LIVIVO - Search results -

Search results

Result 1 - 10 of total 599

Search options

Article ; Online: Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone.

Fukuda, Momoko / Fujita, Yuki / Hino, Yuko / Nakao, Mitsuyoshi / Shirahige, Katsuhiko / Yamashita, Toshihide

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: In the adult mammalian brain, neurons are produced from neural stem cells (NSCs) residing in two niches-the subventricular zone (SVZ), which forms the lining of the lateral ventricles, and the subgranular zone in the hippocampus. Epigenetic mechanisms ... ...

Abstract	In the adult mammalian brain, neurons are produced from neural stem cells (NSCs) residing in two niches-the subventricular zone (SVZ), which forms the lining of the lateral ventricles, and the subgranular zone in the hippocampus. Epigenetic mechanisms contribute to maintaining distinct cell fates by suppressing gene expression that is required for deciding alternate cell fates. Several histone deacetylase (HDAC) inhibitors can affect adult neurogenesis in vivo. However, data regarding the role of specific HDACs in cell fate decisions remain limited. Herein, we demonstrate that HDAC8 participates in the regulation of the proliferation and differentiation of NSCs/neural progenitor cells (NPCs) in the adult mouse SVZ. Specific knockout of
MeSH term(s)	Animals ; Mice ; Lateral Ventricles ; Percutaneous Coronary Intervention ; Neural Stem Cells ; Adult Stem Cells ; Histone Deacetylase Inhibitors ; Cell Proliferation ; Mammals
Chemical Substances	Histone Deacetylase Inhibitors
Language	English
Publishing date	2024-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052540
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Reoccurrence of takotsubo cardiomyopathy induced by osimertinib: A case report.

Fukuda, Yuko / Kawa, Yoshitaka / Nonaka, Akiko / Shiotani, Hideyuki

Clinical case reports

2022 Volume 10, Issue 9, Page(s) e6279

Abstract: A patient with lung cancer was administrated osimertinib. She developed symptomatic heart failure due to Takotsubo cardiomyopathy (TC). As her condition improved after discontinuing osimertinib, TC was thought to be caused by osimertinib. Reoccurrence of ...

Abstract	A patient with lung cancer was administrated osimertinib. She developed symptomatic heart failure due to Takotsubo cardiomyopathy (TC). As her condition improved after discontinuing osimertinib, TC was thought to be caused by osimertinib. Reoccurrence of TC was seen after readministrating half dose of osimertinib.
Language	English
Publishing date	2022-09-02
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.6279
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Structure and Additive-free Transamidation of Planar

Yamasaki, Ryu / Okada, Yuko / Iizumi, Hiromi / Ito, Ai / Fukuda, Kazuo / Okamoto, Iwao

The Journal of organic chemistry

2023 Volume 88, Issue 9, Page(s) 5704–5712

Abstract: Although transamidation of amides generally requires metals, additives, or harsh conditions, we present here a facile transamidation ... ...

Abstract	Although transamidation of amides generally requires metals, additives, or harsh conditions, we present here a facile transamidation of
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c00172
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4473: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Swim-up method is superior to density gradient centrifugation for preserving sperm DNA integrity during sperm processing.

Amano, Kenji / Oigawa, Satoko / Ichizawa, Koichiro / Tokuda, Yukiko / Unagami, Mami / Sekiguchi, Mami / Furui, Mayuko / Nakaoka, Kentaro / Ito, Ayumu / Hayashi, Rika / Tamaki, Yuko / Hayashi, Yuko / Fukuda, Yusuke / Katagiri, Yukiko / Nakata, Masahiko / Nagao, Koichi

Reproductive medicine and biology

2024 Volume 23, Issue 1, Page(s) e12562

Abstract: Purpose: This study aimed to evaluate the effects of swim-up and density gradient centrifugation methods on sperm DNA fragmentation.: Methods: Nineteen normozoospermic patient samples with ≥100 × 10: Results: Sperm DNA fragmentation was not ... ...

Abstract	Purpose: This study aimed to evaluate the effects of swim-up and density gradient centrifugation methods on sperm DNA fragmentation. Methods: Nineteen normozoospermic patient samples with ≥100 × 10 Results: Sperm DNA fragmentation was not statistically different between swim-up-(14.4 ± 2.1%, Conclusions: The swim-up method is superior to density gradient centrifugation, evidenced by less sperm DNA fragmentation and higher sperm progressive motility. The recovery rate of progressive motile sperms was better after density gradient centrifugation than after swim-up.
Language	English
Publishing date	2024-01-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2185775-1
ISSN	1447-0578 ; 1445-5781
ISSN (online)	1447-0578
ISSN	1445-5781
DOI	10.1002/rmb2.12562
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6075: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Low-Refractive-Index Deep-Ultraviolet Transparent Poly(fluoroalkyl-

Tsuchiya, Toshiki / Fukuda, Yuko / Kanamura, Kiyoshi / Kajihara, Koichi

The journal of physical chemistry. B

2021 Volume 125, Issue 29, Page(s) 8238–8242

Abstract: Cosolvent-free (solventless) hydrolytic polycondensation of fluoroalkyltrimethoxysilanes of linear fluoroalkyl groups of the form R = ... ...

Abstract	Cosolvent-free (solventless) hydrolytic polycondensation of fluoroalkyltrimethoxysilanes of linear fluoroalkyl groups of the form R = C
MeSH term(s)	Polymers ; Refractometry
Chemical Substances	Polymers
Language	English
Publishing date	2021-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.1c04308
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Mediation of Ferroptosis Suppressor Protein 1 Expression via 4-Hydroxy-2-Nonenal Accumulation Contributes to Acquisition of Resistance to Apoptosis and Ferroptosis in Diffuse Large B-Cell Lymphoma.

Kawade, Genji / Kurata, Morito / Matsuki, Yuko / Fukuda, Sho / Onishi, Iichiroh / Kinowaki, Yuko / Watabe, Shiori / Ishibashi, Sachiko / Ikeda, Masumi / Yamamoto, Masahide / Ohashi, Kenichi / Kitagawa, Masanobu / Yamamoto, Kouhei

Laboratory investigation; a journal of technical methods and pathology

2024 Volume 104, Issue 4, Page(s) 102027

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. New therapeutic strategies are needed for the treatment of refractory DLBCL. 4-Hydroxy-2-nonenal (4-HNE) is a cytotoxic lipid peroxidation marker, which alters intracellular ... ...

Abstract	Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. New therapeutic strategies are needed for the treatment of refractory DLBCL. 4-Hydroxy-2-nonenal (4-HNE) is a cytotoxic lipid peroxidation marker, which alters intracellular signaling and induces genetic mutations. Lipid peroxidation is associated with nonapoptotic cell death, called ferroptosis. However, the relationship between 4-HNE accumulation and feroptotic regulators in DLBCL has not been fully evaluated. Here, we aimed to evaluate the accumulation of lipid peroxide and the expression of ferroptosis suppressor protein 1 (FSP1) in DLBCL using immunohistochemistry. We found a significant increase in the expression of FSP1 in cases with nuclear 4-HNE accumulation (P = .021). Both nuclear and cytoplasmic 4-HNE accumulation and FSP1 positivity were independent predictors of worse prognosis. In vitro exposure to 4-HNE resulted in its concentration- and time-dependent intracellular accumulation and increased expression of FSP1. Furthermore, short-term (0.25 and 1.0 μM) or long-term (0.25 μM) exposure to 4-HNE induced resistance to not only apoptosis but also ferroptosis. Taken together, regulation of FSP1 through 4-HNE accumulation may attenuate resistance to cell death in treatment-resistant DLBCL and might help develop novel therapeutic strategies for refractory DLBCL.
MeSH term(s)	Humans ; Ferroptosis/genetics ; Apoptosis ; Cell Death ; Lymphoma, Large B-Cell, Diffuse/genetics ; Aldehydes
Chemical Substances	4-hydroxy-2-nonenal (K1CVM13F96) ; Aldehydes
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	80178-1
ISSN	1530-0307 ; 0023-6837
ISSN (online)	1530-0307
ISSN	0023-6837
DOI	10.1016/j.labinv.2024.102027
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.164: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Automated artificial intelligence-based phase-recognition system for esophageal endoscopic submucosal dissection (with video).

Furube, Tasuku / Takeuchi, Masashi / Kawakubo, Hirofumi / Maeda, Yusuke / Matsuda, Satoru / Fukuda, Kazumasa / Nakamura, Rieko / Kato, Motohiko / Yahagi, Naohisa / Kitagawa, Yuko

Gastrointestinal endoscopy

2024 Volume 99, Issue 5, Page(s) 830–838

Abstract: Background and aims: Endoscopic submucosal dissection (ESD) for superficial esophageal cancer is a multistep treatment involving several endoscopic processes. Although analyzing each phase separately is worthwhile, it is not realistic in practice owing ... ...

Abstract	Background and aims: Endoscopic submucosal dissection (ESD) for superficial esophageal cancer is a multistep treatment involving several endoscopic processes. Although analyzing each phase separately is worthwhile, it is not realistic in practice owing to the need for considerable manpower. To solve this problem, we aimed to establish a state-of-the-art artificial intelligence (AI)-based system, specifically, an automated phase-recognition system that can automatically identify each endoscopic phase based on video images. Methods: Ninety-four videos of ESD procedures for superficial esophageal cancer were evaluated in this single-center study. A deep neural network-based phase-recognition system was developed in an automated manner to recognize each of the endoscopic phases. The system was trained with the use of videos that were annotated and verified by 2 GI endoscopists. Results: The overall accuracy of the AI model for automated phase recognition was 90%, and the average precision, recall, and F value rates were 91%, 90%, and 90%, respectively. Two representative ESD videos predicted by the model indicated the usability of AI in clinical practice. Conclusions: We demonstrated that an AI-based automated phase-recognition system for esophageal ESD can be established with high accuracy. To the best of our knowledge, this is the first report on automated recognition of ESD treatment phases. Because this system enabled a detailed analysis of phases, collecting large volumes of data in the future may help to identify quality indicators for treatment techniques and uncover unmet medical needs that necessitate the creation of new treatment methods and devices.
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2023.12.037
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 519: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Solubilization of Mouse Sperm Chromatin for Sequencing Analyses Using a Chaperon Protein.

Fukuda, Yuko / Shintomi, Keishi / Yamaguchi, Kosuke / Fujiwara, Yasuhiro / Okada, Yuki

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2577, Page(s) 161–173

Abstract: Sperm chromatin compaction is physiologically essential for sperm to acquire the fertility. However, this unique structure composed of protamines makes us unable to solubilize the chromatin due to its resistance to sonication and enzymes usually used for ...

Abstract	Sperm chromatin compaction is physiologically essential for sperm to acquire the fertility. However, this unique structure composed of protamines makes us unable to solubilize the chromatin due to its resistance to sonication and enzymes usually used for chromatin fragmentation in somatic cells. Even when intense enzymatic treatment is applied, it appears to solubilize only certain portions of sperm chromatin presumably because of the heterogeneous properties. To overcome this issue, we previously developed a method to treat the sperm with recombinant nucleoplasmin, a protamine remover in fertilized embryos, followed by sonication. The nucleoplasmin treatment dramatically increased the efficiency of sperm chromatin solubilization, while a relatively large amount of recombinant nucleoplasmin was required. Here, we describe an improvement of nucleoplasmin method with a less amount of recombinant protein and a shorter reaction time.
MeSH term(s)	Animals ; Chromatin/genetics ; Chromatin/metabolism ; Male ; Mice ; Nuclear Proteins/metabolism ; Nucleoplasmins/metabolism ; Phosphoproteins/metabolism ; Protamines ; Recombinant Proteins/metabolism ; Semen/metabolism ; Spermatozoa/metabolism
Chemical Substances	Chromatin ; Nuclear Proteins ; Nucleoplasmins ; Phosphoproteins ; Protamines ; Recombinant Proteins
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2724-2_11
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: A new lymphedema treatment using pyro-drive jet injection.

Nishiyama, Megumi / Sakaguchi, Yuko / Morito, Sayuri / Nagase, Kei / Sakumoto, Takehisa / Yamashita, Kunihiko / Hashiguchi, Mariko / Fukuda, Makoto / Toda, Shuji / Aoki, Shigehisa

Human cell

2024 Volume 37, Issue 2, Page(s) 465–477

Abstract: Lymphedema, resulting from impaired lymphatic drainage, causes inflammation, fibrosis and tissue damage leading to symptoms such as limb swelling and restricted mobility. Despite various treatments under exploration, no standard effective therapy exists. ...

Abstract	Lymphedema, resulting from impaired lymphatic drainage, causes inflammation, fibrosis and tissue damage leading to symptoms such as limb swelling and restricted mobility. Despite various treatments under exploration, no standard effective therapy exists. Here a novel technique using the pyro-drive jet injection (PJI) was used to create artificial clefts between collagen fibers, which facilitated the removal of excess interstitial fluid. The PJI was used to deliver a mixture of lactated Ringer's solution and air into the tail of animals with secondary skin edema. Edema levels were assessed using micro-CT scanning. Histopathological changes and neovascularization were evaluated on the injury-induced regenerative tissue. Regarding tissue remodeling, we focused on connective tissue growth factor (CTGF) and vascular endothelial growth factor (VEGF)-C. PJI markedly diminished soft tissue volume in the experimental lymphedema animals compared to the non-injected counterparts. The PJI groups exhibited a significantly reduced proportion of inflammatory granulation tissue and an enhanced density of lymphatic vessels and α-smooth muscle actin (αSMA)-positive small vessels in the fibrous granulation tissue compared to the controls. In addition, PJI curtailed the prevalence of CTGF- and VEGF-C-positive cells in regenerative tissue. In a lymphedema animal model, PJI notably ameliorated interstitial edema, promoted lymphatic vessel growth, and bolstered αSMA-positive capillaries in fibrous granulation tissue. PJI's minimal tissue impact post-lymph node dissection indicates significant potential as an early, standard preventative measure. Easily applied in general clinics without requiring specialized training, it offers a cost-effective and highly versatile solution to the management of lymphedema.
MeSH term(s)	Animals ; Vascular Endothelial Growth Factor A/metabolism ; Lymphedema/therapy ; Lymphedema/etiology ; Lymphedema/pathology ; Lymphatic Vessels/diagnostic imaging ; Lymphatic Vessels/pathology ; Skin/metabolism ; Edema/complications ; Edema/metabolism ; Edema/pathology
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2024-01-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1149134-6
ISSN	1749-0774 ; 0914-7470
ISSN (online)	1749-0774
ISSN	0914-7470
DOI	10.1007/s13577-023-01021-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3676: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Bulbar and post-bulbar duodenal ulcers: characteristics based on location.

Okamoto, Takeshi / Okamoto, Satomi / Yamamoto, Kazuki / Takasu, Ayaka / Murashima, Yuko / Fukui, Sho / Fukuda, Katsuyuki

European journal of gastroenterology & hepatology

2023 Volume 35, Issue 9, Page(s) 955–961

Abstract: Objectives: Most research on duodenal ulcers has focused on bulbar ulcers; details on post-bulbar ulcers remain largely unknown. This study was conducted to determine the characteristics of patients with post-bulbar duodenal ulcers depending on their ... ...

Abstract	Objectives: Most research on duodenal ulcers has focused on bulbar ulcers; details on post-bulbar ulcers remain largely unknown. This study was conducted to determine the characteristics of patients with post-bulbar duodenal ulcers depending on their location. Methods and materials: We conducted a retrospective study of hospitalized patients newly diagnosed with duodenal ulcers on endoscopy at a tertiary referral center in Japan between April 2004 and March 2019. Five hundred fifty-one patients diagnosed with duodenal ulcers were extracted for analysis. Results: Ulcers were observed only in the bulbus in 383 cases, only in the post-bulbar duodenum in 82 cases, and were co-existing in both areas in 86 cases. The Bulbar group had less comorbidities and was more likely to have atrophic gastritis, while the Post-bulbar and Co-existing groups were more likely to be admitted for non-gastrointestinal conditions. Regular acid suppressant use was more common in the post-bulbar group than in the Bulbar group. Bulbar ulcers were associated with a shorter length of stay relative to post-bulbar and co-existing ulcers, but ulcer location was not an independent predictor of length of stay. Patients with co-existing bulbar and post-bulbar ulcers have characteristics similar to those with post-bulbar ulcers alone. Conclusion: Patients with post-bulbar ulcers and those with co-existing bulbar and post-bulbar ulcers have different characteristics and outcomes relative to patients with bulbar ulcers.
MeSH term(s)	Humans ; Duodenal Ulcer/complications ; Duodenal Ulcer/diagnosis ; Duodenal Ulcer/epidemiology ; Ulcer ; Retrospective Studies ; Duodenum ; Endoscopy, Gastrointestinal
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002585
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2932: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito