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Article ; Online: Perioperative Neurocognitive Function in Glioma Surgery.

Noll, Kyle R / Bradshaw, Mariana / Sheppard, David / Wefel, Jeffrey S

2024 Volume 26, Issue 5, Page(s) 466–476

Abstract: Purpose of review: This review provides a concise overview of the recent literature regarding preoperative and postoperative neurocognitive functioning (NCF) in patients with glioma. Brief discussion also covers contemporary intraoperative brain mapping ...

Abstract	Purpose of review: This review provides a concise overview of the recent literature regarding preoperative and postoperative neurocognitive functioning (NCF) in patients with glioma. Brief discussion also covers contemporary intraoperative brain mapping work, with a focus on potential influence of mapping upon NCF outcomes following awake surgery. Recent findings: Most patients with glioma exhibit preoperative NCF impairment, with severity varying by germ line and tumoral genetics, tumor grade, and lesion location, among other characteristics. Literature regarding postoperative NCF changes is mixed, though numerous studies indicate a majority of patients exhibit immediate and short-term worsening. This is often followed by recovery over several months; however, a substantial portion of patients harbor persisting declines. Decline appears related to surgically-induced structural and functional brain alterations, both local and distal to the tumor and resection cavity. Importantly, NCF decline may be mitigated to some extent by intraoperative brain mapping, including mapping of both language-mediated and nonverbal functions. Research regarding perioperative NCF in patients with glioma has flourished over recent years. While this has increased our understanding of contributors to NCF and risk of decline associated with surgical intervention, more work is needed to better preserve NCF throughout the disease course.
MeSH term(s)	Humans ; Glioma/surgery ; Glioma/psychology ; Brain Neoplasms/surgery ; Brain Neoplasms/psychology ; Brain Mapping ; Neurosurgical Procedures/adverse effects ; Cognition/physiology
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2057359-5
ISSN	1534-6269 ; 1523-3790
ISSN (online)	1534-6269
ISSN	1523-3790
DOI	10.1007/s11912-024-01522-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Intersection of Neighborhood Environment and Adverse Childhood Experiences: Methods for Creation of a Neighborhood ACEs Index.

Schroeder, Krista / Dumenci, Levent / Sarwer, David B / Noll, Jennie G / Henry, Kevin A / Suglia, Shakira F / Forke, Christine M / Wheeler, David C

International journal of environmental research and public health

2022 Volume 19, Issue 13

Abstract: This study evaluated methods for creating a neighborhood adverse childhood experiences (ACEs) index, a composite measure that captures the association between neighborhood environment characteristics (e.g., crime, healthcare access) and individual-level ... ...

Abstract	This study evaluated methods for creating a neighborhood adverse childhood experiences (ACEs) index, a composite measure that captures the association between neighborhood environment characteristics (e.g., crime, healthcare access) and individual-level ACEs exposure, for a particular population. A neighborhood ACEs index can help understand and address neighborhood-level influences on health among individuals affected by ACEs. Methods entailed cross-sectional secondary analysis connecting individual-level ACEs data from the Philadelphia ACE Survey (
MeSH term(s)	Adverse Childhood Experiences ; Bayes Theorem ; Cross-Sectional Studies ; Health Promotion ; Humans ; Residence Characteristics
Language	English
Publishing date	2022-06-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19137819
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Article: The association between adverse childhood experiences, neighborhood greenspace, and body mass index: A cross-sectional study.

Schroeder, Krista / Forke, Christine M / Noll, Jennie G / Wheeler, David C / Henry, Kevin A / Sarwer, David B

Preventive medicine reports

2022 Volume 29, Page(s) 101915

Abstract: An association between adverse childhood experiences (ACEs) and elevated body mass index (BMI) has been found in previous investigations. ACEs' effects on BMI have been primarily considered via individual-level physiological and behavioral frameworks. ... ...

Abstract	An association between adverse childhood experiences (ACEs) and elevated body mass index (BMI) has been found in previous investigations. ACEs' effects on BMI have been primarily considered via individual-level physiological and behavioral frameworks. Neighborhood factors, such as greenspace, are also associated with BMI and may merit consideration in studies examining ACEs-BMI associations. This exploratory study examined associations of BMI with ACEs and neighborhood greenspace and tested whether greenspace moderated ACEs-BMI associations. Methods entailed secondary analysis of cross-sectional data. ACEs and BMI were captured from 2012/2013 Philadelphia ACE Survey and 2012 Southeastern Household Heath Survey data; greenspace percentage in participants' (n = 1,679 adults) home neighborhoods was calculated using National Land Cover Database data. Multi-level, multivariable linear regression 1) examined associations between BMI, ACEs, (0 ACEs [reference], 1-3 ACEs, 4 + ACEs), and neighborhood greenspace levels (high [reference], medium, low) and 2) tested whether greenspace moderated the ACEs-BMI association (assessed via additive interaction) before and after controlling for sociodemographic and health-related covariates. Experiencing 4 + ACEs (β = 1.21; 95 %CI: 0.26, 2.15; p = 0.01), low neighborhood greenspace (β = 1.51; 95 %CI: 0.67, 2.35; p < 0.01), and medium neighborhood greenspace (β = 1.37; 95 %CI: 0.52, 2.21; p < 0.01) were associated with BMI in unadjusted models. Only low neighborhood greenspace was associated with BMI (β = 0.95; 95 %CI: 0.14, 1.75; p = 0.02) in covariate-adjusted models. The ACEs-greenspace interaction was not significant in unadjusted (p = 0.89-0.99) or covariate-adjusted (p = 0.46-0.79) models. In conclusion, when considered simultaneously, low neighborhood greenspace, but not ACEs, was associated with BMI among urban-dwelling adults in covariate-adjusted models.
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785569-7
ISSN	2211-3355
ISSN	2211-3355
DOI	10.1016/j.pmedr.2022.101915
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Article ; Online: The intersection of adverse childhood experiences and neighborhood determinants of health: An exploratory spatial analysis.

Skiendzielewski, Kristin / Forke, Christine M / Sarwer, David B / Noll, Jennie G / Wheeler, David C / Henry, Kevin A / Schroeder, Krista

Psychological trauma : theory, research, practice and policy

2022 Volume 16, Issue Suppl 1, Page(s) S125–S132

Abstract: Objective: Adverse childhood experiences (ACEs) are associated with elevated risk for poor physical and psychological health outcomes. Nearly all of the literature on the association between ACEs and poor health focuses on the individual and family ... ...

Abstract	Objective: Adverse childhood experiences (ACEs) are associated with elevated risk for poor physical and psychological health outcomes. Nearly all of the literature on the association between ACEs and poor health focuses on the individual and family level; the potential role of neighborhood environment is overlooked. Understanding the relationship between ACEs and characteristics of the neighborhood environment is a necessary first step in determining if and how place-based, trauma-informed interventions might mitigate the negative effects of ACEs. The purpose of this exploratory study was to describe the neighborhood environment of adults who have experienced ≥ 4 versus ≤ 3 ACEs. Method: An exploratory secondary analysis of cross-sectional and geospatial data was conducted during 2021. Data sources included 2011/2012 Philadelphia ACE Survey data, a telephone survey of 1,784 randomly sampled Philadelphia adults, linked with geospatial data on 21 neighborhood-level determinants of health. Neighborhood was defined as participant's home census tract at the time of survey. The sample for this secondary analysis included the 1,679 Philadelphia ACE Survey participants for whom home census tract was available. Bivariate logistic regression examined differences between groups (≤ 3 ACEs vs. ≥ 4 ACEs). Results: Individuals with ≥ 4 ACEs lived in neighborhoods with higher neighborhood poverty rates, less socioeconomic resources, worse food access, poorer perceived physical and mental health, more substance overdose deaths, higher crime, and less green space. Conclusions: Findings suggest future work may benefit from considering neighborhood environments when examining and intervening upon the association between ACEs and poor physical and psychological health. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Adult ; Humans ; Adverse Childhood Experiences ; Cross-Sectional Studies ; Residence Characteristics ; Mental Health ; Surveys and Questionnaires
Language	English
Publishing date	2022-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0001320
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Article: First Line CombinAtion Therapy in the Treatment of Stage II and III Hypertension (FLASH).

Spirk, David / Noll, Sarah / Burnier, Michel / Rimoldi, Stefano / Noll, Georg / Sudano, Isabella

Frontiers in cardiovascular medicine

2020 Volume 7, Page(s) 46

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2020.00046
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Article ; Online: The Intersection of Neighborhood Environment and Adverse Childhood Experiences

Krista Schroeder / Levent Dumenci / David B. Sarwer / Jennie G. Noll / Kevin A. Henry / Shakira F. Suglia / Christine M. Forke / David C. Wheeler

International Journal of Environmental Research and Public Health, Vol 19, Iss 7819, p

Methods for Creation of a Neighborhood ACEs Index

2022 Volume 7819

Abstract	This study evaluated methods for creating a neighborhood adverse childhood experiences (ACEs) index, a composite measure that captures the association between neighborhood environment characteristics (e.g., crime, healthcare access) and individual-level ACEs exposure, for a particular population. A neighborhood ACEs index can help understand and address neighborhood-level influences on health among individuals affected by ACEs. Methods entailed cross-sectional secondary analysis connecting individual-level ACEs data from the Philadelphia ACE Survey ( n = 1677) with 25 spatial datasets capturing neighborhood characteristics. Four methods were tested for index creation (three methods of principal components analysis, Bayesian index regression). Resulting indexes were compared using Akaike Information Criteria for accuracy in explaining ACEs exposure. Exploratory linear regression analyses were conducted to examine associations between ACEs, the neighborhood ACEs index, and a health outcome—in this case body mass index (BMI). Results demonstrated that Bayesian index regression was the best method for index creation. The neighborhood ACEs index was associated with higher BMI, both independently and after controlling for ACEs exposure. The neighborhood ACEs index attenuated the association between BMI and ACEs. Future research can employ a neighborhood ACEs index to inform upstream, place-based interventions and policies to promote health among individuals affected by ACEs.
Keywords	adverse childhood experiences ; geospatial ; index ; methods ; neighborhood ; obesity ; Medicine ; R
Subject code	001
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Effect of Home Blood Pressure Monitoring on Patient's Awareness and Goal Attainment Under Antihypertensive Therapy: The Factors Influencing Results in Anti-HypertenSive Treatment (FIRST) Study.

Spirk, David / Noll, Sarah / Burnier, Michel / Rimoldi, Stefano / Noll, Georg / Sudano, Isabella

Kidney & blood pressure research

2018 Volume 43, Issue 3, Page(s) 979–986

Abstract: Background/aims: Despite availability of a broad spectrum of blood pressure (BP)-lowering drugs many hypertensive patients do not attain BP goals. We aimed to evaluate the influence of home blood pressure monitoring (HBPM) on patient's awareness and ... ...

Abstract	Background/aims: Despite availability of a broad spectrum of blood pressure (BP)-lowering drugs many hypertensive patients do not attain BP goals. We aimed to evaluate the influence of home blood pressure monitoring (HBPM) on patient's awareness and attainment of BP goals under antihypertensive treatment with irbesartan alone or in combination with hydro-chlorothiazide. Methods: In total, 1,268 patients with arterial hypertension were enrolled in the Factors Influencing Results in anti-hypertenSive Treatment (FIRST) study by 348 general practitioners and internal medicine specialists across Switzerland. Patients selected for HBPM received detailed information and training on BP self-management. The study endpoints included patient's awareness and attainment of BP goals, and the efficacy and tolerability of antihypertensive treatment at 3 months. Results: Overall, the mean age was 61±13 years and 616 (49%) were women. The mean systolic/diastolic BP was 161±17/96±11 mmHg, and 239 (19%) patients had diabetes mellitus. 758 (60%) patients were instructed to use HBPM. Both the proportion of patients aware of their BP goals (81% vs. 70%; p< 0.001) and the percentage of patients reaching their BP goal (64% vs. 57%; p=0.028) were higher in those with vs. without HBPM. The mean reduction in systolic/diastolic BP was 23.8/13.2 mmHg. Only 35 (3.0%) patients discontinued antihypertensive therapy. Conclusion: In a large Swiss cohort of patients with arterial hypertension, information and training on BP self-measurement and direct involvement of patients by using HBPM led to improvement in BP control. Treatment with irbesartan alone or in combination with hydrochlorothiazide was well tolerated and markedly reduced BP.
MeSH term(s)	Aged ; Antihypertensive Agents/therapeutic use ; Awareness ; Biphenyl Compounds/therapeutic use ; Blood Pressure/drug effects ; Blood Pressure Monitoring, Ambulatory/methods ; Drug Therapy, Combination/methods ; Female ; Goals ; Humans ; Hydrochlorothiazide/therapeutic use ; Irbesartan ; Male ; Middle Aged ; Self Care/standards ; Switzerland ; Tetrazoles/therapeutic use ; Treatment Outcome
Chemical Substances	Antihypertensive Agents ; Biphenyl Compounds ; Tetrazoles ; Hydrochlorothiazide (0J48LPH2TH) ; Irbesartan (J0E2756Z7N)
Language	English
Publishing date	2018-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1326018-2
ISSN	1423-0143 ; 1420-4096
ISSN (online)	1423-0143
ISSN	1420-4096
DOI	10.1159/000490687
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Article: The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice.

Blanchard, Matthew W / Sigmon, John Sebastian / Brennan, Jennifer / Ahulamibe, Chidima / Allen, Michelle E / Baric, Ralph S / Bell, Timothy A / Farrington, Joeseph / Ciavatta, Dominic / Cruz Cisneros, Marta / Drushal, Madison / Ferris, Martin T / Fry, Rebecca / Gaines, Christiann / Gu, Bin / Heise, Mark T / Hodges, Richard Austin / Kafri, Tal / Lynch, Rachel /

Magnuson, Terry / Miller, Darla / Murphy, Caroline E Y / Nguyen, David Truong / Noll, Kelsey E / Proulx, Megan / Sassetti, Chris / Shaw, Ginger D / Simon, Jeremy M / Smith, Clare / Styblo, Myrek / Tarantino, Lisa / Woo, Joyce / Pardo Manuel de Villena, Fernando

bioRxiv : the preprint server for biology

2024

Abstract: The MiniMUGA genotyping array is a popular tool for genetic QC of laboratory mice and genotyping of samples from most types of experimental crosses involving laboratory strains, particularly for reduced complexity crosses. The content of the production ... ...

Abstract	The MiniMUGA genotyping array is a popular tool for genetic QC of laboratory mice and genotyping of samples from most types of experimental crosses involving laboratory strains, particularly for reduced complexity crosses. The content of the production version of the MiniMUGA array is fixed; however, there is the opportunity to improve array's performance and the associated report's usefulness by leveraging thousands of samples genotyped since the initial description of MiniMUGA in 2020. Here we report our efforts to update and improve marker annotation, increase the number and the reliability of the consensus genotypes for inbred strains and increase the number of constructs that can reliably be detected with MiniMUGA. In addition, we have implemented key changes in the informatics pipeline to identify and quantify the contribution of specific genetic backgrounds to the makeup of a given sample, remove arbitrary thresholds, include the Y Chromosome and mitochondrial genome in the ideogram, and improve robust detection of the presence of commercially available substrains based on diagnostic alleles. Finally, we have made changes to the layout of the report, to simplify the interpretation and completeness of the analysis and added a table summarizing the ideogram. We believe that these changes will be of general interest to the mouse research community and will be instrumental in our goal of improving the rigor and reproducibility of mouse-based biomedical research.
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.29.582794
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Article: The Major Floral Promoter NtFT5 in Tobacco (

Schmidt, Florentin J / Zimmermann, Marius M / Wiedmann, David R / Lichtenauer, Sophie / Grundmann, Lena / Muth, Jost / Twyman, Richard M / Prüfer, Dirk / Noll, Gundula A

Frontiers in plant science

2020 Volume 10, Page(s) 1666

Abstract: ... ...

Abstract	The
Language	English
Publishing date	2020-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2019.01666
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Article ; Online: Angioembolization May Improve Survival in Patients With Severe Hepatic Injuries.

Rozycki, Grace F / Sakran, Joseph V / Manukyan, Mariuxi C / Feliciano, David V / Radisic, Amanda / You, Bin / Hu, Fang / Wooster, Meghan / Noll, Kathy / Haut, Elliott R

The American surgeon

2023 Volume 89, Issue 12, Page(s) 5492–5500

Abstract: Introduction: Although reports on angioembolization (AE) show favorable results for severe hepatic trauma, information is lacking on its benefit in the management and mechanisms of injury (MOI). This study examined patient outcomes with severe hepatic ... ...

Abstract	Introduction: Although reports on angioembolization (AE) show favorable results for severe hepatic trauma, information is lacking on its benefit in the management and mechanisms of injury (MOI). This study examined patient outcomes with severe hepatic injuries to determine the association of in-hospital mortality with AE. The hypothesis is that AE is associated with increased survival in severe hepatic injuries. Methods: Demographics, age, sex, MOI, shock index (SI), ≥6 units packed red blood cells (PRBCs) per hospital length of stay (LOS), intensive care unit LOS, injury severity score (ISS), and AE were collected. The primary outcome was in-hospital mortality. Patients were stratified into groups according to MOI, AE, and operative vs non-operative management. Multivariable logistic regression determined the independent association of mortality with AE vs no AE and operative vs nonoperative management and modeled the odds of mortality controlling for MOI, AE vs no AE, age and ISS groups, SI >.9, and ≥6 units PRBCs/LOS. Results: From 2013 to 2018, 2462 patients (1744 blunt; 718 penetrating) were treated for severe hepatic injuries. AE was used in only 21% of patients. Mortality rates increased with higher ISS and age. AE was associated with mortality when compared to patients who did not undergo AE. The strongest associations with mortality were ISS ≥25, transfusion ≥ 6 units PRBCs/LOS, and age ≥65 years. Conclusions: AE is underutilized in severe hepatic trauma. AE may be a valuable adjunct in the treatment of severe hepatic injuries especially in older patients and those needing exploratory laparotomy.
MeSH term(s)	Humans ; Aged ; Retrospective Studies ; Liver/injuries ; Intensive Care Units ; Injury Severity Score ; Blood Transfusion ; Wounds, Nonpenetrating/complications
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348231157416
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