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  1. Article ; Online: Beauvericin Immunotoxicity Prevention by

    Di Matteo, Giacomo / Cimbalo, Alessandra / Manyes, Lara / Mannina, Luisa

    Toxins

    2023  Volume 15, Issue 9

    Abstract: Beauvericin (BEA) is an emerging mycotoxin produced by some species of Fusarium genera that widely contaminates food and feed. ...

    Abstract Beauvericin (BEA) is an emerging mycotoxin produced by some species of Fusarium genera that widely contaminates food and feed.
    MeSH term(s) Gentiana/chemistry ; Gentiana/metabolism ; Antioxidants/chemistry ; Depsipeptides/toxicity ; Depsipeptides/chemistry ; Flowers/chemistry ; Flowers/metabolism
    Chemical Substances beauvericin (26S048LS2R) ; Antioxidants ; Depsipeptides
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15090538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cost-Utility Analysis Comparing Pegcetacoplan to Anti-C5 Monoclonal Antibodies in the Treatment of Paroxysmal Nocturnal Hemoglobinuria.

    Di Matteo, Sergio / Freilone, Roberto / Bruno, Giacomo Matteo / Notaro, Rosario / Moumene, Sabrin / Martone, Nicoletta / Teruzzi, Cristina / Ciccarone, Antonio / Colombo, Giorgio Lorenzo

    ClinicoEconomics and outcomes research : CEOR

    2024  Volume 16, Page(s) 225–232

    Abstract: Background: Paroxysmal nocturnal hemoglobinuria is a rare, acquired disease characterized by hemolytic episodes and associated with significant clinical burden. The introduction of C5 inhibitory monoclonal antibodies (C5i) represented a major ... ...

    Abstract Background: Paroxysmal nocturnal hemoglobinuria is a rare, acquired disease characterized by hemolytic episodes and associated with significant clinical burden. The introduction of C5 inhibitory monoclonal antibodies (C5i) represented a major breakthrough in PNH treatment, effectively reducing intravascular hemolysis (IVH) but showing limited impact on extravascular hemolysis (EVH). In 2021, the C3 inhibitor pegcetacoplan was approved by EMA and recently reimbursed in Italy, which also has the advantages in the reduction of both IVH and EVH, increasing hemoglobin values and simultaneously improving the quality of life and fatigue of patients. A cost-utility analysis was developed to compare pegcetacoplan to C5i (eculizumab and ravulizumab) in the PNH population who remain anemic after treatment with C5i for at least 3 months.
    Materials and methods: The analysis employed a Markov model with a 5-year time horizon whereby patients can transition among 3 PNH health states, adopting the perspective of the Italian NHS. Efficacy data were sourced from the PEGASUS study, with drug prices reflecting ex-factory costs. Additionally, costs associated with resource utilization, adverse events, and complications were estimated based on outpatient and hospital care rates, excluding indirect expenses. Utility and disutility values related to transfusions were also considered, with pegcetacoplan allowing for dose escalation.
    Results: The cumulative cost of treatment per individual patient at 5 years was estimated to be €1,483,454 for pegcetacoplan, €1,585,763 for eculizumab, and €1,574,826 for ravulizumab. Pegcetacoplan demonstrated a superior increase in quality-adjusted life years (QALYs) compared to both eculizumab (0.51 increase) and ravulizumab (0.27 increase). Furthermore, pegcetacoplan showed a reduction in complication management costs (€22,891 less compared to eculizumab and €22,611 less compared to ravulizumab) and lower transfusion-related expenses (€14,147 less than both C5i treatments).
    Conclusion: Pegcetacoplan emerged as the dominant strategy in this analysis, being more effective, less expensive and improves quality of life in the analyzed population affected by PNH.
    Language English
    Publishing date 2024-04-11
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520698-9
    ISSN 1178-6981
    ISSN 1178-6981
    DOI 10.2147/CEOR.S442906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Neonatal ECMO in 2019: Where Are We Now? Where Next?

    Cavallaro, Giacomo / Di Nardo, Matteo / Hoskote, Aparna / Tibboel, Dick

    Frontiers in pediatrics

    2022  Volume 9, Page(s) 796670

    Language English
    Publishing date 2022-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.796670
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  4. Article: The Value of a Coronary Computed Tomography Angiography plus Stress Cardiac Magnetic Resonance Imaging Strategy for the Evaluation of Patients with Chronic Coronary Syndrome.

    Busi, Gherardo / Amico, Mattia Alexis / Vannini, Matteo / Virgili, Giacomo / Migliorini, Angela / Pontecorboli, Giulia / Pradella, Silvia / Acquafresca, Manlio / Moroni, Mario / Di Mario, Carlo / Valenti, Renato / Carrabba, Nazario

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061556
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  5. Article ; Online: Introduction to the special issue on the 24th annual Workshop on Economic science with Heterogeneous Interacting Agents, London, 2019 (WEHIA 2019).

    Caccioli, Fabio / Di Matteo, Tiziana / Iori, Giulia / Jafarey, Saqib / Livan, Giacomo / Righi, Simone

    Journal of economic interaction and coordination

    2022  Volume 17, Issue 2, Page(s) 401–404

    Language English
    Publishing date 2022-05-03
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2237855-8
    ISSN 1860-7128 ; 1860-711X
    ISSN (online) 1860-7128
    ISSN 1860-711X
    DOI 10.1007/s11403-022-00354-9
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  6. Article: Evaluation of the Antifungal and Antiproliferative Properties of the Lichen

    Frezza, Claudio / Fraioli, Dalia Rosa / Conti, Francesca / Nicolosi, Roberta Maria / Scipione, Luigi / Serafini, Ilaria / Petrucci, Rita / Di Matteo, Paola / Rocco, Daniele / Di Giacomo, Silvia / Di Sotto, Antonella / Bonincontro, Graziana / Simonetti, Giovanna / Garzoli, Stefania / De Vita, Daniela / Foddai, Sebastiano

    Pharmaceutics

    2024  Volume 16, Issue 3

    Abstract: In this work, phytochemical analysis on different extracts ... ...

    Abstract In this work, phytochemical analysis on different extracts of
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16030331
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  7. Article: Economic Evaluation for Palbociclib Plus Fulvestrant vs Ribociclib Plus Fulvestrant and Abemaciclib Plus Fulvestrant in Endocrine-Resistant Advanced or Metastatic Breast Cancer in Italy.

    Colombo, Giorgio Lorenzo / Valentino, Maria Chiara / Fabi, Alessandra / Dieci, Maria Vittoria / Caruggi, Mauro / Bruno, Giacomo Matteo / Lombardi, Gloria / Di Matteo, Sergio

    Therapeutics and clinical risk management

    2023  Volume 19, Page(s) 301–312

    Abstract: Background: To date, no study evaluated the cost-effectiveness of palbociclib (PAL) plus fulvestrant (FUL) vs ribociclib (RIB) plus FUL and abemaciclib (ABM) plus FUL in Italy. Cost-effectiveness analysis comparing the three cyclin-dependent 4/6 kinase ... ...

    Abstract Background: To date, no study evaluated the cost-effectiveness of palbociclib (PAL) plus fulvestrant (FUL) vs ribociclib (RIB) plus FUL and abemaciclib (ABM) plus FUL in Italy. Cost-effectiveness analysis comparing the three cyclin-dependent 4/6 kinase inhibitors in combination with endocrine therapies for the management of postmenopausal women with HR+, HER2- advanced or metastatic breast cancer in Italy was developed.
    Material and methods: To assess the cost-effectiveness of PAL plus FUL vs RIB plus FUL and ABM plus FUL, a cost-minimization has been carried out with a conservative scenario considering three CDK4/6 inhibitors with equal effectiveness in terms of overall survival (OS) (MAIC, Rugo et al 2021). Adverse events (AEs) associated with all therapies were obtained from clinical trials. Ad-hoc analysis was performed to estimate the cost-effectiveness considering the quality-of-life (QoL) data (Lloyd et al 2006).
    Results: Cost-minimization inputs were drugs, visits and exams, AE monitoring and best supportive care (BSC) before the progression state, active and BSC in the progression and terminal phase of the last two weeks of life. Given the comparability of PAL, RIB and ABM in terms of efficacy, this analysis demonstrated slight economic savings over a lifetime for PAL. Results showed saving per patient of €305 (lifetime) when PAL is compared with RIB; for PAL vs ABM a saving of €243 (lifetime) in a conservative scenario. Results of a budget impact analysis showed a potential savings of €319,563 for PAL vs RIB and €297,544 for PAL vs ABM. When QoL data were considered, results may favor PAL due to the lower impact of AE with savings and improvement in the QoL related to fewer AE.
    Conclusion: From the Italian perspective, a cost-saving profile associated with the use of PAL+FUL for the management of advanced/metastatic HR+/HER2- breast cancer compared to RIB+FUL and ABM+FUL emerged.
    Language English
    Publishing date 2023-03-28
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S391769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Colloidal transport by light induced gradients of active pressure

    Nicola Pellicciotta / Matteo Paoluzzi / Dario Buonomo / Giacomo Frangipane / Luca Angelani / Roberto Di Leonardo

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 7

    Abstract: Abstract Active fluids, like all other fluids, exert mechanical pressure on confining walls. Unlike equilibrium, this pressure is generally not a function of the fluid state in the bulk and displays some peculiar properties. For example, when activity is ...

    Abstract Abstract Active fluids, like all other fluids, exert mechanical pressure on confining walls. Unlike equilibrium, this pressure is generally not a function of the fluid state in the bulk and displays some peculiar properties. For example, when activity is not uniform, fluid regions with different activity may exert different pressures on the container walls but they can coexist side by side in mechanical equilibrium. Here we show that by spatially modulating bacterial motility with light, we can generate active pressure gradients capable of transporting passive probe particles in controlled directions. Although bacteria swim faster in the brighter side, we find that bacteria in the dark side apply a stronger pressure resulting in a net drift motion that points away from the low activity region. Using a combination of experiments and numerical simulations, we show that this drift originates mainly from an interaction pressure term that builds up due to the compression exerted by a layer of polarized cells surrounding the slow region. In addition to providing new insights into the generalization of pressure for interacting systems with non-uniform activity, our results demonstrate the possibility of exploiting active pressure for the controlled transport of microscopic objects.
    Keywords Science ; Q
    Subject code 532
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Addition of Spirulina to Craft Beer: Evaluation of the Effects on Volatile Flavor Profile and Cytoprotective Properties.

    Taiti, Cosimo / Stefano, Giovanni / Percaccio, Ester / Di Giacomo, Silvia / Iannone, Matteo / Marianelli, Andrea / Di Sotto, Antonella / Garzoli, Stefania

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: SPME-GC-MS and PTR-ToF-MS techniques were applied to describe the content of volatile flavor compounds in a craft beer before and after adding spirulina. The obtained results showed that the volatile profile of the two beer samples differed. Furthermore, ...

    Abstract SPME-GC-MS and PTR-ToF-MS techniques were applied to describe the content of volatile flavor compounds in a craft beer before and after adding spirulina. The obtained results showed that the volatile profile of the two beer samples differed. Furthermore, to chemically characterize biomass spirulina, a derivatization reaction followed by GC-MS analysis was performed, highlighting a high content of molecules belonging to different chemical classes, such as sugars, fatty acids and carboxylic acids. A spectrophotometric analysis of total polyphenols and tannins, investigation into the scavenging activity towards DPPH and ABTS radicals and confocal microscopy of brewer's yeast cells were carried out. Moreover, the cytoprotective and antioxidant properties towards the oxidative damage induced by tert-butyl hydroperoxide (tBOOH) in human H69 cholangiocytes were investigated. Finally, the modulation of Nrf2 signaling under oxidative stress conditions was also evaluated. Both samples of beer were shown to contain similar levels of total polyphenols and tannins, with slightly increased levels in that containing spirulina 0.25%
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12051021
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  10. Article ; Online: Colloidal transport by light induced gradients of active pressure.

    Pellicciotta, Nicola / Paoluzzi, Matteo / Buonomo, Dario / Frangipane, Giacomo / Angelani, Luca / Di Leonardo, Roberto

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 4191

    Abstract: Active fluids, like all other fluids, exert mechanical pressure on confining walls. Unlike equilibrium, this pressure is generally not a function of the fluid state in the bulk and displays some peculiar properties. For example, when activity is not ... ...

    Abstract Active fluids, like all other fluids, exert mechanical pressure on confining walls. Unlike equilibrium, this pressure is generally not a function of the fluid state in the bulk and displays some peculiar properties. For example, when activity is not uniform, fluid regions with different activity may exert different pressures on the container walls but they can coexist side by side in mechanical equilibrium. Here we show that by spatially modulating bacterial motility with light, we can generate active pressure gradients capable of transporting passive probe particles in controlled directions. Although bacteria swim faster in the brighter side, we find that bacteria in the dark side apply a stronger pressure resulting in a net drift motion that points away from the low activity region. Using a combination of experiments and numerical simulations, we show that this drift originates mainly from an interaction pressure term that builds up due to the compression exerted by a layer of polarized cells surrounding the slow region. In addition to providing new insights into the generalization of pressure for interacting systems with non-uniform activity, our results demonstrate the possibility of exploiting active pressure for the controlled transport of microscopic objects.
    MeSH term(s) Pressure ; Motion ; Swimming
    Language English
    Publishing date 2023-07-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-39974-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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