LIVIVO - Search results -

Search results

Result 1 - 10 of total 156

Search options

Article ; Online: Evolving Outsourcing Landscape in Pharma R&D: Different Collaborative Models and Factors To Consider When Choosing a Contract Research Organization.

DeCorte, Bart L

2020 Volume 63, Issue 20, Page(s) 11362–11367

Abstract: Outsourcing has become an integral part of how research and early development (R&D) is executed ...

Abstract	Outsourcing has become an integral part of how research and early development (R&D) is executed in biotech companies and large pharmaceutical organizations. Drug discovery organizations can choose from several operational models when partnering with a service provider, ranging from short-term, fee-for-service (FFS)-based arrangements to more strategic full-time-equivalent (FTE)-based collaborations and even risk-sharing relationships. Clients should consider a number of criteria when deciding which contract research organization (CRO) is best positioned to help meet their goals. Besides cost, other factors such as intellectual property protection, problem solving skills, value-creation ability, communication, data integrity, safety and personnel policies, ease of communication, geography, duration of engagement, scalability of capacity, and contractual details deserve proper consideration. In the end, the success of a drug discovery partnership will depend in large part on the people who execute the science.
MeSH term(s)	Contracts/economics ; Contracts/legislation & jurisprudence ; Cooperative Behavior ; Drug Discovery/economics ; Drug Discovery/legislation & jurisprudence ; Drug Discovery/organization & administration ; Efficiency, Organizational ; Intellectual Property ; Models, Organizational ; Outsourced Services/economics ; Outsourced Services/legislation & jurisprudence ; Outsourced Services/organization & administration ; Pharmaceutical Research/economics ; Pharmaceutical Research/legislation & jurisprudence ; Pharmaceutical Research/organization & administration
Language	English
Publishing date	2020-06-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.0c00176
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recent radiation within Y-chromosomal haplogroup R-M269 resulted in high Y-STR haplotype resemblance.

Larmuseau, Maarten H D / Vanderheyden, Nancy / Van Geystelen, Anneleen / van Oven, Mannis / de Knijff, Peter / Decorte, Ronny

Annals of human genetics

2014 Volume 78, Issue 2, Page(s) 92–103

Abstract: ... however, indications for Y-STR haplotype resemblance across different subhaplogroups within haplogroup R1b1b2 (R-M269 ... resemblance of Y-STR haplotypes between males belonging to different subhaplogroups of haplogroup R-M269 ... Several subhaplogroups within R-M269 could not be distinguished from each other based on differences in Y-STR haplotype ...

Abstract	Y-chromosomal short tandem repeats (Y-STRs) are often used in addition to Y-chromosomal single-nucleotide polymorphisms (Y-SNP) to detect subtle patterns in a population genetic structure. There are, however, indications for Y-STR haplotype resemblance across different subhaplogroups within haplogroup R1b1b2 (R-M269) which may lead to erosion in the observation of the population genetic pattern. Hence the question arises whether Y-STR haplotypes are still informative beyond high-resolution Y-SNP genotyping for population genetic studies. To address this question, we genotyped the Y chromosomes of more than 1000 males originating from the West-European regions of Flanders (Belgium), North-Brabant and Limburg (the Netherlands) at the highest resolution of the current Y-SNP tree together with 38 commonly used Y-STRs. We observed high resemblance of Y-STR haplotypes between males belonging to different subhaplogroups of haplogroup R-M269. Several subhaplogroups within R-M269 could not be distinguished from each other based on differences in Y-STR haplotype variation. The most likely hypothesis to explain this similarity of Y-STR haplotypes within the population of R-M269 members is a recent radiation where various subhaplogroups originated within a relatively short time period. We conclude that high-resolution Y-SNP typing rather than Y-STR typing might be more useful to study population genetic patterns in (Western) Europe.
MeSH term(s)	Belgium ; Chromosomes, Human, Y/genetics ; European Continental Ancestry Group/classification ; European Continental Ancestry Group/genetics ; Genetic Variation ; Genetics, Population ; Haplotypes ; Humans ; Male ; Microsatellite Repeats ; Netherlands ; Phylogeny ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2014-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	333-5
ISSN	1469-1809 ; 0003-4800
ISSN (online)	1469-1809
ISSN	0003-4800
DOI	10.1111/ahg.12050
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ub I Zs.193: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Fully Automatic Camera for Personalized Highlight Generation in Sporting Events.

Decorte, Robbe / De Bock, Jelle / Taelman, Joachim / Slembrouck, Maarten / Verstockt, Steven

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 3

Abstract: Personally curated content in short-form video formats provides added value for participants and spectators but is often disregarded in lower-level events because it is too labor-intensive to create or is not recorded at all. Our smart sensor-driven ... ...

Abstract	Personally curated content in short-form video formats provides added value for participants and spectators but is often disregarded in lower-level events because it is too labor-intensive to create or is not recorded at all. Our smart sensor-driven tripod focuses on supplying a unified sensor and video solution to capture personalized highlights for participants in various sporting events with low computational and hardware costs. The relevant parts of the video for each participant are automatically determined by using the timestamps of his/her received sensor data. This is achieved through a customizable clipping mechanism that processes and optimizes both video and sensor data. The clipping mechanism is driven by sensing nearby signals of Adaptive Network Topology (ANT+) capable devices worn by the athletes that provide both locality information and identification. The device was deployed and tested in an amateur-level cycling race in which it provided clips with a detection rate of 92.9%. The associated sensor data were used to automatically extract peloton passages and report riders' positions on the course, as well as which participants were grouped together. Insights derived from sensor signals can be processed and published in real time, and an upload optimization scheme is proposed that can provide video clips for each rider a maximum of 5 min after the passage if video upload is enabled.
MeSH term(s)	Humans ; Male ; Female ; Athletes ; Bicycling ; Video Recording
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24030736
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Missing Value Imputation of Wireless Sensor Data for Environmental Monitoring.

Decorte, Thomas / Mortier, Steven / Lembrechts, Jonas J / Meysman, Filip J R / Latré, Steven / Mannens, Erik / Verdonck, Tim

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 8

Abstract: Over the past few years, the scale of sensor networks has greatly expanded. This generates extended spatiotemporal datasets, which form a crucial information resource in numerous fields, ranging from sports and healthcare to environmental science and ... ...

Abstract	Over the past few years, the scale of sensor networks has greatly expanded. This generates extended spatiotemporal datasets, which form a crucial information resource in numerous fields, ranging from sports and healthcare to environmental science and surveillance. Unfortunately, these datasets often contain missing values due to systematic or inadvertent sensor misoperation. This incompleteness hampers the subsequent data analysis, yet addressing these missing observations forms a challenging problem. This is especially the case when both the temporal correlation of timestamps within a single sensor and the spatial correlation between sensors are important. Here, we apply and evaluate 12 imputation methods to complete the missing values in a dataset originating from large-scale environmental monitoring. As part of a large citizen science project, IoT-based microclimate sensors were deployed for six months in 4400 gardens across the region of Flanders, generating 15-min recordings of temperature and soil moisture. Methods based on spatial recovery as well as time-based imputation were evaluated, including Spline Interpolation, MissForest, MICE, MCMC, M-RNN, BRITS, and others. The performance of these imputation methods was evaluated for different proportions of missing data (ranging from 10% to 50%), as well as a realistic missing value scenario. Techniques leveraging the spatial features of the data tend to outperform the time-based methods, with matrix completion techniques providing the best performance. Our results therefore provide a tool to maximize the benefit from costly, large-scale environmental monitoring efforts.
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24082416
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12 sequence: structural refinement of the minor groove R(12,2)- and S(12,2)-alpha-(N2-guanyl) stereoisomers from 1H NMR.

Zegar, I S / Setayesh, F R / DeCorte, B L / Harris, C M / Harris, T M / Stone, M P

Biochemistry

1996 Volume 35, Issue 14, Page(s) 4334–4348

Abstract: The structures of the (R)- and (S)-alpha-(N2-guanyl)styrene oxide adducts at X6 in d(GGCAGXTGGTG).d ... data. These were the R(12,2) and S(12,2) adducts. For the R(12,2) adduct, upfield chemical shifts were ... observed for the T7 H6, H1', and N3H resonances. At 30 degrees C, R-SOG 6 N1H, T7 N3H, and T10 N3H ...

Abstract	The structures of the (R)- and (S)-alpha-(N2-guanyl)styrene oxide adducts at X6 in d(GGCAGXTGGTG).d(CACCACCTGCC), encompassing codon 12 of the human n-ras protooncogene (underlined), were refined from 1H NMR data. These were the R(12,2) and S(12,2) adducts. For the R(12,2) adduct, upfield chemical shifts were observed for the T7 H6, H1', and N3H resonances. At 30 degrees C, R-SOG 6 N1H, T7 N3H, and T10 N3H disappeared due to exchange with solvent. For the S(12,2) adduct, S-SOG6 H1' shifted upfield 0.33 ppm, but all imino resonances were observed. The styrene methylene protons were nonequivalent for both adducts, suggesting hydrogen bonding between the hydroxyl and C18 O2 or O4' in the R(12,2) adduct and C17 O2 in the S(12,2) adduct. The styrene aromatic protons appeared as three signals in the R(12,2) adduct and as two signals in the S(12,2) adduct, suggesting rapid rotation of the styrene ring on the NMR time scale. NOE data revealed that the phenyl ring was oriented in the 3'-direction relative to R-SOG6 for the R(12,2) adduct and in the 5'-direction relative to S-SOG6 for the S(12,2) adduct. A total of 253 and 221 interproton distances were obtained from relaxation matrix analyses of the R(12,2) and S(12,2) adducts, respectively. NOE-restrained molecular dynamics calculations converged with root mean square deviations of 0.8-1.2 A for the R(12,2) adduct and 0.82-1.4 A for the S(12,2) adduct. Complete relaxation matrix analyses of the nine inner base pairs yielded sixth root residual indices between calculated and experimental NOE intensities of 8.8 x 10(-2) for the R(12,2) adduct and 7.9 x 10(-2) for the S(12,2) adduct. The refined structure for the R(12,2) adduct showed a 0.4 A increase in the stretch of R-SOG6.C17 and T7.A16, and a 1-2 A widening of the minor groove at and adjacent to the SO lesion, with the styrene ring oriented edgewise in the minor groove. Smaller minor groove disturbances were observed for the S(12,2) adduct, which had the styrene ring oriented flat in the minor groove. No DNA bending was predicted by the calculated structures.
MeSH term(s)	Base Sequence ; Benzo(a)pyrene/chemistry ; Binding Sites/genetics ; Carcinogens/chemistry ; Codon/genetics ; DNA Adducts/chemistry ; DNA Adducts/genetics ; Epoxy Compounds/chemistry ; Genes, ras ; Guanine/chemistry ; Humans ; In Vitro Techniques ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Molecular Sequence Data ; Molecular Structure ; Nucleic Acid Conformation ; Oligodeoxyribonucleotides/chemistry ; Oligodeoxyribonucleotides/genetics ; Protons ; Thermodynamics
Chemical Substances	Carcinogens ; Codon ; DNA Adducts ; Epoxy Compounds ; Oligodeoxyribonucleotides ; Protons ; benzo(a)pyrene-DNA adduct ; Benzo(a)pyrene (3417WMA06D) ; Guanine (5Z93L87A1R) ; styrene oxide (9QH06NGT6O)
Language	English
Publishing date	1996-04-09
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi952086s
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 217: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: At the Interface of Life and Death: Post-mortem and Other Applications of Vaginal, Skin, and Salivary Microbiome Analysis in Forensics.

Ahannach, Sarah / Spacova, Irina / Decorte, Ronny / Jehaes, Els / Lebeer, Sarah

Frontiers in microbiology

2021 Volume 12, Page(s) 694447

Abstract: Microbial forensics represents a promising tool to strengthen traditional forensic investigative methods and fill related knowledge gaps. Large-scale microbiome studies indicate that microbial fingerprinting can assist forensics in areas such as trace ... ...

Abstract	Microbial forensics represents a promising tool to strengthen traditional forensic investigative methods and fill related knowledge gaps. Large-scale microbiome studies indicate that microbial fingerprinting can assist forensics in areas such as trace evidence, source tracking, geolocation, and circumstances of death. Nevertheless, the majority of forensic microbiome studies focus on soil and internal organ samples, whereas the microbiome of skin, mouth, and especially vaginal samples that are routinely collected in sexual assault and femicide cases remain underexplored. This review discusses the current and emerging insights into vaginal, skin, and salivary microbiome-modulating factors during life (e.g., lifestyle and health status) and after death (e.g., environmental influences and post-mortem interval) based on next-generation sequencing. We specifically highlight the key aspects of female reproductive tract, skin, and mouth microbiome samples relevant in forensics. To fill the current knowledge gaps, future research should focus on the degree to which the post-mortem succession rate and profiles of vaginal, skin, and saliva microbiota are sensitive to abiotic and biotic factors, presence or absence of oxygen and other gases, and the nutrient richness of the environment. Application of this microbiome-related knowledge could provide valuable complementary data to strengthen forensic cases, for example, to shed light on the circumstances surrounding death with (post-mortem) microbial fingerprinting. Overall, this review synthesizes the present knowledge and aims to provide a framework to adequately comprehend the hurdles and potential application of vaginal, skin, and salivary post-mortem microbiomes in forensic investigations.
Language	English
Publishing date	2021-07-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.694447
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Genetic identification in the 21st century--Current status and future developments.

Decorte, Ronny

Forensic science international

2010 Volume 201, Issue 1-3, Page(s) 160–164

Abstract: In 2010, it is the 25th anniversary of the first paper describing the genetic identification of human individuals by DNA fingerprint analysis. Since then DNA analysis has become a major tool to relate biological evidence to the persons involved in a ... ...

Abstract	In 2010, it is the 25th anniversary of the first paper describing the genetic identification of human individuals by DNA fingerprint analysis. Since then DNA analysis has become a major tool to relate biological evidence to the persons involved in a crime or to determine the biological relationship among individuals. The currently used methodology is the result of major technological changes that were partly driven by criticism on previous methodologies, and partly driven by demand especially due to mass disasters such as the '9/11 attack' on the World Trade Center in New York. This review will give an overview of the current methodology in genetic identification and new developments that will have a future impact on forensic identification.
MeSH term(s)	Chromosomes, Human, X ; Chromosomes, Human, Y ; DNA Fingerprinting ; Forensic Genetics/trends ; Humans ; Mass Casualty Incidents ; Polymorphism, Single Nucleotide ; Tandem Repeat Sequences
Language	English
Publishing date	2010-09-10
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2010.02.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1104: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Call for emergency action to restore dietary diversity and protect global food systems in times of COVID-19 and beyond: Results from a cross-sectional study in 38 countries.

Hoteit, Maha / Hoteit, Reem / Aljawaldeh, Ayoub / Van Royen, Kathleen / Pabian, Sara / Decorte, Paulien / Cuykx, Isabelle / Teunissen, Lauranna / De Backer, Charlotte

Heliyon

2023 Volume 9, Issue 11, Page(s) e21585

Abstract: Background: The COVID-19 pandemic has revealed the fragility of the global food system, sending shockwaves across countries' societies and economy. This has presented formidable challenges to sustaining a healthy and resilient lifestyle. The objective ... ...

Abstract	Background: The COVID-19 pandemic has revealed the fragility of the global food system, sending shockwaves across countries' societies and economy. This has presented formidable challenges to sustaining a healthy and resilient lifestyle. The objective of this study is to examine the food consumption patterns and assess diet diversity indicators, primarily focusing on the food consumption score (FCS), among households in 38 countries both before and during the first wave of the COVID-19 pandemic. Methods: A cross-sectional study with 37 207 participants (mean age: 36.70 ± 14.79, with 77 % women) was conducted in 38 countries through an online survey administered between April and June 2020. The study utilized a pre-tested food frequency questionnaire to explore food consumption patterns both before and during the COVID-19 periods. Additionally, the study computed Food Consumption Score (FCS) as a proxy indicator for assessing the dietary diversity of households. Findings: This quantification of global, regional and national dietary diversity across 38 countries showed an increment in the consumption of all food groups but a drop in the intake of vegetables and in the dietary diversity. The household's food consumption scores indicating dietary diversity varied across regions. It decreased in the Middle East and North Africa (MENA) countries, including Lebanon (p < 0.001) and increased in the Gulf Cooperation Council countries including Bahrain (p = 0.003), Egypt (p < 0.001) and United Arab Emirates (p = 0.013). A decline in the household's dietary diversity was observed in Australia (p < 0.001), in South Africa including Uganda (p < 0.001), in Europe including Belgium (p < 0.001), Denmark (p = 0.002), Finland (p < 0.001) and Netherland (p = 0.027) and in South America including Ecuador (p < 0.001), Brazil (p < 0.001), Mexico (p < 0.0001) and Peru (p < 0.001). Middle and older ages [OR = 1.2; 95 % CI = [1.125-1.426] [OR = 2.5; 95 % CI = [1.951-3.064], being a woman [OR = 1.2; 95 % CI = [1.117-1.367], having a high education (p < 0.001), and showing amelioration in food-related behaviors [OR = 1.4; 95 % CI = [1.292-1.709] were all linked to having a higher dietary diversity. Conclusion: The minor to moderate changes in food consumption patterns observed across the 38 countries within relatively short time frames could become lasting, leading to a significant and prolonged reduction in dietary diversity, as demonstrated by our findings.
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21585
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12: minor groove structures of the R(12,1)- and S(12,1)-alpha-(N2-guanyl) stereoisomers determined by 1H nuclear magnetic resonance.

Setayesh, F R / DeCorte, B L / Horton, P / Harris, C M / Harris, T M / Stone, M P

Chemical research in toxicology

1998 Volume 11, Issue 7, Page(s) 766–777

Abstract: ... Setayesh, F. R., DeCorte, B. L., Harris, C. M., Harris, T. M., and Stone, M. P. (1996) Biochemistry 35 ... The R- and S-alpha-(N2-guanyl)styrene oxide (SO) adducts at X5 in d(G1G2C3A4X5G6T7G8G9T10G11).d ... NMR spectroscopy. These were the R(12,1) and S(12,1) adducts, indicating the location of the R or S adduct ...

Abstract	The R- and S-alpha-(N2-guanyl)styrene oxide (SO) adducts at X5 in d(G1G2C3A4X5G6T7G8G9T10G11).d(C12A13C14C15A16C17C18T19G20C21C22 ), encompassing codon 12 of the human N-ras protooncogene (underlined), were examined using 1H NMR spectroscopy. These were the R(12,1) and S(12,1) adducts, indicating the location of the R or S adduct at the first position of codon 12. These differed from the R- and S(12, 2)-alpha-SO adducts [Zegar, I. S., Setayesh, F. R., DeCorte, B. L., Harris, C. M., Harris, T. M., and Stone, M. P. (1996) Biochemistry 35, 4334-4348] in that the base pair 5' to the lesion was changed from G.C to A.T, while the base pair 3' to the lesion was changed from T.A to G.C. Comparison of the R- and S(12,1) adducts with the R- and S(12,2) adducts allowed the effects of flanking bases on the conformations of the alpha-SO adducts to be examined. This change in flanking base affected the R-SO lesion. The R(12,1) adduct structure was disordered at the adduct site, and a refined structure could not be obtained. NOE and chemical shift data suggested that the styrenyl moiety was oriented in the minor groove and in the 3'-direction from the site of adduction. In contrast, this change in flanking base did not affect the S-SO lesion. The S(12,1) adduct yielded a refined structure, with the styrenyl moiety edgewise in the minor groove and oriented in the 5'-direction relative to the site of adduction. A total of 232 interproton distances, including 13 styrene-DNA distances, were obtained. A total of 12 NOE-restrained molecular dynamics calculations converged with pairwise root-mean-square deviation of 1.10 A. The sixth-root residual index between calculated and experimental NOE intensities was 8.0 x 10(-)2 A. The styrene aromatic protons appeared as three resonances, suggesting rapid rotation. The possibility of a hydrogen bond between the styrene hydroxyl and C18 O2 in the S(12,1) adduct could not be confirmed. This work illustrates the dual roles of stereochemistry and sequence in modulating the properties of guanine N2 alpha-SO adducts.
MeSH term(s)	Codon ; Epoxy Compounds/chemistry ; Genes, ras ; Guanine/chemistry ; Humans ; Models, Molecular ; Mutagens/chemistry ; Nuclear Magnetic Resonance, Biomolecular ; Nucleic Acid Conformation ; Oligodeoxyribonucleotides/chemistry ; Stereoisomerism
Chemical Substances	Codon ; Epoxy Compounds ; Mutagens ; Oligodeoxyribonucleotides ; Guanine (5Z93L87A1R) ; styrene oxide (9QH06NGT6O)
Language	English
Publishing date	1998-07
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	639353-6
ISSN	1520-5010 ; 0893-228X
ISSN (online)	1520-5010
ISSN	0893-228X
DOI	10.1021/tx9800147
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2320: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: Extreme Multi-Label Skill Extraction Training using Large Language Models

Decorte, Jens-Joris / Verlinden, Severine / Van Hautte, Jeroen / Deleu, Johannes / Develder, Chris / Demeester, Thomas

2023

Abstract: ... show a consistent increase of between 15 to 25 percentage points in \textit{R-Precision@5} compared ...

Abstract	Online job ads serve as a valuable source of information for skill requirements, playing a crucial role in labor market analysis and e-recruitment processes. Since such ads are typically formatted in free text, natural language processing (NLP) technologies are required to automatically process them. We specifically focus on the task of detecting skills (mentioned literally, or implicitly described) and linking them to a large skill ontology, making it a challenging case of extreme multi-label classification (XMLC). Given that there is no sizable labeled (training) dataset are available for this specific XMLC task, we propose techniques to leverage general Large Language Models (LLMs). We describe a cost-effective approach to generate an accurate, fully synthetic labeled dataset for skill extraction, and present a contrastive learning strategy that proves effective in the task. Our results across three skill extraction benchmarks show a consistent increase of between 15 to 25 percentage points in \textit{R-Precision@5} compared to previously published results that relied solely on distant supervision through literal matches. Comment: Accepted to the International workshop on AI for Human Resources and Public Employment Services (AI4HR&PES) as part of ECML-PKDD 2023
Keywords	Computer Science - Computation and Language
Subject code	006
Publishing date	2023-07-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED