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  1. Article ; Online: The European experience with testing and surveillance during the first phase of the COVID-19 pandemic.

    Stoto, Michael A / Reno, Chiara / Tsolova, Svetla / Fantini, Maria Pia

    Globalization and health

    2023  Volume 19, Issue 1, Page(s) 51

    Abstract: Background: COVID-19 pandemic provides a unique opportunity to learn the challenges encountered by public health emergency preparedness systems, both in terms of problems encountered and adaptations during and after the first wave, as well as successful ...

    Abstract Background: COVID-19 pandemic provides a unique opportunity to learn the challenges encountered by public health emergency preparedness systems, both in terms of problems encountered and adaptations during and after the first wave, as well as successful responses to them.
    Results: This work draws on published literature, interviews with countries and institutional documents as part of a European Centre for Disease Prevention and Control project that aims to identify the implications for preparedness measurement derived from COVID-19 pandemic experience in order to advance future preparedness efforts in European Union member states. The analysis focused on testing and surveillance themes and five countries were considered, namely Italy, Germany, Finland, Spain and Croatia. Our analysis shown that a country's ability to conduct testing at scale was critical, especially early in the pandemic, and the inability to scale up testing operations created critical issues for public health operations such as contact tracing. Countries were required to develop new strategies, approaches, and policies under pressure and to review and revise them as the pandemic evolved, also considering that public health systems operate at the national, regional, and local level with respect to testing, contact tracing, and surveillance, and involve both government agencies as well as private organizations. Therefore, communication among multiple public and private entities at all levels and coordination of the testing and surveillance activities was critical.
    Conclusion: With regard to testing and surveillance, three capabilities that were essential to the COVID-19 response in the first phase, and presumably in other public health emergencies: the ability to scale-up testing, contact tracing, surveillance efforts; flexibility to develop new strategies, approaches, and policies under pressure and to review and revise them as the pandemic evolved; and the ability to coordinate and communicate in complex public health systems that operate at the national, regional, and local level with respect and involve multiple government agencies as well as private organizations.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics/prevention & control ; Civil Defense ; Communication ; Contact Tracing
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2185774-X
    ISSN 1744-8603 ; 1744-8603
    ISSN (online) 1744-8603
    ISSN 1744-8603
    DOI 10.1186/s12992-023-00950-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: SARS-CoV-2/COVID-19 Vaccines: The Promises and the Challenges Ahead.

    Baldo, Vincenzo / Reno, Chiara / Cocchio, Silvia / Fantini, Maria Pia

    Vaccines

    2021  Volume 9, Issue 1

    Abstract: The development of a new vaccine usually consists of a linear sequence of several steps and lasts many years [ ... ]. ...

    Abstract The development of a new vaccine usually consists of a linear sequence of several steps and lasts many years [...].
    Language English
    Publishing date 2021-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9010021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: ICOSL Stimulation by ICOS-Fc Accelerates Cutaneous Wound Healing In Vivo.

    Stoppa, Ian / Gigliotti, Casimiro Luca / Clemente, Nausicaa / Pantham, Deepika / Dianzani, Chiara / Monge, Chiara / Puricelli, Chiara / Rolla, Roberta / Sutti, Salvatore / Renò, Filippo / Boldorini, Renzo / Boggio, Elena / Dianzani, Umberto

    International journal of molecular sciences

    2022  Volume 23, Issue 13

    Abstract: Background: ICOS and its ligand ICOSL are immune receptors whose interaction triggers bidirectional signals that modulate the immune response and tissue repair.: Aim: The aim of this study was to assess the in vivo effects of ICOSL triggering by ICOS- ...

    Abstract Background: ICOS and its ligand ICOSL are immune receptors whose interaction triggers bidirectional signals that modulate the immune response and tissue repair.
    Aim: The aim of this study was to assess the in vivo effects of ICOSL triggering by ICOS-Fc, a recombinant soluble form of ICOS, on skin wound healing.
    Methods: The effect of human ICOS-Fc on wound healing was assessed, in vitro, and, in vivo, by skin wound healing assay using ICOS
    Results: We show that, in wild type mice, treatment with ICOS-Fc improves wound healing, promotes angiogenesis, preceded by upregulation of IL-6 and VEGF expression; increases the number of fibroblasts and T cells, whereas it reduces that of neutrophils; and increases the number of M2 vs. M1 macrophages. Fittingly, ICOS-Fc enhanced M2 macrophage migration, while it hampered that of M1 macrophages. ICOS
    Conclusion: These data show that the ICOS/ICOSL network cooperates in tissue repair, and that triggering of ICOSL by ICOS-Fc improves cutaneous wound healing by increasing angiogenesis and recruitment of reparative macrophages.
    MeSH term(s) Animals ; Immunoglobulin Fc Fragments/immunology ; Immunoglobulin Fc Fragments/pharmacology ; Inducible T-Cell Co-Stimulator Ligand/genetics ; Inducible T-Cell Co-Stimulator Ligand/immunology ; Inducible T-Cell Co-Stimulator Ligand/metabolism ; Inducible T-Cell Co-Stimulator Protein/genetics ; Inducible T-Cell Co-Stimulator Protein/immunology ; Mice ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Recombinant Proteins/pharmacology ; Wound Healing/drug effects
    Chemical Substances Icos protein, mouse ; Icosl protein, mouse ; Immunoglobulin Fc Fragments ; Inducible T-Cell Co-Stimulator Ligand ; Inducible T-Cell Co-Stimulator Protein ; Recombinant Proteins
    Language English
    Publishing date 2022-07-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23137363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Are psychological status and trust in information related to vaccine hesitancy during COVID-19 pandemic? A latent class and mediation analyses in Italy.

    Maietti, Elisa / Reno, Chiara / Sanmarchi, Francesco / Montalti, Marco / Fantini, Maria Pia / Gori, Davide

    Human vaccines & immunotherapeutics

    2022  Volume 18, Issue 7, Page(s) 2157622

    Abstract: Despite the recognized benefits of the COVID-19 vaccination, vaccine hesitancy (VH) remains one of the biggest challenges of the mass vaccination campaign. Most studies investigating VH determinants focused on socio-demographics and direct relationships. ...

    Abstract Despite the recognized benefits of the COVID-19 vaccination, vaccine hesitancy (VH) remains one of the biggest challenges of the mass vaccination campaign. Most studies investigating VH determinants focused on socio-demographics and direct relationships. In this study, we aimed at: 1) identifying subgroups of people differently affected by the pandemic, in terms of psychological status; 2) investigating the role of psychological status and trust in information as possible mediators of the relationship between individual characteristics and VH. To this purpose, a latent class analysis (LCA) followed by a mediation analysis were carried out on data from a survey conducted in January 2021 on 1011 Italian citizens. LCA identified four different subgroups characterized by a differential psychological impact of the pandemic: the extremely affected (21.1%), the highly affected (49.1%), the moderately affected (21.8%) and the slightly affected (8%). We found that VH decreased with the increase of psychological impact (from 59.3% to 23.9%). In the mediation analysis, past vaccination refusal, age 45-54 years and lower-than-average income, were all indirectly related to higher VH through mistrust in COVID-19 information. Differently, the psychological impact counteracted the greater VH in females, the negative effect of social media among youngest (<35 years) and the negative effect of mistrust in the lower-than-average-income subgroup. Knowledge of psychological profile of hesitant individuals, their level of trust and the sources of information they access, together with their sociodemographic characteristics provides a more comprehensive picture of VH determinants that can be used by public health stakeholders to effectively design and adapt communication campaigns.
    MeSH term(s) Female ; Humans ; Middle Aged ; Trust ; Vaccination Hesitancy ; COVID-19/epidemiology ; COVID-19/prevention & control ; Mediation Analysis ; Pandemics ; COVID-19 Vaccines ; Italy/epidemiology ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2022.2157622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The impact of health policies and vaccine rollout on the COVID-19 pandemic waves in Italy.

    Reno, Chiara / Sanmarchi, Francesco / Stoto, Michael A / Fantini, Maria Pia / Lenzi, Jacopo / Golinelli, Davide

    Health policy and technology

    2022  Volume 11, Issue 2, Page(s) 100604

    Abstract: Background: Over the course of the COVID-19 pandemic in Italy, different response measures were taken to contain the spread of the virus. These include a variety of non-pharmaceutical interventions and a mass vaccination campaign. While not definitive, ... ...

    Abstract Background: Over the course of the COVID-19 pandemic in Italy, different response measures were taken to contain the spread of the virus. These include a variety of non-pharmaceutical interventions and a mass vaccination campaign. While not definitive, epidemiological measures provide some indication of the impact of such measures on the dynamics of the pandemic and lessons to better prepare for future emergencies.
    Objective: To describe the impact of vaccine rollout and health policies on the evolution of the COVID-19 pandemic in Italy from March 2020 to October 2021 using a set of epidemiological indicators.
    Methods: We performed a time-trend analysis of new confirmed COVID-19 cases, patients in hospital, and deaths. Using line charts, we informally assessed the relationship of these indicators with the immunization campaign and other health policies. Daily aggregate data were gathered from GitHub repositories of certified data from Italy's Government and Civil Protection.
    Results: The immunization coverage increased starting in March 2021, with a parallel decrease in COVID-19 infections, hospitalizations, and deaths. Despite different implementation approaches, the vaccine coverage growth rate had a similar pattern across regions. A comprehensive approach including measures such as requiring face masks and a "Green Pass" to enter indoor places also helped contain the pandemic.
    Conclusions: The vaccine rollout had a major effect on COVID-19 in Italy, especially on hospitalizations and deaths. Before the vaccine was available, however, other non-pharmaceutical interventions also helped to contain the spread of the virus and mitigate its effect on the population.
    Language English
    Publishing date 2022-02-15
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-8837
    ISSN 2211-8837
    DOI 10.1016/j.hlpt.2022.100604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: ICOSL Stimulation by ICOS-Fc Accelerates Cutaneous Wound Healing In Vivo

    Ian Stoppa / Casimiro Luca Gigliotti / Nausicaa Clemente / Deepika Pantham / Chiara Dianzani / Chiara Monge / Chiara Puricelli / Roberta Rolla / Salvatore Sutti / Filippo Renò / Renzo Boldorini / Elena Boggio / Umberto Dianzani

    International Journal of Molecular Sciences, Vol 23, Iss 7363, p

    2022  Volume 7363

    Abstract: Background: ICOS and its ligand ICOSL are immune receptors whose interaction triggers bidirectional signals that modulate the immune response and tissue repair. Aim: The aim of this study was to assess the in vivo effects of ICOSL triggering by ICOS-Fc, ... ...

    Abstract Background: ICOS and its ligand ICOSL are immune receptors whose interaction triggers bidirectional signals that modulate the immune response and tissue repair. Aim: The aim of this study was to assess the in vivo effects of ICOSL triggering by ICOS-Fc, a recombinant soluble form of ICOS, on skin wound healing. Methods: The effect of human ICOS-Fc on wound healing was assessed, in vitro, and, in vivo, by skin wound healing assay using ICOS −/− and ICOSL −/− knockout (KO) mice and NOD-SCID-IL2R null (NSG) mice. Results: We show that, in wild type mice, treatment with ICOS-Fc improves wound healing, promotes angiogenesis, preceded by upregulation of IL-6 and VEGF expression; increases the number of fibroblasts and T cells, whereas it reduces that of neutrophils; and increases the number of M2 vs. M1 macrophages. Fittingly, ICOS-Fc enhanced M2 macrophage migration, while it hampered that of M1 macrophages. ICOS −/− and ICOSL −/− KO, and NSG mice showed delayed wound healing, and treatment with ICOS-Fc improved wound closure in ICOS −/− and NSG mice. Conclusion: These data show that the ICOS/ICOSL network cooperates in tissue repair, and that triggering of ICOSL by ICOS-Fc improves cutaneous wound healing by increasing angiogenesis and recruitment of reparative macrophages.
    Keywords ICOS:ICOSL system ; wound healing ; reparative macrophages ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 333 ; 570
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: SARS-CoV-2/COVID-19 Vaccines

    Vincenzo Baldo / Chiara Reno / Silvia Cocchio / Maria Pia Fantini

    Vaccines, Vol 9, Iss 21, p

    The Promises and the Challenges Ahead

    2021  Volume 21

    Abstract: The development of a new vaccine usually consists of a linear sequence of several steps and lasts many years [.] ...

    Abstract The development of a new vaccine usually consists of a linear sequence of several steps and lasts many years [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Exploring the Gap Between Excess Mortality and COVID-19 Deaths in 67 Countries.

    Sanmarchi, Francesco / Golinelli, Davide / Lenzi, Jacopo / Esposito, Francesco / Capodici, Angelo / Reno, Chiara / Gibertoni, Dino

    JAMA network open

    2021  Volume 4, Issue 7, Page(s) e2117359

    MeSH term(s) COVID-19/mortality ; Cause of Death ; Cross-Sectional Studies ; Humans ; Mortality ; SARS-CoV-2
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.17359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: [Renal function performance in CKD stage 5: a sealed fate?]

    Cannarile, Daniela Cecilia / De Liberali, Matteo / Gaggi, Rossella / Reno, Chiara / Gibertoni, Dino / Mancini, Elena

    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

    2021  Volume 38, Issue 1

    Abstract: Introduction and aims: ...

    Abstract Introduction and aims:
    MeSH term(s) Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Disease Progression ; Glomerular Filtration Rate ; Humans ; Kidney/physiology ; Renal Insufficiency, Chronic ; Retrospective Studies
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
    Language Italian
    Publishing date 2021-02-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1237110-5
    ISSN 1724-5990 ; 0393-5590
    ISSN (online) 1724-5990
    ISSN 0393-5590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Vaccine Hesitancy towards COVID-19 Vaccination: Investigating the Role of Information Sources through a Mediation Analysis.

    Reno, Chiara / Maietti, Elisa / Di Valerio, Zeno / Montalti, Marco / Fantini, Maria Pia / Gori, Davide

    Infectious disease reports

    2021  Volume 13, Issue 3, Page(s) 712–723

    Abstract: Mass vaccination campaigns have been implemented worldwide to counteract the SARS-CoV-2/COVID-19 pandemic, however their effectiveness could be challenged by vaccine hesitancy. The tremendous rise in the use of social media have made them acquire a ... ...

    Abstract Mass vaccination campaigns have been implemented worldwide to counteract the SARS-CoV-2/COVID-19 pandemic, however their effectiveness could be challenged by vaccine hesitancy. The tremendous rise in the use of social media have made them acquire a leading role as an information source, thus representing a crucial factor at play that could contribute to increase or mitigate vaccine hesitancy, as information sources play a pivotal role in shaping public opinion and perceptions. The aims of the study were to investigate if information sources could affect the attitude towards COVID-19 vaccination and if they could act as a mediator in the relationship between individual characteristics and vaccine hesitancy. A cross-sectional online survey was conducted by a professional panellist on a representative sample of 1011 citizens from the Emilia-Romagna region in Italy in January 2021. A mediation analysis using structural equation modelling was performed. Our results show how social media directly or indirectly increases vaccine hesitancy towards COVID-19 vaccination, while the opposite effect was observed for institutional websites. Given the global widespread use of social media, their use should be enhanced to disseminate scientifically sound information to a greater audience to counteract vaccine hesitancy, while at the same time continuing to promote and update institutional websites that have proven to be effective in reducing vaccine hesitancy.
    Language English
    Publishing date 2021-08-12
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr13030066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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