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Artikel ; Online: [COMPARING LAPAROSCOPIC AND ROBOT-ASSISTED PYELOPLASTY FOR URETERO-PELVIC JUNCTION OBSTRUCTION: INITIAL EXPERIENCE FROM A SINGLE CENTER].

Tatenuma, Tomoyuki / Ito, Hiroki / Komeya, Mitsuru / Ito, Yusuke / Muraoka, Kentaro / Hasumi, Hisashi / Hayashi, Narihiko / Makiyama, Kazuhide

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology

2024 Band 114, Heft 1, Seite(n) 1–7

Abstract: Objective) To compare the initial results of robot-assisted laparoscopic pyeloplasty (RALP) and laparoscopic pyeloplasty (LP) for uretero-pelvic junction obstruction (UPJO). (Methods) Between April 2008 to October 2021, we identified 104 cases of UPJO ... ...

Abstract	(Objective) To compare the initial results of robot-assisted laparoscopic pyeloplasty (RALP) and laparoscopic pyeloplasty (LP) for uretero-pelvic junction obstruction (UPJO). (Methods) Between April 2008 to October 2021, we identified 104 cases of UPJO where LP was performed and 18 cases where RALP was performed at our hospital. We retrospectively analyzed their perioperative outcomes. Furthermore, we recorded the operative times for each cases of LP and RALP. (Results) The median operative time for RALP was 141 minutes, which was significantly shorter than that for LP (204 minutes). No patient in the RALP group demonstrated any Clavien-Dindo complications (≥grade 3). During the observation period, improvement of symptoms was observed in all cases. The median suturing time in RALP was 38 minutes. Compared with the last 20 cases of LP, the time to expose the uretero-pelvic junction, the time of renal pelvis incision, and suturing time were significantly shorter in RALP. In addition, the console and suturing times were stable since the initial stage. In cases with a high grade of hydronephrosis, there was a large variation in the time to expose the uretero-pelvic junction and suture the renal pelvis and ureter in LP; however, this variation was smaller in RALP. (Conclusion) At our hospital, RALP for UPJO is considered to be a safe procedure. In the future, it is necessary to consider the long-term results and effectiveness of RALP.
Mesh-Begriff(e)	Humans ; Ureter/surgery ; Retrospective Studies ; Robotics ; Kidney Pelvis/surgery ; Laparoscopy
Sprache	Japanisch
Erscheinungsdatum	2024-01-19
Erscheinungsland	Japan
Dokumenttyp	English Abstract ; Journal Article
ZDB-ID	958552-7
ISSN	1884-7110 ; 0021-5287 ; 0369-3988
ISSN (online)	1884-7110
ISSN	0021-5287 ; 0369-3988
DOI	10.5980/jpnjurol.114.1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Surgical proficiency in laparoscopic radical cystectomy with extracorporeal urinary diversion and its adequacy for the execution of robot-assisted radical cystectomy with intracorporeal urinary diversion.

Suzuki, Atsuto / Ito, Hiroki / Uemura, Koichi / Muraoka, Kentaro / Tatenuma, Tomoyuki / Osaka, Kimito / Yokomizo, Yumiko / Hayashi, Narihiko / Hasumi, Hisashi / Makiyama, Kazuhide

Asian journal of endoscopic surgery

2024 Band 17, Heft 2, Seite(n) e13289

Abstract: Introduction: The number of facilities adopting intracorporeal urinary diversion (ICUD) using robots instead of extracorporeal urinary diversion (ECUD) is increasing. However, guidance on how to introduce robot-assisted radical cystectomy (RARC) + ICUD ... ...

Abstract	Introduction: The number of facilities adopting intracorporeal urinary diversion (ICUD) using robots instead of extracorporeal urinary diversion (ECUD) is increasing. However, guidance on how to introduce robot-assisted radical cystectomy (RARC) + ICUD in each urological institute remains unclear. This study aimed to verify the feasibility of the transition from laparoscopic radical cystectomy (LRC) + ECUD to RARC + ICUD. Methods: We retrospectively analyzed 26 consecutive patients who underwent ICUD with an ileal conduit after RARC between 2018 and 2020 (RARC + ICUD early group). We then compared these patients with 26 consecutive patients who underwent ECUD with an ileal conduit after LRC between 2012 and 2019 (LRC + ECUD late group) at Yokohama City University Hospital. Results: In the RARC + ICUD early group compared with the LRC + ECUD late group, the median total operation time was 516 versus 532.5 min (P = .217); time to cystectomy, 191 versus 206.5 min (P = .234); time of urinary diversion with an ileal conduit, 198 versus 220 min (P = .016); postoperative maximum C-reactive protein levels, 6.98 versus 12.46 mg/L (P = .001); number of days to oral intake, 3 versus 5 days (P = .003); length of hospital stay, 17 versus 32 days (P < .001). The postoperative complication rates (within 90 days) were 23.1% and 42.3% in the RARC + ICUD early and LRC + ECUD late groups, respectively (P = .237). Clavien-Dindo classification ≥3 was noted in 1 and 4 patients in the RARC + ICUD early and LRC + ECUD late groups, respectively (P = .350). Conclusion: Regarding perioperative outcomes, the RARC + ICUD early group was not inferior to the LRC + ECUD late group. This study suggests the feasibility of a transition from LRC + ECUD to RARC + ICUD.
Mesh-Begriff(e)	Humans ; Cystectomy/adverse effects ; Robotics ; Retrospective Studies ; Urinary Bladder Neoplasms/surgery ; Robotic Surgical Procedures/adverse effects ; Urinary Diversion/adverse effects ; Postoperative Complications/etiology ; Laparoscopy/adverse effects ; Treatment Outcome
Sprache	Englisch
Erscheinungsdatum	2024-02-14
Erscheinungsland	Japan
Dokumenttyp	Journal Article
ZDB-ID	2503256-2
ISSN	1758-5910 ; 1758-5902
ISSN (online)	1758-5910
ISSN	1758-5902
DOI	10.1111/ases.13289
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impacts of Complete Endophytic Renal Tumors on Surgical, Functional, and Oncological Outcomes of Robot-Assisted Partial Nephrectomy.

Ito, Hiroki / Uemura, Koichi / Ikeda, Maiko / Jikuya, Ryosuke / Kondo, Takuya / Tatenuma, Tomoyuki / Kawahara, Takashi / Komeya, Mitsuru / Ito, Yusuke / Muraoka, Kentaro / Hasumi, Hisashi / Makiyama, Kazuhide

Journal of endourology

2024 Band 38, Heft 4, Seite(n) 347–352

Abstract: Objective: ...

Abstract	Objective:
Mesh-Begriff(e)	Humans ; Robotics ; Treatment Outcome ; Retrospective Studies ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Robotic Surgical Procedures ; Nephrectomy ; Margins of Excision
Sprache	Englisch
Erscheinungsdatum	2024-02-26
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2023.0608
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Hereditary kidney cancer syndromes: Genetic disorders driven by alterations in metabolism and epigenome regulation.

Hasumi, Hisashi / Yao, Masahiro

Cancer science

2018 Band 109, Heft 3, Seite(n) 581–586

Abstract: Although hereditary kidney cancer syndrome accounts for approximately five percent of all kidney cancers, the mechanistic insight into tumor development in these rare conditions has provided the foundation for the development of molecular targeting ... ...

Abstract	Although hereditary kidney cancer syndrome accounts for approximately five percent of all kidney cancers, the mechanistic insight into tumor development in these rare conditions has provided the foundation for the development of molecular targeting agents currently used for sporadic kidney cancer. In the late 1980s, the comprehensive study for hereditary kidney cancer syndrome was launched in the National Cancer Institute, USA and the first kidney cancer-associated gene, VHL, was identified through kindred analysis of von Hippel-Lindau (VHL) syndrome in 1993. Subsequent molecular studies on VHL function have elucidated that the VHL protein is a component of E3 ubiquitin ligase complex for hypoxia-inducible factor (HIF), which provided the basis for the development of tyrosine kinase inhibitors targeting the HIF-VEGF/PDGF pathway. Recent whole-exome sequencing analysis of sporadic kidney cancer exhibited the recurrent mutations in chromatin remodeling genes and the later study has revealed that several chromatin remodeling genes are altered in kidney cancer kindred at the germline level. To date, more than 10 hereditary kidney cancer syndromes together with each responsible gene have been characterized and most of the causative genes for these genetic disorders are associated with either metabolism or epigenome regulation. In this review article, we describe the molecular mechanisms of how an alteration of each kidney cancer-associated gene leads to renal tumorigenesis as well as denote therapeutic targets elicited by studies on hereditary kidney cancer.
Mesh-Begriff(e)	Epigenesis, Genetic ; Gene Regulatory Networks ; Genetic Predisposition to Disease ; Humans ; Kidney Neoplasms/genetics ; Neoplastic Syndromes, Hereditary/genetics ; Whole Exome Sequencing
Sprache	Englisch
Erscheinungsdatum	2018-02-15
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1347-9032
ISSN (online)	1349-7006
ISSN	1347-9032
DOI	10.1111/cas.13503
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Real-World Data on the Effectiveness of Microporous Polysaccharide Hemospheres for Allowing Even Novice Surgeons to Perform Robot-Assisted Radical Prostatectomy Safely.

Nirei, Takuma / Tatenuma, Tomoyuki / Muraoka, Kentaro / Aomori, Kota / Ito, Yusuke / Hasumi, Hisashi / Hayashi, Narihiko / Nakaigawa, Noboru / Makiyama, Kazuhide

Urology research & practice

2023 Band 49, Heft 4, Seite(n) 241–245

Abstract: Objective: Radical prostatectomy can be performed more safely and with fewer com- plications since the advent of robot-assisted surgery. However, increased bleeding is a concern when robot-assisted radical prostatectomy includes lymph node dissection ... ...

Abstract	Objective: Radical prostatectomy can be performed more safely and with fewer com- plications since the advent of robot-assisted surgery. However, increased bleeding is a concern when robot-assisted radical prostatectomy includes lymph node dissection and nerve sparing. In real-world clinical practice, inexperienced surgeons sometimes perform robot-assisted radical prostatectomy. In this study, we investigated the effec- tiveness of microporous polysaccharide hemospheres as a local hemostatic agent in robot-assisted radical prostatectomy. Methods: We retrospectively evaluated 301 patients who underwent robot-assisted radical prostatectomy at our institution between December 2017 and November 2020. The patients were divided into 2 groups according to whether their surgery was per- formed after the introduction of microporous polysaccharide hemospheres as a local hemostatic agent (group A, n = 140) or before it (group B, n = 161: historical control). Results: Preoperative androgen deprivation therapy was significantly more common in group A than in group B (23 vs. 11, P = .009). Furthermore, surgeons were significantly less experienced (P < .001) and the operation time was significantly longer (260 min- utes vs. 229 minutes; P < .001) in group A than in group B. There was no significant difference in any other patient background characteristics or in the surgical outcomes between the groups. Conclusion: The use of microporous polysaccharide hemospheres allowed even inex- perienced surgeons to perform robot-assisted radical prostatectomy without compro- mising surgical outcomes.
Sprache	Englisch
Erscheinungsdatum	2023-10-25
Erscheinungsland	Turkey
Dokumenttyp	Journal Article
ISSN	2980-1478
ISSN (online)	2980-1478
DOI	10.5152/tud.2023.22242
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Correlation between Higher Aging Males' Symptoms Scores and a Higher Risk of Lower Urinary Tract Symptoms.

Kawahara, Takashi / Ninomiya, Sahoko / Takeshima, Teppei / Saito, Tomoki / Ito, Hiroki / Komeya, Mitsuru / Hasumi, Hisashi / Yumura, Yasushi / Makiyama, Kazuhide / Uemura, Hiroji

Journal of clinical medicine

2023 Band 12, Heft 24

Abstract: Background: Late-onset hypogonadism (LOH) is a condition caused by the decline of testosterone levels with aging and is associated with various symptoms, including lower urinary tract symptoms (LUTSs). Although some reports have shown that testosterone ... ...

Abstract	Background: Late-onset hypogonadism (LOH) is a condition caused by the decline of testosterone levels with aging and is associated with various symptoms, including lower urinary tract symptoms (LUTSs). Although some reports have shown that testosterone replacement treatment for LOH improves LUTSs, no large study has revealed a correlation between LUTSs and LOH. This study investigated the correlation between the severity of LOH and LUTSs in Japanese males >40 years of age using a web-based questionnaire with the Aging Males' Symptoms (AMS) scale. Methods: We asked 2000 Japanese males to answer both the AMS and IPSS/QOL questionnaires using a web-based survey. Among these 2000 individuals, 500 individuals were assigned to each age group. Results: The IPSS total score was positively correlated with the severity of AMS (shown as median [mean ± SD]): no/little group, 2 (3.67 ± 5.36); mild group, 6 (7.98 ± 6.91); moderate group, 11 (12.49 ± 8.63); and severe group, 16 (14.83 ± 9.24) ( Conclusions: Individuals with higher AMS values, representing cases with severe LOH symptoms, had a higher risk of experiencing nocturia and LUTSs than those with lower AMS values.
Sprache	Englisch
Erscheinungsdatum	2023-12-06
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12247528
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Enfortumab vedotin prolongs overall survival in metastatic urothelial carcinoma following pembrolizumab therapy in real-world data.

Uemura, Koichi / Ito, Hiroki / Jikuya, Ryosuke / Kondo, Takuya / Tatenuma, Tomoyuki / Kawahara, Takashi / Ito, Yusuke / Komeya, Mitsuru / Muraoka, Kentaro / Hasumi, Hisashi / Uemura, Hiroji / Makiyama, Kazuhide

International journal of urology : official journal of the Japanese Urological Association

2024

Abstract: Objective: In December 2021, enfortumab vedotin (EV), an antibody-drug conjugate directed against nectin-4, was approved in Japan as a new treatment after platinum-containing chemotherapy and PD-1/PD-L1 inhibitors. This study evaluated, using real-world ...

Abstract	Objective: In December 2021, enfortumab vedotin (EV), an antibody-drug conjugate directed against nectin-4, was approved in Japan as a new treatment after platinum-containing chemotherapy and PD-1/PD-L1 inhibitors. This study evaluated, using real-world data, the efficacy and safety of EV therapy in patients with metastatic urothelial carcinoma (mUC). Materials and methods: Fifty-five patients with mUC who discontinued pembrolizumab therapy due to disease progression between June 2018 and April 2023 at Yokohama City University Hospital were evaluated retrospectively. Of the 55 patients, 25 received EV therapy (EV group) and 30 did not (non-EV group). All patients who underwent EV therapy were diagnosed with disease progression after the approval of EV in Japan. Results: The median (range) follow-up period after pembrolizumab discontinuation was 6.3 (0.7-31.1) months. There were eight (32.0%) deaths due to cancer in the EV group and 27 (90.0%) in the non-EV group. The overall survival (OS) after pembrolizumab discontinuation was not reached in the EV group versus 2.6 months in the non-EV group (p < 0.001). A multivariate analysis revealed that EV therapy (EV vs. non-EV group; hazard ratio 0.26; 95% confidence interval 0.16-0.41; p < 0.001) was an independent prognostic factor for OS. Conclusion: EV prolonged OS in mUC following pembrolizumab therapy in real-world data.
Sprache	Englisch
Erscheinungsdatum	2024-02-25
Erscheinungsland	Australia
Dokumenttyp	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.15437
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Predictive factors for pentafecta achievement in robot-assisted partial nephrectomy for intermediate highly complex RENAL tumors (RENAL score ≥ 7).

Uemura, Koichi / Ito, Hiroki / Ikeda, Maiko / Uehara, Koichiro / Tatenuma, Tomoyuki / Komeya, Mitsuru / Ito, Yusuke / Muraoka, Kentaro / Hasumi, Hisashi / Makiyama, Kazuhide

International journal of urology : official journal of the Japanese Urological Association

2023 Band 30, Heft 12, Seite(n) 1096–1102

Abstract: Objectives: To investigate the predictive factors for pentafecta achievement of robot-assisted partial nephrectomy (RAPN) for intermediate highly complex renal tumors (RENAL score ≥ 7).: Methods: We retrospectively analyzed the data of 247 patients ... ...

Abstract	Objectives: To investigate the predictive factors for pentafecta achievement of robot-assisted partial nephrectomy (RAPN) for intermediate highly complex renal tumors (RENAL score ≥ 7). Methods: We retrospectively analyzed the data of 247 patients with renal tumors with a RENAL score ≥ 7 who underwent RAPN. Baseline characteristics and perioperative outcomes were compared between the pentafecta achieved group and the unachieved group. A multivariable logistic regression model was used to identify the predictive factors for pentafecta achievement for cT1 renal tumors with a RENAL score ≥ 7. Results: Of the 247 patients, 75 (30.3%) patients were in the achieved group and 172 (69.7%) patients were in the unachieved group. The median warm ischemia time and total operation time were 18 min versus 23 min (p < 0.001) and 179 min versus 201 min (p < 0.001) in the achieved and unachieved groups, respectively. In the unachieved group, six patients (3.4%) had major perioperative complications (Clavien-Dindo classification system ≥3). The median preservation rates of estimated GFR at the 1-year postoperative period were 96.5% versus 83.0% (p < 0.001) in the achieved and unachieved groups. Multivariable logistic regression models revealed that age and tumor size were independent predictive factors for pentafecta achievement for cT1 renal tumors with a RENAL score ≥ 7. There were no significant differences in cancer-free survival between the two groups (p = 0.456). Conclusion: Age and tumor size were independent predictive factors for pentafecta achievement, although there was no difference in oncological outcomes between the pentafecta achieved group and the unachieved group in RAPN for cT1 renal tumors with a RENAL score ≥ 7.
Mesh-Begriff(e)	Humans ; Retrospective Studies ; Robotics ; Treatment Outcome ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Nephrectomy/adverse effects ; Robotic Surgical Procedures/adverse effects
Sprache	Englisch
Erscheinungsdatum	2023-08-17
Erscheinungsland	Australia
Dokumenttyp	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.15274
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impact of chronic kidney disease stages on surgical and functional outcomes in robot-assisted partial nephrectomy for localized renal tumors.

Ito, Hiroki / Muraoka, Kentaro / Uemura, Koichi / Jikuya, Ryosuke / Kondo, Takuya / Tatenuma, Tomoyuki / Kawahara, Takashi / Komeya, Mitsuru / Ito, Yusuke / Hasumi, Hisashi / Makiyama, Kazuhide

Journal of robotic surgery

2024 Band 18, Heft 1, Seite(n) 109

Abstract: The influence of chronic kidney disease stage on robot-assisted partial nephrectomy outcomes remains underexplored. This study aimed to assess the impact of chronic kidney disease stage on functional and surgical outcomes of robot-assisted partial ... ...

Abstract	The influence of chronic kidney disease stage on robot-assisted partial nephrectomy outcomes remains underexplored. This study aimed to assess the impact of chronic kidney disease stage on functional and surgical outcomes of robot-assisted partial nephrectomy and identify preoperative predictors of significant postoperative 1-year renal-function loss (RFL). Clinical data of 408 patients who underwent robot-assisted partial nephrectomy at Yokohama City University Hospital between 2016 and 2023 were retrospectively reviewed. The da Vinci Surgical System was applied in all patients, and outcomes assessed included surgical parameters, postoperative estimated glomerular filtration rate, trifecta and pentafecta achievements, and complications. Significant RFL was defined as estimated glomerular filtration rate reduction ≥ 25% from baseline. Higher chronic kidney disease stages correlated with older age, hypertension, diabetes, and solitary kidneys. Postoperative estimated glomerular filtration rate decline was most pronounced in patients with chronic kidney disease stages 4-5. Although the chronic kidney disease stage did not significantly affect most surgical parameters, pentafecta achievement was higher in patients with chronic kidney disease stage 3 than in those with stages 4-5. Two patients required hemodialysis after robot-assisted partial nephrectomy. Multivariable logistic regression analysis showed that preoperative hemoglobin level and maximum tumor diameter were significant predictive factors for significant RFL. In conclusion, preoperative CKD stage did not influence on surgical outcome except for pentafecta achievement. RAPN may be feasible for patients with CKD stages 4-5 because of no rapid progression to hemodialysis induction and no procedure-related mortality. Preoperative hemoglobin levels and tumor diameter emerged as predictors of significant RFL.
Mesh-Begriff(e)	Humans ; Robotic Surgical Procedures/methods ; Retrospective Studies ; Robotics ; Kidney Neoplasms/surgery ; Renal Insufficiency, Chronic/complications ; Nephrectomy ; Hemoglobins
Chemische Substanzen	Hemoglobins
Sprache	Englisch
Erscheinungsdatum	2024-03-05
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-024-01873-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Correlation between Higher Aging Males’ Symptoms Scores and a Higher Risk of Lower Urinary Tract Symptoms

Takashi Kawahara / Sahoko Ninomiya / Teppei Takeshima / Tomoki Saito / Hiroki Ito / Mitsuru Komeya / Hisashi Hasumi / Yasushi Yumura / Kazuhide Makiyama / Hiroji Uemura

Journal of Clinical Medicine, Vol 12, Iss 24, p

2023 Band 7528

Abstract	Background: Late-onset hypogonadism (LOH) is a condition caused by the decline of testosterone levels with aging and is associated with various symptoms, including lower urinary tract symptoms (LUTSs). Although some reports have shown that testosterone replacement treatment for LOH improves LUTSs, no large study has revealed a correlation between LUTSs and LOH. This study investigated the correlation between the severity of LOH and LUTSs in Japanese males >40 years of age using a web-based questionnaire with the Aging Males’ Symptoms (AMS) scale. Methods: We asked 2000 Japanese males to answer both the AMS and IPSS/QOL questionnaires using a web-based survey. Among these 2000 individuals, 500 individuals were assigned to each age group. Results: The IPSS total score was positively correlated with the severity of AMS (shown as median [mean ± SD]): no/little group, 2 (3.67 ± 5.36); mild group, 6 (7.98 ± 6.91); moderate group, 11 (12.49 ± 8.63); and severe group, 16 (14.83 ± 9.24) ( p < 0.0001). Conclusions: Individuals with higher AMS values, representing cases with severe LOH symptoms, had a higher risk of experiencing nocturia and LUTSs than those with lower AMS values.
Schlagwörter	lower urinary tract syndrome ; LOH ; questionnaire ; Medicine ; R
Thema/Rubrik (Code)	310
Sprache	Englisch
Erscheinungsdatum	2023-12-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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