Article ; Online: Innate immunity: regulation of caspases by IAP-dependent ubiquitylation.
2012 Volume 31, Issue 12, Page(s) 2750–2752
Abstract: Caspases are widely known as initiators and executioners of cell death. Full activation of caspases leading to cleavage of many cellular substrates was long considered to be a point-of-no-return in the apoptosis pathway. However, it also has been known ... ...
Abstract | Caspases are widely known as initiators and executioners of cell death. Full activation of caspases leading to cleavage of many cellular substrates was long considered to be a point-of-no-return in the apoptosis pathway. However, it also has been known that activated caspases do not always have the ability to kill, but instead initiate non-apoptotic processes such as cell differentiation or activation of innate immune responses. In this issue of The EMBO Journal, Meinander et al (2012) explore the contribution of polyubiquitination of Dredd, a known initiator caspase, to the activation of innate immunity. The authors show that infection with gram-negative bacteria leads to DIAP2-dependent ubiquitylation of Dredd which in turn is required for processing of Relish (Rel) and expression of antimicrobial peptide (AMP) genes that are indispensable for fighting the infection. |
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MeSH term(s) | Animals ; Carrier Proteins/metabolism ; Caspases/metabolism ; Drosophila/immunology ; Drosophila Proteins/metabolism ; Gene Expression Regulation ; Gram-Negative Bacteria/immunology ; Inhibitor of Apoptosis Proteins/metabolism ; Ubiquitination |
Chemical Substances | Carrier Proteins ; DIAP2 protein, Drosophila ; Drosophila Proteins ; Inhibitor of Apoptosis Proteins ; peptidoglycan recognition protein ; Caspases (EC 3.4.22.-) ; dredd protein, Drosophila (EC 3.4.22.-) |
Language | English |
Publishing date | 2012-05-15 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Comment |
ZDB-ID | 586044-1 |
ISSN | 1460-2075 ; 0261-4189 |
ISSN (online) | 1460-2075 |
ISSN | 0261-4189 |
DOI | 10.1038/emboj.2012.148 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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