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Article: The antiaging property of aqueous extract of

Jumnongprakhon, Pichaya / Pinkaew, Decha / Phuneerub, Pravaree

Journal of advanced pharmaceutical technology & research

2021 Volume 12, Issue 1, Page(s) 14–21

Abstract: Cellular senescence is the key mediator of cellular dysfunction before undergoing degenerative disease such as Alzheimer's disease. The aging process was mainly by the overactivation of senescence associated β-galactosidase (SA-β-gal) enzyme before ... ...

Abstract	Cellular senescence is the key mediator of cellular dysfunction before undergoing degenerative disease such as Alzheimer's disease. The aging process was mainly by the overactivation of senescence associated β-galactosidase (SA-β-gal) enzyme before mediated several negative responses, including intracellular reactive oxygen species (ROS) production, cellular senescence regulation, and death prior encourage synaptic loss. Thus, in the recent work, we evaluated the
Language	English
Publishing date	2021-01-09
Publishing country	India
Document type	Journal Article
ISSN	2231-4040
ISSN	2231-4040
DOI	10.4103/japtr.JAPTR_187_20
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Article: Fortilin: A Potential Target for the Prevention and Treatment of Human Diseases.

Pinkaew, Decha / Fujise, Ken

Advances in clinical chemistry

2017 Volume 82, Page(s) 265–300

Abstract: Fortilin is a highly conserved 172-amino-acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. It is a multifunctional protein that protects cells against apoptosis, promotes cell growth and cell cycle ... ...

Abstract	Fortilin is a highly conserved 172-amino-acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. It is a multifunctional protein that protects cells against apoptosis, promotes cell growth and cell cycle progression, binds calcium (Ca
MeSH term(s)	Animals ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Bacterial Infections/drug therapy ; Bacterial Infections/prevention & control ; Biomarkers/analysis ; Biomarkers, Tumor/analysis ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/prevention & control ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/prevention & control ; Liver Diseases/drug therapy ; Liver Diseases/prevention & control ; Malaria/drug therapy ; Malaria/prevention & control ; Neoplasms/drug therapy ; Neoplasms/prevention & control ; Virus Diseases/drug therapy ; Virus Diseases/prevention & control
Chemical Substances	Biomarkers ; Biomarkers, Tumor ; tumor protein, translationally-controlled 1
Language	English
Publishing date	2017-08-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	210505-6
ISSN	0065-2423
ISSN	0065-2423
DOI	10.1016/bs.acc.2017.06.006
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Article: Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure.

Chunhacha, Preedakorn / Pinkaew, Decha / Sinthujaroen, Patuma / Bowles, Dawn E / Fujise, Ken

Cell death discovery

2021 Volume 7, Issue 1, Page(s) 310

Abstract: Heart failure (HF) has reached epidemic proportions in developed countries, affecting over 20 million people worldwide. Despite modern medical and device therapies, 60-70% of HF patients still die within 5 years of diagnosis as it relentlessly progresses ...

Abstract	Heart failure (HF) has reached epidemic proportions in developed countries, affecting over 20 million people worldwide. Despite modern medical and device therapies, 60-70% of HF patients still die within 5 years of diagnosis as it relentlessly progresses through pervasive apoptotic loss of cardiomyocytes. Although fortilin, a 172-amino-acid anti-p53 molecule, is one of the most expressed proteins in the heart, its precise role there has remained unknown. Also unclear is how cardiomyocytes are protected against apoptosis. Here, we report that failing human hearts express less fortilin than do non-failing hearts. We also found that mice lacking fortilin in the heart (fortilin
Language	English
Publishing date	2021-10-23
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-021-00692-w
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Article ; Online: Phonophoresis of Phyllanthus amarus nanoparticle gel improves functional capacity in individuals with knee osteoarthritis: A randomized controlled trial.

Pinkaew, Decha / Kiattisin, Kanokwan / Wonglangka, Khanittha / Awoot, Pisittawoot

Journal of bodywork and movement therapies

2019 Volume 24, Issue 1, Page(s) 15–18

Abstract: Objective: This study examined the effects of treatment with Phyllanthus amarus nanoparticle gel applied by phonophoresis (PP) and ultrasound therapy (UT) in patients with symptomatic knee osteoarthritis (OA) using a randomized, double-blind, controlled ...

Abstract	Objective: This study examined the effects of treatment with Phyllanthus amarus nanoparticle gel applied by phonophoresis (PP) and ultrasound therapy (UT) in patients with symptomatic knee osteoarthritis (OA) using a randomized, double-blind, controlled trial. Methods: Patients with knee OA (n = 40; mean age ± SD, 64.30 ± 9.71 years), who had visual analogue scale (VAS) scores for knee pain intensity of 68.00 ± 9.58 (UT group) and 71.00 ± 8.74 (PP group, respectively) before treatment, were randomly allocated into two groups. Both groups were treated with an ultrasound program in continuous mode, 1.0 W/cm Results: VAS and 6-MWT showed significant improvement after treatment in both groups (p < 0.05). The PP group showed more significant effects than the UT group, in terms of both reducing the VAS pain score (p < 0.05) and improving 6-MWT (p < 0.05). Conclusions: PP is suggested as an effective method for the treatment of symptomatic knee OA for reducing pain and improving functional capacity.
MeSH term(s)	Administration, Cutaneous ; Aged ; Combined Modality Therapy ; Double-Blind Method ; Female ; Humans ; Knee Joint/physiopathology ; Male ; Middle Aged ; Osteoarthritis, Knee/therapy ; Pain Measurement ; Phonophoresis/methods ; Phyllanthus ; Skin Cream/therapeutic use ; Time Factors ; Treatment Outcome ; Ultrasonic Therapy/methods
Language	English
Publishing date	2019-05-04
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2029441-4
ISSN	1532-9283 ; 1360-8592
ISSN (online)	1532-9283
ISSN	1360-8592
DOI	10.1016/j.jbmt.2019.04.013
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Article: Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis.

Decha, Pinkaew / Kanokwan, Kiattisin / Jiraporn, Tocharus / Pichaya, Jumnongprakhon / Pisittawoot, Awoot

Chinese journal of integrative medicine

2019 Volume 25, Issue 9, Page(s) 691–695

Abstract: Objective: To determine the changes in serum levels of inflammatory biomarkers and antioxidant levels among the knee osteoarthritis (OA) patients after treatment with Phyllanthus amarus (PP) by nanoparticle gel phonophoresis.: Methods: This study was ...

Abstract	Objective: To determine the changes in serum levels of inflammatory biomarkers and antioxidant levels among the knee osteoarthritis (OA) patients after treatment with Phyllanthus amarus (PP) by nanoparticle gel phonophoresis. Methods: This study was a randomized, double-blind, placebo-control, parallel-group, clinical trial involving 30 subjects with mild-to-moderate degree of knee OA. The patients were allocated to two groups using a computer-generated random numbers, and received conventional ultrasound therapy (control group, 15 cases) and PP (treatment group, 15 cases) once daily for 10 sessions. The pain was evaluated by visual analogue scale (VAS). Serum levels of tumor necrosis factor-α (TNF-α) were determined by enzyme-linked immunosorbnent assay (ELISA). Nitric oxide (NO) was determined by modified Griess reagent. The antioxidant effects, including superoxide dismutase (SOD) and total antioxidant capacity (TAC), were also measured by ELISA assay. Results: The VAS score was significantly decreased in the treatment group compared with the control group after treatment (P<0.01). The serum concentrations of TNF-α and NO were significantly reduced in the treatment group compared with the control group (P<0.01) after treatment. However, the serum concentrations of SOD and TAC in the treatment group were significantly higher after treatment compared with the control group (P<0.01). Conclusion: PP could alleviate knee pain and significantly reduce systemic anti-inflammatory effects in knee OA patients.
MeSH term(s)	Adult ; Aged ; Antioxidants/metabolism ; Biomarkers/metabolism ; Gels/therapeutic use ; Humans ; Inflammation Mediators/metabolism ; Middle Aged ; Nanoparticles/chemistry ; Nitrates/metabolism ; Nitrites/metabolism ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/pathology ; Osteoarthritis, Knee/therapy ; Oxidative Stress ; Pain/etiology ; Pain Measurement ; Phyllanthus/chemistry ; Superoxide Dismutase/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Ultrasonics
Chemical Substances	Antioxidants ; Biomarkers ; Gels ; Inflammation Mediators ; Nitrates ; Nitrites ; Tumor Necrosis Factor-alpha ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2019-10-24
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-019-3202-8
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Zs.A 5823: Show issues

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Article ; Online: Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: a preliminary study.

Leelarungrayub, Jirakrit / Pinkaew, Decha / Puntumetakul, Rungthip / Klaphajone, Jakkrit

International journal of chronic obstructive pulmonary disease

2017 Volume 12, Page(s) 1415–1425

Abstract: Background: The aim of this study was to evaluate the efficiency of a simple prototype device for training respiratory muscles in lung function, respiratory muscle strength, walking capacity, quality of life (QOL), dyspnea, and oxidative stress in ... ...

Abstract	Background: The aim of this study was to evaluate the efficiency of a simple prototype device for training respiratory muscles in lung function, respiratory muscle strength, walking capacity, quality of life (QOL), dyspnea, and oxidative stress in patients with COPD. Methods: Thirty COPD patients with moderate severity of the disease were randomized into three groups: control (n=10, 6 males and 4 females), standard training (n=10, 4 males and 6 females), and prototype device (n=10, 5 males and 5 females). Respiratory muscle strength (maximal inspiratory pressure [PImax] and maximal expiratory pressure [PEmax]), lung function (forced vital capacity [FVC], percentage of FVC, forced expiratory volume in 1 second [FEV Results: All parameters between the groups had no statistical difference before training, and no statistical change in the control group after week 6. FVC, FEV Conclusion: This study proposes that a simple prototype device can be used clinically in COPD patients as a standard device to train respiratory muscles, improving lung function and QOL, as well as involving MDA and NO levels.
Language	English
Publishing date	2017
Publishing country	New Zealand
Document type	Journal Article
ISSN	1178-2005
ISSN (online)	1178-2005
DOI	10.2147/COPD.S131062
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Article ; Online: GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy.

Ei, Zin Zin / Choochuay, Kanuengnit / Tubsuwan, Alisa / Pinkaew, Decha / Suksomtip, Maneewan / Vinayanuwattikun, Chanida / Chanvorachote, Pithi / Chunhacha, Preedakorn

Scientific reports

2021 Volume 11, Issue 1, Page(s) 22448

Abstract: Cisplatin (CDDP) induces senescence characterized by senescence-associated secretory phenotypes (SASP) and the unfolded protein response (UPR). In this study, we investigated the proteins related to the UPR during the senescence cell fate. Strikingly, we ...

Abstract	Cisplatin (CDDP) induces senescence characterized by senescence-associated secretory phenotypes (SASP) and the unfolded protein response (UPR). In this study, we investigated the proteins related to the UPR during the senescence cell fate. Strikingly, we found that one of the critical ER-resident proteins, GRP78/BiP, was significantly altered. Here we show that GRP78 levels differentially expressed depending on non-small lung cancer subtypes. GRP78 indeed regulates the evasion of senescence in adenocarcinoma A549 cells, in which the increased GRP78 levels enable them to re-proliferate after CDDP removal. Conversely, GRP78 is downregulated in the senescence H460 cells, making them lacking senescence evasion capability. We observed that the translational regulation critically contributed to the GRP78 protein levels in CDDP-induces senescence. Furthermore, the increased GRP78 level during senescence confers resistance to senolytic drug, Bortezomib, as observed by a twofold increase in IC
MeSH term(s)	A549 Cells ; Antineoplastic Agents/pharmacology ; Bortezomib/pharmacology ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cellular Senescence/drug effects ; Cellular Senescence/genetics ; Cisplatin/pharmacology ; Down-Regulation/genetics ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Endoplasmic Reticulum Chaperone BiP/genetics ; Endoplasmic Reticulum Chaperone BiP/metabolism ; Humans ; Inhibitory Concentration 50 ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Transfection ; Unfolded Protein Response/drug effects ; Up-Regulation/genetics
Chemical Substances	Antineoplastic Agents ; Endoplasmic Reticulum Chaperone BiP ; HSPA5 protein, human ; Bortezomib (69G8BD63PP) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2021-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-01540-8
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Article ; Online: Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation

Decha Pinkaew / Erik Martinez-Hackert / Wei Jia / Matthew D. King / Fei Miao / Nicole R. Enger / Runglawan Silakit / Kota Ramana / Shi-You Chen / Ken Fujise

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 13

Abstract: Fortilin prevents the activation of the TGF-β1 receptor by occupying the pocket of TGF-β1 and competing with TGF-βRII to bind with TGF-β1. This inhibits Smad3 phosphorylation and the differentiation of C3H10T1/2 mesenchymal progenitor cells to smooth ... ...

Abstract	Fortilin prevents the activation of the TGF-β1 receptor by occupying the pocket of TGF-β1 and competing with TGF-βRII to bind with TGF-β1. This inhibits Smad3 phosphorylation and the differentiation of C3H10T1/2 mesenchymal progenitor cells to smooth muscle cells.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy

Zin Zin Ei / Kanuengnit Choochuay / Alisa Tubsuwan / Decha Pinkaew / Maneewan Suksomtip / Chanida Vinayanuwattikun / Pithi Chanvorachote / Preedakorn Chunhacha

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 15

Abstract: Abstract Cisplatin (CDDP) induces senescence characterized by senescence-associated secretory phenotypes (SASP) and the unfolded protein response (UPR). In this study, we investigated the proteins related to the UPR during the senescence cell fate. ... ...

Abstract	Abstract Cisplatin (CDDP) induces senescence characterized by senescence-associated secretory phenotypes (SASP) and the unfolded protein response (UPR). In this study, we investigated the proteins related to the UPR during the senescence cell fate. Strikingly, we found that one of the critical ER-resident proteins, GRP78/BiP, was significantly altered. Here we show that GRP78 levels differentially expressed depending on non-small lung cancer subtypes. GRP78 indeed regulates the evasion of senescence in adenocarcinoma A549 cells, in which the increased GRP78 levels enable them to re-proliferate after CDDP removal. Conversely, GRP78 is downregulated in the senescence H460 cells, making them lacking senescence evasion capability. We observed that the translational regulation critically contributed to the GRP78 protein levels in CDDP-induces senescence. Furthermore, the increased GRP78 level during senescence confers resistance to senolytic drug, Bortezomib, as observed by a twofold increase in IC50 in A549 senescence cells compared to the wild-type. This observation is also consistent in the cells that have undergone genetic manipulation by transfection with pcDNA3.1(+)-GRP78/BiP plasmids and pSpCas9(BB)-2A-Puro containing guide RNA sequence targeting GRP78 exon 3 to induce the overexpression and downregulation of GRP78 in H460 cells, respectively. Our findings reveal a unique role of GRP78 on the senescence evasion cell fate and senolytic drug resistance after cisplatin-based chemotherapy.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation.

Pinkaew, Decha / Martinez-Hackert, Erik / Jia, Wei / King, Matthew D / Miao, Fei / Enger, Nicole R / Silakit, Runglawan / Ramana, Kota / Chen, Shi-You / Fujise, Ken

Communications biology

2022 Volume 5, Issue 1, Page(s) 157

Abstract: Fortilin is a 172-amino acid multifunctional protein present in both intra- and extracellular spaces. Although fortilin binds and regulates various cellular proteins, the biological role of extracellular fortilin remains unknown. Here we report that ... ...

Abstract	Fortilin is a 172-amino acid multifunctional protein present in both intra- and extracellular spaces. Although fortilin binds and regulates various cellular proteins, the biological role of extracellular fortilin remains unknown. Here we report that fortilin specifically interacts with TGF-β1 and prevents it from activating the TGF-β1 signaling pathway. In a standard immunoprecipitation-western blot assay, fortilin co-immunoprecipitates TGF-β1 and its isoforms. The modified ELISA assay shows that TGF-β1 remains complexed with fortilin in human serum. Both bio-layer interferometry and surface plasmon resonance (SPR) reveal that fortilin directly bind TGF-β1. The SPR analysis also reveals that fortilin and the TGF-β receptor II (TGFβRII) compete for TGF-β1. Both luciferase and secreted alkaline phosphatase reporter assays show that fortilin prevents TGF-β1 from activating Smad3 binding to Smad-binding element. Fortilin inhibits the phosphorylation of Smad3 in both quantitative western blot assays and ELISA. Finally, fortilin inhibits TGFβ-1-induced differentiation of C3H10T1/2 mesenchymal progenitor cells to smooth muscle cells. A computer-assisted virtual docking reveals that fortilin occupies the pocket of TGF-β1 that is normally occupied by TGFβRII and that TGF-β1 can bind either fortilin or TGFβRII at any given time. These data support the role of extracellular fortilin as a negative regulator of the TGF-β1 signaling pathway.
MeSH term(s)	Humans ; Phosphorylation ; Receptors, Transforming Growth Factor beta/metabolism ; Signal Transduction ; Transforming Growth Factor beta1/metabolism ; Tumor Protein, Translationally-Controlled 1/metabolism
Chemical Substances	Receptors, Transforming Growth Factor beta ; TGFB1 protein, human ; TPT1 protein, human ; Transforming Growth Factor beta1 ; Tumor Protein, Translationally-Controlled 1
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03112-6
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