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  1. Article ; Online: Use of Combined Do-Not-Resuscitate/Do-Not Intubate Orders Without Documentation of Intubation Preferences: A Retrospective Observational Study at an Academic Level 1 Trauma Center Code Status and Intubation Preferences.

    Rubins, Jeffrey B

    Chest

    2020  Volume 158, Issue 1, Page(s) 292–297

    Abstract: Background: Combining orders for do-not-resuscitate (DNR) for cardiac arrest with do-not-intubate (DNI) orders into a DNR/DNI code status is not evidence-based practice and may violate patient autonomy and informed consent when providers discuss ... ...

    Abstract Background: Combining orders for do-not-resuscitate (DNR) for cardiac arrest with do-not-intubate (DNI) orders into a DNR/DNI code status is not evidence-based practice and may violate patient autonomy and informed consent when providers discuss intubation only in the context of CPR.
    Research question: How often do providers refer to patients with a DNR order as "DNR/DNI" without documentation of refusal of intubation for non-arrest situations?
    Methods: Retrospective observational study of adults (18 years of age or older) hospitalized in a Level 1 trauma/academic hospital between July 2017 and June 2018 inclusive with DNR orders placed during hospitalization.
    Results: Of 422 hospitalized adults with DNR orders, 261 (61.9%) had code status written in progress notes as DNR/DNI. Providers' use of the term DNR/DNI in progress notes was significantly (OR, 2.21; 99% CI, 1.12-4.37) more common on medical hospital services (hospitalist, family medicine, internal medicine) than on nonmedical ward services (medical/surgical ICUs, surgery, psychiatry, neurology services). Of 261 "DNR/DNI" patients, providers did not document informed refusal of intubation for nonarrest situations for 68 (26.0%) of patients. By comparison, of 161 patients for whom providers documented code status in progress notes as DNR alone, 69 (42.9%) did have documentation of refusal of intubation for nonarrest events. Therefore, if a DNR/DNI code status was used in a nonarrest emergency to determine whether to intubate a patient, 68 (16.1%) of 422 patients could inappropriately be denied intubation without informed refusal (or despite their informed acceptance), and 69 (16.4%) could inappropriately be intubated despite their documented refusal of intubation.
    Conclusions: Conflation of DNR and DNI into DNR/DNI does not reliably distinguish patients who refuse or accept intubation for indications other than cardiac arrest, and thus may inappropriately deny desired intubation for those who would accept it, and inappropriately impose intubation on patients who would not.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Documentation ; Female ; Hospitalization ; Humans ; Intubation, Intratracheal ; Male ; Middle Aged ; Patient Preference ; Resuscitation Orders ; Retrospective Studies ; Trauma Centers
    Language English
    Publishing date 2020-02-25
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Underutilization of Portable Orders for Life-Sustaining Treatment at Discharge from Hospital: Observational Study at US Academic Trauma Center.

    Rubins, Jeffrey B

    Journal of general internal medicine

    2020  Volume 35, Issue 7, Page(s) 2065–2068

    Abstract: Background: Decisions to limit use of life-sustaining treatment occur frequently during hospitalizations, and portable medical orders (also known as Portable Orders for Life-Sustaining Treatment (POLST)) can ensure that patient preferences regarding ... ...

    Abstract Background: Decisions to limit use of life-sustaining treatment occur frequently during hospitalizations, and portable medical orders (also known as Portable Orders for Life-Sustaining Treatment (POLST)) can ensure that patient preferences regarding resuscitation are followed after discharge.
    Objective: To determine the frequency and predictors of completion of POLST orders for adults with change during hospitalization in resuscitation status to Do Not Resuscitate.
    Design: Retrospective observational study at level 1 trauma and academic hospital in Minneapolis, MN, USA PARTICIPANTS: All adults (18 years or older) hospitalized between June 2017 and June 2018, inclusive, with code status changed from Full Code to DNR. For patients with more than one hospitalization during this study interval, only the first hospitalization when DNR was ordered was included in this analysis.
    Main measures: Completion of POLST orders by time of discharge.
    Key results: From 2017 to 2018, 160 adults had a change from Full Code to DNR status during index hospitalization and survived to discharge, most (156 patients) to a nursing care facility. Of these, only 50 (31.2%) had POLST orders provided at discharge. Documentation of informed refusal of intubation in addition to DNR status was a significant predictor (OR 4.1, 99% CI 1.5-11.0) of POLST orders on discharge, as was admission to a medical service compared with non-medical service (OR 3.2, 99% CI 1.1-12.2). Palliative care consultants, rather than primary providers on the hospital services, completed most POLST orders.
    Conclusions: Despite primary hospital providers engaging in conversations regarding resuscitation and entering DNR orders during hospitalization, the majority of patients in our study discharged to other care facilities without POLST orders. POLST orders are a simple palliative care tool available to primary hospital providers to help ensure continuity of plan of care at discharge for patients who wish to avoid invasive life-sustaining treatments and/or cardiopulmonary resuscitation.
    MeSH term(s) Adult ; Advance Directives ; Hospitals ; Humans ; Patient Discharge ; Resuscitation Orders ; Trauma Centers
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-05698-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Predicting Outcomes of In-Hospital Cardiac Arrest: Retrospective US Validation of the Good Outcome Following Attempted Resuscitation Score.

    Rubins, Jeffrey B / Kinzie, Spencer D / Rubins, David M

    Journal of general internal medicine

    2019  Volume 34, Issue 11, Page(s) 2530–2535

    Abstract: Background: Providers should estimate a patient's chance of surviving an in-hospital cardiac arrest with good neurologic outcome when initially admitting a patient, in order to participate in shared decision making with patients about their code status.! ...

    Abstract Background: Providers should estimate a patient's chance of surviving an in-hospital cardiac arrest with good neurologic outcome when initially admitting a patient, in order to participate in shared decision making with patients about their code status.
    Objective: To examine the utility of the "Good Outcome Following Attempted Resuscitation (GO-FAR)" score in predicting prognosis after in-hospital cardiac arrest in a US trauma center.
    Design: Retrospective observational study SETTING: Level 1 trauma and academic hospital in Minneapolis, MN, USA PARTICIPANTS: All cases of pulseless in-hospital cardiac arrest occurring in adults (18 years or older) admitted to the hospital between Jan 2009 and Sept 2018 are included. For patients with more than one arrest, only the first was included in this analysis.
    Main measures: For each patient with verified in-hospital cardiac arrest, we calculated a GO-FAR score based on variables present in the electronic health record at time of admission. Pre-determined outcomes included survival to discharge and survival to discharge with good neurologic outcome.
    Key results: From 2009 to 2018, 403 adults suffered in-hospital cardiac arrest. A majority (65.5%) were male with a mean age of 60.3 years. Overall survival to discharge was 33.0%; survival to discharge with good neurologic outcome was 17.4%. GO-FAR score calculated at the time of admission correlated with survival to discharge with good neurologic outcome (AUC 0.68), which occurred in 5.3% of patients with below average survival likelihood by GO-FAR score, 22.5% with average survival likelihood, and 34.1% with above average survival likelihood.
    Conclusions: The GO-FAR score can estimate, at time of admission to the hospital, the probability that a patient will survive to discharge with good neurologic outcome after an in-hospital cardiac arrest. This prognostic information can help providers frame discussions with patients on admission regarding whether to attempt cardiopulmonary resuscitation in the event of cardiac arrest.
    MeSH term(s) Aged ; Cardiopulmonary Resuscitation/statistics & numerical data ; Decision Support Techniques ; Female ; Heart Arrest/mortality ; Heart Arrest/therapy ; Humans ; Male ; Middle Aged ; Registries ; Retrospective Studies ; United States/epidemiology
    Language English
    Publishing date 2019-09-11
    Publishing country United States
    Document type Journal Article ; Observational Study ; Validation Study
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-019-05314-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Extracorporeal Membrane Oxygenation in Adults #339.

    Feinstein, Edward / Rubins, Jeffrey / Rosielle, Drew A

    Journal of palliative medicine

    2017  Volume 20, Issue 11, Page(s) 1291–1292

    MeSH term(s) Extracorporeal Membrane Oxygenation/adverse effects ; Family/psychology ; Humans ; Palliative Care ; Patient Satisfaction ; Terminal Care
    Language English
    Publishing date 2017-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2017.0462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The current approach to the diagnosis of pulmonary embolism: lessons from PIOPED II.

    Rubins, Jeffrey B

    Postgraduate medicine

    2008  Volume 120, Issue 1, Page(s) 1–7

    Abstract: The rapid diagnosis of PE is essential to reducing the significant morbidity and mortality of this disease. The recently published PIOPED II reinforces the important lesson of assessing pretest clinical probability to correctly interpret test results, ... ...

    Abstract The rapid diagnosis of PE is essential to reducing the significant morbidity and mortality of this disease. The recently published PIOPED II reinforces the important lesson of assessing pretest clinical probability to correctly interpret test results, and supports a central role of CT angiography in patients with clinically suspected PE. The diagnostic algorithm discussed in this review allows clinicians to utilize the available diagnostic resources practically and efficiently to quickly diagnose and treat PE.
    MeSH term(s) Angiography ; Humans ; Leg/blood supply ; Multicenter Studies as Topic ; Prospective Studies ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2008-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.3810/pgm.2008.04.1753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Formoterol fumarate inhalation solution (Perforomist) for COPD.

    Rubins, Jeffrey B

    Expert review of clinical immunology

    2008  Volume 4, Issue 4, Page(s) 415–423

    Abstract: Formoterol fumarate is an effective treatment for chronic obstructive pulmonary disease (COPD) patients with moderate or greater severity of airflow obstruction. Published studies indicate that formoterol has a rapid onset of bronchodilation, which may ... ...

    Abstract Formoterol fumarate is an effective treatment for chronic obstructive pulmonary disease (COPD) patients with moderate or greater severity of airflow obstruction. Published studies indicate that formoterol has a rapid onset of bronchodilation, which may enhance compliance, and sustained bronchodilation over 12 h, which produces a cumulative effect when inhaled twice daily. With long-term use, formoterol fumarate increases trough forced expiratory volume in 1 s and improves measures of hyperinflation, which correlate with relief of symptoms and a decreased need for additional short-acting bronchodilators as rescue treatment. The combination of formoterol with anticholinergic bronchodilators, especially the long-acting anticholinergic tiotropium, appears to further improve bronchodilation, decrease hyperinflation, improve symptoms and decrease the need for rescue therapy, compared with either agent alone. The availability of formoterol fumarate inhalation solution (Perforomist) for treatment of COPD now extends these benefits to patients who prefer nebulizer therapy and/or cannot use metered-dose or dry-powder inhalers effectively.
    Language English
    Publishing date 2008-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1586/1744666X.4.4.415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Alveolar macrophages: wielding the double-edged sword of inflammation.

    Rubins, Jeffrey B

    American journal of respiratory and critical care medicine

    2003  Volume 167, Issue 2, Page(s) 103–104

    MeSH term(s) Animals ; Disease Models, Animal ; Inflammation/prevention & control ; Inflammation Mediators/metabolism ; Macrophages, Alveolar/metabolism ; Mice ; Pneumonia, Pneumococcal/diagnosis ; Pneumonia, Pneumococcal/prevention & control ; Prognosis ; Sensitivity and Specificity
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2003-01-15
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 1073-449X ; 0003-0805
    ISSN (online) 1535-4970
    ISSN 1073-449X ; 0003-0805
    DOI 10.1164/rccm.2210007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Contemporary issues in the diagnosis and treatment of obstructive sleep apnea.

    Rubins, Jeffrey B / Kunisaki, Ken M

    Postgraduate medicine

    2008  Volume 120, Issue 2, Page(s) 46–52

    Abstract: Obstructive sleep apnea (OSA) is a common disease associated with significant morbidity and use of health care resources. Therapy with continuous positive airway pressure (CPAP) devices has low risk and a potentially large benefit in treating this ... ...

    Abstract Obstructive sleep apnea (OSA) is a common disease associated with significant morbidity and use of health care resources. Therapy with continuous positive airway pressure (CPAP) devices has low risk and a potentially large benefit in treating this disease. The Centers for Medicare and Medicaid Services (CMS) recently issued a memo revising their earlier position that authorized payment for CPAP only if formal polysomnography (PSG) was performed and was diagnostic for OSA. The revised memo states that CMS will be pay for CPAP therapy for 12 weeks (and subsequently if OSA improves) for adults diagnosed with either PSG or with unattended home sleep monitoring devices. The use of portable home monitoring devices can greatly increase access to diagnosis and treatment of OSA. However, these devices must be used as part of a comprehensive sleep evaluation program that includes access to board-certified sleep specialists, PSG facilities, and therapists experienced in fitting and troubleshooting CPAP devices.
    MeSH term(s) Continuous Positive Airway Pressure/instrumentation ; Equipment Design ; Humans ; Monitoring, Ambulatory/instrumentation ; Patient Compliance ; Polysomnography/instrumentation ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/etiology ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2008-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.3810/pgm.2008.07.1790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Preclinical evaluation of [

    Bennacef, Idriss / Rubins, Daniel / Riffel, Kerry / Williams, Mangay / Posavec, Diane J / Holahan, Marie A / Purcell, Mona L / Haley, Hyking D / Wolf, Mary / Stachel, Shawn J / Lubbers, Laura S / Wesolowski, Gregg A / Duong, Le T / Hamill, Terence G / Evelhoch, Jeffrey L / Hostetler, Eric D

    Journal of labelled compounds & radiopharmaceuticals

    2020  Volume 64, Issue 4, Page(s) 159–167

    Abstract: The cathepsin K (CatK) enzyme is abundantly expressed in osteoclasts, and CatK inhibitors have been developed for the treatment of osteoporosis. In our effort to support discovery and clinical evaluations of a CatK inhibitor, we sought to discover a ... ...

    Abstract The cathepsin K (CatK) enzyme is abundantly expressed in osteoclasts, and CatK inhibitors have been developed for the treatment of osteoporosis. In our effort to support discovery and clinical evaluations of a CatK inhibitor, we sought to discover a radioligand to determine target engagement of the enzyme by therapeutic candidates using positron emission tomography (PET). L-235, a potent and selective CatK inhibitor, was labeled with carbon-11. PET imaging studies recording baseline distribution of [
    MeSH term(s) Animals ; Bone and Bones/diagnostic imaging ; Carbon Radioisotopes/chemistry ; Cathepsin K/antagonists & inhibitors ; Cysteine Proteinase Inhibitors/chemistry ; Drug Evaluation, Preclinical ; Female ; Ligands ; Macaca mulatta ; Osteoporosis/diagnostic imaging ; Positron Emission Tomography Computed Tomography/methods ; Protein Binding ; Rabbits ; Radiopharmaceuticals/adverse effects ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution
    Chemical Substances Carbon Radioisotopes ; Cysteine Proteinase Inhibitors ; Ligands ; Radiopharmaceuticals ; Cathepsin K (EC 3.4.22.38)
    Language English
    Publishing date 2020-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 196095-7
    ISSN 1099-1344 ; 0362-4803 ; 0022-2135
    ISSN (online) 1099-1344
    ISSN 0362-4803 ; 0022-2135
    DOI 10.1002/jlcr.3896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Managing stable COPD in 2009: incorporating results from recent clinical studies into a goal-directed approach for clinicians.

    Rubins, Jeffrey B / Raci, Erin / Kunisaki, Ken M

    Postgraduate medicine

    2009  Volume 121, Issue 1, Page(s) 104–112

    Abstract: Chronic obstructive pulmonary disease (COPD) is prevalent in primary care practice and an important cause of functional decline, hospitalizations, and death. Recent clinical trials of COPD therapy demonstrate the ability of bronchodilators (especially ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is prevalent in primary care practice and an important cause of functional decline, hospitalizations, and death. Recent clinical trials of COPD therapy demonstrate the ability of bronchodilators (especially long-acting beta2-agonists and anticholinergics), either alone or in combination with inhaled corticosteroids, to achieve the goals of managing stable disease. These management goals include: symptom relief, improvement in exercise tolerance and health status, prevention of exacerbations and progression of disease, and reduction in mortality. Recent studies of COPD treatment also provide important safety information to help clinicians address patient concerns about treatment risks. We reviewed recent clinical trials to develop concepts of care for the non-specialist clinician managing patients with stable COPD.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Bronchodilator Agents/therapeutic use ; Goals ; Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Randomized Controlled Trials as Topic ; Severity of Illness Index ; Spirometry
    Chemical Substances Adrenal Cortex Hormones ; Bronchodilator Agents
    Language English
    Publishing date 2009-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.3810/pgm.2009.01.1959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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