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Article ; Online: Follow-up after oral cancer treatment-Transition to a personalized approach.

Brands, Marieke / Verbeek, André / Geurts, Sandra / Merkx, Thijs

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

2021 Volume 50, Issue 5, Page(s) 429–434

Abstract: Background: Guidelines for follow-up after oral cancer treatment are not site-specific and encompass the entire head and neck area rather than the oral cavity alone. This one-size-fits-all protocol disregards the differences in aetiology, treatment and ... ...

Abstract	Background: Guidelines for follow-up after oral cancer treatment are not site-specific and encompass the entire head and neck area rather than the oral cavity alone. This one-size-fits-all protocol disregards the differences in aetiology, treatment and differential distribution of new disease between the subsites. With the effectiveness of follow-up in early detection of new disease being put into question, the focus of follow-up programmes might shift to other aspects of survivorship care. Personalization of follow-up is important, considering patient-specific features and needs. Furthermore, the COVID-19 pandemic urges us to rethink our follow-up practice. Findings: This paper discusses ways in which routine follow-up in patients treated for oral cancer can be optimized. Patients with a high risk of new disease might benefit from an intensified follow-up regimen, whilst patients with a low risk of new disease, a low chance of cure or limited life expectancy could benefit from a de-intensified follow-up regimen. The latter could include a shorter follow-up period and focus on goals other than early detection of new disease. Education of patients to report new symptoms early is of vital importance as the majority of new disease presents symptomatically. Other health care professionals such as specialist nurses and dentists need to play an important leading role in survivorship care. Remote consultations may be useful to perform more efficient and patient-centred follow-up care. Conclusion: Routine follow-up needs to be seen as an integrated part of an individualized survivorship plan that is provided by the entire multidisciplinary team.
MeSH term(s)	COVID-19 ; Follow-Up Studies ; Humans ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/therapy ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-01-11
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1021270-x
ISSN	1600-0714 ; 0904-2512
ISSN (online)	1600-0714
ISSN	0904-2512
DOI	10.1111/jop.13147
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Article ; Online: Corrigendum to "Effectiveness of L-serine supplementation in children with a GRIN2B loss-of-function mutation: Rationale and protocol for single patient (n-of-1) multiple cross-over trials" [Contemp. Clin. Trials Commun. 36 (2023)/ DOI: 10.1016/j.conctc.2023.101233].

Hollander, Bibiche den / Rothuizen-Lindenschot, Marieke / Geertjens, Lisa / Vaz, Frédéric M / Brands, Marion M / Le, Hoang Lan / van Eeghen, Agnies M / van de Ven, Peter M / Cornel, Martina C / Jacobs, Bart A W / Bruining, Hilgo / van Karnebeek, Clara D

Contemporary clinical trials communications

2024 Volume 38, Page(s) 101264

Abstract: This corrects the article DOI: 10.1016/j.conctc.2023.101233.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.conctc.2023.101233.].
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Published Erratum
ISSN	2451-8654
ISSN (online)	2451-8654
DOI	10.1016/j.conctc.2024.101264
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Article ; Online: Limited rights of minors in the Dutch healthcare.

Brands, Wolter / Brands, Marieke / Brands-Bottema, Gea

The Journal of forensic odonto-stomatology

2014 Volume 32 Suppl 1, Page(s) 30–33

Abstract: In many countries, if not all, the autonomy of minors is limited. Especially in countries with comprehensive legislation in the field of health law the (lack of) autonomy of minors may create challenges. These problems become more complex if the costs of ...

Abstract	In many countries, if not all, the autonomy of minors is limited. Especially in countries with comprehensive legislation in the field of health law the (lack of) autonomy of minors may create challenges. These problems become more complex if the costs of treatment are not paid by the government or covered by insurance. Some challenges are: At what age is a minor able to decide about his health? As not every treatment is the same, how should the system take this into account? The Netherlands has a long history of very comprehensive health care legislation. This legislation includes a section about the treatment of minors that addresses the questions of the conditions in which the autonomy of minors is limited. Though this legislation is limited to the Netherlands other countries face the same challenges.
MeSH term(s)	Adolescent ; Child ; Humans ; Minors/legislation & jurisprudence ; Netherlands ; Patient Rights/legislation & jurisprudence ; Personal Autonomy
Language	English
Publishing date	2014-11-30
Publishing country	Australia
Document type	Journal Article
ZDB-ID	605921-1
ISSN	2219-6749 ; 0258-414X
ISSN (online)	2219-6749
ISSN	0258-414X
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Article ; Online: Effectiveness of L-serine supplementation in children with a

den Hollander, Bibiche / Rothuizen-Lindenschot, Marieke / Geertjens, Lisa / Vaz, Frédéric M / Brands, Marion M / Le, Hoang Lan / van Eeghen, Agnies M / van de Ven, Peter M / Cornel, Martina C / Jacobs, Bart A W / Bruining, Hilgo / van Karnebeek, Clara D

Contemporary clinical trials communications

2023 Volume 36, Page(s) 101233

Abstract: Rationale: Loss-of-function (LoF) mutations in : Methods/design: These n-of-1 trials, consisting of 2 cycles of 6 months, will be performed to evaluate the effect of L-serine compared to placebo in 4 patients with a : Conclusion: This study ... ...

Abstract	Rationale: Loss-of-function (LoF) mutations in Methods/design: These n-of-1 trials, consisting of 2 cycles of 6 months, will be performed to evaluate the effect of L-serine compared to placebo in 4 patients with a Conclusion: This study employs an innovative methodological approach to evaluate the effectiveness of L-serine for patients with a GRIN2B LoF mutation. The results will establish a foundation for implementing L-serine as a disease-modifying treatment in GRIN2B-NDD.
Language	English
Publishing date	2023-11-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	2451-8654
ISSN (online)	2451-8654
DOI	10.1016/j.conctc.2023.101233
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Article ; Online: Effectiveness of L-serine supplementation in children with a GRIN2B loss-of-function mutation

Bibiche den Hollander / Marieke Rothuizen-Lindenschot / Lisa Geertjens / Frédéric M. Vaz / Marion M. Brands / Hoang Lan Le / Agnies M. van Eeghen / Peter M. van de Ven / Martina C. Cornel / Bart A.W. Jacobs / Hilgo Bruining / Clara D. van Karnebeek

Contemporary Clinical Trials Communications, Vol 36, Iss , Pp 101233- (2023)

Rationale and protocol for single patient (n-of-1) multiple cross-over trials

2023

Abstract: Rationale: Loss-of-function (LoF) mutations in GRIN2B result in neurologic abnormalities due to N-methyl-D-aspartate receptor (NMDAR) dysfunction. Affected persons present with various symptoms, including intellectual developmental disability (IDD), ... ...

Abstract	Rationale: Loss-of-function (LoF) mutations in GRIN2B result in neurologic abnormalities due to N-methyl-D-aspartate receptor (NMDAR) dysfunction. Affected persons present with various symptoms, including intellectual developmental disability (IDD), hypotonia, communication deficits, motor impairment, complex behavior, seizures, sleep disorders and gastrointestinal disturbance. Recently, in vitro experiments showed that D-serine mitigates function to GluN2B (mutation)-containing NMDARs. 11 previous case reports are published on (experimental) L-serine treatment of patients between 1.5 and 12 years old with GRIN2B missense or null mutations, some of whom showed notable improvement in motor and cognitive performance, communication, behavior and abnormalities on electro encephalography (EEG). Our objective is to further evaluate the effectiveness of L-serine for GRIN2B-related neurodevelopmental disorder (GRIN2B-NDD), using an n-of-1 trial design, increasing the level of evidence. Methods/design: These n-of-1 trials, consisting of 2 cycles of 6 months, will be performed to evaluate the effect of L-serine compared to placebo in 4 patients with a GRIN2B LoF mutation. The aggregation of multiple n-of-1 trials will provide an estimate of the average treatment effects.The primary outcome is the Perceive-Recall-Plan-Perform of Task Analysis, assessing developmental skills. Secondary outcomes include Goal Attainment Scaling, seizure log books, EEGs, sleep log books, the irritability subscale of the Aberrant Behavior Checklist, the Bristol Stool Scale and the Pediatric Quality of Life Inventory. Conclusion: This study employs an innovative methodological approach to evaluate the effectiveness of L-serine for patients with a GRIN2B LoF mutation. The results will establish a foundation for implementing L-serine as a disease-modifying treatment in GRIN2B-NDD.
Keywords	GRIN2B1 ; L-serine2 ; Intellectual developmental disability3 ; N-methyl-D-aspartate receptor4 ; Personalized medicine5 ; n-of-16 ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Should we be rethinking follow-up for oral cancer patients?

Brands, Marieke T / Merkx, Matthias A W / Geurts, Sandra M E / Brennan, Peter A

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

2017 Volume 46, Issue 9, Page(s) 665–666

MeSH term(s)	Aftercare ; Follow-Up Studies ; Humans ; Mouth Neoplasms/therapy ; Neoplasm Recurrence, Local/prevention & control ; Neoplasms, Second Primary/prevention & control ; Quality of Life ; Risk Factors ; Social Support ; Survival
Language	English
Publishing date	2017-10-02
Publishing country	Denmark
Document type	Editorial
ZDB-ID	1021270-x
ISSN	1600-0714 ; 0904-2512
ISSN (online)	1600-0714
ISSN	0904-2512
DOI	10.1111/jop.12596
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Article ; Online: Surgical specimen handover from the operating theatre to laboratory-Can we improve patient safety by learning from aviation and other high-risk organisations?

Brennan, Peter A / Brands, Marieke T / Caldwell, Lucy / Fonseca, Felipe Paiva / Turley, Nic / Foley, Susie / Rahimi, Siavash

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

2017 Volume 47, Issue 2, Page(s) 117–120

Abstract: Essential communication between healthcare staff is considered one of the key requirements for both safety and quality care when patients are handed over from one clinical area to other. This is particularly important in environments such as the ... ...

Abstract	Essential communication between healthcare staff is considered one of the key requirements for both safety and quality care when patients are handed over from one clinical area to other. This is particularly important in environments such as the operating theatre and intensive care where mistakes can be devastating. Health care has learned from other high-risk organisations (HRO) such as aviation where the use of checklists and human factors awareness has virtually eliminated human error and mistakes. To our knowledge, little has been published around ways to improve pathology specimen handover following surgery, with pathology request forms often conveying the bare minimum of information to assist the laboratory staff. Furthermore, the request form might not warn staff about potential hazards. In this article, we provide a brief summary of the factors involved in human error and introduce a novel checklist that can be readily completed at the same time as the routine pathology request form. This additional measure enhances safety, can help to reduce processing and mislabelling errors and provides essential information in a structured way assisting both laboratory staff and pathologists when handling head and neck surgical specimens.
MeSH term(s)	Aviation/methods ; Checklist/methods ; Checklist/standards ; Humans ; Medical Errors/prevention & control ; Patient Care Management ; Patient Care Team ; Patient Handoff ; Patient Safety ; Patient Transfer/standards ; Specimen Handling
Language	English
Publishing date	2017-08-20
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1021270-x
ISSN	1600-0714 ; 0904-2512
ISSN (online)	1600-0714
ISSN	0904-2512
DOI	10.1111/jop.12614
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Article ; Online: Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands.

van Dijk, Boukje A C / Brands, Marieke T / Geurts, Sandra M E / Merkx, Matthias A W / Roodenburg, Jan L N

International journal of cancer

2016 Volume 139, Issue 3, Page(s) 574–583

Abstract: Information on epidemiology is essential to evaluate care for the growing group of oral cancer patients. We investigated trends in incidence, mortality and relative survival rates for oral cavity cancer (OCC) and its subsites in the Netherlands from 1991 ...

Abstract	Information on epidemiology is essential to evaluate care for the growing group of oral cancer patients. We investigated trends in incidence, mortality and relative survival rates for oral cavity cancer (OCC) and its subsites in the Netherlands from 1991 to 2010, and relate these to changes in stage and treatment. Patient (age, sex), tumour (subsite, stage) and treatment characteristics of patients diagnosed with OCC (ICD-O-3: C02-C06) in 1991-2010 were extracted from the Netherlands Cancer Registry. Incidence, mortality and 5-year relative survival rates over time are presented, as well as trends in type of treatment. The incidence of OCC increased with +1.2% (95%CI: +0.9%;+1.6%) per year: more strongly in women, stage I and IV disease, and in cancers of the tongue and gum. The mortality rate slightly rose (+0.8%, 95%CI: +0.3%;+1.3% per year), but differed by subsite. The 5-year relative survival improved from 57% in 1991-1995 to 62% in 2006-2010. The 5-year relative survival was better for women compared with men (64% and 55%, respectively), decreased with increasing stage, was the best for tongue cancer (63%) and the worst for cancer of the gum (56%) and floor of mouth cancer (55%). The relative excess risk of dying was higher for non-surgery-based treatments. Surgery was the main treatment option and the proportion of "surgery only" rose in stage I and III disease. The incidence and, to a lesser extent, mortality of OCC are increasing and therefore, even with slightly improving survival rates, OCC is an increasingly important health problem.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/epidemiology ; Mouth Neoplasms/mortality ; Mouth Neoplasms/therapy ; Neoplasm Staging ; Netherlands/epidemiology ; Registries ; Survival Rate ; Treatment Outcome
Language	English
Publishing date	2016--01
Publishing country	United States
Document type	Journal Article
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.30107
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Integrated prediction and decision models are valuable in informing personalized decision making.

Govers, Tim M / Rovers, Maroeska M / Brands, Marieke T / Dronkers, Emilie A C / Baatenburg de Jong, Robert J / Merkx, Matthias A W / Takes, Robert P / Grutters, Janneke P C

Journal of clinical epidemiology

2018 Volume 104, Page(s) 73–83

Abstract: Objectives: To show how prediction models can be incorporated into decision models, to allow for personalized decisions, and to assess the value of this approach using the management of the neck in early-stage oral cavity squamous cell carcinoma as an ... ...

Abstract	Objectives: To show how prediction models can be incorporated into decision models, to allow for personalized decisions, and to assess the value of this approach using the management of the neck in early-stage oral cavity squamous cell carcinoma as an example. Study design and setting: In a decision model, three approaches were compared: a "population-based" approach in which patients undergo the strategy that is optimal for the population; a "perfectly predicted" approach, in which each patient receives the optimal strategy for that specific patient; and a "prediction model" approach in which each patient receives the strategy that is optimal based on prediction models. The average differences in costs and quality-adjusted life years (QALYs) for the population between these approaches were studied. Results: The population-based approach resulted on average in 4.9158 QALYs with €8,675 in costs, per patient. The perfectly predicted approach yielded 0.21 more QALYs and saved €1,024 per patient. The prediction model approach yielded 0.0014 more QALYs and saved €152 per patient compared with the population-based approach. Conclusion: The perfectly predicted approach shows that personalized care is worthwhile. However, current prediction models in the field of oral cavity squamous cell carcinoma have limited value. Incorporating prediction models into decision models appears to be a valuable method to assess the value of personalized decision making.
MeSH term(s)	Aged ; Clinical Decision-Making ; Cost-Benefit Analysis ; Decision Support Systems, Clinical ; Decision Support Techniques ; Female ; Humans ; Lymph Node Excision/economics ; Male ; Middle Aged ; Models, Economic ; Mouth Neoplasms/therapy ; Neck ; Precision Medicine/economics ; Quality-Adjusted Life Years ; Squamous Cell Carcinoma of Head and Neck/therapy
Language	English
Publishing date	2018-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2018.08.016
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Article ; Online: Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis.

Gunasekera, Kenneth S / Marcy, Olivier / Muñoz, Johanna / Lopez-Varela, Elisa / Sekadde, Moorine P / Franke, Molly F / Bonnet, Maryline / Ahmed, Shakil / Amanullah, Farhana / Anwar, Aliya / Augusto, Orvalho / Aurilio, Rafaela Baroni / Banu, Sayera / Batool, Iraj / Brands, Annemieke / Cain, Kevin P / Carratalá-Castro, Lucía / Caws, Maxine / Click, Eleanor S /

Cranmer, Lisa M / García-Basteiro, Alberto L / Hesseling, Anneke C / Huynh, Julie / Kabir, Senjuti / Lecca, Leonid / Mandalakas, Anna / Mavhunga, Farai / Myint, Aye Aye / Myo, Kyaw / Nampijja, Dorah / Nicol, Mark P / Orikiriza, Patrick / Palmer, Megan / Sant'Anna, Clemax Couto / Siddiqui, Sara Ahmed / Smith, Jonathan P / Song, Rinn / Thuong Thuong, Nguyen Thuy / Ung, Vibol / van der Zalm, Marieke M / Verkuijl, Sabine / Viney, Kerri / Walters, Elisabetta G / Warren, Joshua L / Zar, Heather J / Marais, Ben J / Graham, Stephen M / Debray, Thomas P A / Cohen, Ted / Seddon, James A

The Lancet. Child & adolescent health

2023 Volume 7, Issue 5, Page(s) 336–346

Abstract: Background: Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality. Recent advances in childhood tuberculosis algorithm development have incorporated prediction modelling, but studies so far ... ...

Abstract	Background: Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality. Recent advances in childhood tuberculosis algorithm development have incorporated prediction modelling, but studies so far have been small and localised, with limited generalisability. We aimed to evaluate the performance of currently used diagnostic algorithms and to use prediction modelling to develop evidence-based algorithms to assist in tuberculosis treatment decision making for children presenting to primary health-care centres. Methods: For this meta-analysis, we identified individual participant data from a WHO public call for data on the management of tuberculosis in children and adolescents and referral from childhood tuberculosis experts. We included studies that prospectively recruited consecutive participants younger than 10 years attending health-care centres in countries with a high tuberculosis incidence for clinical evaluation of pulmonary tuberculosis. We collated individual participant data including clinical, bacteriological, and radiological information and a standardised reference classification of pulmonary tuberculosis. Using this dataset, we first retrospectively evaluated the performance of several existing treatment-decision algorithms. We then used the data to develop two multivariable prediction models that included features used in clinical evaluation of pulmonary tuberculosis-one with chest x-ray features and one without-and we investigated each model's generalisability using internal-external cross-validation. The parameter coefficient estimates of the two models were scaled into two scoring systems to classify tuberculosis with a prespecified sensitivity target. The two scoring systems were used to develop two pragmatic, treatment-decision algorithms for use in primary health-care settings. Findings: Of 4718 children from 13 studies from 12 countries, 1811 (38·4%) were classified as having pulmonary tuberculosis: 541 (29·9%) bacteriologically confirmed and 1270 (70·1%) unconfirmed. Existing treatment-decision algorithms had highly variable diagnostic performance. The scoring system derived from the prediction model that included clinical features and features from chest x-ray had a combined sensitivity of 0·86 [95% CI 0·68-0·94] and specificity of 0·37 [0·15-0·66] against a composite reference standard. The scoring system derived from the model that included only clinical features had a combined sensitivity of 0·84 [95% CI 0·66-0·93] and specificity of 0·30 [0·13-0·56] against a composite reference standard. The scoring system from each model was placed after triage steps, including assessment of illness acuity and risk of poor tuberculosis-related outcomes, to develop treatment-decision algorithms. Interpretation: We adopted an evidence-based approach to develop pragmatic algorithms to guide tuberculosis treatment decisions in children, irrespective of the resources locally available. This approach will empower health workers in primary health-care settings with high tuberculosis incidence and limited resources to initiate tuberculosis treatment in children to improve access to care and reduce tuberculosis-related mortality. These algorithms have been included in the operational handbook accompanying the latest WHO guidelines on the management of tuberculosis in children and adolescents. Future prospective evaluation of algorithms, including those developed in this work, is necessary to investigate clinical performance. Funding: WHO, US National Institutes of Health.
MeSH term(s)	United States ; Adolescent ; Humans ; Child ; Retrospective Studies ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis ; Triage ; Algorithms
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2352-4650
ISSN (online)	2352-4650
DOI	10.1016/S2352-4642(23)00004-4
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