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Article ; Online: Food safety issues related to wildlife have not been taken seriously from SARS to COVID-19.

Wei, Guangyue

2020 Volume 186, Page(s) 109605

Abstract: 17 years after the outbreak of SARS, the 2019-nCoV broke out in December 2019. It's an unprecedented huge challenge and disaster for people all over the world. According to Web of Science database, The author found that 95,724 virology papers have been ... ...

Abstract	17 years after the outbreak of SARS, the 2019-nCoV broke out in December 2019. It's an unprecedented huge challenge and disaster for people all over the world. According to Web of Science database, The author found that 95,724 virology papers have been published in the past 17 years, 68,632 of which are supported by fund (71.7%). Meanwhile, 50,567 papers related to food safety have been published in the past 17 years, 28,165 of which are supported by fund (55.7%%). It seems that people's safety and global stability are greatly guaranteed. However, whether SARS or 2019-nCoV, scientists were targeting wildlife, the author found that only 515 studies on food safety related to wildlife have been published worldwide in the past 17 years. After SARS, the whole world did not pay enough attention to food safety related to wildlife.
MeSH term(s)	Animals ; Animals, Wild ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Food Safety ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
Keywords	covid19
Language	English
Publishing date	2020-04-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2020.109605
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Food safety issues related to wildlife have not been taken seriously from SARS to COVID-19

Wei, Guangyue

Environmental Research

2020 Volume 186, Page(s) 109605

Keywords	Biochemistry ; General Environmental Science ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2020.109605
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Drug development and potential targets for Cushing's syndrome.

Wei, Wei / Xu, Qianqian / Wu, Liuyi / Gong, Guangyue / Tian, Yucheng / Huang, Huidan / Li, Zhiyu

European journal of medicinal chemistry

2024 Volume 270, Page(s) 116333

Abstract: Cushing's syndrome (CS) is a complex disorder characterized by the excessive secretion of cortisol, with Cushing's disease (CD), particularly associated with pituitary tumors, exhibiting heightened morbidity and mortality. Although transsphenoidal ... ...

Abstract	Cushing's syndrome (CS) is a complex disorder characterized by the excessive secretion of cortisol, with Cushing's disease (CD), particularly associated with pituitary tumors, exhibiting heightened morbidity and mortality. Although transsphenoidal pituitary surgery (TSS) stands as the primary treatment for CD, there is a crucial need to optimize patient prognosis. Current medical therapy serves as an adjunctive measure due to its unsatisfactory efficacy and unpredictable side effects. In this comprehensive review, we delve into recent advances in understanding the pathogenesis of CS and explore therapeutic options by conducting a critical analysis of potential drug targets and candidates. Additionally, we provide an overview of the design strategy employed in previously reported candidates, along with a summary of structure-activity relationship (SAR) analyses and their biological efficacy. This review aims to contribute valuable insights to the evolving landscape of CS research, shedding light on potential avenues for therapeutic development.
Language	English
Publishing date	2024-03-22
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2024.116333
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Article: Food safety issues related to wildlife have not been taken seriously from SARS to COVID-19

Wei, Guangyue

Environ Res

Abstract	17 years after the outbreak of SARS, the 2019-nCoV broke out in December 2019. It's an unprecedented huge challenge and disaster for people all over the world. According to Web of Science database, The author found that 95,724 virology papers have been published in the past 17 years, 68,632 of which are supported by fund (71.7%). Meanwhile, 50,567 papers related to food safety have been published in the past 17 years, 28,165 of which are supported by fund (55.7%%). It seems that people's safety and global stability are greatly guaranteed. However, whether SARS or 2019-nCoV, scientists were targeting wildlife, the author found that only 515 studies on food safety related to wildlife have been published worldwide in the past 17 years. After SARS, the whole world did not pay enough attention to food safety related to wildlife.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #125310
Database	COVID19

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Article: Food safety issues related to wildlife have not been taken seriously from SARS to COVID-19

Wei, Guangyue

Environmental research. 2020 July, v. 186

2020

Abstract	17 years after the outbreak of SARS, the 2019-nCoV broke out in December 2019. It's an unprecedented huge challenge and disaster for people all over the world. According to Web of Science database, The author found that 95,724 virology papers have been published in the past 17 years, 68,632 of which are supported by fund (71.7%). Meanwhile, 50,567 papers related to food safety have been published in the past 17 years, 28,165 of which are supported by fund (55.7%%). It seems that people's safety and global stability are greatly guaranteed. However, whether SARS or 2019-nCoV, scientists were targeting wildlife, the author found that only 515 studies on food safety related to wildlife have been published worldwide in the past 17 years. After SARS, the whole world did not pay enough attention to food safety related to wildlife.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; databases ; food safety ; research ; virology ; wildlife
Language	English
Dates of publication	2020-07
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2020.109605
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Multi-omics in food safety and authenticity in terms of food components.

Su, Guangyue / Yu, Chong / Liang, Shuwen / Wang, Wei / Wang, Haifeng

Food chemistry

2023 Volume 437, Issue Pt 2, Page(s) 137943

Abstract: One of the main goals of food science is to ensure the high quality and safety of food. The inspection technology for known hazards has matured, and the identification of unknown and potential food safety hazards, as well as the identification of their ... ...

Abstract	One of the main goals of food science is to ensure the high quality and safety of food. The inspection technology for known hazards has matured, and the identification of unknown and potential food safety hazards, as well as the identification of their composition and origin, is a challenge faced by food safety. Food safety and authenticity require multi-omics methods to support the implementation of qualitative discrimination to precise quantitative analysis, from targeted screening to non-target detection, and from multi component to full component analysis to address these challenges. The present review aims to provide characterizations, advantages, the latest progress, and prospects of using omics (including genomics, proteomics, and metabonomics) in food safety and authenticity. Multi omics strategies used to detect and verify different standard biomarkers of food will contribute to understanding the basic relationship between raw materials, processing, foods, nutrition, food safety, and human health.
MeSH term(s)	Humans ; Multiomics ; Food Safety ; Genomics ; Proteomics/methods ; Food Technology
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.137943
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of freezing and drying programs on IgY aggregation and activity during microwave freeze-drying: Protective effects and interactions of trehalose and mannitol.

Wang, Zhe / Liu, Wenchao / Duan, Xu / Ren, Guangyue / Li, Linlin / Cao, Weiwei / Guo, Jingfang / Jiao, Xueyuan / Zhu, Lewen / Wei, Xinyu

International journal of biological macromolecules

2024 Volume 260, Issue Pt 1, Page(s) 129448

Abstract: The acquisition of high quality lyophilized IgY products, characterized by an aesthetically pleasing visage, heightened stability, and a marked preservation of activity, constitutes an indispensable pursuit in augmenting the safety and pragmatic utility ... ...

Abstract	The acquisition of high quality lyophilized IgY products, characterized by an aesthetically pleasing visage, heightened stability, and a marked preservation of activity, constitutes an indispensable pursuit in augmenting the safety and pragmatic utility of IgY. Within this context, an exploration was undertaken to investigate an innovative modality encompassing microwave freeze-drying (MFD) as a preparatory methodology of IgY. Morphological assessments revealed that both cryogenic freezing and subsequent MFD procedures resulted in aggregation of IgY, with the deleterious influence posed by the MFD phase transcending that of the freezing phase. The composite protective agent comprised of trehalose and mannitol engendered a safeguarding effect on the structural integrity of IgY, thereby attenuating reducing aggregation between IgY during the freeze-drying process. Enzyme-linked immunosorbent assay (ELISA) outcomes demonstrated a discernible correlation between IgY aggregation and a notable reduction in its binding affinity towards the pertinent antigen. Comparative analysis vis-à-vis the control sample delineated that when the trehalose-to-mannitol ratio was upheld at 1:3, a two-fold outcome was achieved: a mitigation of the collapse susceptibility within the final product as well as a deterrence of IgY agglomeration, concomitant with an elevated preservation rate of active antibodies (78.57 %).
MeSH term(s)	Freezing ; Trehalose/pharmacology ; Trehalose/chemistry ; Mannitol/chemistry ; Freeze Drying/methods ; Immunoglobulins
Chemical Substances	Trehalose (B8WCK70T7I) ; Mannitol (3OWL53L36A) ; IgY ; Immunoglobulins
Language	English
Publishing date	2024-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.129448
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Article ; Online: Effect of gum arabic and thermal modification of whey protein isolate on the characteristics of Cornus officinalis flavonoid microcapsules.

Liang, Luodan / Cao, Weiwei / Li, Linlin / Liu, Wenchao / Wei, Xinyu / Chen, Junliang / Ren, Guangyue / Duan, Xu

Journal of food science

2024 Volume 89, Issue 2, Page(s) 1012–1021

Abstract: Whey protein isolates (WPIs) were treated at 50, 60, 70, and 80°C to obtain thermally modified WPI. Gum arabic (GA) and thermal modification of WPI were used as novel wall materials to improve the quality of Cornus officinalis flavonoid (COF) ... ...

Abstract	Whey protein isolates (WPIs) were treated at 50, 60, 70, and 80°C to obtain thermally modified WPI. Gum arabic (GA) and thermal modification of WPI were used as novel wall materials to improve the quality of Cornus officinalis flavonoid (COF) microcapsules using microwave freeze-drying technique in this study. Results showed that all the thermal modification treatment decreased emulsifying activity index of WPI, whereas the solubility and emulsifying stability index (ESI) of WPI gradually increased with the increase of heating temperature. Compared to the untreated protein, the thermal modification treatment at 70°C increased the solubility and ESI of WPI by 14.91% ± 0.71% and 26.70% ± 0.94%, respectively. The microcapsules prepared with the modified protein at 60°C had the highest encapsulation efficiency (95.13% ± 2.36%), the lowest moisture content (1.42% ± 0.34%), and the highest solubility (84.41% ± 0.91). Scanning electron microscopy images showed that COF microcapsules were uniformly spherical, and the sizes of the microcapsules were in the following order: 12.42 ± 0.37 µm (80°C) > 11.7 ± 0.23 µm (untreated group) > 9.44 ± 0.33 µm (60°C) > 9.24 ± 0.14 µm (50°C) > 7.69 ± 0.29 µm (70°C). In the simulated in vitro digestion experiments, the release rate of COF microcapsules in the gastric digestion phase was less than that in the intestinal digestion phase, and it reached 66.46% at intestinal digestion phase. These results suggested that heated WPI and GA could be an effective nanocarrier to enhance the stability of COF.
MeSH term(s)	Gum Arabic ; Whey Proteins ; Cornus ; Flavonoids ; Capsules
Chemical Substances	Gum Arabic (9000-01-5) ; Whey Proteins ; Flavonoids ; Capsules
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	241615-3
ISSN	1750-3841 ; 0022-1147
ISSN (online)	1750-3841
ISSN	0022-1147
DOI	10.1111/1750-3841.16897
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Diseased Fish Detection in the Underwater Environment Using an Improved YOLOV5 Network for Intensive Aquaculture

Zhen Wang / Haolu Liu / Guangyue Zhang / Xiao Yang / Lingmei Wen / Wei Zhao

Fishes, Vol 8, Iss 169, p

2023 Volume 169

Abstract: In intensive aquaculture, the real-time detection and monitoring of common infectious disease is an important basis for scientific fish epidemic prevention strategies that can effectively reduce fish mortality and economic loss. However, low-quality ... ...

Abstract	In intensive aquaculture, the real-time detection and monitoring of common infectious disease is an important basis for scientific fish epidemic prevention strategies that can effectively reduce fish mortality and economic loss. However, low-quality underwater images and low-identification targets present great challenges to diseased fish detection. To overcome these challenges, this paper proposes a diseased fish detection model, using an improved YOLOV5 network for aquaculture (DFYOLO). The specific implementation methods are as follows: (1) the C3 structure is used instead of the CSPNet structure of the YOLOV5 model to facilitate the industrial deployment of the algorithm; (2) all the 3 × 3 convolutional kernels in the backbone network are replaced by a convolutional kernel group consisting of parallel 3 × 3, 1 × 3 and 3 × 1 convolutional kernels; and (3) the convolutional block attention module is added to the YOLOV5 algorithm. Experimental results in a fishing ground showed that the DFYOLO is better than that of the original YOLOV5 network, and the average precision was improved from 94.52% to 99.38% (when the intersection over union is 0.5), for an increase of 4.86%. Therefore, the DFYOLO network can effectively detect diseased fish and is applicable in intensive aquaculture.
Keywords	real-time ; epidemic prevention ; algorithm ; target detection ; convolution kernel group ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
Subject code	006
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Single-cell transcriptome sequencing analysis reveals intra-tumor heterogeneity in esophageal squamous cell carcinoma.

Nie, Yuanliu / Yao, Guangyue / Wei, Yanjun / Wu, Sheng / Zhang, Wentao / Xu, Xiaoying / Li, Qiang / Zhou, Fengge / Yang, Zhe

Environmental toxicology

2024

Abstract: Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor of the digestive system that poses a significant threat to human life and health. It is crucial to thoroughly investigate the mechanisms of esophageal carcinogenesis and identify ... ...

Abstract	Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor of the digestive system that poses a significant threat to human life and health. It is crucial to thoroughly investigate the mechanisms of esophageal carcinogenesis and identify potential key molecular events in its carcinogenesis. Single-cell transcriptome sequencing is an emerging technology that has gained prominence in recent years for studying molecular mechanisms, which may help to further explore the underlying mechanisms of the ESCC tumor microenvironment in depth. The single-cell dataset was obtained from GSE160269 in the Gene Expression Omnibus database, including 60 tumor samples and four paracancer samples. The single-cell data underwent dimensional reduction clustering analysis to identify clusters and annotate expression profiles. Subcluster analysis was conducted for each cellular taxon. Copy number variation analysis of tumor cell subpopulations was performed to primarily identify malignant cells within them. A proposed chronological analysis was performed to obtain the process of cell differentiation. In addition, cell communication, transcription factor analysis, and tumor pathway analysis were also performed. Relevant risk models and key genes were established by univariate COX regression and LASSO analysis. The key genes obtained from the screen were subjected to appropriate silencing and cellular assays, including CCK-8, 5-ethynyl-2'-deoxyuridine, colony formation, and western blot. Single-cell analysis revealed that normal samples contained a large number of fibroblasts, T cells, and B cells, with fewer other cell types, whereas tumor samples exhibited a relatively balanced distribution of cell types. Subclassification analysis of immune cells, fibroblasts, endothelial cells, and epithelial cells revealed their specific spatial characteristics. The prognostic risk model, we constructed successfully, achieved accurate prognostic stratification for ESCC patients. The screened key gene, UPF3A, was found to be significantly associated with the development of ESCC by cellular assays. This process might be linked to the phosphorylation of ERK and P38. Single-cell transcriptome analysis successfully revealed the distribution of cell types and major expressed factors in ESCC patients, which could facilitate future in-depth studies on the therapeutic mechanisms of ESCC.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24243
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