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  1. Article ; Online: CTLA4Ig Limits Both Incidence and Severity of Early Cytokine Release Syndrome following Haploidentical Peripheral Blood Stem Cell Transplantation.

    Jaiswal, Sarita Rani / Chakrabarti, Suparno

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2020  Volume 26, Issue 4, Page(s) e86–e87

    MeSH term(s) Cytokine Release Syndrome ; Graft vs Host Disease/etiology ; Humans ; Incidence ; Peripheral Blood Stem Cell Transplantation/adverse effects ; Transplantation, Haploidentical
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2019.12.767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5082: Show issues Location:
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  2. Article ; Online: Long-Term Follow-Up of Abatacept, Post-Transplantation Cyclophosphamide, and Sirolimus-Based Haploidentical Transplantation in Younger Patients with Nonmalignant Diseases.

    Jaiswal, Sarita Rani / Agarwal, Mahak / Bhagawati, Gitali / Das, Bhudev Chandra / Baligar, Prakash / Garg, Manoj / Biswas, Subhrajit / Chakrabarti, Suparno

    Transplantation and cellular therapy

    2024  

    Abstract: Haploidentical (haplo) hematopoietic cell transplantation (HCT) for nonmalignant disease (NMD) carries inherent challenges of both alloreactivity and graft failure. Building on promising results from pilot studies in which abatacept was combined with ... ...

    Abstract Haploidentical (haplo) hematopoietic cell transplantation (HCT) for nonmalignant disease (NMD) carries inherent challenges of both alloreactivity and graft failure. Building on promising results from pilot studies in which abatacept was combined with post-transplantation cyclophosphamide (PTCy) and sirolimus (AbaCyS) in younger NMD patients undergoing haplo-HCT, we present the long-term outcomes of this protocol. On the back of uniform disease-specific conditioning regimens containing antithymocyte globulin 4.5 mg/kg from day -9 to day -7, GVHD prophylaxis with AbaCyS consisted of abatacept administered on days 0, +5, +20, +35, and monthly until 180 days with PTCy and sirolimus. The patients were followed up with longitudinal assessment of immune reconstitution, growth, and reproductive development and quality of life (QoL) analyses. Among 40 patients (aplastic anemia, n = 24; hemoglobinopathies, n = 14; and primary immunodeficiencies, n = 2) with a median age of 10 years (range, 2 to 25 years), 95% achieved sustained engraftment. Post-transplantation hemophagocytic syndrome was detected in 3 patients, leading to graft failure in 2 cases. The incidence of acute graft-versus-host disease (GVHD) was 2.6%, and that of chronic GVHD (cGVHD) was 14.3%. Cytomegalovirus, adenovirus, and Epstein-Barr virus infections were observed in 45%, 5%, and 0% respectively. Rates of nonrelapse mortality, overall survival, event-free survival, and GVHD-free, event-free survival were 5%, 95%, 90%, and 82%, respectively, at a median follow-up of 4.6 years. Absence of cGVHD correlated with younger patient age and early sustained recovery of regulatory T cells and mature natural killer cells, which in turn was associated with improved QoL and lack of late infections. The AbaCyS protocol was associated with excellent long-term survival, with attenuation of both early and late alloreactivity in >80% of younger patients undergoing haplo-HCT for NMD. This study sheds light on predispositions to cGVHD and its impact on QoL, warranting further optimization of this approach.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2024.03.010
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  3. Article ; Online: Immunohistochemical Characterisation of Cell of Origin in Diffuse Large B-cell Lymphoma and its Association with the Double Expressor Phenotype

    Prachi / Hemamalini Aiyer / Gaurav Sharma / Suparno Chakrabarti / Sarita Rani Jaiswal

    Journal of Clinical and Diagnostic Research, Vol 16, Iss 5, Pp EC15-EC

    A Retrospective Study

    2022  Volume 18

    Abstract: Introduction: Diffuse Large B-cell Lymphoma (DLBCL) is the most common type of Non-Hodgkin Lymphoma (NHL) and is categorised into the Germinal Centre B-cell (GCB) and Activated B-cell (ABC/Non GCB) subtypes as per the Cell Of Origin (COO) model with the ... ...

    Abstract Introduction: Diffuse Large B-cell Lymphoma (DLBCL) is the most common type of Non-Hodgkin Lymphoma (NHL) and is categorised into the Germinal Centre B-cell (GCB) and Activated B-cell (ABC/Non GCB) subtypes as per the Cell Of Origin (COO) model with the help of gene expression profiling/immunohistochemistry. The non GCB subtype has been found to associate with the Double Expressor (DE) phenotype (i.e., co-expression of BCL-2 and c-myc by IHC and this association was substantiated and proven to be statistically significant in the present study. Aim: To categorise all DLBCL cases into GCB and Non GCB and further into DE and Non-DE by using Hans and Choi IHC alogrithm. Materials and Methods: A retrospective study of 50 patients was carried out with the help of archival material filed in the Department of Anatomic Pathology at Dharamshila Narayana Superspeciality Hospital, New Delhi, India from 1st January 2019 to 30th June 2020. The study was approved by Instituitional Ethics Committee (IEC). The study cohort was divided into two groups- group A with nodal presentation and group B with extranodal presentation. By using the Hans and Choi IHC algorithms, the cases were categorised into the GCB and non GCB subtypes in both the groups. Chi-square test and Yates correction were used for statistical analysis. Results: The median age at presentation was 49 years (20-81 years) with a male to female ratio of 2.3:1 (35 males and 15 females). Group A with nodal disease included 28 patients and group B with extranodal disease included 22 patients. The DE phenotype was determined in each case by the co-expression of c-myc (>40%) and BCL-2 (>50%) by IHC. By using the statistical chi-square test analysis and Yates correction, the association of DE was found to be statistically significant with non GCB type lymphomas and non DE with GCB lymphomas with p-value being 0.0005 and 0.00168, respectively. Conclusion: Due to the heterogeneity inherent in DLBCL, prediction of the DE phenotype and the COO by IHC is a sensitive tool ...
    Keywords cell of origin model ; hans and choi algorithm ; immunohistochemistry ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Natural killer cell-based immunotherapy with CTLA4Ig-primed donor lymphocytes following haploidentical transplantation.

    Jaiswal, Sarita Rani / Chakrabarti, Suparno

    Immunotherapy

    2019  Volume 11, Issue 14, Page(s) 1221–1230

    Abstract: NK cell-based immunotherapy is one of the more exciting propositions in the field of cellular therapy for hematological malignancies. Current protocols are largely based on expanded and activated NK cells which are used both with and without allogeneic ... ...

    Abstract NK cell-based immunotherapy is one of the more exciting propositions in the field of cellular therapy for hematological malignancies. Current protocols are largely based on expanded and activated NK cells which are used both with and without allogeneic transplantation. Based on our recent findings, we discuss the concept of CTLA4Ig-primed donor lymphocyte infusions following haploidentical transplantation as an effective tool to garner NK cell-mediated antitumor effect with abrogation of T cell-mediated alloreactivity. This approach might widen the possibility of immunotherapy following haploidentical transplantation without increase in graft-versus-host disease. Further studies would be needed to establish the veracity of this concept with better understanding of the antitumor effect via this pathway. Future studies would decide if CTLA4Ig might be used to augment NK-cell activation
    MeSH term(s) Abatacept/therapeutic use ; Graft vs Host Disease/immunology ; Graft vs Host Disease/pathology ; Graft vs Host Disease/prevention & control ; Hematologic Neoplasms/immunology ; Hematologic Neoplasms/pathology ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunotherapy ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Lymphocyte Transfusion ; Tissue Donors ; Transplantation, Haploidentical
    Chemical Substances Abatacept (7D0YB67S97)
    Language English
    Publishing date 2019-09-03
    Publishing country England
    Document type Journal Article
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt-2019-0037
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  5. Article: Allogeneic Hematopoietic Stem Cell Transplantation for Myeloma: Time for an Obituary or Not Just Yet!

    Jaiswal, Sarita Rani / Chakrabarti, Suparno

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2019  Volume 35, Issue 3, Page(s) 416–422

    Abstract: The management of myeloma has evolved dramatically in the last two decades. High dose melphalan and autologous hematopoietic stem cell transplantation (HSCT) marked the beginning of this journey. This was followed by an explosion of novel agents which ... ...

    Abstract The management of myeloma has evolved dramatically in the last two decades. High dose melphalan and autologous hematopoietic stem cell transplantation (HSCT) marked the beginning of this journey. This was followed by an explosion of novel agents which were approved for management of myeloma. Allogeneic HSCT which was deemed as the only curative option was largely abhorred due to high transplant-related mortality (TRM) until the advent of reduced intensity conditioning (RIC). An approach of tandem autologous and RIC-allogeneic transplantations has showed the best promise for cure for this condition, particularly for those with high-risk cytogenetics. Yet, allogeneic HSCT seems to have fallen out of favor due to the projected high TRM and late relapses, even though the alternatives do not offer a cure, but merely prolong survival. Offering an allogeneic HSCT as a final resort in unlikely to yield gratifying results. At the same time, allogeneic HSCT needs to evolve in a disease-specific manner to address the relevant concerns regarding TRM and relapse. With the introduction of effective GVHD prophylaxis in the form of post-transplantation cyclophosphamide, transplantation from a haploidentical family donor has become a reality. The challenge lies in segregating graft-vs-myeloma effect from a graft-versus-host effect. We discuss the pro-survival and anti-apoptotic pathways via CD28-CD86 interactions which confer survival advantages to myeloma cells and the possibility of disruption of this pathway in the context of haploidentical transplantation through the use of CTLA4Ig without incurring T cell alloreactivity.
    Language English
    Publishing date 2019-01-23
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-019-01077-x
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  6. Article: Augmenting Vaccine Efficacy against Delta Variant with 'Mycobacterium-

    Jaiswal, Sarita Rani / Saifullah, Ashraf / Arunachalam, Jaganath / Lakhchaura, Rohit / Tailor, Dhanir / Mehta, Anupama / Bhagawati, Gitali / Aiyer, Hemamalini / Biswas, Subhrajit / Khamar, Bakulesh / Malhotra, Sanjay V / Chakrabarti, Suparno

    Vaccines

    2023  Volume 11, Issue 2

    Abstract: Mycobacterium- ...

    Abstract Mycobacterium-
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11020328
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  7. Article: Focusing On A Unique Innate Memory Cell Population Of Natural Killer Cells In The Fight Against COVID-19: Harnessing The Ubiquity Of Cytomegalovirus Exposure.

    Jaiswal, Sarita Rani / Malhotra, Pankaj / Mitra, Dipendra K / Chakrabarti, Suparno

    Mediterranean journal of hematology and infectious diseases

    2020  Volume 12, Issue 1, Page(s) e2020047

    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2020.047
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  8. Article ; Online: Discovery, SAR and mechanistic studies of quinazolinone-based acetamide derivatives in experimental visceral leishmaniasis.

    Ansari, Alisha / Seth, Anuradha / Dutta, Mukul / Qamar, Tooba / Katiyar, Sarita / Jaiswal, Arvind K / Rani, Ankita / Majhi, Swetapadma / Kumar, Mukesh / Bhatta, Rabi S / Guha, Rajdeep / Mitra, Kalyan / Sashidhara, Koneni V / Kar, Susanta

    European journal of medicinal chemistry

    2023  Volume 257, Page(s) 115524

    Abstract: Towards identification of novel therapeutic candidates, a series of quinazolinone-based acetamide derivatives were synthesized and assessed for their anti-leishmanial efficacy. Amongst synthesized derivatives, compounds F12, F27 and F30 demonstrated ... ...

    Abstract Towards identification of novel therapeutic candidates, a series of quinazolinone-based acetamide derivatives were synthesized and assessed for their anti-leishmanial efficacy. Amongst synthesized derivatives, compounds F12, F27 and F30 demonstrated remarkable activity towards intracellular L. donovani amastigotes in vitro, with IC
    MeSH term(s) Cricetinae ; Animals ; Mice ; Leishmaniasis, Visceral/drug therapy ; Leishmaniasis, Visceral/metabolism ; Leishmania donovani ; Quinazolinones/pharmacology ; Quinazolinones/therapeutic use ; Quinazolinones/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/therapeutic use ; Acetamides/pharmacology ; Acetamides/therapeutic use ; Acetamides/metabolism ; Mice, Inbred BALB C
    Chemical Substances Quinazolinones ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Antiprotozoal Agents ; Acetamides
    Language English
    Publishing date 2023-06-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115524
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  9. Article: Limiting the Impact of Methicillin-Resistant

    Jaiswal, Sarita Rani / Bhagwati, Gitali / Aiyer, Hema Malini / Sharma, Navneet / Chakrabarti, Suparno

    Mediterranean journal of hematology and infectious diseases

    2020  Volume 12, Issue 1, Page(s) e2020024

    Language English
    Publishing date 2020-05-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2020.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Haploidentical Transplantation in Children with Acute Leukemia: The Unresolved Issues.

    Jaiswal, Sarita Rani / Chakrabarti, Suparno

    Advances in hematology

    2016  Volume 2016, Page(s) 3467672

    Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) remains a curative option for children with high risk and advanced acute leukemia. Yet availability of matched family donor limits its use and although matched unrelated donor or mismatched ... ...

    Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) remains a curative option for children with high risk and advanced acute leukemia. Yet availability of matched family donor limits its use and although matched unrelated donor or mismatched umbilical cord blood (UCB) are viable options, they fail to meet the global need. Haploidentical family donor is almost universally available and is emerging as the alternate donor of choice in adult patients. However, the same is not true in the case of children. The studies of haploidentical HSCT in children are largely limited to T cell depleted grafts with not so encouraging results in advanced leukemia. At the same time, emerging data from UCBT are challenging the existing paradigm of less stringent HLA match requirements as perceived in the past. The use of posttransplantation cyclophosphamide (PTCY) has yielded encouraging results in adults, but data in children is sorely lacking. Our experience of using PTCY based haploidentical HSCT in children shows inadequacy of this approach in younger children compared to excellent outcome in older children. In this context, we discuss the current status of haploidentical HSCT in children with acute leukemia in a global perspective and dwell on its future prospects.
    Language English
    Publishing date 2016-03-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2494501-8
    ISSN 1687-9112 ; 1687-9104
    ISSN (online) 1687-9112
    ISSN 1687-9104
    DOI 10.1155/2016/3467672
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