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  1. Article: Zinc requirements of Aspergillus niger.

    ROLINSON, G N

    Nature

    2004  Volume 168, Issue 4266, Page(s) 210

    MeSH term(s) Aspergillus ; Aspergillus niger ; Zinc
    Chemical Substances Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2004-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/168210a0
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  2. Article: 6-Aminopenicillanic acid.

    ROLINSON, G N

    Chemotherapia

    2003  Volume 2, Page(s) 52–59

    MeSH term(s) Humans ; Penicillanic Acid ; Penicillins/chemistry
    Chemical Substances Penicillins ; Penicillanic Acid (87-53-6) ; aminopenicillanic acid (QR0C4R7XVN)
    Language English
    Publishing date 2003-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1515-5
    ISSN 0366-7170
    ISSN 0366-7170
    DOI 10.1159/000219493
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  3. Article: The 50th anniversary of the discovery of 6-aminopenicillanic acid (6-APA).

    Rolinson, G N / Geddes, A M

    International journal of antimicrobial agents

    2007  Volume 29, Issue 1, Page(s) 3–8

    Abstract: This year (2007) marks the 50th anniversary of [corrected] discovery of 6-aminopenicillanic acid (6-APA), the precursor of all semi-synthetic penicillins [corrected] This review, by a scientist who played a major part in the discovery and a physician who ...

    Abstract This year (2007) marks the 50th anniversary of [corrected] discovery of 6-aminopenicillanic acid (6-APA), the precursor of all semi-synthetic penicillins [corrected] This review, by a scientist who played a major part in the discovery and a physician who participated in the early clinical trials of these antibiotics, tells the story of the discovery and of the early development of the beta-lactam antibiotics that revolutionised the treatment of infections.
    MeSH term(s) Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/microbiology ; Bacterial Infections/prevention & control ; Cephalosporins/metabolism ; Cephalosporins/therapeutic use ; Humans ; Hydrolysis ; Penicillanic Acid/analogs & derivatives ; Penicillanic Acid/metabolism ; Penicillins/metabolism ; Penicillins/therapeutic use ; Thienamycins/metabolism ; Thienamycins/therapeutic use ; beta-Lactamase Inhibitors ; beta-Lactamases/metabolism ; beta-Lactams/metabolism ; beta-Lactams/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins ; Penicillins ; Thienamycins ; beta-Lactamase Inhibitors ; beta-Lactams ; Penicillanic Acid (87-53-6) ; beta-Lactamases (EC 3.5.2.6) ; aminopenicillanic acid (QR0C4R7XVN)
    Language English
    Publishing date 2007-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2006.09.003
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  4. Article: Forty years of beta-lactam research.

    Rolinson, G N

    The Journal of antimicrobial chemotherapy

    1998  Volume 41, Issue 6, Page(s) 589–603

    Abstract: For more than 40 years the author has been involved in research in the field of beta-lactam antibiotics. Much of this work was concerned with the development of the semisynthetic penicillins, following the isolation of the penicillin nucleus, 6- ... ...

    Abstract For more than 40 years the author has been involved in research in the field of beta-lactam antibiotics. Much of this work was concerned with the development of the semisynthetic penicillins, following the isolation of the penicillin nucleus, 6-aminopenicillanic acid. This work resulted in the introduction of a number of important antibiotics including methicillin, cloxacillin, flucloxacillin, ampicillin, amoxycillin, carbenicillin and ticarcillin. Many of these compounds also provided the incentive or the basis for studies of a more fundamental nature in cell biology and antibacterial chemotherapy. The following is the author's personal account of some of the studies in the beta-lactam field in which he has been involved.
    MeSH term(s) Animals ; Anti-Bacterial Agents/history ; Anti-Bacterial Agents/pharmacology ; History, 20th Century ; Humans ; Methicillin Resistance ; Penicillins/history ; Pseudomonas aeruginosa/drug effects ; Staphylococcus/drug effects ; Staphylococcus/metabolism ; beta-Lactam Resistance ; beta-Lactamases/metabolism ; beta-Lactams
    Chemical Substances Anti-Bacterial Agents ; Penicillins ; beta-Lactams ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 1998-06
    Publishing country England
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/41.6.589
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    Zs.MO 124: Show issues

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  5. Article: A clarithromycin sensitivity survey.

    Rolinson, G N

    The Journal of antimicrobial chemotherapy

    1994  Volume 34, Issue 3, Page(s) 444–445

    MeSH term(s) Clarithromycin/pharmacology ; Haemophilus influenzae/drug effects ; Microbial Sensitivity Tests ; beta-Lactamases/metabolism
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; Clarithromycin (H1250JIK0A)
    Language English
    Publishing date 1994-09
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/34.3.444
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  6. Article: A review of the microbiology of amoxycillin/clavulanic acid over the 15 year period 1978-1993.

    Rolinson, G N

    Journal of chemotherapy (Florence, Italy)

    1994  Volume 6, Issue 5, Page(s) 283–318

    Abstract: A review of the published literature over the period 1978-1993 was undertaken to assess any changes in the prevalence of beta-lactamase-producing bacterial pathogens and also any changes in the susceptibility in these pathogens to amoxycillin/clavulanate. ...

    Abstract A review of the published literature over the period 1978-1993 was undertaken to assess any changes in the prevalence of beta-lactamase-producing bacterial pathogens and also any changes in the susceptibility in these pathogens to amoxycillin/clavulanate. The review has involved the examination of over 1500 publications. The review shows that in general there has been an increase in the frequency of beta-lactamase-producing pathogens resistant to ampicillin and amoxycillin but there is no evidence for any significant increase in resistance to amoxycillin/clavulanate over the period of the review.
    MeSH term(s) Amoxicillin/pharmacology ; Amoxicillin-Potassium Clavulanate Combination ; Bacteroides/drug effects ; Clavulanic Acids/pharmacology ; Drug Therapy, Combination/pharmacology ; Escherichia coli/drug effects ; Klebsiella/drug effects ; Microbial Sensitivity Tests ; Moraxella (Branhamella) catarrhalis/drug effects ; Staphylococcus/drug effects
    Chemical Substances Clavulanic Acids ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4) ; Amoxicillin (804826J2HU)
    Language English
    Publishing date 1994-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009x.1994.11741165
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    Zs.MO 387: Show issues

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  7. Article: Absorption and excretion studies of the potassium salt of 6-(alpha-phenoxypropionamido) penicillanic acid.

    KNUDSEN, E T / ROLINSON, G N

    Lancet (London, England)

    2003  Volume 2, Issue 7112, Page(s) 1105–1109

    MeSH term(s) Humans ; Penicillanic Acid ; Penicillins/metabolism ; Potassium ; Research
    Chemical Substances Penicillins ; Penicillanic Acid (87-53-6) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2003-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(59)90096-0
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  8. Article: 6-Aminopenicillanic acid. II. Formation of 6-aminopenicillanic acid by Emericellopsis minima (Stolk) and related fungi.

    COLE, M / ROLINSON, G N

    Proceedings of the Royal Society of London. Series B, Biological sciences

    2003  Volume 154, Page(s) 490–497

    MeSH term(s) Fungi/metabolism ; Hypocreales ; Penicillanic Acid ; Penicillins/metabolism
    Chemical Substances Penicillins ; Penicillanic Acid (87-53-6) ; aminopenicillanic acid (QR0C4R7XVN)
    Language English
    Publishing date 2003-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0950-1193 ; 0080-4649 ; 0962-8452
    ISSN (online) 1471-2954
    ISSN 0950-1193 ; 0080-4649 ; 0962-8452
    DOI 10.1098/rspb.1961.0046
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  9. Article: CHARACTERISTICS OF METHICILLIN-RESISTANT STAPHYLOCOCCI.

    SUTHERLAND, R / ROLINSON, G N

    Journal of bacteriology

    2003  Volume 87, Page(s) 887–899

    Abstract: Sutherland, R. (Beecham Research Laboratories Ltd., Betchworth, Surrey, England), and G. N ... Rolinson. Characteristics of methicillin-resistant staphylococci. J. Bacteriol. 87:887-899. 1964.-Cultures ...

    Abstract Sutherland, R. (Beecham Research Laboratories Ltd., Betchworth, Surrey, England), and G. N. Rolinson. Characteristics of methicillin-resistant staphylococci. J. Bacteriol. 87:887-899. 1964.-Cultures of naturally occurring methicillin-resistant staphylococci obtained from a number of hospitals were examined for the nature and degree of resistance to methicillin and other antibiotics. All the cultures tested were similar in that they consisted of mixed populations in which the majority of cells were of normal sensitivity to methicillin with a minority showing methicillin resistance. The resistant members also differed from the rest of the population in that they grew more slowly even in the absence of methicillin. Pure cultures of the resistant minority were obtained readily but, on repeated transfer in the absence of methicillin, resistance was lost and the cultures reverted to mixed populations similar to the original naturally occurring strains. When methicillin-sensitive staphylococci were repeatedly subcultured in the presence of methicillin, a mixed population was obtained in which only a minority of cells were resistant to the antibiotic; in this respect, the cultures of methicillin-resistant staphylococci selected in vitro resembled the naturally occurring strains. The original cultures of methicillin-resistant staphylococci comprised populations of cells with uniform sensitivity or insensitivity to other antibiotics. The resistance of these staphylococci to methicillin was not due to increased ability to inactivate the drug but to intrinsic insensitivity to methicillin.
    MeSH term(s) Anti-Bacterial Agents ; Bacteriological Techniques ; Drug Resistance, Microbial ; Methicillin ; Methicillin Resistance ; Penicillin Resistance ; Phenylthiourea/analogs & derivatives ; Research ; Staphylococcus
    Chemical Substances Anti-Bacterial Agents ; thiocarlide (43M23X81Y2) ; Phenylthiourea (6F82C6Q54C) ; Methicillin (Q91FH1328A)
    Language English
    Publishing date 2003-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.87.4.887-899.1964
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  10. Article: Evolution of beta-lactamase inhibitors.

    Rolinson, G N

    Reviews of infectious diseases

    1991  Volume 13 Suppl 9, Page(s) S727–32

    Abstract: The production of beta-lactamase is the most important mechanism of bacterial resistance to beta-lactam antibiotics. Attempts to find an inhibitor of beta-lactamase were made as early as the 1940s and 1950s but without success. In the early 1950s, it was ...

    Abstract The production of beta-lactamase is the most important mechanism of bacterial resistance to beta-lactam antibiotics. Attempts to find an inhibitor of beta-lactamase were made as early as the 1940s and 1950s but without success. In the early 1950s, it was found that certain semisynthetic penicillins could function as beta-lactamase inhibitors, but none found a clinical place in this capacity. A program of screening microorganisms for the production of naturally occurring inhibitors was begun in 1967. This process led to the discovery of the olivanic acids and clavulanic acid. Clavulanic acid, formulated with amoxicillin and later with ticarcillin, became available for clinical use in 1981. Since the introduction of clavulanic acid, other beta-lactamase inhibitors have been developed, including sulbactam and tazobactam. It remains to be seen whether these will have any advantage over clavulanate for clinical use.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/enzymology ; Clavulanic Acid ; Clavulanic Acids/pharmacology ; Drug Resistance, Microbial ; Humans ; Lactams ; Penicillanic Acid/pharmacology ; Sulbactam/pharmacology ; Tazobactam ; beta-Lactamase Inhibitors ; beta-Lactams
    Chemical Substances Anti-Bacterial Agents ; Clavulanic Acids ; Lactams ; beta-Lactamase Inhibitors ; beta-Lactams ; Clavulanic Acid (23521W1S24) ; olivanic acid (64761-66-6) ; Penicillanic Acid (87-53-6) ; Sulbactam (S4TF6I2330) ; Tazobactam (SE10G96M8W)
    Language English
    Publishing date 1991-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 441228-x
    ISSN 0162-0886
    ISSN 0162-0886
    DOI 10.1093/clinids/13.supplement_9.s727
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