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Article ; Online: Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium.

Cabral-Marques, Otávio / Moll, Guido / Catar, Rusan / Preuß, Beate / Bankamp, Lukas / Pecher, Ann-Christin / Henes, Joerg / Klein, Reinhild / Kamalanathan, A S / Akbarzadeh, Reza / van Oostveen, Wieke / Hohberger, Bettina / Endres, Matthias / Koolmoes, Bryan / Levarht, Nivine / Postma, Rudmer / van Duinen, Vincent / van Zonneveld, Anton Jan / de Vries-Bouwstra, Jeska /

Fehres, Cynthia / Tran, Florian / do Vale, Fernando Yuri Nery / da Silva Souza, Kamilla Batista / Filgueiras, Igor Salerno / Schimke, Lena F / Baiocchi, Gabriela Crispim / de Miranda, Gustavo Cabral / da Fonseca, Dennyson Leandro Mathias / Freire, Paula Paccielli / Hackel, Alexander M / Grasshoff, Hanna / Stähle, Anja / Müller, Antje / Dechend, Ralf / Yu, Xinhua / Petersen, Frank / Sotzny, Franziska / Sakmar, Thomas P / Ochs, Hans D / Schulze-Forster, Kai / Heidecke, Harald / Scheibenbogen, Carmen / Shoenfeld, Yehuda / Riemekasten, Gabriela

Autoimmunity reviews

2023 Volume 22, Issue 5, Page(s) 103310

Abstract: G protein-coupled receptors (GPCR) are involved in various physiological and ... e.g., systemic sclerosis and systemic lupus erythematosus). Beyond their association with disease ...

Abstract	G protein-coupled receptors (GPCR) are involved in various physiological and pathophysiological processes. Functional autoantibodies targeting GPCRs have been associated with multiple disease manifestations in this context. Here we summarize and discuss the relevant findings and concepts presented in the biennial International Meeting on autoantibodies targeting GPCRs (the 4th Symposium), held in Lübeck, Germany, 15-16 September 2022. The symposium focused on the current knowledge of these autoantibodies' role in various diseases, such as cardiovascular, renal, infectious (COVID-19), and autoimmune diseases (e.g., systemic sclerosis and systemic lupus erythematosus). Beyond their association with disease phenotypes, intense research related to the mechanistic action of these autoantibodies on immune regulation and pathogenesis has been developed, underscoring the role of autoantibodies targeting GPCRs on disease outcomes and etiopathogenesis. The observation repeatedly highlighted that autoantibodies targeting GPCRs could also be present in healthy individuals, suggesting that anti-GPCR autoantibodies play a physiologic role in modeling the course of diseases. Since numerous therapies targeting GPCRs have been developed, including small molecules and monoclonal antibodies designed for treating cancer, infections, metabolic disorders, or inflammatory conditions, anti-GPCR autoantibodies themselves can serve as therapeutic targets to reduce patients' morbidity and mortality, representing a new area for the development of novel therapeutic interventions.
MeSH term(s)	Humans ; Autoantibodies ; Autoimmunity ; COVID-19 ; Autoimmune Diseases ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Autoantibodies ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2023-03-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2023.103310
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Article ; Online: Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.1290A > G (p.T351A) or c.2067A > G (p.T610A) in the RHOT1 gene encoding Miro1.

Chemla, Axel / Arena, Giuseppe / Saraiva, Claudia / Berenguer-Escuder, Clara / Grossmann, Dajana / Grünewald, Anne / Klein, Christine / Seibler, Philip / Schwamborn, Jens C / Krüger, Rejko

Stem cell research

2023 Volume 69, Page(s) 103085

Abstract: ... mutations in the RHOT1 gene encoding Miro1, namely c.1290A > G (Miro1 p.T351A) and c.2067A > G (Miro1 p ... related molecular mechanisms underlying neurodegeneration in iPSC-derived neuronal models (e.g., midbrain ...

Abstract	Primary skin fibroblasts from two Parkinson's disease (PD) patients carrying distinct heterozygous mutations in the RHOT1 gene encoding Miro1, namely c.1290A > G (Miro1 p.T351A) and c.2067A > G (Miro1 p.T610A), were converted into induced pluripotent stem cells (iPSCs) by episomal reprogramming. The corresponding isogenic gene-corrected lines have been generated using CRISPR/Cas9 technology. Here, we provide a comprehensive characterization and quality assurance of both isogenic pairs, which will be used to study Miro1-related molecular mechanisms underlying neurodegeneration in iPSC-derived neuronal models (e.g., midbrain dopaminergic neurons and astrocytes).
MeSH term(s)	Humans ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Induced Pluripotent Stem Cells/metabolism ; Mutation/genetics ; Fibroblasts/metabolism ; Dopaminergic Neurons/metabolism ; rho GTP-Binding Proteins/metabolism ; Mitochondrial Proteins/genetics
Chemical Substances	RHOT1 protein, human (EC 3.6.1.-) ; rho GTP-Binding Proteins (EC 3.6.5.2) ; Mitochondrial Proteins
Language	English
Publishing date	2023-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2023.103085
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Article ; Online: Higher risk for chronic graft-versus-host disease (GvHD) in HLA-G mismatched transplants following allogeneic hematopoietic stem cell transplantation: A retrospective study.

Neuchel, Christine / Gowdavally, Sowmya / Tsamadou, Chrysanthi / Platzbecker, Uwe / Sala, Elisa / Wagner-Drouet, Eva / Valerius, Thomas / Kröger, Nicolaus / Wulf, Gerald / Einsele, Hermann / Thurner, Lorenz / Schaefer-Eckart, Kerstin / Freitag, Sebastian / Casper, Jochen / Dürholt, Mareike / Kaufmann, Martin / Hertenstein, Bernd / Klein, Stefan / Ringhoffer, Mark /

Frank, Sandra / Amann, Elisa Maria / Rode, Immanuel / Schrezenmeier, Hubert / Mytilineos, Joannis / Fürst, Daniel

HLA

2022 Volume 100, Issue 4, Page(s) 349–360

Abstract: ... The HLA-class Ib molecule HLA-G has been shown to promote tolerogenicity through its interaction ... HLA-G mismatches may negatively impact the HLA-G-mediated tolerogenicity either due to inefficient ... of mismatched HLA-G on host cells by the immune cells of the donor.: Methods: In order to explore ...

Abstract	Introduction: Graft-versus-host disease (GvHD) is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is highly influenced by the degree of HLA matching between recipient and donor. The HLA-class Ib molecule HLA-G has been shown to promote tolerogenicity through its interaction with inhibitory receptors found on several immunocompetent cells. We hypothesized that in an allo-HSCT setting, HLA-G mismatches may negatively impact the HLA-G-mediated tolerogenicity either due to inefficient interaction with the inhibitory receptors of the transplanted immune cells or due to direct allorecognition of mismatched HLA-G on host cells by the immune cells of the donor. Methods: In order to explore this hypothesis, we investigated the impact of HLA-G mismatching in 2.083 10/10 matched high resolution HLA-typed allo-HSCT transplants. Results: We found that the risk of chronic GvHD was significantly higher in HLA-G-mismatched transplant cases as compared with the HLA-G-matched control group (HR: 1.46, 95%CI = 1.11-1.91, p = 0.006). Sub-analysis of the mismatch vector revealed that this effect was only detectable in the GvH (HR: 1.89, 95%CI 1.39-2.57, p < 0.001) but not the HvG direction (HR: 1.01, 95%CI = 0.63-1.63, p = 0.967). In addition, the negative impact of HLA-G mismatching on chronic GvHD was only significant in younger patients (<30y HR: 3.02, 95%CI = 1.25-7.28, p = 0.014; >29y HR: 1.28, 95%CI = 0.94-1.72, p = 0.113). Discussion: Our results indicate that HLA-G mismatches may contribute to the onset of chronic GvHD, especially in younger patients and should therefore be avoided when possible.
MeSH term(s)	Alleles ; Graft vs Host Disease ; HLA-G Antigens ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukemia, Myeloid, Acute ; Retrospective Studies
Chemical Substances	HLA-G Antigens
Language	English
Publishing date	2022-07-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.14733
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Article ; Online: A Novel Simian Adenovirus Associating with Human Adeno-virus Species G Isolated from Long-Tailed Macaque Feces.

Kosoltanapiwat, Nathamon / van der Hoek, Lia / Kinsella, Cormac M / Tongshoob, Jarinee / Prasittichai, Luxsana / Klein, Michelle / Jebbink, Maarten F / Deijs, Martin / Reamtong, Onrapak / Boonnak, Kobporn / Khongsiri, Wathusiri / Phadungsombat, Juthamas / Tongthainan, Daraka / Tulayakul, Phitsanu / Yindee, Marnoch

Viruses

2023 Volume 15, Issue 6

Abstract: Metagenomics has demonstrated its capability in outbreak investigations and pathogen surveillance and discovery. With high-throughput and effective bioinformatics, many disease-causing agents, as well as novel viruses of humans and animals, have been ... ...

Abstract	Metagenomics has demonstrated its capability in outbreak investigations and pathogen surveillance and discovery. With high-throughput and effective bioinformatics, many disease-causing agents, as well as novel viruses of humans and animals, have been identified using metagenomic analysis. In this study, a VIDISCA metagenomics workflow was used to identify potential unknown viruses in 33 fecal samples from asymptomatic long-tailed macaques (
MeSH term(s)	Animals ; Humans ; Macaca fascicularis ; Adenoviruses, Simian/genetics ; Thailand/epidemiology ; Macaca mulatta ; Adenoviridae ; Adenoviridae Infections/veterinary ; Enterovirus ; Enterovirus Infections ; Feces ; Phylogeny
Language	English
Publishing date	2023-06-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15061371
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Article ; Conference proceedings: G G G-najaarsdag: 'Afwisseling'.

Haneveld, Johan Klein

Tijdschrift voor diergeneeskunde

2010 Volume 135, Issue 23, Page(s) 920–921

Title translation	GGG-najaarsdag: 'Variation'.
MeSH term(s)	Animal Diseases/epidemiology ; Animal Diseases/prevention & control ; Animals ; Humans ; Netherlands ; Societies ; Veterinary Medicine/trends ; Wounds and Injuries/epidemiology ; Wounds and Injuries/prevention & control ; Wounds and Injuries/veterinary
Language	Dutch
Publishing date	2010-12-01
Publishing country	Netherlands
Document type	Congresses
ZDB-ID	422558-2
ISSN	0040-7453
ISSN	0040-7453
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Zs.B 1158: Show issues

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Article ; Online: Validation of the German Version of the Mind Excessively Wandering Scale (MEWS-G).

Nakovics, Helmut / Benoit, Dorit / Asherson, Philip / Luderer, Matthias / Alm, Barbara / Vollstädt-Klein, Sabine / Philipsen, Alexandra / Mowlem, Florence / Fischer, Nicole / Sobanski, Esther

Fortschritte der Neurologie-Psychiatrie

2021 Volume 89, Issue 12, Page(s) 607–616

Abstract: ... G) in terms of factorial structure and factor stability, internal consistency and construct validity ... argues for the one factorial structure of the scale. Mean MEWS-G score in ADHD was 23.77 ± 7.85 compared ... ADHD and controls is at MEWS-G score = 13. On the symptom level, MEWS-G score was correlated with ADHD ...

Title translation	Die deutsche Version der Mind Excessively Wandering Scale (MWES-G): eine Validierungsstudie.
Abstract	Increasing evidence shows that unintentional mind wandering is linked to Attention Deficit Hyperactivity Disorder (ADHD) and that its frequency contributes to symptom severity and functional impairment in ADHD. However, empirical data on mind wandering in adult ADHD are still scarce, and a validated scale to assess mind wandering in German adult ADHD patients is lacking. The primary aim of this study is to assess the psychometric properties of the German version of the recently published Mind Excessively Wandering Scale (MEWS-G) in terms of factorial structure and factor stability, internal consistency and construct validity. Analyses were performed in 128 adults with ADHD, clinical and healthy controls. As described for the original English 15-item version of the scale, we found lowest item-total-correlations for items 6, 10 and 14 with item-total correlation of all: 0.54/ADHD: 0.32 (item 6), all: 0.55/ADHD: 0.39 (item 10) and all: 0.11/ADHD: -0.04 (item 14). Item-total correlations for the remaining items were 0.65-0.86 and Cronbach Alpha was 0.96 indicating good internal consistency of the 12-item version of scale, on which we based all further analyses. Principal component analysis indicated a one- and two- factorial scale structure respectively explaining 71.7 % and 78.7 % of variance. Both factors showed good stability with lower stability of the factor-2 solution if sample size was reduced. The two-factorial solution also had many cross-loadings and a strong correlation of both factors in confirmatory factorial analysis (rf1f2 = 0.87). It probably describes related and interdependent, but not distinct facets of mind wandering, which strongly argues for the one factorial structure of the scale. Mean MEWS-G score in ADHD was 23.77 ± 7.85 compared to 7.64 ± 7.27 in controls (p < .0001). According to ROC, the optimal cut-off point to discriminate ADHD and controls is at MEWS-G score = 13. On the symptom level, MEWS-G score was correlated with ADHD, depressive and total psychiatric symptom scores, on the personality level with neuroticsm and negatively with conscientiousness and on the functional level with social interaction difficulties and impaired self-efficacy. In summary, our study shows that MEWS-G is a reliable, valid instrument to assess spontaneous mind wandering in adult ADHD and to discriminate between ADHD and controls.
MeSH term(s)	Adult ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Humans ; Personality ; Psychometrics ; Reproducibility of Results
Language	English
Publishing date	2021-02-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	625328-3
ISSN	1439-3522 ; 0720-4299
ISSN (online)	1439-3522
ISSN	0720-4299
DOI	10.1055/a-1362-9743
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Ui II Zs.110: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui II Zs.110/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Survival and short-term respiratory outcomes of <750 g infants initially intubated with 2.0 mm vs. 2.5 mm endotracheal tubes.

Berger, Jennifer N / Elgin, Timothy G / Dagle, John M / Klein, Jonathan M / Colaizy, Tarah T

Journal of perinatology : official journal of the California Perinatal Association

2021 Volume 42, Issue 2, Page(s) 202–208

Abstract: Objectives: To compare survival and short-term respiratory outcomes of infants weighing <750 g ... observational cohort study.: Results: Of 149 inborn infants weighing <750 g admitted to the NICU, 69 (46 ... 24 weeks (24, 25) p < 0.0001), smaller (median birth weight 545 g (450, 616) vs. 648 g (579, 700), p ...

Abstract	Objectives: To compare survival and short-term respiratory outcomes of infants weighing <750 g initially intubated with 2.0 mm versus 2.5 mm endotracheal tube (ETT). Study design: Retrospective, observational cohort study. Results: Of 149 inborn infants weighing <750 g admitted to the NICU, 69 (46%) were intubated with 2.0 mm ETT, 78 with 2.5 mm ETT (53%), and 2 infants never required intubation. Infants intubated with 2.0 mm ETT were more premature (median gestational age (GA) 23 weeks (22, 24) vs. 24 weeks (24, 25) p < 0.0001), smaller (median birth weight 545 g (450, 616) vs. 648 g (579, 700), p < 0.0001), and more frequently intubated at delivery (96% vs. 68%, p < 0.00001). Survival to discharge was similar 77%, 53/69 and 87%, 68/78 (p = 0.09). Adjusted for GA, there were no significant differences in ventilator days (p = 0.7338) or Grade 3 BPD. Conclusions: Premature infants born at a median GA of 23 weeks and median birth weight of 545 g can be successfully managed with 2.0 mm ETT.
MeSH term(s)	Birth Weight ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; Intubation, Intratracheal ; Retrospective Studies
Language	English
Publishing date	2021-10-21
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-021-01227-y
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Article: Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein Receptor.

Gong, Ying / Klein Wolterink, Roel G J / Janssen, Ian / Groot, Arjan J / Bos, Gerard M J / Germeraad, Wilfred T V

Molecular therapy. Methods & clinical development

2020 Volume 17, Page(s) 634–646

Abstract: ... expression, thereby facilitating viral transduction. We found that the transduction efficiency of VSV-G ...

Abstract	Adoptive natural killer (NK) cell therapy is attaining promising clinical outcomes in recent years, but improvements are needed. Genetic modification of NK cells with a tumor antigen-specific receptor on their surface coupled to intracellular signaling domains may lead to enhanced cytotoxicity against malignant cells. One of the most common approaches is by lentivirus-mediated transduction. However, NK cells are difficult to transduce and various methods have been attempted with different success rates. Because the low-density lipoprotein-receptor (LDLR) is the receptor of vesicular stomatitis virus (VSV) and is expressed only at low levels on NK cells, we tested the potential of 5 statins and 5 non-statin compounds to increase the LDLR expression, thereby facilitating viral transduction. We found that the transduction efficiency of VSV-G pseudotyped lentivirus is augmented by statins that induced higher LDLR expression. In both NK-92 cells and primary NK cells, the transduction efficiency increased after treatment with statins. Furthermore, statins have been reported to suppress NK cell cytotoxicity; however, we showed that this can be completely reversed by adding geranylgeranyl-pyrophosphate (GGPP). Among the statins tested, we found that the combination of rosuvastatin with GGPP most potently improved viral transduction without affecting the cytotoxic properties of the NK cells.
Language	English
Publishing date	2020-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2872938-9
ISSN	2329-0501 ; 2329-0501
ISSN (online)	2329-0501
ISSN	2329-0501
DOI	10.1016/j.omtm.2020.03.017
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Zs.A 7107: Show issues

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Book ; Thesis: Die Bedeutung des G-Protein G-alpha 13 für das Schaltverhalten kardialer L-Typ-Calciumkanäle in Kardiomyozyten sowie für die Entwicklung von kardialer Hypertrophie von Insuffizienz von Mäusen bei Überexpression des beta 2-Adrenorezeptors

Klein, Christoph

2009

Author's details	vorgelegt von Christoph Klein
Language	German
Size	103 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Köln, Univ., Diss., 2009
HBZ-ID	HT016177071
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Correction: Kosoltanapiwat et al. A Novel Simian Adenovirus Associating with Human Adenovirus Species G Isolated from Long-Tailed Macaque Feces.

Viruses

2023 Volume 15, Issue 9

Abstract: After publication of the article, the authors received comments from a member of ... ...

Abstract	After publication of the article, the authors received comments from a member of the
Language	English
Publishing date	2023-09-04
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15091871
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