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  1. Article ; Online: Sharing COVID data? Check these recommendations and guidelines.

    Hanahoe, Hilary / Austin, Claire C / Shanahan, Hugh

    Nature

    2021  Volume 592, Issue 7855, Page(s) 507

    MeSH term(s) COVID-19 ; Computational Biology ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-021-01028-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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  2. Article ; Online: Attributable Costs of Stroke in Ontario, Canada and Their Variation by Stroke Type and Social Determinants of Health.

    Vyas, Manav V / Fang, Jiming / de Oliveira, Claire / Austin, Peter C / Yu, Amy Y X / Kapral, Moira K

    Stroke

    2023  Volume 54, Issue 11, Page(s) 2824–2831

    Abstract: Background: Estimates of attributable costs of stroke are scarce, as most prior studies do not account for the baseline health care costs in people at risk of stroke. We estimated the attributable costs of stroke in a universal health care setting and ... ...

    Abstract Background: Estimates of attributable costs of stroke are scarce, as most prior studies do not account for the baseline health care costs in people at risk of stroke. We estimated the attributable costs of stroke in a universal health care setting and their variation across stroke types and several social determinants of health.
    Methods: We undertook a population-based administrative database-derived matched retrospective cohort study in Ontario, Canada. Community-dwelling adults aged ≥40 years with a stroke between 2003 and 2018 were matched (1:1) on demographics and comorbidities with controls without stroke. Using a difference-in-differences approach, we estimated the mean 1-year direct health care costs attributable to stroke from a public health care payer perspective, accounting for censoring with a weighted available sample estimator. We described health sector-specific costs and reported variation across stroke type and social determinants of health.
    Results: The mean 1-year attributable costs of stroke were Canadian dollars 33 522 (95% CI, $33 231-$33 813), with higher costs for intracerebral hemorrhage ($40 244; $39 193-$41 294) than ischemic stroke ($32 547; $32 252-$32 843). Most of these costs were incurred in acute care hospitals ($15 693) and rehabilitation facilities ($7215). Compared with all patients with stroke, the mean attributable costs were higher among immigrants ($40 554; $39 316-$41 793), those aged <65 years ($35 175; $34 533-$35 818), and those residing in low-income neighborhoods ($34 687; $34 054-$35 320) and lower among rural residents ($29 047; $28 362-$29 731).
    Conclusions: Our findings of high attributable costs of stroke, especially in immigrants, younger patients, and residents of low-income neighborhoods, can be used to evaluate potential health care cost savings associated with different primary stroke prevention strategies.
    MeSH term(s) Adult ; Humans ; Ontario/epidemiology ; Retrospective Studies ; Social Determinants of Health ; Stroke/epidemiology ; Stroke/therapy ; Health Care Costs
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.043369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
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  3. Book: The Royal Horticultural Society encyclopedia of plants and flowers

    Brickell, Christopher / Austin, Claire

    2008  

    Title variant Encyclopedia of plants and flowers
    Institution Royal Horticultural Society
    Author's details ed.-in-chief: Christopher Brickell. [Photogr.: Claire Austin ...]
    Language English
    Size 743 S. : überw. Ill., graph. Darst.
    Edition [reprint of the 4. ed.]
    Publisher Dorling Kindersley
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015423592
    ISBN 978-1-4053-3097-8 ; 1-4053-3097-X
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    084/134 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: Changes in migraine interictal burden following treatment with galcanezumab: Results from a phase III randomized, placebo-controlled study.

    Lipton, Richard B / Buse, Dawn C / Sandoe, Claire H / Ford, Janet H / Hand, Austin L / Jedynak, Jakub P / Port, Martha D / Detke, Holland C

    Headache

    2023  Volume 63, Issue 5, Page(s) 683–691

    Abstract: Objective: To evaluate changes in interictal burden with galcanezumab versus placebo in patients with episodic (EM) or chronic migraine (CM).: Background: The disruptive effects of migraine occur both during attacks (ictal period) and between attacks ...

    Abstract Objective: To evaluate changes in interictal burden with galcanezumab versus placebo in patients with episodic (EM) or chronic migraine (CM).
    Background: The disruptive effects of migraine occur both during attacks (ictal period) and between attacks (interictal period), affecting work, school, family, and social life. Migraine clinical trials typically assess ictal burden endpoints, neglecting interictal burden.
    Methods: CONQUER was a 3-month, double-blind study that randomized adult patients with EM or CM who had experienced failure of two to four standard-of-care migraine preventive medication categories to receive monthly galcanezumab (n = 232) or placebo (n = 230), followed by 3 months of open-label galcanezumab. The mean change in interictal burden, a secondary objective, was measured using the four-item Migraine Interictal Burden Scale (MIBS-4). The total score for MIBS-4 can range from zero to 12, with scores ≥5 indicating severe interictal burden. Post hoc analyses evaluated shifts in MIBS-4 severity categories and item-level improvement.
    Results: The MIBS-4 total score indicated severe interictal burden at baseline (mean [SD]: all patients, 5.5 [3.5]; EM, 5.0 [3.4]; CM, 6.2 [3.5]). Reductions in the MIBS-4 score were significantly greater with galcanezumab versus placebo at Month 3 (mean [SE]: all patients -1.9 [0.2] vs. -0.8 [0.2], p < 0.0001; EM, -1.8 [0.3] vs. -1.1 [0.3], p = 0.033; CM, -1.8 [0.4] vs. -0.3 [0.4], p < 0.001), with further improvement at Month 6 after all patients had received galcanezumab (mean [SE]: all patients, -2.4 [0.2] vs. -2.0 [0.2]; EM, -2.3 [0.3] vs. -2.2 [0.3]; CM, -2.1 [0.4] vs. -1.5 [0.4]). The percentage of patients with severe interictal burden decreased substantially for the galcanezumab-treated patients, from 59% (137/232) at baseline to 27% (58/217) at Month 6 (EM from 51% [70/137] to 23% [30/131]; CM from 71% [67/95] to 33% [28/86]).
    Conclusion: In addition to the known efficacy of galcanezumab in the ictal period, these findings suggest treatment with galcanezumab results in a significant reduction in interictal burden.
    MeSH term(s) Adult ; Humans ; Treatment Outcome ; Double-Blind Method ; Antibodies, Monoclonal, Humanized/therapeutic use ; Migraine Disorders/drug therapy
    Chemical Substances galcanezumab (55KHL3P693) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 539: Show issues Location:
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  5. Article ; Online: Validation of case-ascertainment algorithms using health administrative data to identify people who inject drugs in Ontario, Canada.

    Greenwald, Zoë R / Werb, Dan / Feld, Jordan J / Austin, Peter C / Fridman, Daniel / Bayoumi, Ahmed M / Gomes, Tara / Kendall, Claire E / Lapointe-Shaw, Lauren / Scheim, Ayden I / Bartlett, Sofia R / Benchimol, Eric I / Bouck, Zachary / Boucher, Lisa M / Greenaway, Christina / Janjua, Naveed Z / Leece, Pamela / Wong, William Wl / Sander, Beate /
    Kwong, Jeffrey C

    Journal of clinical epidemiology

    2024  , Page(s) 111332

    Abstract: Objective: Health administrative data can be used to improve the health of people who inject drugs by informing public health surveillance and program planning, monitoring, and evaluation. However, methodological gaps in the use of these data persist ... ...

    Abstract Objective: Health administrative data can be used to improve the health of people who inject drugs by informing public health surveillance and program planning, monitoring, and evaluation. However, methodological gaps in the use of these data persist due to challenges in accurately identifying injection drug use at the population level. In this study, we validated case-ascertainment algorithms for identifying people who inject drugs using health administrative data in Ontario, Canada.
    Study design and setting: Data from cohorts of people with recent (past 12 month) injection drug use, including those participating in community-based research studies or seeking drug treatment were linked to health administrative data in Ontario from 1992-2020. We assessed the validity of algorithms to identify injection drug use over varying lookback periods (i.e., all years of data [1992 onwards] or within the past 1-5 years), including inpatient and outpatient physician billing claims for drug use, emergency department visits or hospitalizations for drug use or injection-related infections, and opioid agonist treatment (OAT).
    Results: Algorithms were validated using data from 15,241 people with recent IDU (918 in community cohorts, 14,323 seeking drug treatment). An algorithm consisting of ≥1 physician visit, emergency department visit or hospitalization for drug use, or OAT record could effectively identify IDU history (91.6% sensitivity, 94.2% specificity) and recent IDU (using 3 years lookback: 80.4% sensitivity, 99% specificity) among community cohorts. Algorithms were generally more sensitive among people who inject drugs seeking drug treatment.
    Conclusion: Validated algorithms using health administrative data performed well in identifying people who inject drugs. Despite high sensitivity and specificity, the positive predictive value of these algorithms will vary depending on the underlying prevalence of injection drug use in the population in which they are applied.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2024.111332
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.206: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Preservation of Individuals’ Privacy in Shared COVID-19 Related Data

    Sauermann, Stefan / Kanjala, Chifundo / Templ, Matthias / Austin, Claire C.

    SSRN Electronic Journal ; ISSN 1556-5068

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3648430
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: COVID-19 Surveillance Data and Models

    Austin, Claire C. / Widyastuti, Anna / El Jundi, Nada / Nagrani, Rajini

    SSRN Electronic Journal ; ISSN 1556-5068

    Review and Analysis, Part 1

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3695335
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Breast cancer diagnosis, treatment, and outcomes of patients from sex and gender minority groups.

    Miller, Claire / Bleicher, Richard J / Williams, Austin D

    Translational cancer research

    2023  Volume 12, Issue 10, Page(s) 2458–2460

    Language English
    Publishing date 2023-09-25
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-23-833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: COVID-19 Emergency Public Health and Economic Measures Causal Loops

    Tonnang, Henri / Greenfield, Jay / Mazzaferro, Gary / Austin, Claire C.

    SSRN Electronic Journal ; ISSN 1556-5068

    A Computable Framework

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3686027
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Metal-DNA interactions: Exploring the impact of metal ions on key stages of forensic DNA analysis.

    Bonsu, Dan Nana Osei / Higgins, Denice / Simon, Claire / Henry, Julianne M / Austin, Jeremy J

    Electrophoresis

    2023  

    Abstract: Forensic DNA analysis continues to be hampered by the complex interactions between metals and DNA. Metal ions may cause direct DNA damage, inhibit DNA extraction and polymerase chain reaction (PCR) amplification or both. This study evaluated the impact ... ...

    Abstract Forensic DNA analysis continues to be hampered by the complex interactions between metals and DNA. Metal ions may cause direct DNA damage, inhibit DNA extraction and polymerase chain reaction (PCR) amplification or both. This study evaluated the impact of metal ions on DNA extraction, quantitation, and short tandem repeat profiling using cell-free and cellular (saliva) DNA. Of the 11 metals assessed, brass exhibited the strongest PCR inhibitory effects, for both custom and Quantifiler Trio quantitation assays. Metal ion inhibition varied across the two quantitative PCR assays and the amount of DNA template used. The Quantifiler Trio internal PCR control (IPC) only revealed evidence of PCR inhibition at higher metal ion concentrations, limiting the applicability of IPC as an indicator of the presence of metal inhibitor in a sample. Notably, ferrous ions were found to significantly decrease the extraction efficiency of the DNA-IQ DNA extraction system. The amount of DNA degradation and inhibition in saliva samples caused by metal ions increased with a dilution of the sample, suggesting that the saliva matrix provides protection from metal ion effects.
    Language English
    Publishing date 2023-08-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 619001-7
    ISSN 1522-2683 ; 0173-0835
    ISSN (online) 1522-2683
    ISSN 0173-0835
    DOI 10.1002/elps.202300070
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