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Article ; Online: Obesity among Asian American people in the United States: A review.

Li, Zhaoping / Daniel, Sunil / Fujioka, Ken / Umashanker, Devika

2023 Volume 31, Issue 2, Page(s) 316–328

Abstract: Standard measures of obesity, i.e., body weight and BMI, suggest that Asian American people have a lower obesity prevalence than other racial groups in the United States. However, Asian American people face a unique challenge in their pattern of ... ...

Abstract	Standard measures of obesity, i.e., body weight and BMI, suggest that Asian American people have a lower obesity prevalence than other racial groups in the United States. However, Asian American people face a unique challenge in their pattern of adiposity with central obesity, which raises the risk for multiple comorbidities, such as type 2 diabetes, metabolic syndrome, and cardiovascular disease, at a lower BMI compared with other populations. Several organizations recommend lower BMI cutoffs for obesity in Asian people (BMI ≥25.0 or ≥27.5 kg/m
MeSH term(s)	Humans ; Asian ; Body Mass Index ; Diabetes Mellitus, Type 2/epidemiology ; Metabolic Syndrome/epidemiology ; Obesity/epidemiology ; United States/epidemiology
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23639
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Article ; Online: Barriers and Solutions for Prescribing Obesity Pharmacotherapy.

Fujioka, Ken / Harris, Samantha R

Endocrinology and metabolism clinics of North America

2020 Volume 49, Issue 2, Page(s) 303–314

Abstract: There are many valid reasons why health care providers are reluctant to use pharmacotherapy for weight management: the negative track record of weight loss medications has led to numerous safety concerns, and there is lack of formal training in obesity ... ...

Abstract	There are many valid reasons why health care providers are reluctant to use pharmacotherapy for weight management: the negative track record of weight loss medications has led to numerous safety concerns, and there is lack of formal training in obesity medicine and a general discomfort with using these medications. New medications have improved safety profiles, and their mechanisms are based on recent discoveries of how humans regulate weight. This, combined with a change in American health coverage, has slowly increased the use weight loss medication. This article examines the barriers and changes that are increasing the use of anti-obesity medications.
MeSH term(s)	Anti-Obesity Agents/adverse effects ; Anti-Obesity Agents/therapeutic use ; Drug Prescriptions/statistics & numerical data ; Humans ; Insurance Coverage/statistics & numerical data ; Obesity/drug therapy ; Practice Patterns, Physicians'/statistics & numerical data
Chemical Substances	Anti-Obesity Agents
Language	English
Publishing date	2020-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	92116-6
ISSN	1558-4410 ; 0889-8529
ISSN (online)	1558-4410
ISSN	0889-8529
DOI	10.1016/j.ecl.2020.02.007
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Article ; Online: Safety and tolerability of medications approved for chronic weight management.

Fujioka, Ken

Obesity (Silver Spring, Md.)

2015 Volume 23 Suppl 1, Page(s) S7–11

Abstract: In 2014 we have 4 new weight loss medications and one older medication with very different mechanisms of action – all approved for chronic weight management. Each medication has its own unique risk profile that makes patient selection important. ... ...

Abstract	In 2014 we have 4 new weight loss medications and one older medication with very different mechanisms of action – all approved for chronic weight management. Each medication has its own unique risk profile that makes patient selection important. Knowledge of the contraindications and safety issues can guide physicians to the most appropriate choice for a particular patient. Obesity medicine is entering a new era where our available options for prescribing have been very well studied. There should be no surprises, because bupropion, naltrexone, phentermine, topiramate and liraglutide have been prescribed for many years in millions of patients and lorcaserin has high specificity for a single receptor subtype. The FDA demanded very detailed risk-oriented studies to have these medications approved. In addition, the FDA has established REMS programs or risk management strategies to help ensure that the patients do not receive inappropriate medications. These medications were approved by the US FDA after very thorough testing. The decision to approve these medications was based on the benefits out-weighing the risks. Thus, if following the appropriate guidelines according to package labels, the practitioner can feel safe in prescribing these medications.
MeSH term(s)	Anti-Obesity Agents/adverse effects ; Anti-Obesity Agents/therapeutic use ; Benzazepines/therapeutic use ; Bupropion/adverse effects ; Delayed-Action Preparations ; Drug-Related Side Effects and Adverse Reactions ; Drugs, Investigational/therapeutic use ; Fructose/analogs & derivatives ; Fructose/therapeutic use ; Glucagon-Like Peptide 1/analogs & derivatives ; Glucagon-Like Peptide 1/therapeutic use ; Humans ; Liraglutide ; Naltrexone/therapeutic use ; Obesity/drug therapy ; Obesity/prevention & control ; Phentermine/therapeutic use ; United States ; United States Food and Drug Administration ; Weight Loss/drug effects
Chemical Substances	Anti-Obesity Agents ; Benzazepines ; Delayed-Action Preparations ; Drugs, Investigational ; Bupropion (01ZG3TPX31) ; topiramate (0H73WJJ391) ; Fructose (30237-26-4) ; Naltrexone (5S6W795CQM) ; lorcaserin (637E494O0Z) ; Liraglutide (839I73S42A) ; Glucagon-Like Peptide 1 (89750-14-1) ; Phentermine (C045TQL4WP)
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.21094
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Article ; Online: Home access to a weight scale in the Hispanic/Latino population attending a community-based free clinic.

Fujioka, Ken / Fujioka, Jacob / Mafong, Kaley / Wetherhold, Nicole / Kim, Sally / Rasul, Amin / Lopez, Alyssa / Cummins, Kevin

Obesity science & practice

2023 Volume 10, Issue 1, Page(s) e711

Abstract: Background: Daily weighing has been shown to help with weight management. In primary care, the majority of virtual visits will ask patients about their weight. However, little is known about whether patients, especially those in the Hispanic/Latino ... ...

Abstract	Background: Daily weighing has been shown to help with weight management. In primary care, the majority of virtual visits will ask patients about their weight. However, little is known about whether patients, especially those in the Hispanic/Latino population, have access to a weight scale. Our aim was to determine scale access and perceived height and weight in the Hispanic/Latino population attending a volunteer, no cost, community clinic. Methods: Questionnaires were issued to patients attending the community clinic and a comparator group attending a medically insured primary care practice. Results: Only 52% of the Hispanic/Latino patients attending the community clinic had access to a scale compared with 85% of patients in the primary care office. Patients underreported weight and overreported height leading to underreporting body mass index by 0.6 ± 3.2 kg/m Conclusions: Healthcare providers who care for uninsured Hispanic/Latino patients in community clinics may need to be aware that patients may not have access to a scale.
Language	English
Publishing date	2023-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2836381-4
ISSN	2055-2238 ; 2055-2238
ISSN (online)	2055-2238
ISSN	2055-2238
DOI	10.1002/osp4.711
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Article ; Online: Additional superdrainage reduces anastomotic fistula and stenosis after gastric tube reconstruction with cervical anastomosis for esophageal cancer.

Fujioka, Masaki / Taniguchi, Ken / Yoneda, Akira / Fukui, Kiyoko / Yoshino, Kentaro / Idemitsu, Marie

JTCVS techniques

2023 Volume 19, Page(s) 142–146

Abstract: Objective: Gastric pull-up is a common procedure to reconstruct the continuity of the upper digestive tract after esophagectomy. However, this technique sometimes causes postoperative anastomotic leakage or stricture, resulting from congestion of the ... ...

Abstract	Objective: Gastric pull-up is a common procedure to reconstruct the continuity of the upper digestive tract after esophagectomy. However, this technique sometimes causes postoperative anastomotic leakage or stricture, resulting from congestion of the gastric tube. We performed additional microvascular venous anastomoses to solve this problem. The purpose of this study was to compare postoperative anastomotic leaks and strictures in cases with or without additional venous superdrainage after gastric tube reconstruction. Methods: A total of 117 consecutive patients with cervical and thoracic esophageal cancer who underwent thoracoscopic esophagectomy with gastric tube reconstruction in the National Nagasaki Medical Center between 2011 and 2021 were analyzed retrospectively. Of these patients, 46 did not undergo additional venous anastomoses (standard group), and 71 who underwent gastric pull-up surgery after November 2014 have added this surgical procedure to their routine (superdrainage group). We compared the frequency of postsurgical leakage and stricture in the 2 groups retrospectively. Results: Fifteen patients (32.6%) developed postoperative leakage in the standard group and 6 (8.5%) did so in the superdrainage group. Twelve patients (26.1%) showed postoperative anastomotic stricture in the standard group and 7 (9.9%) did so in the superdrainage group. Patients who did not undergo additional venous superdrainage were significantly more likely to develop postsurgical leakage (χ Conclusions: Our study revealed that performing additional venous anastomosis for as little as 1 hour can significantly reduce the incidence of postoperative leakage and stenosis. This procedure is of merit to perform after total esophagectomy with gastric tube reconstruction.
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article
ISSN	2666-2507
ISSN (online)	2666-2507
DOI	10.1016/j.xjtc.2023.03.005
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Article: Obesity Pharmacotherapy in Patients With Type 2 Diabetes.

Kahan, Scott / Fujioka, Ken

Diabetes spectrum : a publication of the American Diabetes Association

2017 Volume 30, Issue 4, Page(s) 250–257

Abstract: ... IN ... ...

Abstract	IN BRIEF
Language	English
Publishing date	2017-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211544-4
ISSN	1040-9165
ISSN	1040-9165
DOI	10.2337/ds17-0044
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Article ; Online: Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin.

Mizuno, Masashi / Fujioka, Asuka / Bitani, Shiho / Minato, Ken-Ichiro / Sakakibara, Hiroyuki

International journal of molecular sciences

2022 Volume 23, Issue 20

Abstract: In recent years, the incidence of type I hypersensitivity including hay fever has been increasing year by year in Japan. Our previous study using mice showed that only oral, but not intraperitoneal, administration of fucoidan extracted from seaweed ( ...

Abstract	In recent years, the incidence of type I hypersensitivity including hay fever has been increasing year by year in Japan. Our previous study using mice showed that only oral, but not intraperitoneal, administration of fucoidan extracted from seaweed (
MeSH term(s)	Mice ; Animals ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Kaempferols ; Anti-Allergic Agents/pharmacology ; Anti-Allergic Agents/therapeutic use ; Flavonols ; Vegetables ; Immunoglobulin E ; Hypersensitivity, Immediate ; Food Ingredients ; Galectins
Chemical Substances	Quercetin (9IKM0I5T1E) ; Kaempferols ; fucoidan (9072-19-9) ; Anti-Allergic Agents ; Flavonols ; Immunoglobulin E (37341-29-0) ; Food Ingredients ; Galectins
Language	English
Publishing date	2022-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232012163
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Article: Binge-Eating Disorder and Type 2 Diabetes: A Review.

Harris, Samantha R / Carrillo, Maritza / Fujioka, Ken

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

2020 Volume 27, Issue 2, Page(s) 158–164

Abstract: Objective: To familiarize health care providers with diagnosis and treatment of binge-eating disorder (BED), a common comorbidity of type 2 diabetes (T2DM).: Methods: Literature review of binge eating and T2DM. Key words used in search include BED, ... ...

Abstract	Objective: To familiarize health care providers with diagnosis and treatment of binge-eating disorder (BED), a common comorbidity of type 2 diabetes (T2DM). Methods: Literature review of binge eating and T2DM. Key words used in search include BED, T2DM, obesity, and treatment. Results: The prevalence of BED in patients with T2DM appears to be much higher than the 2% to 3.5% prevalence seen in the general population. Studies suggest that up to 20% of patients with T2DM have an underlying eating disorder, the most common of which is binge eating. BED is probably underdiagnosed, even though there are multiple simple tools that providers can use to improve screening for the disorder. Though the relationship between BED and hemoglobin A1c control can vary, it appears that binge-eating behaviors can worsen metabolic markers, including glycemic control. Various medications used by patients with diabetes have been associated with new-onset BED, and treatment may be as simple as removing or replacing such agents. Several medications have been found to significantly reduce binge-eating frequency, and potentially, weight. Patients with BED generally benefit from psychotherapy, including cognitive behavioral therapy. Conclusion: BED, only recently added to the International Classification of Disease-10 diagnostic list, is very common in patients with obesity and T2DM. The diagnosis is important to establish, as treatment or referral for treatment, could potentially improve many of the comorbidities and metrics of T2DM.
MeSH term(s)	Binge-Eating Disorder/diagnosis ; Binge-Eating Disorder/epidemiology ; Binge-Eating Disorder/therapy ; Cognitive Behavioral Therapy ; Comorbidity ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/therapy ; Humans ; Obesity/complications ; Obesity/epidemiology
Language	English
Publishing date	2020-12-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1473503-9
ISSN	1530-891X
ISSN	1530-891X
DOI	10.1016/j.eprac.2020.10.005
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Article ; Online: Impact of Telemedicine During the COVID-19 Pandemic on Patient Attendance.

Aras, Mohini / Tchang, Beverly G / Crawford, Andrew / Bledsoe, Melissa / Fujioka, Ken / Aronne, Louis J

Obesity (Silver Spring, Md.)

2021 Volume 29, Issue 7, Page(s) 1093–1094

MeSH term(s)	COVID-19 ; Counseling ; Humans ; Pandemics ; SARS-CoV-2 ; Telemedicine
Language	English
Publishing date	2021-05-07
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23180
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Article ; Online: Effects of "Essential AD2" Supplement on Blood Acetaldehyde Levels in Individuals Who Have Aldehyde Dehydrogenase (ALDH2) Deficiency.

Fujioka, Ken / Gordon, Spencer

American journal of therapeutics

2018 Volume 26, Issue 5, Page(s) 583–588

Abstract: Background: It is estimated that 1 billion people in the world have a point mutation in the gene encoding the aldehyde dehydrogenase 2 (ALDH2) enzyme, the primary enzyme responsible for the metabolism of acetaldehyde. The presence of this mutation is ... ...

Abstract	Background: It is estimated that 1 billion people in the world have a point mutation in the gene encoding the aldehyde dehydrogenase 2 (ALDH2) enzyme, the primary enzyme responsible for the metabolism of acetaldehyde. The presence of this mutation is called ALDH2 deficiency. Because of limited ability to metabolize acetaldehyde, individuals with ALDH2 deficiency experience elevated levels of blood acetaldehyde after exposure to various common sources such as recreational alcohol. Because of higher levels of acetaldehyde, individuals with ALDH2 deficiency are at higher risk for numerous diseases, including liver cirrhosis, esophageal and gastric cancer, osteoporosis, and Alzheimer disease. Study question: The present trial was designed to study the effectiveness, safety, and tolerability of a nutritional supplement (Essential AD2). Measures and outcomes: The primary outcome was change in acetaldehyde levels in the blood after exposure to alcohol in individuals with ALDH2 deficiency before and after the use of study nutritional supplement. Study design: This was a 28-day open-label trial, comparing initial acetaldehyde levels after alcohol ingestion to levels after 28 days of a nutritional supplement (Essential AD2). The study consisted of 12 subjects genotyped to be heterozygous for the ALDH2 gene mutation. Results and conclusions: ALDH2 deficient subjects showed a significant decrease in average blood acetaldehyde level 20 minutes after alcohol consumption (from 0.91 mg/dL to 0.71 mg/dL, P value = 0.02) after receiving 28 days of the nutritional supplement. Acetaldehyde levels taken at 10 minutes and 40 minutes also showed a decrease, although they were not statistically significant. In addition, safety tests looking at liver function tests showed a decrease in aspartate transaminase and alanine transaminase liver proteins from 27.3 to 15.2 and 20.9 to 13.2, respectively, over the 28 days. The treatment was well tolerated and no significant side effects were noted.
MeSH term(s)	Acetaldehyde/blood ; Acetaldehyde/metabolism ; Adult ; Alcohol Drinking/blood ; Alcohol Drinking/metabolism ; Aldehyde Dehydrogenase, Mitochondrial/deficiency ; Aldehyde Dehydrogenase, Mitochondrial/genetics ; Asians/genetics ; Dietary Supplements/adverse effects ; Ethanol/administration & dosage ; Ethanol/adverse effects ; Ethanol/metabolism ; Female ; Healthy Volunteers ; Humans ; Liver/drug effects ; Liver/metabolism ; Liver Function Tests ; Male ; Middle Aged ; Pilot Projects ; Placebos/administration & dosage ; Placebos/adverse effects ; Point Mutation ; Treatment Outcome ; Young Adult
Chemical Substances	Placebos ; Ethanol (3K9958V90M) ; ALDH2 protein, human (EC 1.2.1.3) ; Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3) ; Acetaldehyde (GO1N1ZPR3B)
Language	English
Publishing date	2018-03-07
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/MJT.0000000000000744
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