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  1. Article ; Online: Strengths and limitations of mathematical models in pandemicsthe case of COVID-19 in Chile.

    Rojas-Vallejos, Jorge

    Medwave

    2020  Volume 20, Issue 3, Page(s) e7876

    Abstract: This short paper focuses on the role of mathematical models to analyze the impact of pandemics on health resources and the different trade-offs that may be included in them. There is a large body of literature suggesting that mathematical modeling may be ...

    Title translation Fortalezas y limitaciones de los modelos matemáticos en las pandemias: el caso de COVID-19 en Chile.
    Abstract This short paper focuses on the role of mathematical models to analyze the impact of pandemics on health resources and the different trade-offs that may be included in them. There is a large body of literature suggesting that mathematical modeling may be helpful to estimate how much additional equipment and infrastructure are necessary to mitigate an increase in demand for health services during a large-scale outbreak of an infectious disease. I comment on the crucial role of these models with a special focus on their strengths and limitations.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Chile ; Coronavirus Infections/epidemiology ; Health Resources ; Humans ; Models, Theoretical ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2818022-7
    ISSN 0717-6384 ; 0717-6384
    ISSN (online) 0717-6384
    ISSN 0717-6384
    DOI 10.5867/medwave.2020.03.7874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Strengths and limitations of mathematical models in pandemics—the case of COVID-19 in Chile

    Jorge Rojas-Vallejos

    Medwave, Vol 20, Iss 03, Pp e7874-e

    2020  Volume 7874

    Abstract: This short paper focuses on the role of mathematical models to analyze the impact of pandemics on health resources and the different trade-offs that may be included in them. There is a large body of literature suggesting that mathematical modeling may be ...

    Abstract This short paper focuses on the role of mathematical models to analyze the impact of pandemics on health resources and the different trade-offs that may be included in them. There is a large body of literature suggesting that mathematical modeling may be helpful to estimate how much additional equipment and infrastructure are necessary to mitigate an increase in demand for health services during a large-scale outbreak of an infectious disease. I comment on the crucial role of these models with a special focus on their strengths and limitations.
    Keywords coronavirus ; covid-19 ; epidemiology ; mathematical models ; Medicine ; R ; Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Medwave Estudios Limitada
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Fortalezas y limitaciones de los modelos matemáticos en las pandemias: el caso de COVID-19 en Chile./ Fortalezas y limitaciones de los modelos matemáticos en las pandemias: el caso de COVID-19 en Chile./ Strengths and limitations of mathematical models in pandemicsthe case of COVID-19 in Chile

    Rojas-Vallejos, Jorge

    Medwave

    Abstract: This short paper focuses on the role of mathematical models to analyze the impact of pandemics on health resources and the different trade-offs that may be included in them. There is a large body of literature suggesting that mathematical modeling may be ...

    Abstract This short paper focuses on the role of mathematical models to analyze the impact of pandemics on health resources and the different trade-offs that may be included in them. There is a large body of literature suggesting that mathematical modeling may be helpful to estimate how much additional equipment and infrastructure are necessary to mitigate an increase in demand for health services during a large-scale outbreak of an infectious disease. I comment on the crucial role of these models with a special focus on their strengths and limitations.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #158322
    Database COVID19

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  4. Article ; Online: Successful stem cell transplantation after nelarabine, pegylated asparaginase, vincristine, doxorubicin, and prednisone in refractory early T-cell precursor acute lymphoblastic leukemia

    Marcela Espinoza / Pablo Ramírez / Yuho Najima / Jorge Rojas-Vallejos

    Medwave, Vol 23, Iss 04, Pp e2664-e

    A case report

    2023  Volume 2664

    Abstract: Early T-cell precursor Acute Lymphoblastic Leukemia (ALL) has a dismal prognosis. Nelarabine is a purine nucleoside analog that increases the apoptosis rate in T-cell lymphoblasts. We present a 30-year-old patient diagnosed with T-cell ALL. He was a high- ...

    Abstract Early T-cell precursor Acute Lymphoblastic Leukemia (ALL) has a dismal prognosis. Nelarabine is a purine nucleoside analog that increases the apoptosis rate in T-cell lymphoblasts. We present a 30-year-old patient diagnosed with T-cell ALL. He was a high-risk patient because of an early precursor phenotype and a complex karyotype that had been refractory to three previous lines of treatment. He started a course of nelarabine (1500 mg/m for three days), pegylated-asparaginase, doxorubicin, vincristine, and prednisone (Nelarabine Peg-Asp AdmVP). He reached complete remission and received an allogeneic sibling hematopoietic stem cell transplant with fludarabine, total body irradiation, and cyclophosphamide as the conditioning regimen. He developed a pulmonary mycosis, which resolved, and grade-2 neurotoxicity in his upper and lower limbs. He was discharged after 40 days and to date remains with 23 months of complete remission. The Nelarabine Peg-Asp AdmVP regimen seems to be effective and safe. Further research is needed to establish it as an induction treatment in refractory early T-cell precursor acute lymphoblastic leucemia.
    Keywords nelarabine ; early t-cell ; acute lymphoblastic leukemia ; neurotoxicity ; hematology ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Medwave Estudios Limitada
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: The income inequality and carbon emissions trade-off revisited

    Rojas-Vallejos, Jorge / Lastuka, Amy

    Energy policy. 2020 Apr., v. 139

    2020  

    Abstract: This paper investigates the marginal effect of income inequality on carbon emissions per-capita. We use a panel consisting of 68 countries over a 50-year period from 1961 to 2010. We report estimates that support the hypothesis that there is a trade-off ... ...

    Abstract This paper investigates the marginal effect of income inequality on carbon emissions per-capita. We use a panel consisting of 68 countries over a 50-year period from 1961 to 2010. We report estimates that support the hypothesis that there is a trade-off between carbon emissions per-capita and income inequality. This trade-off is not homogeneous across countries and depends upon the level of development measured by income per-capita. Using panel smooth transition regression, we find that this relationship is negative for countries with low to moderate income per-capita but becomes slightly positive after passing a threshold located around fifteen thousand 2011 US dollars. Moreover, the inequality elasticity of emissions per-capita is comparable in magnitude to its income elasticity. Therefore, both inequality and income levels are crucial to define policies to reduce carbon emissions. This implies a challenge to policymakers who pursue to reduce both income inequality and carbon emissions.
    Keywords carbon ; emissions ; income elasticities ; issues and policy ; per-capita income ; social inequality
    Language English
    Dates of publication 2020-04
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0301-4215
    DOI 10.1016/j.enpol.2020.111302
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Tariff reduction and income inequality

    Rojas-Vallejos, Jorge / Turnovsky, Stephen J

    Open economies review Vol. 28, No. 4 , p. 603-631

    some empirical evidence

    2017  Volume 28, Issue 4, Page(s) 603–631

    Author's details Jorge Rojas-Vallejos, Stephen J. Turnovsky
    Keywords Tariff reduction ; Income inequality ; Empirical evidence
    Language English
    Publisher Springer Science + Business Media B.V
    Publishing place Dordrecht [u.a.]
    Document type Article
    ZDB-ID 1073291-3 ; 1478937-1
    ISSN 1573-708X ; 0923-7992
    ISSN (online) 1573-708X
    ISSN 0923-7992
    Database ECONomics Information System

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  7. Article ; Online: Personalidad de marca como área de investigación en Educación Superior

    Carmen Jiménez-Bucarey / Luis Araya-Castillo / Jorge Rojas-Vallejos

    Revista de Ciencias Sociales, Vol 26, Iss 4, Pp 394-

    2020  Volume 418

    Abstract: La personalidad de marca facilita el proceso de decisión de compra de los estudiantes e influencia sus intenciones de comportamiento. Dado lo anterior, la presente investigación aplica la metodología de la cienciometría para estudiar el desarrollo de la ... ...

    Abstract La personalidad de marca facilita el proceso de decisión de compra de los estudiantes e influencia sus intenciones de comportamiento. Dado lo anterior, la presente investigación aplica la metodología de la cienciometría para estudiar el desarrollo de la literatura de personalidad de marca en el contexto de la educación superior. Se identifican 7 artículos que pueden ser considerados como origen de este conocimiento, los cuales están espaciados temporalmente entre 2013 a 2019, se encuentran en 6 revistas indexadas en WoS, en las categorías de business, education educational research, anthropology y economics, y con filiación a 18 organizaciones ubicadas en 10 países. Además, como resultado se destaca que en 4 de estos artículos contribuyen autores afiliados a instituciones de un mismo país y 3 artículos se publican en la forma de cooperación internacional, y también sólo 3 artículos superan las 3 citas. Asimismo, los artículos se agrupan tanto en tres conjuntos por referencias comunes, como en tres agregados por uso común de palabras minadas, destacándose 22 palabras relevantes. Por tanto, se concluye que la personalidad de marca es un tema aún naciente en términos de educación superior, aun cuando la producción científica está sirviendo de referencia para otros textos en WoS
    Keywords personalidad de marca ; educación superior ; cienciometría ; wos ; líneas de investigación ; Political science (General) ; JA1-92 ; Social sciences (General) ; H1-99
    Language Spanish
    Publishing date 2020-11-01T00:00:00Z
    Publisher Universidad del Zulia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The short-term impact of urban air pollution on student achievement

    Jorge Rojas-Vallejos / Carmen Gloria Jiménez Bucarey / Marcela Espinoza / Luis Araya-Castillo

    Desarrollo y Sociedad, Vol 87, Iss 1, Pp 11-

    2021  Volume 32

    Abstract: Goal: The relationship between air pollution and human health has been widely studied in medicine and economics. However, only a few recent articles have estimated the direct impact of air pollution on academic achievement. Methodology: We collect daily ... ...

    Abstract Goal: The relationship between air pollution and human health has been widely studied in medicine and economics. However, only a few recent articles have estimated the direct impact of air pollution on academic achievement. Methodology: We collect daily air pollution data from all monitoring stations in the city of Santiago, Chile, and combine it with academic results recorded by the National Learning Outcome Assessment System of (SIMCE in Spanish) for fourth grade students over the past decade, to create a unique pooled cross-sectional dataset. Results: Applying different econometric strategies, we find that certain air pollutants have a negative impact on the test scores of the cohort. Our estimated effects are negative and statistically significant, ranging between 0.02 and 0.06 standard deviations. Conclusions: These results seem to be small, but are equivalent to around 30% of a successful educational policy that specifically targets performance. Recommendations: Public policy must consider the positive externalities of reducing air pollution.
    Keywords government policy ; academic performance ; pollutants ; chile ; Economic history and conditions ; HC10-1085 ; Economics as a science ; HB71-74
    Subject code 333
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Universidad de los Andes (Bogotá)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Mieloma múltiple en Chile: Respuesta a tratamiento en pacientes con mieloma múltiple elegibles para trasplante autólogo de progenitores hematopoyéticos.

    Peña, Camila / Rojas-Vallejos, Jorge / Espinoza, Marcela / Donoso, Javiera / Soto, Pablo / Cardemil, Daniela / Aranda, Sandra / Contreras, Carolina / Vergara, Carmen Gloria / LA Rocca, Gabriel / Osorio, Rocío / López-Vidal, Hernán / Chandía, Mauricio / Rojas, Christine

    Revista medica de Chile

    2020  Volume 147, Issue 12, Page(s) 1561–1568

    Abstract: Background The treatment of choice of newly diagnosed multiple myeloma (NDMM) is an induction with proteasome inhibitors followed autologous stem cell transplantation (HSCT). Since 2013, the treatment of these patients in the public system is based on ... ...

    Title translation Response rates to first-line treatment in eligible patients to autologous stem transplantation in Chile.
    Abstract Background The treatment of choice of newly diagnosed multiple myeloma (NDMM) is an induction with proteasome inhibitors followed autologous stem cell transplantation (HSCT). Since 2013, the treatment of these patients in the public system is based on CTD (cyclophosphamide, thalidomide, and dexamethasone). Aim To evaluate the response rates achieved with CTD, and the results of HSCT in patients with NDMM in the public setting. Material and Methods Data from patients considered as candidates for HSCT from different centers of the National Adult Antineoplastic Drug Program (PANDA, for its acronym in Spanish), diagnosed between 2013 and 2017, was analyzed. The response to treatment of first and second lines of treatment was evaluated, in addition to the results of HSCT. An optimal Response was defined as the sum of strict complete remission, complete remission and very good partial response (sCR, CR and VGPR). Results One hundred and seventy-seven patients were analyzed, 54% women, and 53% with IgG multiple myeloma. Information about the international staging system was retrieved in 127 patients (71%). Seventeen percent were ISS I, 22% in ISS II and 32% ISS III. CTD was used as first treatment in 106 patients (60%), and cyclophosphamide, bortezomib and dexamethasone (CyBorD) in 13 (7%). As first line, CTD had an overall response of 50.9%, and CyBorD of 76.9%. Thirty patients were treated with bortezomib as second line treatment. Forty patients (22%) underwent HSCT. The 5-year Overall Survival (OS) in transplanted patients and non-transplanted patients was 100 and 62% respectively (p < 0.01). Conclusions The response rate achieved by CTD in these patients is suboptimal. The response to CyBorD was better.
    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols ; Bortezomib/administration & dosage ; Combined Modality Therapy ; Cyclophosphamide/administration & dosage ; Dexamethasone/administration & dosage ; Disease-Free Survival ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multiple Myeloma/mortality ; Multiple Myeloma/therapy ; Retrospective Studies ; Time Factors ; Transplantation, Autologous
    Chemical Substances Bortezomib (69G8BD63PP) ; Dexamethasone (7S5I7G3JQL) ; Cyclophosphamide (8N3DW7272P)
    Language Spanish
    Publishing date 2020-03-18
    Publishing country Chile
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/S0034-98872019001201561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immune Profile and Clinical Outcome of Breakthrough Cases After Vaccination With an Inactivated SARS-CoV-2 Vaccine.

    Duarte, Luisa F / Gálvez, Nicolás M S / Iturriaga, Carolina / Melo-González, Felipe / Soto, Jorge A / Schultz, Bárbara M / Urzúa, Marcela / González, Liliana A / Vázquez, Yaneisi / Ríos, Mariana / Berríos-Rojas, Roslye V / Rivera-Pérez, Daniela / Moreno-Tapia, Daniela / Pacheco, Gaspar A / Vallejos, Omar P / Hoppe-Elsholz, Guillermo / Navarrete, María S / Rojas, Álvaro / Fasce, Rodrigo A /
    Fernández, Jorge / Mora, Judith / Ramírez, Eugenio / Zeng, Gang / Meng, Weining / González-Aramundiz, José V / González, Pablo A / Abarca, Katia / Bueno, Susan M / Kalergis, Alexis M

    Frontiers in immunology

    2021  Volume 12, Page(s) 742914

    Abstract: Constant efforts to prevent infections by severe acute respiratory syndrome coronavirus 2 ( ... ...

    Abstract Constant efforts to prevent infections by severe acute respiratory syndrome coronavirus 2 (SARS
    MeSH term(s) Adult ; Aged ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19 Vaccines/immunology ; Chile ; Comorbidity ; Female ; Humans ; Immunization Schedule ; Immunogenicity, Vaccine/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Interferon-gamma/immunology ; Lymphocyte Count ; Male ; Middle Aged ; SARS-CoV-2/immunology ; Severity of Illness Index ; T-Lymphocytes/immunology ; Vaccination ; Vaccines, Inactivated/immunology ; Young Adult
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; IFNG protein, human ; Immunoglobulin G ; Vaccines, Inactivated ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-09-29
    Publishing country Switzerland
    Document type Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.742914
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