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  1. Article ; Online: Different Effects of Cannabis Abuse on Adolescent and Adult Brain.

    Dhein, Stefan

    Pharmacology

    2020  Volume 105, Issue 11-12, Page(s) 609–617

    Abstract: Cannabis abuse is a common phenomenon among adolescents. The dominant psychoactive substance in Cannabis sativa is tetrahydrocannabinol (THC). However, in the past 40 years the content of the psychoactive ingredient THC in most of the preparations is not ...

    Abstract Cannabis abuse is a common phenomenon among adolescents. The dominant psychoactive substance in Cannabis sativa is tetrahydrocannabinol (THC). However, in the past 40 years the content of the psychoactive ingredient THC in most of the preparations is not constant but has increased due to other breeding and culturing conditions. THC acts as the endocannabinoids at CB1 and CB2 receptors but pharmacologically can be described as a partial (not a pure) agonist. Recent evidence shows that activation of the CB1 receptor by THC can diminish the production of neuronal growth factor in neurons and affect other signalling cascades involved in synapsis formation. Since these factors play an important role in the brain development and in the neuronal conversion processes during puberty, it seems reasonable that THC can affect the adolescent brain in another manner than the adult brain. Accordingly, in adolescent cannabis users structural changes were observed with loss of grey matter in certain brain areas. Moreover, recent studies show different effects of THC on adolescent and adult brains and on behaviour. These studies indicate that early THC abuse can result in neuropsychological deficits. This review gives an overview over the present knowledge in this field.
    MeSH term(s) Adolescent ; Adult ; Behavior/drug effects ; Brain/drug effects ; Cannabis/chemistry ; Cannabis/toxicity ; Dronabinol/pharmacology ; Endocannabinoids/physiology ; Humans ; Marijuana Abuse/complications ; Marijuana Abuse/psychology ; Receptors, Cannabinoid/chemistry ; Receptors, Cannabinoid/physiology
    Chemical Substances Endocannabinoids ; Receptors, Cannabinoid ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2020-07-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 206671-3
    ISSN 1423-0313 ; 0031-7012
    ISSN (online) 1423-0313
    ISSN 0031-7012
    DOI 10.1159/000509377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 332: Show issues Location:
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  2. Book ; Online: Cardiovascular gap junctions

    Dhein, Stefan

    gives insight into the fascinating field of intercellular communication

    2006  

    Author's details vol. ed.: Stefan Dhein
    Language English
    Size VIII + 298 S.
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    HBZ-ID TT050388056
    ISBN 978-3-318-01317-7 ; 3-318-01317-X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Cardiovascular gap junctions

    Dhein, Stefan

    4 tables

    (Advances in cardiology ; 42)

    2006  

    Author's details vol. ed.: Stefan Dhein
    Series title Advances in cardiology ; 42
    Collection
    Keywords Heart Conduction System / physiology ; Gap Junctions / physiology ; Gap Junctions / drug effects ; Heart Diseases / physiopathology ; Kardiovaskuläres System ; Gap junction ; Kardiovaskuläre Krankheit
    Subject Gap-junction ; Herz-Kreislauf-Krankheit ; Herz-Kreislauf-Erkrankung ; Kardiovaskuläres System ; Cardiovasculäre Krankheit ; Kardiovaskuläre Krankheiten ; Herz-Kreislauf-System ; Cardiovasculäres System
    Language English
    Size VIII, 298 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT014739165
    ISBN 3-8055-8077-0 ; 978-3-8055-8077-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 2764 order for loan Magazin

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  4. Book: Practical methods in cardiovascular research

    Dhein, Stefan

    with 33 tables

    2005  

    Author's details Stefan Dhein (ed.)
    Keywords Kardiovaskuläres System ; Forschung ; Kardiovaskuläre Krankheit ; Tiermodell
    Subject Herz-Kreislauf-Krankheit ; Herz-Kreislauf-Erkrankung ; Kardiovaskuläres System ; Cardiovasculäre Krankheit ; Kardiovaskuläre Krankheiten ; Wissenschaftliche Forschung ; Forschungen ; Herz-Kreislauf-System ; Cardiovasculäres System
    Language German
    Edition 1. Aufl.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014232270
    ISBN 3-540-40763-4 ; 978-3-540-40763-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 5635 order for loan Magazin

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  5. Book ; Online: Mind the gap! Gap junction channels and their importance in pathogenesis

    Dhein, Stefan / Blanke, Katja / Salameh, Aida

    2014  

    Abstract: Cells live together, but die singly, this sentence wrote the German physiologist Theodor Engelmann in 1875 and although he had no particular knowledge of gap junction channels (their structure was discovered around 100 years later) he described their ... ...

    Abstract Cells live together, but die singly, this sentence wrote the German physiologist Theodor Engelmann in 1875 and although he had no particular knowledge of gap junction channels (their structure was discovered around 100 years later) he described their functions very well: gap junction channels are essential for intercellular communication and crucial for the development of tissue and organs. But besides providing an opportunity for cells to communicate gap junction channels might also prevent intercellular communication by channel closure thereby preserving the surrounding healthy tissue in case of cellular necrosis. According to today's understanding gap junction channels play an important role during embryonic development, during growth, wound healing and cell differentiation and are also involved in the process of learning.-

    In the past decades most intensive research was done not only to unravel the physiological role of gap junction channels but also to extend our knowledge of the contribution of these channels in pathogenesis. A new frontier emerges in the field pharmacology of gap junctions with the aim to control growth, differentiation, or electrical coupling via targeting gap junction channels pharmacologically. As we know today disturbances in gap junction synthesis, assembly and cellular distribution may account for various organic disorders from most different medical fields, such as the Charcot-Marie-Tooth neuropathy, epilepsy, Chagas-disease, Naxos-syndrome, congenital cardiac malformations, arrhythmias, cancer and as a very common disease in industrial countries atherosclerosis.-

    Point mutations in gap junction channels have been found to cause hereditary diseases like the congenital deafness or the Charcot-Marie-Tooth neuropathy but the exact molecular mechanisms of gap junction malfunction from most of the mentioned illnesses are not fully understood. Moreover, in the last few years research has expanded on the role and function of connexin hemichannels and on a relatively new field the pannexins. The purpose of this volume is to give a comprehensive overview of the involvement of gap junction channels, hemichannels and pannexins on pathogenesis of inborn and acquired diseases and on emerging pharmacological strategies to target these channels. We welcome our colleagues to contribute their findings on the influence of gap junctions on pathogenesis and to unravel the secrets of intercellular communication. Take the lid off!
    Keywords Neurology. Diseases of the nervous system ; Medicine (General) ; Therapeutics. Pharmacology ; Science (General)
    Size 1 electronic resource (252 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090023
    ISBN 9782889192380 ; 2889192385
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article: Effects of hallucinogenic drugs on the human heart.

    Neumann, Joachim / Dhein, Stefan / Kirchhefer, Uwe / Hofmann, Britt / Gergs, Ulrich

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1334218

    Abstract: Hallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5- ... ...

    Abstract Hallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5-HT
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1334218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Antiarrhythmika und antiarrhythmische Therapie

    Dhein, Stefan / Stark, Gerhard

    Pathophysiologie, Klinik und Pharmakologie der Herzrhythmusstörungen ; mit 16 Tabellen und 23 Arzneimittel-Steckbriefen

    (Medizinisch-pharmakologisches Kompendium ; 20)

    2008  

    Author's details von Stefan Dhein und Gerhard Stark
    Series title Medizinisch-pharmakologisches Kompendium ; 20
    Collection
    Keywords Herzrhythmusstörung ; Pharmakotherapie
    Subject Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie ; Arrhythmie ; Herz ; Herzrhythmusstörungen
    Language German
    Size XII, 232 S. : Ill., graph. Darst.
    Publisher Wiss. Verl.-Ges
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT015517152
    ISBN 978-3-8047-2410-5 ; 3-8047-2410-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 2701 order for loan Magazin

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  8. Article ; Online: Effects of congeners of amphetamine on the human heart.

    Neumann, Joachim / Dhein, Stefan / Kirchhefer, Uwe / Hofmann, Britt / Gergs, Ulrich

    Naunyn-Schmiedeberg's archives of pharmacology

    2024  

    Abstract: Central stimulatory and hallucinogenic drugs of abuse like amphetamine and most congeners of amphetamine can have cardiac harmful effects. These cardiac side effects can lead to morbidities and death. In this paper, we review current knowledge on the ... ...

    Abstract Central stimulatory and hallucinogenic drugs of abuse like amphetamine and most congeners of amphetamine can have cardiac harmful effects. These cardiac side effects can lead to morbidities and death. In this paper, we review current knowledge on the direct and indirect effects of these amphetamine congeners on the mammalian heart-more specifically, the isolated human heart muscle preparation. In detail, we address the question of whether and how these drugs affect cardiac contractility and their mechanisms of action. Based on this information, further research areas are defined, and further research efforts are proposed.
    Language English
    Publishing date 2024-02-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-024-02983-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.5: Show issues Location:
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  9. Article ; Online: Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease.

    Neumann, Joachim / Hofmann, Britt / Dhein, Stefan / Gergs, Ulrich

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Serotonin acts solely via 5- ... ...

    Abstract Serotonin acts solely via 5-HT
    MeSH term(s) Animals ; Humans ; Heart ; Myocardial Contraction/physiology ; Receptors, Serotonin, 5-HT4/metabolism ; Serotonin/metabolism ; Heart Diseases/metabolism
    Chemical Substances Receptors, Serotonin, 5-HT4 (158165-40-3) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Role of Dopamine in the Heart in Health and Disease.

    Neumann, Joachim / Hofmann, Britt / Dhein, Stefan / Gergs, Ulrich

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Dopamine has effects on the mammalian heart. These effects can include an increase in the force of contraction, and an elevation of the beating rate and the constriction of coronary arteries. Depending on the species studied, positive inotropic effects ... ...

    Abstract Dopamine has effects on the mammalian heart. These effects can include an increase in the force of contraction, and an elevation of the beating rate and the constriction of coronary arteries. Depending on the species studied, positive inotropic effects were strong, very modest, or absent, or even negative inotropic effects occurred. We can discern five dopamine receptors. In addition, the signal transduction by dopamine receptors and the regulation of the expression of cardiac dopamine receptors will be of interest to us, because this might be a tempting area of drug development. Dopamine acts in a species-dependent fashion on these cardiac dopamine receptors, but also on cardiac adrenergic receptors. We will discuss the utility of drugs that are currently available as tools to understand cardiac dopamine receptors. The molecule dopamine itself is present in the mammalian heart. Therefore, cardiac dopamine might act as an autocrine or paracrine compound in the mammalian heart. Dopamine itself might cause cardiac diseases. Moreover, the cardiac function of dopamine and the expression of dopamine receptors in the heart can be altered in diseases such as sepsis. Various drugs for cardiac and non-cardiac diseases are currently in the clinic that are, at least in part, agonists or antagonists at dopamine receptors. We define the research needs in order to understand dopamine receptors in the heart better. All in all, an update on the role of dopamine receptors in the human heart appears to be clinically relevant, and is thus presented here.
    MeSH term(s) Animals ; Humans ; Dopamine/pharmacology ; Heart ; Receptors, Adrenergic ; Heart Diseases ; Receptors, Dopamine ; Myocardial Contraction ; Mammals
    Chemical Substances Dopamine (VTD58H1Z2X) ; Receptors, Adrenergic ; Receptors, Dopamine
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24055042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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