LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU=Tomanek Robert J
  2. AU="Warot, G"
  3. AU=Dong Ningzheng
  4. AU="Giber, Fabiana"
  5. AU="Gocke, Peter"
  6. AU="Tarozzi, Alessandro"
  7. AU="Szeto, Tommy"
  8. AU=Cao Mengcen
  9. AU=Chabert Steren
  10. AU="Dunman, P M"
  11. AU="Lima, Marco Antonio"
  12. AU="Giansanti, Celeste"
  13. AU="Chang, Susan"
  14. AU="Schneider, Henning"
  15. AU="Quirion, Philippe"
  16. AU="Kinnunen, Ritva"
  17. AU=Doherty Taylor A.
  18. AU="Ganesha Rai"
  19. AU="Edwards, Kurtis"
  20. AU="Schneider, Clément"
  21. AU="Lara-Hernandez, A"
  22. AU=Turck J
  23. AU="Aali, Ghazaleh"
  24. AU="Catapano, Joshua S"
  25. AU=Zoloth Laurie
  26. AU="Scholtz, Clarke H"
  27. AU="Meirelles, Gustavo de Souza Portes"
  28. AU=Demirbilek Nevzat
  29. AU="Larrosa-Escartín, Nieves"
  30. AU=Crago Aimee M.
  31. AU="Mármora, Lelio"
  32. AU="Asbell, Madison"
  33. AU="Yuka Ikeda"
  34. AU="Oppenheimer, Federic"
  35. AU=Guillevin Loic
  36. AU="Sabiha Alam"
  37. AU="Taher, Bianca Petra"
  38. AU="Obier, Frank"
  39. AU=Davila Eduardo AU=Davila Eduardo
  40. AU="Albizu, Constanza Lopez"
  41. AU="Antonova, Anastasiia"
  42. AU=Crowther L. M.
  43. AU=Zhan Xiping
  44. AU="Xuhui Bao"
  45. AU="Zuman Dou"

Suchergebnis

Treffer 1 - 10 von insgesamt 54

Suchoptionen

  1. Artikel ; Online: The coronary capillary bed and its role in blood flow and oxygen delivery: A review.

    Tomanek, Robert J

    Anatomical record (Hoboken, N.J. : 2007)

    2022  Band 305, Heft 11, Seite(n) 3199–3211

    Abstract: The assumption that the coronary capillary blood flow is exclusively regulated by precapillary vessels is not supported by recent data. Rather, the complex coronary capillary bed has unique structural and geometric characteristics that invalidate many ... ...

    Abstract The assumption that the coronary capillary blood flow is exclusively regulated by precapillary vessels is not supported by recent data. Rather, the complex coronary capillary bed has unique structural and geometric characteristics that invalidate many assumptions regarding red blood cell (RBC) transport, for example, data based on a single capillary or that increases in flow are the result of capillary recruitment. It is now recognized that all coronary capillaries are open and that their variations in flow are due to structural differences, local O
    Mesh-Begriff(e) Adenosine ; Capillaries ; Erythrocytes/physiology ; Nitric Oxide ; Oxygen ; Phenylephrine
    Chemische Substanzen Phenylephrine (1WS297W6MV) ; Nitric Oxide (31C4KY9ESH) ; Adenosine (K72T3FS567) ; Oxygen (S88TT14065)
    Sprache Englisch
    Erscheinungsdatum 2022-05-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.24951
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ub I Zs.65: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Buch: Formation of the heart and its regulation

    Tomanek, Robert J.

    (Cardiovascular molecular morphogenesis)

    2001  

    Verfasserangabe ed. by Robert J. Tomanek
    Serientitel Cardiovascular molecular morphogenesis
    Sprache Englisch
    Umfang XIV, 276 S. : Ill., graph. Darst.
    Verlag Birkhäuser
    Erscheinungsort Boston
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT013093945
    ISBN 0-8176-4216-1 ; 978-0-8176-4216-7
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2001 A 4417 bestellbar zur Ausleihe Magazin

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Buch: Assembly of the vasculature and its regulation

    Tomanek, Robert J.

    (Cardiovascular molecular morphogenesis)

    2002  

    Verfasserangabe Robert J. Tomanek, ed
    Serientitel Cardiovascular molecular morphogenesis
    Schlagwörter Blood Vessels / embryology ; Blood Vessels / physiology ; Endothelium, Vascular / embryology ; Endothelium, Vascular / physiology ; Morphology ; Blutgefäßsystem ; Embryonalentwicklung ; Angiogenese ; Regulation ; Organogenese
    Schlagwörter Embryo ; Embryogenese ; Keimesentwicklung ; Gefäßentwicklung ; Organbildung ; Organentwicklung ; Gefäß-System
    Sprache Englisch
    Umfang XVII, 279 S. : Ill., graph. Darst.
    Verlag Birkhäuser
    Erscheinungsort Boston u.a.
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    Anmerkung Literaturangaben
    HBZ-ID HT013368941
    ISBN 3-7643-4229-3 ; 0-8176-4229-3 ; 978-3-7643-4229-6 ; 978-0-8176-4229-7
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2003 A 1143 bestellbar zur Ausleihe Magazin

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Developmental Progression of the Coronary Vasculature in Human Embryos and Fetuses.

    Tomanek, Robert J

    Anatomical record (Hoboken, N.J. : 2007)

    2016  Band 299, Heft 1, Seite(n) 25–41

    Abstract: Although considerable advances in our understanding of mammalian and avian embryonic coronary development have occurred during the last decade, our current knowledge of this topic in humans is limited. Accordingly, the aim of this study was to determine ... ...

    Abstract Although considerable advances in our understanding of mammalian and avian embryonic coronary development have occurred during the last decade, our current knowledge of this topic in humans is limited. Accordingly, the aim of this study was to determine if the development of the human coronary vasculature in humans is like that of other mammals and avians. The data document a progression of events involving mesenchymal cell-containing villi from the proepicardium, establishment of blood islands and a capillary network. The major finding of the study is direct evidence that the capillary plexus associated with spindle cells and erythroblasts invades the base of the aorta to form coronary ostia. A role for the dorsal mesocardium is also indicated by the finding that cells from this region are continuous with the aorta and pulmonary artery. The development of the tunica media of the coronary arteries follows the same base-apex progression as in other species, with the development of branches occurring late in the embryonic period. The fetal period is characterized by 1) growth and a numerical increase in the smallest arterial branches, veins, and venules, 2) innervation of arteries, and 3) inclusion of elastic fibers in the tunica media of the coronary arteries and development of the tunica adventitia. In conclusion, the data demonstrate that the development of the coronary system in humans is similar to that of other mammalian and avian species, and for the first time documents that the formation of the ostia and coronary stems in humans occurs by ingrowth of a vascular plexus and associated cells from the epicardium.
    Mesh-Begriff(e) Coronary Vessels/embryology ; Endothelium, Vascular/embryology ; Fetus/embryology ; Heart/embryology ; Humans ; Image Processing, Computer-Assisted ; Microscopy
    Sprache Englisch
    Erscheinungsdatum 2016-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.23283
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ub I Zs.65: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Buch: Coronary vasculature

    Tomanek, Robert J

    development, structure-function, and adaptations

    2013  

    Verfasserangabe Robert J. Tomanek
    Mesh-Begriff(e) Coronary Vessels/physiology ; Coronary Vessels/anatomy & histology ; Cardiovascular Diseases ; Adaptation, Physiological
    Sprache Englisch
    Umfang xviii, 276 p. :, ill.
    Verlag Springer
    Erscheinungsort New York
    Dokumenttyp Buch
    ISBN 9781461448860 ; 9781461448877 ; 1461448867 ; 1461448875
    Datenquelle Katalog der US National Library of Medicine (NLM)

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Buch ; Online: Coronary Vasculature

    Tomanek, Robert J

    Development, Structure-Function, and Adaptations

    2013  

    Abstract: ... myocardial perfusion was written by Dr. Robert J. Tomanek, Emeritus Professor of Anatomy and Cell Biology ...

    Verfasserangabe by Robert J. Tomanek
    Abstract Ischemic heart disease is the leading cause of morbidity and mortality in the developed world. The high metabolism and oxygen demand of the cardiac myocardium depends on both a high blood flow and a rich capillary density. For this reason, the growth of the coronary vasculature is vital, not only in early development, but also in the adult faced with various stresses. Novel technologies have enabled the discovery of the molecular mechanisms underlying the growth and assembly coronary vessels, and this volume covers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood, and senescence. Chapters address normal coronary development, coronary anomalies and their possible underlying developmental errors, coronary vessel adaptations to exercise training, aging, hypoxia, myocardial ischemia, and cardiac hypertrophy.This comprehensive overview of current research in coronary vessels and myocardial perfusion was written by Dr. Robert J. Tomanek, Emeritus Professor of Anatomy and Cell Biology at the University of Iowa. The book reviews, discusses, and integrates findings from various areas of coronary vasculature research, and as a result, will be a valuable reference source for cardiovascular scientists and physicians for many years to come.
    Mesh-Begriff(e) Adaptation, Physiological ; Cardiovascular Diseases ; Coronary Vessels/anatomy & histology ; Coronary Vessels/physiology
    Schlagwörter Cardiology ; Medicine ; Technik / Wissen # Biologie
    Sprache Englisch
    Umfang Online-Ressource (XVIII, 276 p. 74 illus., 59 illus. in color), digital
    Verlag Springer
    Erscheinungsort Boston, MA
    Dokumenttyp Buch ; Online
    Anmerkung Description based upon print version of record
    ISBN 9781461448860 ; 9781461448877 ; 1461448867 ; 1461448875
    DOI 10.1007/978-1-4614-4887-7
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  7. Artikel ; Online: Coronary anomalies in mice with congenital heart defects.

    Tomanek, Robert J / Yu, Qing / Lo, Cecilia W

    Anatomical record (Hoboken, N.J. : 2007)

    2015  Band 298, Heft 2, Seite(n) 408–417

    Abstract: Background: Coronary anomalies are frequently associated with congenital cardiac defects. Accordingly, we tested the hypothesis that the development of the tunica media of coronary arteries/arterioles is compromised in mice with cardiac defects of the ... ...

    Abstract Background: Coronary anomalies are frequently associated with congenital cardiac defects. Accordingly, we tested the hypothesis that the development of the tunica media of coronary arteries/arterioles is compromised in mice with cardiac defects of the outflow tract (persistent truncus arteriosus, double outlet right ventricle and transposition of the great arteries) by studying hearts of G7-9 generation mice bred from mutagenized mice caused by N-ethyl-N-nitrosourea. Mice were studied at embryonic days E16.5, E17.5, and postnatal days 1 and 11. Data were based on immunohistochemistry of serial sections.
    Results: In 21 of 24 mice with outflow tract defects, the development of smooth muscle in arteries and arterioles was retarded; most commonly arterioles had an incomplete layer of smooth muscle or in a few instances, lacked a tunica media. In this model, an absence of a coronary ostium occurred in only 2 mice, indicating that the mechanisms underlying the formation of coronary ostia and the recruitment and differentiation of vascular smooth muscle differ. Coronary fistulas were present in 20% and dilated vessels in 30% of the hearts with cardiac defects.
    Conclusions: The data suggest that vascular smooth muscle recruitment and differentiation are not necessarily linked to other coronary anomalies, such as absence of a main coronary artery or branching patterns.
    Mesh-Begriff(e) Animals ; Animals, Newborn ; Coronary Vessel Anomalies/pathology ; Heart Defects, Congenital/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Smooth, Vascular/pathology ; Tunica Media/pathology
    Sprache Englisch
    Erscheinungsdatum 2015-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.23056
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ub I Zs.65: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  8. Artikel: Formation of the coronary vasculature during development.

    Tomanek, Robert J

    Angiogenesis

    2005  Band 8, Heft 3, Seite(n) 273–284

    Abstract: The formation of the coronary vasculature involves a series of carefully regulated temporal events that include vasculogenesis, angiogenesis, arteriogenesis and remodeling. This review explores these events, which begin with the migration of ... ...

    Abstract The formation of the coronary vasculature involves a series of carefully regulated temporal events that include vasculogenesis, angiogenesis, arteriogenesis and remodeling. This review explores these events, which begin with the migration of proepicardial cells to form the epicardium and end with postnatal growth and remodeling. Coronary endothelial, smooth muscle and fibroblast cells differentiate via epithelial-mesenchymal transformation; these cells delaminate from the epicardium. Following the formation of a tubular network by endothelial cells, an aortic ring of endothelial cells penetrates the aorta at the left and right aortic cusps to form the two ostia. Smooth muscle cell recruitment occurs rapidly and the coronary artery network begins forming as blood flow is established. Recent studies have identified a number of regulatory molecules that play key roles in epicardial formation and the transformation of its component cells into mesenchyme. Moreover, we are finally gaining some understanding regarding the interplay of angiogenic growth factors in the complex process of establishing the coronary vascular tree. Understanding coronary embryogenesis is important for interventions regarding adult cardiovascular diseases as well as those necessary to correct congenital defects.
    Mesh-Begriff(e) Cell Differentiation/physiology ; Coronary Vessels/embryology ; Coronary Vessels/growth & development ; Endothelial Cells/physiology ; Endothelial Growth Factors/metabolism ; Humans ; Models, Biological ; Muscle, Smooth/physiology ; Neovascularization, Physiologic/physiology
    Chemische Substanzen Endothelial Growth Factors
    Sprache Englisch
    Erscheinungsdatum 2005
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1484717-6
    ISSN 0969-6970
    ISSN 0969-6970
    DOI 10.1007/s10456-005-9014-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5094: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  9. Artikel ; Online: The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury.

    Mapuskar, Kranti A / Pulliam, Casey F / Tomanek-Chalkley, Ann / Rastogi, Prerna / Wen, Hsiang / Dayal, Sanjana / Griffin, Benjamin R / Zepeda-Orozco, Diana / Sindler, Amy L / Anderson, Carryn M / Beardsley, Robert / Kennedy, Eugene P / Spitz, Douglas R / Allen, Bryan G

    Redox biology

    2024  Band 70, Seite(n) 103022

    Abstract: ... Experimental design: Young and old C57BL/6 J murine models of cisplatin-induced AKI and CKD were treated with the SOD ...

    Abstract Purpose: Cisplatin contributes to acute kidney injury (AKI) and chronic kidney disease (CKD) that occurs with greater frequency and severity in older patients. Age-associated cisplatin sensitivity in human fibroblasts involves increased mitochondrial superoxide produced by older donor cells.
    Experimental design: Young and old C57BL/6 J murine models of cisplatin-induced AKI and CKD were treated with the SOD mimetic avasopasem manganese to investigate the potential antioxidant and anti-inflammatory effects. Adverse event reporting from a phase 2 and a phase 3 randomized clinical trial (NCT02508389 and NCT03689712) conducted in patients treated with cisplatin and AVA was determined to have established the incidence and severity of AKI.
    Results: Cisplatin-induced AKI and CKD occurred in all mice, however, was more pronounced in older mice. AVA reduced cisplatin-induced mortality, AKI, and CKD, in older animals. AVA also alleviated cisplatin-induced alterations in mitochondrial electron transport chain (ETC) complex activities and NADPH Oxidase 4 (NOX4) and inhibited the increased levels of the inflammation markers, TNFα, IL1, ICAM-1, and VCAM-1. Analysis of age-stratified subjects treated with cisplatin from clinical trials (NCT02508389, NCT03689712) also supported that the incidence of AKI increased with age and AVA reduced age-associated therapy-induced adverse events (AE), including hypomagnesemia, increased creatinine, and AKI.
    Conclusions: Older mice and humans are more susceptible to cisplatin-induced kidney injury, and treatment with AVA mitigates age-associated damage. Mitochondrial ETC and NOX4 activities represent sources of superoxide production contributing to cisplatin-induced kidney injury, and pro-inflammatory cytokine production and endothelial dysfunction may also be increased by superoxide formation.
    Mesh-Begriff(e) Humans ; Mice ; Animals ; Aged ; Cisplatin/pharmacology ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Superoxides ; Mice, Inbred C57BL ; Kidney ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Renal Insufficiency, Chronic ; Anti-Inflammatory Agents/pharmacology ; Organometallic Compounds
    Chemische Substanzen Cisplatin (Q20Q21Q62J) ; Antioxidants ; avasopasem manganese (EY1WA413UL) ; Superoxides (11062-77-4) ; Anti-Inflammatory Agents ; Organometallic Compounds
    Sprache Englisch
    Erscheinungsdatum 2024-01-01
    Erscheinungsland Netherlands
    Dokumenttyp Randomized Controlled Trial ; Clinical Trial, Phase II ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2023.103022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  10. Artikel ; Online: Structural composition of myocardial infarction scar in middle-aged male and female rats: does sex matter?

    Bogatyryov, Yevgen / Tomanek, Robert J / Dedkov, Eduard I

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2013  Band 61, Heft 11, Seite(n) 833–848

    Abstract: The present study was designed to determine whether the structural composition of the scar in middle-aged post-myocardial infraction (MI) rats is affected by the biological sex of the animals. A large MI was induced in 12-month-old male (M-MI) and female ...

    Abstract The present study was designed to determine whether the structural composition of the scar in middle-aged post-myocardial infraction (MI) rats is affected by the biological sex of the animals. A large MI was induced in 12-month-old male (M-MI) and female (F-MI) Sprague-Dawley rats by ligation of the left coronary artery. Four weeks after the MI, rats with transmural infarctions, greater than 50% of the left ventricular (LV) free wall, were evaluated. The extent of LV remodeling and fractional volumes of fibrillar collagen (FC), myofibroblasts, vascular smooth muscle (SM) cells, and surviving cardiac myocytes (CM) in the scars were compared between the two sexes. The left ventricle of post-MI male and female rats underwent a similar degree of remodeling as evidenced by the analogous scar thinning ratio (0.46 ± 0.02 vs. 0.42 ± 0.05) and infarct expansion index (1.06 ± 0.07 vs. 1.12 ± 0.08), respectively. Most important, the contents of major structural components of the scar revealed no evident difference between M-MI and F-MI rats (interstitial FC, 80.74 ± 2.08 vs. 82.57 ± 4.53; myofibroblasts, 9.59 ± 1.68 vs.9.56 ± 1.15; vascular SM cells, 2.27 ± 0.51 vs. 3.38 ± 0.47; and surviving CM, 3.26 ± 0.39 vs. 3.05 ± 0.38, respectively). Our data are the first to demonstrate that biological sex does not influence the structural composition of a mature scar in middle-aged post-MI rats.
    Mesh-Begriff(e) Age Factors ; Animals ; Cicatrix/pathology ; Female ; Immunohistochemistry ; Male ; Myocardial Infarction/pathology ; Myocardium/pathology ; Rats ; Rats, Sprague-Dawley ; Sex Factors ; Ventricular Remodeling
    Sprache Englisch
    Erscheinungsdatum 2013-07-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/0022155413499794
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Uc I Zs.321: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang