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  1. Article ; Online: Intramuscular anti-D treatment for immune thrombocytopenia-Response.

    Bussel, James B

    British journal of haematology

    2023  Volume 203, Issue 4, Page(s) e108

    MeSH term(s) Humans ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Thrombocytopenia/therapy ; Rho(D) Immune Globulin
    Chemical Substances RHO(D) antibody ; Rho(D) Immune Globulin
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immune thrombocytopenia (ITP) in pregnancy.

    Bussel, James B / Knightly, Katherine A

    British journal of haematology

    2024  Volume 204, Issue 4, Page(s) 1176–1177

    Abstract: Immune thrombocytopenia (ITP) in pregnancy is challenging for both mother and fetus. Understanding the pathophysiology, treatments, and risks to the mother and fetus leads to proper management resulting in successful pregnancy and delivery in almost all ... ...

    Abstract Immune thrombocytopenia (ITP) in pregnancy is challenging for both mother and fetus. Understanding the pathophysiology, treatments, and risks to the mother and fetus leads to proper management resulting in successful pregnancy and delivery in almost all cases.
    MeSH term(s) Pregnancy ; Female ; Humans ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Purpura, Thrombocytopenic, Idiopathic/complications ; Platelet Count ; Pregnancy Complications, Hematologic/diagnosis ; Pregnancy Complications, Hematologic/therapy ; Thrombocytopenia/etiology
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Why should intramuscular anti-D be different from intravenous anti-D?

    Bussel, James B

    British journal of haematology

    2022  Volume 200, Issue 3, Page(s) 275–276

    Abstract: For reasons of safety the use of intravenous anti D to treat ITP has largely been abandoned because of the risk it incurs of intravascular haemolysis. Intramuscular delivery of anti-D could be a safer approach and deserves to be further evaluated. IV ... ...

    Abstract For reasons of safety the use of intravenous anti D to treat ITP has largely been abandoned because of the risk it incurs of intravascular haemolysis. Intramuscular delivery of anti-D could be a safer approach and deserves to be further evaluated. IV anti-D was a mainstay of ITP treatment in the United States in the 1990's until the development of intravascular hemolysis (IVH) and its serious even fatal consequences was appreciated. Subsequently, treatment of patients with ITP with IV anti-D has become very rare given other alternatives and the IVH risk. IM anti-D does not carry a risk for IVH and it should be re-evaluated and reconsidered as an option for D+ DAT-negative not splenectomized adults who do not have a long duration of ITP and require maintenance treatment. Commentary on: Lakhwani, et al. Intramuscular Anti-D treatment for immune thrombocytopenia: A single centre experience. Br J Haematol 2023;200:353-357.
    MeSH term(s) Adult ; Humans ; Purpura, Thrombocytopenic, Idiopathic ; Rho(D) Immune Globulin ; Hemolysis ; Administration, Intravenous ; Immunoglobulins, Intravenous/therapeutic use
    Chemical Substances RHO(D) antibody ; Rho(D) Immune Globulin ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2022-11-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Desialylation unmasks HPA-9B alloantibodies.

    Ahlen, Maria Therese / Bussel, James Bruce

    Blood

    2023  Volume 142, Issue 22, Page(s) 1853–1854

    MeSH term(s) Humans ; Platelet Membrane Glycoprotein IIb ; Isoantibodies ; N-Acetylneuraminic Acid
    Chemical Substances Platelet Membrane Glycoprotein IIb ; Isoantibodies ; N-Acetylneuraminic Acid (GZP2782OP0)
    Language English
    Publishing date 2023-11-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023022495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treatment of immune thrombocytopenia during pregnancy with thrombopoietin receptor agonists.

    Rottenstreich, Amihai / Bussel, James B

    British journal of haematology

    2023  Volume 203, Issue 5, Page(s) 872–885

    Abstract: The introduction of thrombopoietin receptor agonists (TPO-RAs) led to a paradigm shift in the management of immune thrombocytopenia (ITP). However, TPO-RAs are not approved for use during pregnancy due to the absence of evidence and concerns for possible ...

    Abstract The introduction of thrombopoietin receptor agonists (TPO-RAs) led to a paradigm shift in the management of immune thrombocytopenia (ITP). However, TPO-RAs are not approved for use during pregnancy due to the absence of evidence and concerns for possible effects on the fetus due to their expected transplacental transfer. This comprehensive review examines the safety and efficacy of TPO-RA in 45 pregnancies of women with ITP (romiplostim n = 22; eltrombopag n = 21; both in the same pregnancy n = 2). Mothers experienced failure of the median of three treatment lines during pregnancy prior to TPO-RA administration. A platelet response (>30 × 10
    MeSH term(s) Infant, Newborn ; Humans ; Female ; Pregnancy ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Purpura, Thrombocytopenic, Idiopathic/chemically induced ; Receptors, Thrombopoietin/agonists ; Benzoates/adverse effects ; Hydrazines/adverse effects ; Thrombopoietin/adverse effects ; Receptors, Fc/therapeutic use ; Recombinant Fusion Proteins/adverse effects
    Chemical Substances eltrombopag (S56D65XJ9G) ; Receptors, Thrombopoietin ; Benzoates ; Hydrazines ; Thrombopoietin (9014-42-0) ; Receptors, Fc ; Recombinant Fusion Proteins
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Improving the chances of response to splenectomy in immune thrombocytopenia.

    Audia, Sylvain / Bussel, James

    British journal of haematology

    2023  Volume 204, Issue 1, Page(s) 24–25

    Abstract: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by isolated thrombocytopenia. Its pathogenesis is complex relying in large part on destruction of platelets recognized by autoantibodies within the spleen. However, other ... ...

    Abstract Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by isolated thrombocytopenia. Its pathogenesis is complex relying in large part on destruction of platelets recognized by autoantibodies within the spleen. However, other mechanisms, such as platelet desialylation, may play a role in platelet reduction by accelerating their clearance in the liver. In their study, Mendoza and colleagues reported on platelet scintigraphy performed in 51 ITP patients, showing a response in 87.5% when the sequestration occurred in the spleen versus 45% in case of non-splenic destruction. Platelet desialylation was also measured after splenectomy and found to be higher in non-responder patients. These latter results, while requiring confirmation prior to splenectomy, support platelet desialylation may also be a potential biomarker of non-response to splenectomy. Commentary on: Mendoza et al. Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response. Br J Haematol 2024;204:315-323.
    MeSH term(s) Humans ; Purpura, Thrombocytopenic, Idiopathic ; Splenectomy ; Thrombocytopenia/pathology ; Blood Platelets/pathology ; Spleen/pathology
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: The changing landscape of secondary ITP

    Bussel, James B.

    (Seminars in hematology ; 46,1, Suppl. 2)

    2009  

    Author's details James B. Bussel, guest ed
    Series title Seminars in hematology ; 46,1, Suppl. 2
    Collection
    Language English
    Size S61 S. : graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT015886879
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 328 -46,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  8. Article ; Online: Early combination treatment of immune thrombocytopenia: Is this the way?

    Bussel, James B

    American journal of hematology

    2020  Volume 95, Issue 12, Page(s) 1452–1453

    MeSH term(s) Adult ; Autoantigens/administration & dosage ; Autoantigens/adverse effects ; Dexamethasone/administration & dosage ; Dexamethasone/adverse effects ; Drug Therapy, Combination ; Female ; Humans ; Iodide Peroxidase/administration & dosage ; Iodide Peroxidase/adverse effects ; Iron-Binding Proteins/administration & dosage ; Iron-Binding Proteins/adverse effects ; Male ; Pregnancy ; Pregnancy Complications, Hematologic/drug therapy ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Rituximab/administration & dosage ; Rituximab/adverse effects
    Chemical Substances Autoantigens ; Iron-Binding Proteins ; Rituximab (4F4X42SYQ6) ; Dexamethasone (7S5I7G3JQL) ; TPO protein, human (EC 1.11.1.7) ; Iodide Peroxidase (EC 1.11.1.8)
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The role of genetics in refractory immune thrombocytopenia.

    Zehnder, James L / Bussel, James B / Cooper, Nichola

    British journal of haematology

    2023  Volume 203, Issue 1, Page(s) 62–64

    Abstract: Patients with refractory immune thrombocytopenia (rITP) have increased morbidity and mortality. Currently, there is limited understanding of the cause of refractoriness and no markers to help direct novel treatment options. Understanding the reason(s) ... ...

    Abstract Patients with refractory immune thrombocytopenia (rITP) have increased morbidity and mortality. Currently, there is limited understanding of the cause of refractoriness and no markers to help direct novel treatment options. Understanding the reason(s) for refractoriness is crucial to determining novel treatment options. The pathogenesis underlying rITP has generally been thought to be an underlying genetic predisposition with an environmental trigger. Familial ITP remains rare, and there are few twin studies, suggesting that a simple genetic cause is unlikely. However, genetic mutations provide the background for several autoimmune diseases. In this review, we explore the evidence of either an inherited genetic cause of rITP or an acquired mutation, in particular one resulting in clonal expansion of cytotoxic T cells.
    MeSH term(s) Humans ; Purpura, Thrombocytopenic, Idiopathic/genetics ; Genetic Predisposition to Disease ; Mutation ; T-Lymphocytes, Cytotoxic
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An "ATRA-ctive" new treatment of ITP?

    Lee, Eun-Ju / Bussel, James B

    Blood

    2022  Volume 139, Issue 3, Page(s) 307–308

    MeSH term(s) Humans ; Inosine Triphosphate ; Leukemia, Promyelocytic, Acute ; Tretinoin
    Chemical Substances Inosine Triphosphate (132-06-9) ; Tretinoin (5688UTC01R)
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021014490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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