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Article ; Online: Mutation rate of AmpC-β-lactamase-producing Enterobacterales and treatment in clinical practice: A word of caution.

Maillard, Alexis / Dortet, Laurent / Delory, Tristan / Lafaurie, Matthieu / Bleibtreu, Alexandre

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Abstract: In a retrospective multicenter study of 575 patients with bloodstream infections or pneumonia due to wild-type AmpC β-lactamase-producing Enterobacterales, species with low in-vitro mutation rates for AmpC derepression were associated to fewer treatment ... ...

Abstract	In a retrospective multicenter study of 575 patients with bloodstream infections or pneumonia due to wild-type AmpC β-lactamase-producing Enterobacterales, species with low in-vitro mutation rates for AmpC derepression were associated to fewer treatment failures due to AmpC overproduction (aHR 0.5, 95%CI 0.2-0.9). However, compared to cefepime/carbapenems using 3GC as definitive therapy remained associated with this adverse outcome (15% vs. 1%).
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae160
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Zs.MO 480: Show issues

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Article ; Online: Postoperative infections after sinus lifts and onlay grafts in penicillin allergic patients.

Boussaïd, Mehdi / Samama, Mickael / Foy, Jean Philippe / Bleibtreu, Alexandre / Bertolus, Chloé / Gellee, Timothée

Journal of stomatology, oral and maxillofacial surgery

2024 Volume 125, Issue 5, Page(s) 101764

Abstract: Introduction: The primary objective of this retrospective study was to determine whether patients treated with clindamycin due to a reported allergy to penicillin have an increased risk of postsurgical infections after sinus lifts and onlay grafts.: ... ...

Abstract	Introduction: The primary objective of this retrospective study was to determine whether patients treated with clindamycin due to a reported allergy to penicillin have an increased risk of postsurgical infections after sinus lifts and onlay grafts. Material and methods: A retrospective cohort study was performed on patients who underwent bone reconstruction procedures between October 2018 and December 2020. Data from all patients operated at the Pitié Salpêtrière University Hospital for sinus lifts or onlay grafts were collected. All surgical procedures studied were performed under preoperative and postoperative antibiotic prophylaxis with either amoxicillin (+/- clavulanic acid) or clindamycin for patients with reported penicillin allergy. Bone graft-associated infections as well as graft failures were recorded. Results: In this study, 111 patients received bone reconstructions (89 sinus lifts and 148 onlay grafts). In the sinus lifts group, infections occurred in 5 of 89 sites (5.6 %). The infection rate was 28.5 % (7 graft sites) and only 3.9 % (82 graft sites) for clindamycin and for amoxicillin, respectively. In the onlay graft group, infections occurred in 25 of 148 sites (16.8 %). The infection rate was 56 % and only 12 % for clindamycin (18 graft sites) and for amoxicillin, respectively (130 graft sites). Non-Penicillin treated patients had a higher risk of infection with an odd ratio of 7.8 (95 % CI 1.1-54.8, P = 0.04) and 4.8 (95 % CI 1.9-12.3, P = 0.001) compared with patients receiving amoxicillin for onlay grafts and sinus lifts. Conclusion: Penicillin allergy and clindamycin use after sinus lift and onlay graft procedures were associated with a higher rate of infection and may be a risk factor for complications related to bone reconstruction surgery.
Language	English
Publishing date	2024-01-11
Publishing country	France
Document type	Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2024.101764
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Article: Impact of clinical pharmacist interventions in a bone and joint infection orthoseptic surgery unit.

Coiffard, Julie / Aubry, Alexandra / Bleibtreu, Alexandre / Fourniols, Eric / Junot, Helga

Annales pharmaceutiques francaises

2023 Volume 81, Issue 5, Page(s) 826–832

Abstract: Objectives: To assess the impact of interventions of a clinical pharmacist in a unit of orthopedic surgery specialized in bone and joint infections.: Methods: Daily, in routine, a clinical pharmacist analyzed medication prescribed to inpatients via a ...

Abstract	Objectives: To assess the impact of interventions of a clinical pharmacist in a unit of orthopedic surgery specialized in bone and joint infections. Methods: Daily, in routine, a clinical pharmacist analyzed medication prescribed to inpatients via a computerized physician order entry (CPOE) (Phedra software). His attention was particularly focused on the impact of antibiotics on other medications. For this study, all of the pharmacist interventions (PI) have been retrospectively collected, then anonymized, and assessed over a two-month period. Results: Thirty-eight patients were hospitalized during the study period, with a mean age of 63 years old. Forty-five interventions were identified which represents a mean of 1.18 pharmaceutical interventions per patient. Most of them concerned lack of follow-up (24%) and drug-drug interactions (22%) and widely non-anti-infectious medication (35 interventions) with levothyroxine (10 interventions) as the most involved non-anti-infectious molecule. Among antibiotics, with respectively 9 and 8 interventions, rifampicin and fluoroquinolones (6 interventions for moxifloxacin) were the most concerned notably for drug-drug interactions with usual treatment. Conclusion: In this observational retrospective study, 1.18 pharmacist interventions (PI) per patient were observed. Most of them are lack of follow-up and drug-drug interactions especially with usual treatment of patients. Moxifloxacin and rifampicin were the most antibiotics involved. Patients' characteristics (older, polypharmacy), long-term hospitalization and surgery are known to be predictive factors of medication errors and this study highlights the importance of the presence of clinical pharmacist in orthopedic surgery wards.
MeSH term(s)	Humans ; Middle Aged ; Retrospective Studies ; Pharmacists ; Moxifloxacin ; Rifampin ; Anti-Bacterial Agents/therapeutic use ; Pharmacy Service, Hospital
Chemical Substances	Moxifloxacin (U188XYD42P) ; Rifampin (VJT6J7R4TR) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-04-17
Publishing country	France
Document type	Observational Study ; Journal Article
ZDB-ID	307-4
ISSN	0003-4509
ISSN	0003-4509
DOI	10.1016/j.pharma.2023.04.004
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Zs.A 223: Show issues

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Article ; Online: Service-, needs-, and quality-based hospital capacity planning - The evolution of a revolution in Switzerland.

Bleibtreu, Elena / von Ahlen, Christine / Geissler, Alexander

Health policy (Amsterdam, Netherlands)

2022 Volume 126, Issue 12, Page(s) 1277–1282

Abstract: Most developed countries spend a large amount of their health budget on hospital capacities and inpatient services. However, those capacities and services are often not comprehensively planned what leads to vague service delivery steering and non-need ... ...

Abstract	Most developed countries spend a large amount of their health budget on hospital capacities and inpatient services. However, those capacities and services are often not comprehensively planned what leads to vague service delivery steering and non-need driven hospital facilities. Switzerland is different as the planning procedure was completely reformed in 2012 and is further refined in 2021/2022. The Canton of Zurich, the frontrunner in Switzerland, has made a comprehensive update of its hospital capacity planning model for acute, psychiatric, and rehabilitative care. The result of this model is the hospital list. This list includes all hospitals which fulfill predefined quality, efficiency, and need requirements. Hospitals on the list receive a mandate to provide inpatient treatments for specific and selected service groups (n = 196), clustered in three areas (acute care, psychiatry, rehabilitation). The underlying health care policy process is transparent and is characterized by a high participation of all relevant actors. The building blocks of the planning model are a classification system of service groups, different quality and efficiency requirements attached to these groups, and an analysis of current and future need for health care. Hospitals which are willing to perform services must apply and demonstrate that the requirements are fulfilled. The canton then decides needs-based which hospital can deliver which services.
MeSH term(s)	Humans ; Switzerland ; Delivery of Health Care ; Hospitalization ; Hospitals
Language	English
Publishing date	2022-09-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605805-x
ISSN	1872-6054 ; 0168-8510
ISSN (online)	1872-6054
ISSN	0168-8510
DOI	10.1016/j.healthpol.2022.09.011
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Zs.B 2250: Show issues

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Article: Naissance d’un groupe transdisciplinaire français dédié à la phagothérapie !

Bleibtreu, Alexandre / Debarbieux, Laurent / Froissart, Rémy / Gilmer, David / Laurent, Frédéric / Torres-Barceló, Clara

Virologie (Montrouge, France)

2023 Volume 27, Issue 4, Page(s) 217–218

Title translation	The French "Phage therapy" transdisciplinary group is born!
MeSH term(s)	Bacteriophages ; Phage Therapy
Language	French
Publishing date	2023-08-10
Publishing country	France
Document type	Editorial
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/vir.2023.1014
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Article ; Online: Drug-Resistant Bacteremia after Fecal Microbiota Transplant.

Bleibtreu, Alexandre / Kapel, Nathalie / Galperine, Tatiana

The New England journal of medicine

2020 Volume 382, Issue 20, Page(s) 1961

MeSH term(s)	Bacteremia ; Escherichia coli ; Fecal Microbiota Transplantation ; Humans ; Microbiota
Language	English
Publishing date	2020-04-28
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2002496
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Article ; Online: Antibiotic Stewardship in Treatment of Osteoarticular Infections Based on Local Epidemiology and Bacterial Growth Times.

Vidal, Pauline / Fourniols, Eric / Junot, Helga / Meloni, Cyril / Bleibtreu, Alexandre / Aubry, Alexandra

Microbiology spectrum

2022 Volume 10, Issue 6, Page(s) e0143022

Abstract: Incubation for 14 days is recommended for the culture of microorganisms from osteoarticular infections (OAI), but there are no recommendations for postoperative antibiotic stewardship concerning empirical antimicrobial therapy (EAT), while prolonging ... ...

Abstract	Incubation for 14 days is recommended for the culture of microorganisms from osteoarticular infections (OAI), but there are no recommendations for postoperative antibiotic stewardship concerning empirical antimicrobial therapy (EAT), while prolonging broad-spectrum EAT results in adverse effects. The aim of this study was to describe the local OAI epidemiology with consideration of bacterial growth times to determine which antibiotic stewardship intervention should be implemented in cases of negative culture after 2 days of incubation. We performed a 1-year, single-center, noninterventional cohort study at the Pitié-Salpêtrière hospital OAI reference center. Samples were taken as part of the local standard of care protocol for adult patients who underwent surgery for OAI (native or device related) and received EAT (i.e., piperacillin-tazobactam plus daptomycin [PTD]) following surgery. The time to culture positivity was monitored daily. Overall, 147 patients were recruited, accounting for 151 episodes of OAI, including 112 device-related infections. Microbiological cultures were positive in 144 cases, including 42% polymicrobial infections. Overall, a definitive microbiological result was obtained within 48 h in 118 cases (78%) and within 5 days in 130 cases (86%). After 5 days, only Gram-positive bacteria were recovered, especially Cutibacterium acnes, Staphylococcus spp., and Streptococcus spp. Overall, 90% of culture-positive OAI were correctly treated with the locally established EAT. EAT guidance for OAI was in agreement with our local epidemiology. Our results supported antibiotic stewardship intervention consisting of stopping piperacillin-tazobactam treatment at day 5 in cases of negative culture.
MeSH term(s)	Adult ; Humans ; Cohort Studies ; Microbial Sensitivity Tests ; Antimicrobial Stewardship ; Mycobacterium tuberculosis ; Anti-Bacterial Agents/therapeutic use ; Piperacillin, Tazobactam Drug Combination
Chemical Substances	Anti-Bacterial Agents ; Piperacillin, Tazobactam Drug Combination (157044-21-8)
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01430-22
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Article ; Online: Fungal versus non-fungal supra-inguinal prosthetic vascular graft infections: A cohort study.

Monnier, Baptiste / Couture, Thibault / Dechartres, Agnès / Sitruk, Samuel / Gaillard, Johann / Bleibtreu, Alexandre / Chiche, Laurent / Gaudric, Julien / Arzoine, Jérémy

Infectious diseases now

2023 Volume 54, Issue 1, Page(s) 104792

Abstract: Objectives: Fungal prosthetic vascular graft infections are rare and mainly supra-inguinal. Current guidelines are based on the few studies that have specifically investigated this population, with few risk factors described. The objective of this study ...

Abstract	Objectives: Fungal prosthetic vascular graft infections are rare and mainly supra-inguinal. Current guidelines are based on the few studies that have specifically investigated this population, with few risk factors described. The objective of this study is to compare fungal and non-fungal supra-inguinal prosthetic vascular graft infections (PVGI), describing their specificities, identifying risk factors, and evaluating outcomes. Patients and methods: This is a single-center retrospective cohort study carried out at the Pitié-Salpêtrière Hospital in Paris, including all patients who were treated for a supra-inguinal PVGI between January 1st, 2009 and February 28th, 2021. Preoperative, intraoperative and postoperative data were compared between fungal and non-fungal PVGI. Results: Out of the 475 patients screened, 148 developed a supra-inguinal PVGI: 32 fungal and 116 non-fungal. Factors independently associated with fungal PVGI were presence of a prostheto-digestive fistula (OR 5.98; 95% CI 2.29-15.62) and preoperative antibiotic therapy of seven days or more (OR 2.87; 95% CI 1.12-7.38). Mortality rate at 180 days was significantly higher for fungal as compared to non-fungal PVGIs (38% vs. 16% p = 0.009) and for fungal PVGI with prostheto-digestive fistula. However, there was no statistically significant relation between mortality due to prostheto-digestive fistula in contrast with fungal PVGI alone (p = 0.21). Conclusion: Prostheto-digestive fistula was strongly associated with fungal PVGI, which leads us to suggest that in such cases, an anti-fungal agent should be prescribed.
MeSH term(s)	Humans ; Blood Vessel Prosthesis Implantation/adverse effects ; Cohort Studies ; Blood Vessel Prosthesis/adverse effects ; Retrospective Studies ; Fistula/etiology
Language	English
Publishing date	2023-09-28
Publishing country	France
Document type	Journal Article
ISSN	2666-9919
ISSN (online)	2666-9919
DOI	10.1016/j.idnow.2023.104792
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Article ; Online: Pneumocystis prophylaxis in French heart transplant centers: A nationwide survey.

Aggoun, Dahlia / Bleibtreu, Alexandre / Desiré, Eva / Lecuyer, Lucien / Leprince, Pascal / Varnous, Shaida / Coutance, Guillaume / Lescroart, Mickael

Transplant infectious disease : an official journal of the Transplantation Society

2023 Volume 25, Issue 3, Page(s) e14053

MeSH term(s)	Humans ; Pneumocystis ; Pneumonia, Pneumocystis/prevention & control ; Heart Transplantation/adverse effects ; Pneumocystis carinii ; Retrospective Studies
Language	English
Publishing date	2023-03-07
Publishing country	Denmark
Document type	Letter
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.14053
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Zs.A 5100: Show issues

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Article ; Online: Imported malaria in metropolitan France, from recommendations to clinical practice - proposal for improvement.

Dupré, A / Argy, N / Houze, S / Leleu, A / Choquet, C / Matheron, S / Bleibtreu, A

Infectious diseases now

2021 Volume 51, Issue 8, Page(s) 667–672

Abstract: Background: Approximately 5000 cases of imported malaria are observed each year in metropolitan France. Guidelines for the prevention and management of imported malaria were published by the French infectious disease society (French acronym SPILF) in ... ...

Abstract	Background: Approximately 5000 cases of imported malaria are observed each year in metropolitan France. Guidelines for the prevention and management of imported malaria were published by the French infectious disease society (French acronym SPILF) in 2017. Objective: Study objective was to describe in a retrospective analysis (2015-2016) imported malaria cases recorded in a Parisian hospital, to analyze the congruence to previous guidelines (2014), deviation in respect to post hoc published guidelines and potential areas for improvement. Results: Two hundred and one cases were analyzed using medical charts. There was a majority of men (sex ratio 2/1), with a mean age of 43 years at diagnosis. The main area of infection acquisition was sub-Saharan Africa (97%). The average time since return from the endemic area was 20 days. Patients consulted the emergency department for flu-like syndrome (32%), fever or chills (28%), and gastrointestinal symptoms (22%). Blood smears mainly identified Plasmodium falciparum (n=180, 90%). There were 52 (26%) severe malaria episodes. Conclusion: The analysis of national guideline adequacy highlighted difficulties in obtaining a complete biological workup at baseline, managing patients with vomiting, and in the post-treatment follow-up.
MeSH term(s)	Adult ; Antimalarials/therapeutic use ; France/epidemiology ; Humans ; Malaria/diagnosis ; Male ; Retrospective Studies ; Travel
Chemical Substances	Antimalarials
Language	English
Publishing date	2021-08-28
Publishing country	France
Document type	Journal Article
ISSN	2666-9919
ISSN (online)	2666-9919
DOI	10.1016/j.idnow.2021.08.002
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