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Article ; Online: Plasma

Mazidi, Mohsen / Ferns, Gordon A

Journal of the American Nutrition Association

2023 Volume 42, Issue 5, Page(s) 427–434

Abstract: Objective: To investigate the association between plasma : Methods: Participants (the National Health and Nutrition Examination Survey) with measured data on BMD and TFAs were included. TFAs were measured by gas chromatography-mass spectrometry and ... ...

Abstract	Objective: To investigate the association between plasma Methods: Participants (the National Health and Nutrition Examination Survey) with measured data on BMD and TFAs were included. TFAs were measured by gas chromatography-mass spectrometry and BMD was measured using dual-energy x-ray absorptiometry densitometers. Results: Of the 4022 eligible participants, 48.1% were men. The mean age of the population sample was 44.6 years. In the model adjusted for age, sex, race, education, income, physical activity, smoking, fasting blood glucose, systolic and diastolic blood pressure, body mass index, diabetes, and hypertension, across the increasing quartiles (Q) of individual plasma TFAs, BMD decreased for most of the sites measure: for example, Q1 vs. Q4 1.04 vs. 0.095 g/cm Conclusions: Our findings highlight, for the first time, the potentially detrimental impact of plasma TFAs on bone health that does not appear to be moderated through inflammation.
MeSH term(s)	Adult ; Male ; Humans ; Female ; Bone Density ; Trans Fatty Acids ; Nutrition Surveys ; Inflammation ; Diabetes Mellitus ; Fractures, Bone/epidemiology
Chemical Substances	Trans Fatty Acids
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article
ISSN	2769-707X
ISSN (online)	2769-707X
DOI	10.1080/07315724.2019.1635051
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Article ; Online: Surrogate markers of insulin resistance and arterial stiffness.

Mazidi, Mohsen

Journal of diabetes and its complications

2019 Volume 34, Issue 6, Page(s) 107491

MeSH term(s)	Biomarkers ; Cardiovascular Diseases/epidemiology ; Female ; Humans ; Insulin Resistance ; Male ; Vascular Stiffness
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-11-21
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2019.107491
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Article ; Online: Plasma Trans Fatty Acids Concentrations Are Inversely Related to Bone Mineral Density and This Appears to Be Independent of Inflammation

Mazidi, Mohsen / Ferns, Gordon A.

Journal of the American Nutrition Association. 2023 July 4, v. 42, no. 5, p. 427-434

2023 , Page(s) 427–434

Abstract: To investigate the association between plasma trans fatty acids (TFAs) and bone mineral density (BMD) and risk of fracture among US adults. Furthermore, we have evaluated the impact of inflammation on this relationship. Participants (the National Health ... ...

Abstract	To investigate the association between plasma trans fatty acids (TFAs) and bone mineral density (BMD) and risk of fracture among US adults. Furthermore, we have evaluated the impact of inflammation on this relationship. Participants (the National Health and Nutrition Examination Survey) with measured data on BMD and TFAs were included. TFAs were measured by gas chromatography–mass spectrometry and BMD was measured using dual-energy x-ray absorptiometry densitometers. Of the 4022 eligible participants, 48.1% were men. The mean age of the population sample was 44.6 years. In the model adjusted for age, sex, race, education, income, physical activity, smoking, fasting blood glucose, systolic and diastolic blood pressure, body mass index, diabetes, and hypertension, across the increasing quartiles (Q) of individual plasma TFAs, BMD decreased for most of the sites measure: for example, Q1 vs. Q4 1.04 vs. 0.095 g/cm² for palmitelaidic acid and 1.11 vs. 0.099 g/cm² for elaidic acid (all p < 0.001). In models using the same adjustment, linear regression displayed a significant negative association between plasma TFAs and BMD for most of the sites measured (all p < 0.001). Moderation analysis revealed that inflammation [assessed as a serum C-reactive protein (CRP)] was not significantly implicated in the relationship between BMD and TFAs. There was no significant difference in percentage of fractures (hip, spine, wrist) observed across quartiles of plasma TFAs (all p > 0.125). Our findings highlight, for the first time, the potentially detrimental impact of plasma TFAs on bone health that does not appear to be moderated through inflammation.
Keywords	C-reactive protein ; National Health and Nutrition Examination Survey ; blood glucose ; blood serum ; body mass index ; bone density ; bone health ; densitometers ; diabetes ; diastolic blood pressure ; dual-energy X-ray absorptiometry ; education ; elaidic acid ; gas chromatography-mass spectrometry ; hips ; hypertension ; income ; inflammation ; models ; nutrition ; physical activity ; regression analysis ; risk ; Trans fatty acids ; bone mineral density ; fracture
Language	English
Dates of publication	2023-0704
Size	p. 427-434
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	2769-707X
DOI	10.1080/07315724.2019.1635051
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Construct Validity and Measurement Invariance of the Difficulties in Emotion Regulation Scale - Short Form (DERS-SF): Further Evidence From Community and Student Samples.

Asgarizadeh, Ahmad / Mazidi, Mahdi / Preece, David A / Dehghani, Mohsen

Journal of personality assessment

2024 , Page(s) 1–11

Abstract: The current study aimed to evaluate the psychometric properties of the Difficulties in Emotion Regulation Scale-Short Form (DERS-SF) in Iran, including testing its measurement invariance across sexes, as well as community and student populations. Two ... ...

Abstract	The current study aimed to evaluate the psychometric properties of the Difficulties in Emotion Regulation Scale-Short Form (DERS-SF) in Iran, including testing its measurement invariance across sexes, as well as community and student populations. Two samples were recruited: a community sample of 583 participants (58.7% female; M
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	121962-5
ISSN	1532-7752 ; 0022-3891
ISSN (online)	1532-7752
ISSN	0022-3891
DOI	10.1080/00223891.2024.2340506
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Article ; Online: Higher Plasma Levels of Valerate Produced by Gut Microbiota May Have a Beneficial Impact on Renal Function.

Mazidi, Mohsen / Katsiki, Niki / Banach, Maciej

Journal of the American Nutrition Association

2023 Volume 42, Issue 6, Page(s) 534–540

Abstract: Objective: Observational studies have evaluated the relationships among plasma short chain fatty acids (SCFA) produced by gut microbiota, renal function, and risk of chronic kidney disease (CKD). In the present study, Mendelian Randomization (MR) ... ...

Abstract	Objective: Observational studies have evaluated the relationships among plasma short chain fatty acids (SCFA) produced by gut microbiota, renal function, and risk of chronic kidney disease (CKD). In the present study, Mendelian Randomization (MR) analysis was applied to obtain unconfounded estimates of the casual association of genetically determined plasma valerate (an SCFA) with kidney function and risk of CKD. Method: MR was performed by using summary-level data from the largest genome-wide association studies (GWAS) conducted on plasma valerate, CKD, and estimated glomerular filtration rate (eGFR; separately in diabetic and nondiabetic individuals). Inverse variance weighted method (IVW), weighted median-based method, MR-Egger, as well as MR-Pleiotropy RESidual Sum and Outlier (PRESSO) were applied. Sensitivity analysis was conducted using the leave-one-out method. Results: No significant association was observed between plasma valerate and CKD (IVW: β = 0.234, Conclusions: Individuals with higher plasma valerate levels had better renal function, defined by eGFR. This finding was observed in the total population and in nondiabetic subjects, but not in those with diabetes. Further research is needed to elucidate the links among plasma valerate, kidney function, and CKD.
MeSH term(s)	Humans ; Gastrointestinal Microbiome/genetics ; Genome-Wide Association Study ; Kidney/physiology ; Renal Insufficiency, Chronic/genetics ; Valerates ; Mendelian Randomization Analysis
Chemical Substances	Valerates
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article
ISSN	2769-707X
ISSN (online)	2769-707X
DOI	10.1080/07315724.2019.1664955
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Article ; Online: The link between serum 25-hydroxyvitamin D, inflammation and glucose/insulin homoeostasis is mediated by adiposity factors in American adults.

Mazidi, Mohsen / Siervo, Mario

The British journal of nutrition

2021 Volume 130, Issue 3, Page(s) 423–432

Abstract: We used an established mediation analysis to investigate the role of adiposity in the relation between serum 25(OH)D with markers of inflammation and glucose and insulin metabolism. We used data from National Health and Nutrition Examination Survey (2005- ...

Abstract	We used an established mediation analysis to investigate the role of adiposity in the relation between serum 25(OH)D with markers of inflammation and glucose and insulin metabolism. We used data from National Health and Nutrition Examination Survey (2005-2010), to evaluate the associations between serum 25(OH)D and markers of insulin resistance (IR) or inflammation, and whether these associations are mediated by adiposity factors. Analysis of co-variance and conceptual causal mediation analysis were conducted taking into consideration the survey design and sample weights. BMI was found to have significant mediation effects (to varied extent) on the associations between serum 25(OH)D and CRP, apo-B, fasting glucose, insulin, HOMA-IR, HOMA-B and HbA1c (all
MeSH term(s)	Adult ; Humans ; United States/epidemiology ; Adiposity ; Glycated Hemoglobin ; Nutrition Surveys ; Blood Glucose/analysis ; Vitamin D ; Insulin Resistance ; Obesity ; Insulin ; Calcifediol ; Inflammation ; Homeostasis ; Body Mass Index
Chemical Substances	25-hydroxyvitamin D (A288AR3C9H) ; Glycated Hemoglobin ; Blood Glucose ; Vitamin D (1406-16-2) ; Insulin ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2021-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114521000209
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Article ; Online: Egg Intake: Getting the Balance Right!

Mazidi, Mohsen / Banach, Maciej

Angiology

2020 Volume 71, Issue 7, Page(s) 585

MeSH term(s)	Coronary Artery Disease ; Energy Metabolism ; Humans
Language	English
Publishing date	2020-04-03
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/0003319720912153
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Article ; Online: The role of inflammation and the possibilities of inflammation reduction to prevent cardiovascular events.

Maierean, Serban / Webb, Richard / Banach, Maciej / Mazidi, Mohsen

European heart journal open

2022 Volume 2, Issue 4, Page(s) oeac039

Abstract: Chronic systemic inflammation is a risk factor for cardiovascular (CV) disease (CVD). Whether this relationship extends to subclinical inflammation, quantified by values of circulating markers associated with inflammation in the high range of the normal ... ...

Abstract	Chronic systemic inflammation is a risk factor for cardiovascular (CV) disease (CVD). Whether this relationship extends to subclinical inflammation, quantified by values of circulating markers associated with inflammation in the high range of the normal interval, remains debatable. This narrative review evaluates evidence exploring this relationship. A review of pharmacological and non-pharmacological interventions, including diet and lifestyle strategies, supplements, nutraceuticals, and other natural substances aimed at reducing inflammation was also conducted, since few reviews have synthesized this literature. PubMed and EMBASE were used to search the literature and several well-studied triggers of inflammation [oxidized LDL, Lp(a), as well as C-reactive protein (CRP)/high-sensitivity CRP (hs-CRP)] were included to increase sensitivity and address the lack of existing reviews summarizing their influence in the context of inflammation. All resulting references were assessed. Overall, there is good data supporting associations between circulating hs-CRP and CV outcomes. However, the same was not seen in studies evaluating triggers of inflammation, such as oxidized LDL or Lp(a). There is also insufficient evidence showing treatments to target inflammation and lead to reductions in hs-CRP result in improvements in CV outcomes, particularly in those with normal baseline levels of hs-CRP. Regarding pharmacological interventions, statins, bempedoic acid, and apabetalone significantly reduce circulating hs-CRP, unlike PCSK-9 inhibitors. A variety of natural substances and vitamins were also evaluated and none reduced hs-CRP. Regarding non-pharmacological interventions, weight loss was strongly associated with reductions in circulating hs-CRP, whereas various dietary interventions and exercise regimens were not, unless accompanied by weight loss.
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Journal Article ; Review
ISSN	2752-4191
ISSN (online)	2752-4191
DOI	10.1093/ehjopen/oeac039
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Article ; Online: Predicted impact of increasing average ambient temperature over the coming century on mortality from cardiovascular disease and stroke in the USA.

Mazidi, Mohsen / Speakman, John R

Atherosclerosis

2020 Volume 313, Page(s) 1–7

Abstract: Background and aims: Future climate change may adversely impact human health. The direct effects of extreme hot temperatures on mortality are well established, and their future impact well modelled. However, less extreme changes in ambient temperature ( ... ...

Abstract	Background and aims: Future climate change may adversely impact human health. The direct effects of extreme hot temperatures on mortality are well established, and their future impact well modelled. However, less extreme changes in ambient temperature (Ta) have been previously associated with increased mortality from circulatory and metabolic diseases, but their future impact is less clear. Methods: We evaluated the spatial association between cardiovascular diseases (CVD) and stroke mortality with average Ta across the US mainland, and then used this relationship to model future temporal trends in mortality from CVD and stroke until the end of the century (2099), using different warming scenarios for each US county. Results: Ta was significantly associated with crude levels of CVD mortality (R Conclusions: By 2099 modelling suggests between 8844 and 25,486 extra deaths each year from CVD, and between 2,063 and 13,039 extra deaths for stroke, beyond the increases expected from population expansion. Mortality due to changes in the mean Ta may be as, or more, significant than the impacts of extreme hot weather events.
MeSH term(s)	Cardiovascular Diseases/diagnosis ; Climate Change ; Hot Temperature ; Humans ; Mortality ; Stroke/diagnosis ; Temperature ; United States/epidemiology
Language	English
Publishing date	2020-09-08
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2020.08.035
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Article ; Online: The association of appendicular lean mass and grip strength with low-density lipoprotein, very low-density lipoprotein, and high-density lipoprotein particle diameter: a Mendelian randomization study of the UK Biobank cohort.

Kirwan, Richard / Mazidi, Mohsen / Butler, Tom / Perez de Heredia, Fatima / Lip, Gregory Y H / Davies, Ian G

European heart journal open

2024 Volume 4, Issue 2, Page(s) oeae019

Abstract: Aims: Reduced muscle mass and reduced strength are frequently associated with both alterations in blood lipids and poorer cardiometabolic outcomes in epidemiological studies; however, a causal association cannot be determined from such observations. Two- ...

Abstract	Aims: Reduced muscle mass and reduced strength are frequently associated with both alterations in blood lipids and poorer cardiometabolic outcomes in epidemiological studies; however, a causal association cannot be determined from such observations. Two-sample Mendelian randomization (MR) was applied to assess the association of genetically determined appendicular lean mass (ALM) and handgrip strength (HGS) with serum lipid particle diameter. Methods and results: Mendelian randomization was implemented using summary-level data from the largest genome-wide association studies on ALM ( Conclusion: There were potentially causal associations between both increasing ALM and HGS and increasing HDL particle size and decreasing VLDL particle size. These causal associations may offer possibilities for interventions aimed at improving cardiovascular disease risk profile.
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ISSN	2752-4191
ISSN (online)	2752-4191
DOI	10.1093/ehjopen/oeae019
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