmodified forms of ECT are used and considered equally effective, although the former is better tolerated. Use of unmodified ECT remains significant in LMICs due to its low cost and limited resource requirements. In general, there is satisfaction with ECT and its outcomes. The education of patients and families, content process, and research have been noted as areas to improve. Conclusions: ECT is perceived as an effective intervention in LMICs, but use of unmodified ECT remains controversial. There is a need for the development and use of global guidelines to improve clinician training, knowledge sharing with patients and their families, and outcome research.
MeSH term(s)	Humans ; Electroconvulsive Therapy/methods ; Developing Countries ; Schizophrenia/therapy ; Bipolar Disorder/therapy ; Surveys and Questionnaires ; Treatment Outcome
Language	English
Publishing date	2023-12-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2023.103856
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Book ; Online: From External to Swap Regret 2.0

Dagan, Yuval / Daskalakis, Constantinos / Fishelson, Maxwell / Golowich, Noah

An Efficient Reduction and Oblivious Adversary for Large Action Spaces

2023

Abstract: ... regret is bounded by {\epsilon} after $\log(N)^{O(1/\epsilon)}$ rounds and with $O(N)$ per iteration ... Lugosi require $O(N/\epsilon^2)$ rounds and at least $\Omega(N^2)$ per iteration complexity. Our result ... that the number of rounds must be $\tilde\Omega(N/\epsilon^2)$ or exponential in $1/\epsilon$. Our reduction ...

Abstract	We provide a novel reduction from swap-regret minimization to external-regret minimization, which improves upon the classical reductions of Blum-Mansour [BM07] and Stolz-Lugosi [SL05] in that it does not require finiteness of the space of actions. We show that, whenever there exists a no-external-regret algorithm for some hypothesis class, there must also exist a no-swap-regret algorithm for that same class. For the problem of learning with expert advice, our result implies that it is possible to guarantee that the swap regret is bounded by {\epsilon} after $\log(N)^{O(1/\epsilon)}$ rounds and with $O(N)$ per iteration complexity, where $N$ is the number of experts, while the classical reductions of Blum-Mansour and Stolz-Lugosi require $O(N/\epsilon^2)$ rounds and at least $\Omega(N^2)$ per iteration complexity. Our result comes with an associated lower bound, which -- in contrast to that in [BM07] -- holds for oblivious and $\ell_1$-constrained adversaries and learners that can employ distributions over experts, showing that the number of rounds must be $\tilde\Omega(N/\epsilon^2)$ or exponential in $1/\epsilon$. Our reduction implies that, if no-regret learning is possible in some game, then this game must have approximate correlated equilibria, of arbitrarily good approximation. This strengthens the folklore implication of no-regret learning that approximate coarse correlated equilibria exist. Importantly, it provides a sufficient condition for the existence of correlated equilibrium which vastly extends the requirement that the action set is finite, thus answering a question left open by [DG22; Ass+23]. Moreover, it answers several outstanding questions about equilibrium computation and learning in games.
Keywords	Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; Computer Science - Computer Science and Game Theory
Subject code	005
Publishing date	2023-10-30
Publishing country	us
Document type	Book ; Online
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Article ; Online: Within-subject reliability of concurrent TMS-fMRI during a single session.

Hawco, Colin / Steeves, Jennifer K E / Voineskos, Aristotle N / Blumberger, Daniel M / Daskalakis, Zafiris J

Psychophysiology

2023 Volume 60, Issue 7, Page(s) e14252

Abstract: Concurrent transcranial magnetic stimulation with functional MRI (concurrent TMS-fMRI) allows real-time causative probing of brain connectivity. However, technical challenges, safety, and tolerability may limit the number of trials employed during a ... ...

Abstract	Concurrent transcranial magnetic stimulation with functional MRI (concurrent TMS-fMRI) allows real-time causative probing of brain connectivity. However, technical challenges, safety, and tolerability may limit the number of trials employed during a concurrent TMS-fMRI experiment. We leveraged an existing data set with 100 trials of active TMS compared to a sub-threshold control condition to assess the reliability of the evoked BOLD response during concurrent TMS-fMRI. This data will permit an analysis of the minimum number of trials that should be employed in a concurrent TMS-fMRI protocol in order to achieve reliable spatial changes in activity. Single-subject maps of brain activity were created by splitting the trials within the same experimental session into groups of 50, 40, 30, 25, 20, 15, or 10 trials, correlations (R) between t-maps derived from paired subsets of trials within the same individual were calculated as reliability. R was moderate-high for 50 trials (mean R = .695) and decreased as the number of trials decreased. Consistent with previous findings of high individual variability in the spatial patterns of evoked neuronal changes following a TMS pulse, the spatial pattern of Rs differed across participants, but regional R was correlated with the magnitude of TMS-evoked activity. These results demonstrate concurrent TMS-fMRI produces a reliable pattern of activity at the individual level at higher trial numbers, particularly within localized regions. The spatial pattern of reliability is individually idiosyncratic and related to the individual pattern of evoked changes.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Brain Mapping/methods ; Reproducibility of Results ; Brain/diagnostic imaging ; Brain/physiology ; Transcranial Magnetic Stimulation/methods ; Evoked Potentials, Motor/physiology
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209486-1
ISSN	1540-5958 ; 0048-5772
ISSN (online)	1540-5958
ISSN	0048-5772
DOI	10.1111/psyp.14252
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Book ; Online: Gated-ViGAT

Gkalelis, Nikolaos / Daskalakis, Dimitrios / Mezaris, Vasileios

Efficient Bottom-Up Event Recognition and Explanation Using a New Frame Selection Policy and Gating Mechanism

2023

Abstract: In this paper, Gated-ViGAT, an efficient approach for video event recognition, utilizing bottom-up (object) information, a new frame sampling policy and a gating mechanism is proposed. Specifically, the frame sampling policy uses weighted in-degrees ( ... ...

Abstract	In this paper, Gated-ViGAT, an efficient approach for video event recognition, utilizing bottom-up (object) information, a new frame sampling policy and a gating mechanism is proposed. Specifically, the frame sampling policy uses weighted in-degrees (WiDs), derived from the adjacency matrices of graph attention networks (GATs), and a dissimilarity measure to select the most salient and at the same time diverse frames representing the event in the video. Additionally, the proposed gating mechanism fetches the selected frames sequentially, and commits early-exiting when an adequately confident decision is achieved. In this way, only a few frames are processed by the computationally expensive branch of our network that is responsible for the bottom-up information extraction. The experimental evaluation on two large, publicly available video datasets (MiniKinetics, ActivityNet) demonstrates that Gated-ViGAT provides a large computational complexity reduction in comparison to our previous approach (ViGAT), while maintaining the excellent event recognition and explainability performance. Gated-ViGAT source code is made publicly available at https://github.com/bmezaris/Gated-ViGAT Comment: Accepted for publication in the proceedings of IEEE Int. Symposium on Multimedia (ISM), Naples, Italy, Dec. 2022
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	004
Publishing date	2023-01-18
Publishing country	us
Document type	Book ; Online
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