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Article ; Online: Establishment of a risk prediction model for acute exacerbation in patients with chronic obstructive pulmonary disease.

Xie, Chengxin / Luan, Qiyun / Ma, Tao / Abudukadeer, Ayiguzali / Li, Feifei / Sun, Xin / Yu, Lin / Li, Li

2024

Language	English
Publishing date	2024-02-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123586-2
ISSN	1827-1669 ; 0026-4806
ISSN (online)	1827-1669
ISSN	0026-4806
DOI	10.23736/S0026-4806.24.09148-1
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Article: Delayed Diagnosis and Multi-TKI Intolerance: A Case Report of CML Concurrent With COVID-19.

Luan, Chengxin / Wang, Haixia / Zhou, Junjie / Ma, Xiaoyu / Long, Zhangbiao / Cheng, Xin / Chen, Xiaowen / Xia, Ruixiang / Ge, Jian

Frontiers in oncology

2022 Volume 12, Page(s) 921587

Abstract: Introduction: The hematological manifestations of corona virus disease 2019 (COVID-19) can confound the diagnosis and therapy of other diseases. In this paper, we firstly reported a case of chronic myeloid leukemia (CML) of delayed diagnosis and ... ...

Abstract	Introduction: The hematological manifestations of corona virus disease 2019 (COVID-19) can confound the diagnosis and therapy of other diseases. In this paper, we firstly reported a case of chronic myeloid leukemia (CML) of delayed diagnosis and intolerance to tyrosine kinase inhibitors (TKIs) concurrent with COVID-19. Case presentation: A 56-year-old female was diagnosed as COVID-19 with no obvious leukocytosis [white blood cell (WBC), ≤17 × 10 Conclusion: The offset effect between CML and SARS-CoV-2 infection was supposed to be the underlying mechanism for the absence of leukocytosis or splenomegaly. The impact of immune network by SARS-CoV-2 preserved and disrupted the patient's response to TKIs despite the virus' ablation. We suggest that a continued elevation of basophils may be a useful indicator for CML concurrent with COVID-19, and individualized treatment with adjusted dosage and suitable type of TKIs should be considered to improve the patient's health outcome.
Language	English
Publishing date	2022-06-08
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.921587
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Article ; Online: Dexamethasone enhances venetoclax-induced apoptosis in acute myeloid leukemia cells.

Wang, Haixia / Zhou, Junjie / Ma, Xiaoyu / Jiao, Changqing / Chen, Enbo / Wu, Zhonghui / Zhang, Yan / Pan, Mengya / Cui, Jianling / Luan, Chengxin / Ge, Jian

Medical oncology (Northwood, London, England)

2023 Volume 40, Issue 7, Page(s) 193

Abstract: Acute myeloid leukemia (AML) therapies have been significantly improved by the development of medicines that can target BCL-2. On the other hand, non-recurrent alterations in oncogenic pathways and gene expression patterns have already been linked to ... ...

Abstract	Acute myeloid leukemia (AML) therapies have been significantly improved by the development of medicines that can target BCL-2. On the other hand, non-recurrent alterations in oncogenic pathways and gene expression patterns have already been linked to therapeutic resistance to venetoclax therapy. Bone marrow mesenchymal stromal cells (BM-MSCs) support leukemic cells in preventing chemotherapy-induced apoptosis by mitochondrial transfer in leukemic microenvironment. In this study, we investigated the enhancement of the antitumor effect of BCL-2 inhibitor venetoclax by dexamethasone. In particular, dexamethasone had no significant effect on the viability of AML cells, but dexamethasone combined with venetoclax could significantly increase the apoptosis of AML cells induced by venetoclax. When AML cells were co-cultured with BM-MSCs, dexamethasone combined with venetoclax showed additional anti-tumor effect compared to venetoclax alone. Venetoclax increased reactive oxygen species level in co-cultured AML cells, contributed to transfer more mitochondria from BM-MSCs to AML cells and protect AML cells from apoptosis. Dexamethasone combined with venetoclax induced more apoptosis, but dexamethasone reduced the venetoclax-induced reactive oxygen species level in AML cells and reduced the transfer of mitochondria from BM-MSCs to AML cells. This may lead to a diminished protective effect of BM-MSCs on AML cells. Together, our findings indicated that venetoclax in combination with dexamethasone could be a promising therapy in AML.
MeSH term(s)	Humans ; Reactive Oxygen Species ; Leukemia, Myeloid, Acute/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Apoptosis ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Dexamethasone/pharmacology ; Tumor Microenvironment
Chemical Substances	venetoclax (N54AIC43PW) ; Reactive Oxygen Species ; Proto-Oncogene Proteins c-bcl-2 ; Bridged Bicyclo Compounds, Heterocyclic ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-023-02056-z
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Zs.A 1899: Show issues

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Article ; Online: IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein.

Wu, Yujing / Zhang, Aijun / Chen, Wensheng / Xin, Qianling / Pan, Wenwen / Hu, Xiaoxi / Li, Tao / Chen, Hengshi / Zhang, Jing / Luan, Chengxin / Ge, Jian / Wei, Wei

Pharmacological research

2023 Volume 189, Page(s) 106686

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy. Excessive IgD may play a role in T cell activation via IgD Fc receptor ( ... ...

Abstract	T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy. Excessive IgD may play a role in T cell activation via IgD Fc receptor (FcδR). Here we aimed to investigate the effects of IgD in T-ALL and demonstrated the potential benefit by targeting IgD/FcδR in T-ALL patients with IgD-Fc-Ig fusion protein. In T-ALL patients' blood samples and cell lines, the level of IgD, the percentage of FcδR expressing cells and the binding affinity were determined by flow cytometry. T cell viability, proliferation and apoptosis were analyzed. A mouse xenograft model was used to evaluate the in vivo effect of IgD-Fc-Ig, an IgD-FcδR blocker. The levels of serum IgD and FcδR were abnormally increased in part of T-ALL patients and IgD could induce over-proliferation and inhibit apoptosis of T-ALL cells in vitro. FcδR was constitutively expressed on T-ALL cells. IgD-Fc-Ig showed similar binding affinity to FcδR and selectively blocked the stimulation effect of IgD on T-ALL cells in vitro. In vivo study exhibited that IgD-Fc-Ig may also have therapeutic benefit. IgD-Fc-Ig administration inhibited human T-ALL growth and extended survival in xenograft T-ALL mice. In conclusion, this work supports the idea of targeting IgD/FcδR in T-ALL patients with excessive IgD. IgD-Fc-Ig fusion protein might be a potential biological drug with high selectivity for T-ALL treatment.
MeSH term(s)	Humans ; Mice ; Animals ; B-Lymphocytes ; Immunoglobulin D/physiology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ; T-Lymphocytes
Chemical Substances	Immunoglobulin D
Language	English
Publishing date	2023-02-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2023.106686
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Zs.A 721: Show issues

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Article ; Online: Distance-based quantification of miRNA-21 by the coffee-ring effect using paper devices.

Zhang, Dagan / Wu, Chao / Luan, Chengxin / Gao, Peng / Wang, Huan / Chi, Junjie / Kong, Tiantian

Mikrochimica acta

2020 Volume 187, Issue 9, Page(s) 513

Abstract: Enabled by the coffee-ring effect, a paper-based signal transduce method is employed for catalytic hairpin assembly (CHA) amplification and hybridization chain reaction (HCR) to achieve miRNA quantification. Once the target miRNAs appeared, it was ... ...

Abstract	Enabled by the coffee-ring effect, a paper-based signal transduce method is employed for catalytic hairpin assembly (CHA) amplification and hybridization chain reaction (HCR) to achieve miRNA quantification. Once the target miRNAs appeared, it was circularly used by CHA to initiate HCR amplification to produce a large number of G-quadruplex, which is combined with hemin to form a hemin/G-quadruplex DNAzyme. The DNAzyme catalyzes a colorimetric reaction to produce colored nanoparticles, which were converted to the end edge of the paper by evaporation-driven flow, forming a visible colored band. Higher concentration of miRNA led to more colored nanoparticles and thus a longer colored band that can simply be measured by a ruler. The results of determination of miRNA in samples demonstrate that the relative standard deviation of the proposed approach is 5.2%, highly sensitive and repeatable, with a working range 1.0 to 1000 pM and a LOD of 0.2 pM. The paper-based analytical device as a novel platform offers a new signal transduce pathway toward the detection of low-abundance biomarkers for diagnosis.Graphical abstract Schematic representation of the principle for quantification of miRNA on paper based on the coffee-ring effect.
MeSH term(s)	Biomarkers, Tumor/blood ; Colorimetry/instrumentation ; Colorimetry/methods ; DNA Probes/chemistry ; DNA, Catalytic/chemistry ; G-Quadruplexes ; Hemin/chemistry ; Humans ; Iodine/chemistry ; Limit of Detection ; MicroRNAs/blood ; Nucleic Acid Amplification Techniques ; Paper
Chemical Substances	Biomarkers, Tumor ; DNA Probes ; DNA, Catalytic ; MIRN21 microRNA, human ; MicroRNAs ; Hemin (743LRP9S7N) ; Iodine (9679TC07X4)
Language	English
Publishing date	2020-08-24
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-020-04500-7
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Article ; Online: Hydrogel based 3D carriers in the application of stem cell therapy by direct injection

Luan Chengxin / Liu Ping / Chen Runzhe / Chen Baoan

Nanotechnology Reviews, Vol 6, Iss 5, Pp 435-

2017 Volume 448

Abstract: Compared with systematic administration such as peripheral intravenous infusion, stem cell therapy by direct injection is theoretically more effective, but some technical barriers such as low stem cell retention rate and low engraftment rate still need ... ...

Abstract	Compared with systematic administration such as peripheral intravenous infusion, stem cell therapy by direct injection is theoretically more effective, but some technical barriers such as low stem cell retention rate and low engraftment rate still need to be overcome before its application in humans. Stem cell therapy supported by hydrogel carriers has been increasingly studied in recent years. These hydrogels with properties similar to natural tissues are able to fabricate various forms of carriers, which include in situ forming hydrogels, ex situ forming hydrogels, surface immobilization carriers, microencapsules, and microgels. Some of them are 3D carriers and promise to overcome the technical barriers of stem cell therapy by direct injection. They have different characteristics, application, and prospect in the application of stem cell therapy by direct injection, which is summarized by this review.
Keywords	3d microcarriers ; direct injection ; hydrogel ; stem cell therapy ; Technology ; T ; Chemical technology ; TP1-1185 ; Physical and theoretical chemistry ; QD450-801
Subject code	571
Language	English
Publishing date	2017-10-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Signal Improvement Strategies for Fluorescence Detection of Biomacromolecules.

Luan, Chengxin / Yang, Zixue / Chen, Baoan

Journal of fluorescence

2016 Volume 26, Issue 3, Page(s) 1131–1139

Abstract: For analysis of biomacromolecules, a sensitive, specified and reliable method is indispensable. Fluorescent dyes or fluorophores have been widely used as mediums to obtain readout signals in various assays or bioimaging because of their versatilities ... ...

Abstract	For analysis of biomacromolecules, a sensitive, specified and reliable method is indispensable. Fluorescent dyes or fluorophores have been widely used as mediums to obtain readout signals in various assays or bioimaging because of their versatilities such as biocompatibility. Those fluorescent dyes based techniques manipulate many molecular interactions for analysis of biomacromolecules including antibody-protein interaction, base complementation, glycan-lectin interaction, etc. The strategies to manipulate those molecular interactions are various and always updating due to the development of biotechnological tools and instruments. In this minireview, we summarize the state of the art of signal improvement techniques for fluorescence detection of biomacromolecules especially proteins and nucleic acids. We focus on the principle and mechanism of those techniques for fluorescence detection of biomacromolecules. We also discuss the future trend of the techniques for fluorescence detection of biomacromolecules.
Language	English
Publishing date	2016-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2016892-5
ISSN	1573-4994 ; 1053-0509
ISSN (online)	1573-4994
ISSN	1053-0509
DOI	10.1007/s10895-016-1806-3
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Article: The functional role of microRNA in acute lymphoblastic leukemia: relevance for diagnosis, differential diagnosis, prognosis, and therapy.

Luan, Chengxin / Yang, Zixue / Chen, Baoan

OncoTargets and therapy

2015 Volume 8, Page(s) 2903–2914

Abstract: MicroRNAs (miRNAs), a new class of noncoding RNAs, which can hybridize to target messenger RNAs and regulate their expression posttranscriptionally, express differentially in distinct stages of lymphopoiesis and influence the direction of lymphoid ... ...

Abstract	MicroRNAs (miRNAs), a new class of noncoding RNAs, which can hybridize to target messenger RNAs and regulate their expression posttranscriptionally, express differentially in distinct stages of lymphopoiesis and influence the direction of lymphoid precursor maturation. Hence, there is aberrant expression of miRNAs involved in malignant lymphopoiesis, and these aberrations can be used as signatures of acute lymphoblastic leukemia (ALL) with different subtypes. In addition, changes in the expression of several miRNAs may have functional relevance with leukemogenesis or drug resistance. As a result, the reversal of the expression of these miRNAs may alleviate the disease to some extent and improve clinical outcomes. However, among the studies of miRNAs, there are still some problems that need to be solved to understand the function of miRNAs in ALL more thoroughly.
Language	English
Publishing date	2015-10-13
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S92470
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Article ; Online: Aptamer-based hydrogel barcodes for the capture and detection of multiple types of pathogenic bacteria.

Xu, Yueshuang / Wang, Huan / Luan, Chengxin / Liu, Yuxiao / Chen, Baoan / Zhao, Yuanjin

Biosensors & bioelectronics

2018 Volume 100, Page(s) 404–410

Abstract: Rapid and sensitive diagnosing hematological infections based on the separation and detection of pathogenic bacteria in the patient's blood is a significant challenge. To address this, we herein present a new barcodes technology that can simultaneously ... ...

Abstract	Rapid and sensitive diagnosing hematological infections based on the separation and detection of pathogenic bacteria in the patient's blood is a significant challenge. To address this, we herein present a new barcodes technology that can simultaneously capture and detect multiple types of pathogenic bacteria from a complex sample. The barcodes are poly (ethylene glycol) (PEG) hydrogel inverse opal particles with characteristic reflection peak codes that remain stable during bacteria capture on their surfaces. As the spherical surface of the particles has ordered porous nanostructure, the barcodes can provide not only more surface area for probe immobilization and reaction, but also a nanopatterned platform for highly efficient bioreactions. In addition, the PEG hydrogel scaffold could decrease the non-specificity adsorption by its anti-adhesive effect, and the decorated aptamer probes in the scaffolds could increase the sensitivity, reliability, and specificity of the bacteria capture and detection. Moreover, the tagged magnetic nanoparticles in the PEG scaffold could impart the barcodes with controllable movement under magnetic fields, which can be used to significantly increase the reaction speed and simplify the processing of the bioassays. Based on the describe barcodes, it was demonstrated that the bacteria could be captured and identified even at low bacterial concentrations (100 CFU mL
MeSH term(s)	Aptamers, Nucleotide/chemistry ; Bacteria/isolation & purification ; Bacterial Infections/microbiology ; Biosensing Techniques/methods ; Escherichia coli/isolation & purification ; Escherichia coli Infections/microbiology ; Humans ; Hydrogel, Polyethylene Glycol Dimethacrylate/chemistry ; Magnetite Nanoparticles/chemistry ; Polyethylene Glycols/chemistry ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/isolation & purification
Chemical Substances	Aptamers, Nucleotide ; Magnetite Nanoparticles ; Hydrogel, Polyethylene Glycol Dimethacrylate (25852-47-5) ; Polyethylene Glycols (30IQX730WE)
Language	English
Publishing date	2018-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2017.09.032
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Article: Effect of pomalidomide on relapsed/refractory multiple myeloma: a systematic review and meta-analysis.

Chen, Runzhe / Wang, Yujie / Luan, Chengxin / Gao, Chong / Zhang, Xiaoping / Chen, Baoan

Journal of Cancer

2017 Volume 8, Issue 10, Page(s) 1801–1808

Abstract: In this work, we aim to further analyze the effect of pomalidomide for relapsed and/or refractory multiple myeloma (RRMM). A systematic literature search of PubMed, MEDLINE and EMBASE was conducted on September 20, 2016. Pooled effect size (ES) with ... ...

Abstract	In this work, we aim to further analyze the effect of pomalidomide for relapsed and/or refractory multiple myeloma (RRMM). A systematic literature search of PubMed, MEDLINE and EMBASE was conducted on September 20, 2016. Pooled effect size (ES) with corresponding 95% confidence intervals (CIs) were calculated using random-effects model. STATA software (version 12.0; Stata Corporation; College Station, TX, USA) was employed to do all statistical analyses. A total of 8 studies were included for analysis. The combined results demonstrated that the pooled proportion of overall response rate (ORR) was 0.35 (95% CI 0.27 to 0.43,
Language	English
Publishing date	2017-07-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.17999
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