LIVIVO - Search results -

Search results

Result 1 - 10 of total 108

Search options

Article: Microbes and Parkinson’s disease: from associations to mechanisms

Cannon, Tyler / Gruenheid, Samantha

Trends in microbiology. 2022,

2022

Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder influenced by both genetic and ...

Abstract	Parkinson’s disease (PD) is a neurodegenerative disorder influenced by both genetic and environmental factors. The mechanisms leading to neurodegeneration in PD are still under investigation, with several mechanistic models currently proposed. A number of microorganisms have been associated with increased risk of PD in humans, and recent research using newly developed models has begun to elucidate how these microbes may factor into disease development. Newly identified roles for PD-associated genes in host–microbe interactions and response to infections have also recently been uncovered, providing further evidence for microbial contributions to PD. Here we summarize these recent advances in the field and discuss them in the context of both historical and emerging hypotheses for PD development, with a particular focus on the application of rodent models as systems allowing for mechanistic hypothesis testing.
Keywords	Parkinson disease ; animal models ; environmental factors ; fields ; gene interaction ; genetic factors ; host-pathogen relationships ; humans ; mechanistic models ; microorganisms ; risk
Language	English
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	1158963-2
ISSN	1878-4380 ; 0966-842X
ISSN (online)	1878-4380
ISSN	0966-842X
DOI	10.1016/j.tim.2022.01.004
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2005/714: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Radiographic Evaluation of Predictors for Spontaneous Space Closure and Supereruption After the Loss of Permanent First Molars in Yup'ik Children.

Lenaker, Dane / Grünheid, Thorsten

Pediatric dentistry

2023 Volume 45, Issue 3, Page(s) 252–258

Abstract: ... of spontaneous space closure.: Methods: A total of 134 patients aged six to 12 years with extracted PFM(s ...

Abstract	Purpose: The purpose of this study was to evaluate pre-extraction variables associated with spontaneous space closure between the permanent second molar (PSM) and the second premolar following early extraction of the permanent first molar (PFM). Additionally, this study aimed to assess supereruption in compensated and uncompensated maxillary molars to determine if compensating extraction increases the odds of spontaneous space closure. Methods: A total of 134 patients aged six to 12 years with extracted PFM(s) were evaluated for spontaneous man- dibular space closure. Panoramic radiographs were reviewed to assess pre-extraction variables. Bitewing radiographs of 156 patients aged six to 13 years with previous PFM extractions were used to measure supereruption in compensated and uncompensated extractions. Both compensated and uncompensated extractions were evaluated for complete mandibular space closure. Results: Statistically significant predictors of space closure included extraction at age eight to 10 years (P=0.04; 95 percent confidence interval [95% CI] equals 0.08 to 0.91), permanent third molar presence (P=0.02; 95% CI equals 1.16 to 4.9), and follow-up time (P=0.001; 95% CI equals 1.16 to 1.69). The odds of uncompensated PFM super- eruption were greater than those of compensated PFM supereruption (P<0.001; 95% CI equals 1.86 to 6.92). Additional follow-up increased the odds of supereruption (P<0.001; 95% CI equals 1.08 to 1.30). Uncompensated extractions did not reduce the odds of spontaneous space closure (P=0.54; 95% CI equals 0.56 to 3.08). Conclusions: Permanent first molar extraction later than age 10 years is a negative predictor for spontaneous space closure, while permanent third molar presence is a positive predictor. Uncompensated maxillary PFMs do not inhibit spontaneous per- manent mandibular second molar space closure; however, uncompensated extractions are more likely to supererupt.
MeSH term(s)	Humans ; Child ; Molar/diagnostic imaging ; Molar, Third ; Mandible ; Radiography, Panoramic ; Tooth Eruption
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	604709-9
ISSN	1942-5473 ; 0164-1263
ISSN (online)	1942-5473
ISSN	0164-1263
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2458: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Direct evidence of host-mediated glycosylation of NleA and its dependence on interaction with the COPII complex.

Burns, Lindsay / Le Mauff, François / Gruenheid, Samantha

Gut microbes

2024 Volume 16, Issue 1, Page(s) 2305477

Abstract: Non-LEE-encoded Effector A (NleA) is a type III secreted effector protein of enterohaemorrhagic and ... ...

Abstract	Non-LEE-encoded Effector A (NleA) is a type III secreted effector protein of enterohaemorrhagic and enteropathogenic
MeSH term(s)	Animals ; Mice ; Escherichia coli Proteins/metabolism ; Virulence Factors/metabolism ; Glycosylation ; Gastrointestinal Microbiome ; Bacterial Proteins/metabolism ; Enteropathogenic Escherichia coli
Chemical Substances	Escherichia coli Proteins ; Virulence Factors ; Bacterial Proteins
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2024.2305477
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Microbes and Parkinson's disease: from associations to mechanisms.

Cannon, Tyler / Gruenheid, Samantha

Trends in microbiology

2022 Volume 30, Issue 8, Page(s) 749–760

Abstract: Parkinson's disease (PD) is a neurodegenerative disorder influenced by both genetic and environmental factors. The mechanisms leading to neurodegeneration in PD are still under investigation, with several mechanistic models currently proposed. A number ... ...

Abstract	Parkinson's disease (PD) is a neurodegenerative disorder influenced by both genetic and environmental factors. The mechanisms leading to neurodegeneration in PD are still under investigation, with several mechanistic models currently proposed. A number of microorganisms have been associated with increased risk of PD in humans, and recent research using newly developed models has begun to elucidate how these microbes may factor into disease development. Newly identified roles for PD-associated genes in host-microbe interactions and response to infections have also recently been uncovered, providing further evidence for microbial contributions to PD. Here we summarize these recent advances in the field and discuss them in the context of both historical and emerging hypotheses for PD development, with a particular focus on the application of rodent models as systems allowing for mechanistic hypothesis testing.
MeSH term(s)	Humans ; Neurodegenerative Diseases ; Parkinson Disease/genetics
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1158963-2
ISSN	1878-4380 ; 0966-842X
ISSN (online)	1878-4380
ISSN	0966-842X
DOI	10.1016/j.tim.2022.01.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3738: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Simulated Colonic Fluid Replicates the

Gilliland, Ashley / Gavino, Christina / Gruenheid, Samantha / Raivio, Tracy

Infection and immunity

2022 Volume 90, Issue 9, Page(s) e0031422

Abstract: Citrobacter rodentium is an attaching and effacing (A/E) pathogen used to model enteropathogenic and enterohemorrhagic Escherichia coli infections in mice. During colonization, C. rodentium must adapt to stresses in the gastrointestinal tract, such as ... ...

Abstract	Citrobacter rodentium is an attaching and effacing (A/E) pathogen used to model enteropathogenic and enterohemorrhagic Escherichia coli infections in mice. During colonization, C. rodentium must adapt to stresses in the gastrointestinal tract, such as antimicrobial peptides, pH changes, and bile salts. The Cpx envelope stress response (ESR) is a two-component system used by some bacteria to remediate stress by modulating gene expression, and it is necessary for C. rodentium pathogenesis in mice. Here, we utilized simulated colonic fluid (SCF) to mimic the gastrointestinal environment, which we show strongly induces the Cpx ESR and highlights a fitness defect specific to the Δ
MeSH term(s)	Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bile Acids and Salts ; Citrobacter rodentium/genetics ; Enterobacteriaceae Infections/microbiology ; Mice ; Regulon ; Virulence/genetics
Chemical Substances	Bacterial Proteins ; Bile Acids and Salts
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/iai.00314-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 684: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Authors' response.

Grünheid, Thorsten / Tasca, Amy W / Kanyusik, John S / Walters, Shelley-Ann / Larson, Brent E

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

2023 Volume 163, Issue 4, Page(s) 452

Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	356699-7
ISSN	1097-6752 ; 0889-5406 ; 0002-9416
ISSN (online)	1097-6752
ISSN	0889-5406 ; 0002-9416
DOI	10.1016/j.ajodo.2023.01.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul III Zs.73: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Assessment of orthodontic treatment efficacy of Clarity Aligners using the Peer Assessment Rating index and the American Board of Orthodontics Cast-Radiograph Evaluation.

Grünheid, Thorsten / Tasca, Amy W / Kanyusik, John S / Walters, Shelley-Ann / Larson, Brent E

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

2022 Volume 162, Issue 6, Page(s) 861–869

Abstract: Introduction: 3M Oral Care Solutions (St Paul, Minn) has recently introduced Clarity Aligners into the market. This cohort study evaluated the orthodontic treatment efficacy of this clear aligner system using the Peer Assessment Rating (PAR) index and ... ...

Abstract	Introduction: 3M Oral Care Solutions (St Paul, Minn) has recently introduced Clarity Aligners into the market. This cohort study evaluated the orthodontic treatment efficacy of this clear aligner system using the Peer Assessment Rating (PAR) index and the American Board of Orthodontics Cast-Radiograph Evaluation (CR-Eval). Methods: Pretreatment and posttreatment dental models of 87 subjects who had undergone orthodontic treatment using Clarity Aligners in both arches to align their teeth to a target setup were independently evaluated by 4 examiners using the PAR index and the American Board of Orthodontics CR-Eval. Changes in CR-Eval and PAR scores from pretreatment to posttreatment were calculated, with PAR score reductions also expressed as percentages. Results: Treatment with Clarity Aligners reduced the CR-Eval scores from 39.05 ± 14.98 to 30.34 ± 8.76, resulting in a statistically significant difference of 8.76 ± 11.45 between pretreatment and posttreatment scores. Similarly, aligner treatment reduced the weighted PAR scores from 13.40 ± 9.26 to 5.80 ± 4.84, resulting in a statistically significant difference of 7.50 ± 7.56 between pretreatment and posttreatment scores. The overall median PAR reduction was 53%, with 94% of the subjects having reduced PAR scores after treatment. Seventy-eight percent of subjects had >30% PAR reduction, 57% had >50% PAR reduction, and 33% had >70% PAR reduction. Conclusions: The results suggest that Clarity Aligners may be an effective treatment modality in mild to moderate malocclusions.
MeSH term(s)	Humans ; Orthodontics ; Orthodontics, Corrective/methods ; Cohort Studies ; Malocclusion/diagnostic imaging ; Malocclusion/therapy ; Treatment Outcome
Language	English
Publishing date	2022-09-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	356699-7
ISSN	1097-6752 ; 0889-5406 ; 0002-9416
ISSN (online)	1097-6752
ISSN	0889-5406 ; 0002-9416
DOI	10.1016/j.ajodo.2021.07.023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul III Zs.73: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Midpalatal suture density ratio: Assessing the predictive power of a novel predictor of skeletal response to maxillary expansion.

Titus, Samuel / Larson, Brent E / Grünheid, Thorsten

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

2020 Volume 159, Issue 2, Page(s) e157–e167

Abstract: Introduction: Rapid maxillary expansion (RME) is a common orthodontic treatment to correct maxillary transverse deficiency; however, the inability to determine the precise timing of fusion of the midpalatal suture creates difficulty for clinicians to ... ...

Abstract	Introduction: Rapid maxillary expansion (RME) is a common orthodontic treatment to correct maxillary transverse deficiency; however, the inability to determine the precise timing of fusion of the midpalatal suture creates difficulty for clinicians to prescribe the appropriate treatment, surgical or nonsurgical expansion. The purpose of this study was to assess the predictive power of the midpalatal suture density ratio (MPSD) for a skeletal response to RME. Methods: Pre- and posttreatment cone-beam computed tomography scans were obtained from 78 orthodontic patients aged from 8 to 18 years treated with RME. MPSDs were calculated from pretreatment scans, and a prediction was made for the amount of skeletal expansion obtained at the level of the palate after comprehensive orthodontic treatment. Predicted values were compared with actual outcomes as assessed from posttreatment scans, followed by regression analyses to investigate correlations between MPSD and skeletal expansion and equivalence testing to analyze the performance of the predicted measurements. Results: The MPSDs were not statistically significantly (P >0.05) correlated with the amount of skeletal expansion achieved. In addition, the predicted skeletal expansion using MPSD was not statistically equivalent to the skeletal expansion achieved using an equivalence margin of ±0.05. Conclusions: The results suggest that the MPSD obtained from pretreatment cone-beam computed tomography scans were not correlated well enough with the amount of skeletal expansion achieved to be an effective predictor of the amount of long-term skeletal expansion after RME.
MeSH term(s)	Adolescent ; Aged ; Child ; Cone-Beam Computed Tomography ; Cranial Sutures/diagnostic imaging ; Humans ; Maxilla/diagnostic imaging ; Palatal Expansion Technique ; Palate/diagnostic imaging ; Sutures
Language	English
Publishing date	2020-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	356699-7
ISSN	1097-6752 ; 0889-5406 ; 0002-9416
ISSN (online)	1097-6752
ISSN	0889-5406 ; 0002-9416
DOI	10.1016/j.ajodo.2020.09.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul III Zs.73: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Motor and non-motor improvements following short-term multidisciplinary day-clinic care in Parkinson´s disease.

Krause, Patricia / Berking, Sara / Astalosch, Melanie / Grünheid, Raymond / Kühn, Andrea A

Journal of neural transmission (Vienna, Austria : 1996)

2022 Volume 129, Issue 12, Page(s) 1419–1426

Abstract: Background: Inpatient as well as outpatient care does often not meet PD-patients' individual needs.: Introduction: Day-clinic concepts encompassing a multidisciplinary team as well as therapy adjustments accompanying everyday demands aim at filling ... ...

Abstract	Background: Inpatient as well as outpatient care does often not meet PD-patients' individual needs. Introduction: Day-clinic concepts encompassing a multidisciplinary team as well as therapy adjustments accompanying everyday demands aim at filling this gap. Methods: This is a retrospective study on short-term effects of a 3 week multidisciplinary rehabilitation program in patients with Parkinson´s disease (PD) embedded in a specialized movement disorder day-clinic. We analyzed short-term outcome of motor and non-motor symptoms (NMS) in 143 PD-patients (mean age 65.3 ± 11.9 years; Hoehn-and-Yahr-score 2.6 ± 0.7) after 3 weeks with 7.4 ± 1.8 active days of interdisciplinary day-care treatment. Participants attended the day-clinic in groups of five patients at a time. Improvements were evaluated by comparison of standardized physical therapy assessments, disease specific scores for motor symptoms (MDS-UPDRS III), mood (BDI), quality of life (PDQ39, SF36), sleep (PDSS, ESS), impulsiveness (QUIP), apathy (SAS), cognition (MMST), as well as change in medication before and directly after the intervention. Results: MDS-UPDRS motor score improved significantly by 22.9 ± 21.5% (p < 0.001) and was accompanied by a significant reduction of imbalance, immobility, and weakness ranging between 6% and 17% in standardized physical therapy tests. In addition, all disease-specific non-motor scales improved significantly. Conclusions: A multidisciplinary day-clinic approach can support benefit on motor, non-motor symptoms and QoL in PD-patients. Given the increase in PD incidence and prevalence as well as the significant treatment effects shown here, more day-clinic treatment opportunities ought to be implemented to improve PD treatment adapted to everyday challenges while still reducing costs to the health care system.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Parkinson Disease/complications ; Quality of Life ; Retrospective Studies ; Severity of Illness Index ; Day Care, Medical
Language	English
Publishing date	2022-11-06
Publishing country	Austria
Document type	Journal Article
ZDB-ID	184163-4
ISSN	1435-1463 ; 0300-9564
ISSN (online)	1435-1463
ISSN	0300-9564
DOI	10.1007/s00702-022-02562-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui II Zs.150: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Over supplementation with vitamin B12 alters microbe-host interactions in the gut leading to accelerated Citrobacter rodentium colonization and pathogenesis in mice.

Forgie, Andrew J / Pepin, Deanna M / Ju, Tingting / Tollenaar, Stephanie / Sergi, Consolato M / Gruenheid, Samantha / Willing, Benjamin P

Microbiome

2023 Volume 11, Issue 1, Page(s) 21

Abstract: Background: Vitamin B12 supplements typically contain doses that far exceed the recommended daily amount, and high exposures are generally considered safe. Competitive and syntrophic interactions for B12 exist between microbes in the gut. Yet, to what ... ...

Abstract	Background: Vitamin B12 supplements typically contain doses that far exceed the recommended daily amount, and high exposures are generally considered safe. Competitive and syntrophic interactions for B12 exist between microbes in the gut. Yet, to what extent excessive levels contribute to the activities of the gut microbiota remains unclear. The objective of this study was to evaluate the effect of B12 on microbial ecology using a B12 supplemented mouse model with Citrobacter rodentium, a mouse-specific pathogen. Mice were fed a standard chow diet and received either water or water supplemented with B12 (cyanocobalamin: ~120 μg/day), which equates to approximately 25 mg in humans. Infection severity was determined by body weight, pathogen load, and histopathologic scoring. Host biomarkers of inflammation were assessed in the colon before and after the pathogen challenge. Results: Cyanocobalamin supplementation enhanced pathogen colonization at day 1 (P < 0.05) and day 3 (P < 0.01) postinfection. The impact of B12 on gut microbial communities, although minor, was distinct and attributed to the changes in the Lachnospiraceae populations and reduced alpha diversity. Cyanocobalamin treatment disrupted the activity of the low-abundance community members of the gut microbiota. It enhanced the amount of interleukin-12 p40 subunit protein (IL12/23p40; P < 0.001) and interleukin-17a (IL-17A; P < 0.05) in the colon of naïve mice. This immune phenotype was microbe dependent, and the response varied based on the baseline microbiota. The cecal metatranscriptome revealed that excessive cyanocobalamin decreased the expression of glucose utilizing genes by C. rodentium, a metabolic attribute previously associated with pathogen virulence. Conclusions: Oral vitamin B12 supplementation promoted C. rodentium colonization in mice by altering the activities of the Lachnospiraceae populations in the gut. A lower abundance of select Lachnospiraceae species correlated to higher p40 subunit levels, while the detection of Parasutterella exacerbated inflammatory markers in the colon of naïve mice. The B12-induced change in gut ecology enhanced the ability of C. rodentium colonization by impacting key microbe-host interactions that help with pathogen exclusion. This research provides insight into how B12 impacts the gut microbiota and highlights potential consequences of disrupting microbial B12 competition/sharing through over-supplementation. Video Abstract.
MeSH term(s)	Humans ; Animals ; Mice ; Vitamin B 12/pharmacology ; Citrobacter rodentium ; Host Microbial Interactions ; Colon ; Dietary Supplements
Chemical Substances	Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2697425-3
ISSN	2049-2618 ; 2049-2618
ISSN (online)	2049-2618
ISSN	2049-2618
DOI	10.1186/s40168-023-01461-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito