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Article ; Online: Detector thickness effects on nanosecond-gated imager response.

Looker, Quinn / Colombo, Anthony P / Porter, John L

2021 Volume 92, Issue 5, Page(s) 53504

Abstract: Hybrid CMOS multi-frame imagers with exposure times down to ∼2 ns have made significant impacts in high energy density physics and inertial confinement fusion research. The detector thickness is a key parameter in both detector quantum efficiency and ... ...

Abstract	Hybrid CMOS multi-frame imagers with exposure times down to ∼2 ns have made significant impacts in high energy density physics and inertial confinement fusion research. The detector thickness is a key parameter in both detector quantum efficiency and temporal response. The Icarus hybrid CMOS imager has been fabricated with Si detector thicknesses of 8, 25, and 100 µm. The temporal response of imaging sensors with exposure time down to 2 ns has been examined and compared to directly measured photodiode current. The 100-μm thick variant displays extended features related to charge carrier collection and is more susceptible to field collapse. We also demonstrate charge collection time effects on spatial response.
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0048519
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Article ; Online: X-ray characterization of the Icarus ultrafast x-ray imager.

Looker, Quinn / Colombo, Anthony P / Kimmel, Mark / Porter, John L

The Review of scientific instruments

2020 Volume 91, Issue 4, Page(s) 43502

Abstract: Ultrafast x-ray imagers developed at Sandia National Laboratories are a transformative diagnostic tool in inertial confinement fusion and high energy density physics experiments. The nanosecond time scales on which these devices operate are a regime with ...

Abstract	Ultrafast x-ray imagers developed at Sandia National Laboratories are a transformative diagnostic tool in inertial confinement fusion and high energy density physics experiments. The nanosecond time scales on which these devices operate are a regime with little precedent, and applicable characterization procedures are still developing. This paper presents pulsed x-ray characterization of the Icarus imager under a variety of illumination levels and timing modes. Results are presented for linearity of response, absolute sensitivity, variation of response with gate width, and image quality.
Language	English
Publishing date	2020-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0004711
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Article ; Online: Toxoplasma gondii Manipulates Expression of Host Long Noncoding RNA during Intracellular Infection.

Menard, Kayla L / Haskins, Breanne E / Colombo, Anthony P / Denkers, Eric Y

Scientific reports

2018 Volume 8, Issue 1, Page(s) 15017

Abstract: Long noncoding RNA (lncRNA) are non-protein-coding transcripts greater than 200 nucleotides that regulate gene expression. The field of transcriptomics is only beginning to understand the role of lncRNA in host defense. Little is known about the role of ... ...

Abstract	Long noncoding RNA (lncRNA) are non-protein-coding transcripts greater than 200 nucleotides that regulate gene expression. The field of transcriptomics is only beginning to understand the role of lncRNA in host defense. Little is known about the role of lncRNA in the response to infection by intracellular pathogens such as Toxoplasma gondii. Using a microarray, we examined the differential expression of 35,923 lncRNAs and 24,881 mRNAs in mouse bone-marrow-derived macrophages during infection with high- and low-virulence T. gondii strains. We found that 1,522 lncRNA molecules were differentially regulated during infection with the high-virulence Type I strain, versus 528 with the less-virulent Type II strain. Of these lncRNAs, 282 were co-regulated with a nearby or overlapping mRNA-including approximately 60 mRNAs with immune-related functions. We validated the microarray for 4 lncRNAs and 4 mRNAs using qRT-PCR. Using deletion strains of T. gondii, we found that the secretory kinase ROP16 controls upregulation of lncRNAs Csf1-lnc and Socs2-lnc, demonstrating that the parasite directly manipulates host lncRNA expression. Given the number of regulated lncRNAs and the magnitude of the expression changes, we hypothesize that these molecules constitute both an additional regulatory layer in the host response to infection and a target for manipulation by T. gondii.
MeSH term(s)	Animals ; Computational Biology/methods ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Genomics/methods ; Host-Parasite Interactions/genetics ; Mice ; Protein-Tyrosine Kinases/metabolism ; Protozoan Proteins/metabolism ; RNA Interference ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics ; Toxoplasma/genetics ; Toxoplasmosis/genetics ; Toxoplasmosis/parasitology
Chemical Substances	Protozoan Proteins ; RNA, Long Noncoding ; RNA, Messenger ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Rop16 protein, Toxoplasma gondii (EC 2.7.10.1)
Language	English
Publishing date	2018-10-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-33274-5
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Article: Decreased Self-reported Physical Fitness Following SARS-CoV-2 Infection and the Impact of Vaccine Boosters in a Cohort Study.

Richard, Stephanie A / Scher, Ann I / Rusiecki, Jennifer / Byrne, Celia / Berjohn, Catherine M / Fries, Anthony C / Lalani, Tahaniyat / Smith, Alfred G / Mody, Rupal M / Ganesan, Anuradha / Huprikar, Nikhil / Colombo, Rhonda E / Colombo, Christopher J / Schofield, Christina / Lindholm, David A / Mende, Katrin / Morris, Michael J / Jones, Milissa U / Flanagan, Ryan /

Larson, Derek T / Ewers, Evan C / Bazan, Samantha E / Saunders, David / Maves, Ryan C / Livezey, Jeffrey / Maldonado, Carlos J / Edwards, Margaret Sanchez / Rozman, Julia S / O'Connell, Robert J / Simons, Mark P / Tribble, David R / Agan, Brian K / Burgess, Timothy H / Pollett, Simon D

Open forum infectious diseases

2023 Volume 10, Issue 12, Page(s) ofad579

Abstract: Background: The long-term effects of coronavirus disease 2019 (COVID-19) on physical fitness are unclear, and the impact of vaccination on that relationship is uncertain.: Methods: We compared survey responses in a 1-year study of US military service ...

Abstract	Background: The long-term effects of coronavirus disease 2019 (COVID-19) on physical fitness are unclear, and the impact of vaccination on that relationship is uncertain. Methods: We compared survey responses in a 1-year study of US military service members with (n = 1923) and without (n = 1591) a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We fit Poisson regression models to estimate the association between history of SARS-CoV-2 infection and fitness impairment, adjusting for time since infection, demographics, and baseline health. Results: The participants in this analysis were primarily young adults aged 18-39 years (75%), and 71.5% were male. Participants with a history of SARS-CoV-2 infection were more likely to report difficulty exercising (38.7% vs 18.4%; Conclusions: In this study of generally young, healthy military service members, SARS-CoV-2 infection was associated with lower self-reported fitness and exercise capacity; vaccination and boosting were associated with lower risk of self-reported fitness loss.
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad579
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Article ; Online: Coherent laser-millimeter-wave interactions en route to coherent population transfer.

Grimes, David D / Barnum, Timothy J / Zhou, Yan / Colombo, Anthony P / Field, Robert W

The Journal of chemical physics

2017 Volume 147, Issue 14, Page(s) 144201

Abstract: We demonstrate coherent two-photon population transfer to Rydberg states of barium atoms using a combination of a pulsed dye laser and a chirped-pulse millimeter-wave spectrometer. Numerical calculations, using a density matrix formalism, reproduce our ... ...

Abstract	We demonstrate coherent two-photon population transfer to Rydberg states of barium atoms using a combination of a pulsed dye laser and a chirped-pulse millimeter-wave spectrometer. Numerical calculations, using a density matrix formalism, reproduce our experimental results and explain the factors responsible for the observed fractional population transferred, optimal experimental conditions, and possibilities for future improvements. The long coherence times associated with the millimeter-wave radiation aid in creating coherence between the ground state and Rydberg states, but higher-coherence laser sources are required to achieve stimulated Raman adiabatic passage and for applications to molecules.
Language	English
Publishing date	2017-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.4997624
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Article ; Online: Persistent COVID-19 Symptoms at 6 Months After Onset and the Role of Vaccination Before or After SARS-CoV-2 Infection.

Richard, Stephanie A / Pollett, Simon D / Fries, Anthony C / Berjohn, Catherine M / Maves, Ryan C / Lalani, Tahaniyat / Smith, Alfred G / Mody, Rupal M / Ganesan, Anuradha / Colombo, Rhonda E / Lindholm, David A / Morris, Michael J / Huprikar, Nikhil / Colombo, Christopher J / Madar, Cristian / Jones, Milissa / Larson, Derek T / Bazan, Samantha E / Mende, Katrin /

Saunders, David / Livezey, Jeffrey / Lanteri, Charlotte A / Scher, Ann I / Byrne, Celia / Rusiecki, Jennifer / Ewers, Evan / Epsi, Nusrat J / Rozman, Julia S / English, Caroline / Simons, Mark P / Tribble, David R / Agan, Brian K / Burgess, Timothy H

JAMA network open

2023 Volume 6, Issue 1, Page(s) e2251360

Abstract: Importance: Understanding the factors associated with post-COVID conditions is important for prevention.: Objective: To identify characteristics associated with persistent post-COVID-19 symptoms and to describe post-COVID-19 medical encounters.: ... ...

Abstract	Importance: Understanding the factors associated with post-COVID conditions is important for prevention. Objective: To identify characteristics associated with persistent post-COVID-19 symptoms and to describe post-COVID-19 medical encounters. Design, setting, and participants: This cohort study used data from the Epidemiology, Immunology, and Clinical Characteristics of Emerging Infectious Diseases With Pandemic Potential (EPICC) study implemented in the US military health system (MHS); MHS beneficiaries aged 18 years or older who tested positive for SARS-CoV-2 from February 28, 2020, through December 31, 2021, were analyzed, with 1-year follow-up. Exposures: SARS-CoV-2 infection. Main outcomes and measures: The outcomes analyzed included survey-reported symptoms through 6 months after SARS-CoV-2 infection and International Statistical Classification of Diseases and Related Health Problems, Tenth Revision diagnosis categories reported in medical records 6 months following SARS-CoV-2 infection vs 3 months before infection. Results: More than half of the 1832 participants in these analyses were aged 18 to 44 years (1226 [66.9%]; mean [SD] age, 40.5 [13.7] years), were male (1118 [61.0%]), were unvaccinated at the time of their infection (1413 [77.1%]), and had no comorbidities (1290 [70.4%]). A total of 728 participants (39.7%) had illness that lasted 28 days or longer (28-89 days: 364 [19.9%]; ≥90 days: 364 [19.9%]). Participants who were unvaccinated prior to infection (risk ratio [RR], 1.39; 95% CI, 1.04-1.85), reported moderate (RR, 1.80; 95% CI, 1.47-2.22) or severe (RR, 2.25; 95% CI, 1.80-2.81) initial illnesses, had more hospitalized days (RR per each day of hospitalization, 1.02; 95% CI, 1.00-1.03), and had a Charlson Comorbidity Index score of 5 or greater (RR, 1.55; 95% CI, 1.01-2.37) were more likely to report 28 or more days of symptoms. Among unvaccinated participants, postinfection vaccination was associated with a 41% lower risk of reporting symptoms at 6 months (RR, 0.59; 95% CI, 0.40-0.89). Participants had higher risk of pulmonary (RR, 2.00; 95% CI, 1.40-2.84), diabetes (RR, 1.46; 95% CI, 1.00-2.13), neurological (RR, 1.29; 95% CI, 1.02-1.64), and mental health-related medical encounters (RR, 1.28; 95% CI, 1.01-1.62) at 6 months after symptom onset than at baseline (before SARS-CoV-2 infection). Conclusions and relevance: In this cohort study, more severe acute illness, a higher Charlson Comorbidity Index score, and being unvaccinated were associated with a higher risk of reporting COVID-19 symptoms lasting 28 days or more. Participants with COVID-19 were more likely to seek medical care for diabetes, pulmonary, neurological, and mental health-related illness for at least 6 months after onset compared with their pre-COVID baseline health care use patterns. These findings may inform the risk-benefit ratio of COVID-19 vaccination policy.
MeSH term(s)	Humans ; Male ; Adult ; Female ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; COVID-19 Vaccines ; Cohort Studies ; Post-Acute COVID-19 Syndrome
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2022.51360
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Article ; Online: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2021 Volume 74, Issue 5, Page(s) 897–900

Abstract: Little is known about severe acute respiratory syndrome coronavirus 2 "vaccine-breakthrough" infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe ... ...

Abstract	Little is known about severe acute respiratory syndrome coronavirus 2 "vaccine-breakthrough" infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.
MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines ; Genetic Variation ; Humans ; Phenotype ; RNA, Messenger ; SARS-CoV-2/genetics ; Vaccines, Synthetic ; Virus Shedding ; mRNA Vaccines
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger ; Vaccines, Synthetic ; mRNA Vaccines
Language	English
Publishing date	2021-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciab543
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Article ; Online: Contribution of endocrine therapy in oestrogen receptor-positive pT1a-b breast cancer: Results of a retrospective study.

Houvenaeghel, Gilles / de Nonneville, Alexandre / Cohen, Monique / Classe, Jean-Marc / Reyal, Fabien / Mazouni, Chafika / Faure, Christelle / Martinez, Alejandra / Chauvet, Marie-Pierre / Daraï, Emile / Coutant, Charles / Colombo, Pierre-Emmanuel / Gimbergues, Pierre / Azuar, Anne-Sophie / Rouzier, Roman / Tunon de Lara, Christine / Crochet, Patrice / Rua, Sandrine / Gonçalves, Anthony

European journal of cancer (Oxford, England : 1990)

2022 Volume 176, Page(s) 58–69

Abstract: ... significantly associated with decreased DFS (hazard ratio, HR = 1.275, p = 0.047, 95% CI[1.003-1.620]) but not ... significantly associated with decreased DFS (HR = 1.502, p = 0.049, 95% CI[1.001-2.252]), but not OS (HR = 1.361 ... p = 0.272). ET omission was not significantly associated with decreased survival in 3047 patients ...

Abstract	Introduction: Few data have been reported regarding endocrine therapy (ET) in patients with small pT1a-b ER-postive breast cancer (BC). Thus, we conducted a study to detect possible survival improvements due to ET in such patients. Methods: Our retrospective observational study included 5545 patients with pT1a-b ER-positive BC treated in 15 French centres, excluding patients with HER2-positive status, neoadjuvant chemotherapy, ER-negative status, unknown pN status or in situ BC. We estimated disease-free survival (DFS), recurrence-free survival (RFS) and overall survival (OS) via univariate analysis and multivariate Cox regression. Results: Most patients (80.3%: 4453) received ET and-when compared to those without ET-experienced increases of 2.5% and 3.3% in DFS and 1.9% and 4.3% in RFS after 5 and 7 years of follow-up, respectively, with little difference in OS. In Cox regression analysis, no ET was significantly associated with decreased DFS (hazard ratio, HR = 1.275, p = 0.047, 95% CI[1.003-1.620]) but not OS or RFS in all patients, while in 2363 patients with pT1a-b ER-positive grade 2-3 BC, no ET was significantly associated with decreased DFS (HR = 1.502, p = 0.049, 95% CI[1.001-2.252]), but not OS (HR = 1.361, p = 0.272). ET omission was not significantly associated with decreased survival in 3047 patients with pT1a-b ER-positive grade 1 BC. Conclusion: Our results indicate that while ET provided a beneficial impact on survival to patients with pT1a-bN0 ER-positive BC-and especially in those with grade 2-3 tumours-no such impact was observed in grade 1 tumours. Consequently, ET should be discussed with these patients, particularly in those with pT1a grade 1 tumours.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Receptors, Estrogen ; Retrospective Studies ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Receptor, ErbB-2
Chemical Substances	Receptors, Estrogen ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2022-10-01
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2022.08.027
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Article ; Online: Clinical, Immunological, and Virological SARS-CoV-2 Phenotypes in Obese and Nonobese Military Health System Beneficiaries.

The Journal of infectious diseases

2021 Volume 224, Issue 9, Page(s) 1462–1472

Abstract: ... equivalents (GE)/reaction and log10 (2.62) higher N2 GE/reaction than nonobese (P = 0.03 and P < .001 ... outpatients (coefficient = 5.48, P < .001).: Conclusions: Obesity is a strong correlate of COVID-19 ...

Abstract	Background: The mechanisms underlying the association between obesity and coronavirus disease 2019 (COVID-19) severity remain unclear. After verifying that obesity was a correlate of severe COVID-19 in US Military Health System (MHS) beneficiaries, we compared immunological and virological phenotypes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in both obese and nonobese participants. Methods: COVID-19-infected MHS beneficiaries were enrolled, and anthropometric, clinical, and demographic data were collected. We compared the SARS-CoV-2 peak IgG humoral response and reverse-transcription polymerase chain reaction viral load in obese and nonobese patients, stratified by hospitalization, utilizing logistic regression models. Results: Data from 511 COVID-19 patients were analyzed, among whom 24% were obese and 14% severely obese. Obesity was independently associated with hospitalization (adjusted odds ratio [aOR], 1.91; 95% confidence interval [CI], 1.15-3.18) and need for oxygen therapy (aOR, 3.39; 95% CI, 1.61-7.11). In outpatients, severely obese had a log10 (1.89) higher nucleocapsid (N1) genome equivalents (GE)/reaction and log10 (2.62) higher N2 GE/reaction than nonobese (P = 0.03 and P < .001, respectively). We noted a correlation between body mass index and peak anti-spike protein IgG in inpatients and outpatients (coefficient = 5.48, P < .001). Conclusions: Obesity is a strong correlate of COVID-19 severity in MHS beneficiaries. These findings offer new pathophysiological insights into the relationship between obesity and COVID-19 severity.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral ; Body Weight ; COVID-19/complications ; COVID-19/diagnosis ; Female ; Hospitalization ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Military Health Services ; Obesity/complications ; Obesity/epidemiology ; Prevalence ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Viral Load ; Young Adult
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2021-07-31
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiab396
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Article ; Online: Spatially Resolved Tumor Microenvironment Predicts Treatment Outcomes in Relapsed/Refractory Hodgkin Lymphoma.

Aoki, Tomohiro / Jiang, Aixiang / Xu, Alexander / Yin, Yifan / Gamboa, Alicia / Milne, Katy / Takata, Katsuyoshi / Miyata-Takata, Tomoko / Chung, Shanee / Rai, Shinya / Wu, Shaocheng / Warren, Mary / Strong, Celia / Goodyear, Talia / Morris, Kayleigh / Chong, Lauren C / Hav, Monirath / Colombo, Anthony R / Telenius, Adele /

Boyle, Merrill / Ben-Neriah, Susana / Power, Maryse / Gerrie, Alina S / Weng, Andrew P / Karsan, Aly / Roth, Andrew / Farinha, Pedro / Scott, David W / Savage, Kerry J / Nelson, Brad H / Merchant, Akil / Steidl, Christian

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2023 Volume 42, Issue 9, Page(s) 1077–1087

Abstract: Purpose: About a third of patients with relapsed or refractory classic Hodgkin lymphoma (r/r CHL) succumb to their disease after high-dose chemotherapy followed by autologous stem-cell transplantation (HDC/ASCT). Here, we aimed to describe spatially ... ...

Abstract	Purpose: About a third of patients with relapsed or refractory classic Hodgkin lymphoma (r/r CHL) succumb to their disease after high-dose chemotherapy followed by autologous stem-cell transplantation (HDC/ASCT). Here, we aimed to describe spatially resolved tumor microenvironment (TME) ecosystems to establish novel biomarkers associated with treatment failure in r/r CHL. Patients and methods: We performed imaging mass cytometry (IMC) on 71 paired primary diagnostic and relapse biopsies using a marker panel specific to CHL biology. For each cell type in the TME, we calculated a spatial score measuring the distance of nearest neighbor cells to the malignant Hodgkin Reed Sternberg cells within the close interaction range. Spatial scores were used as features in prognostic model development for post-ASCT outcomes. Results: Highly multiplexed IMC data revealed shared TME patterns in paired diagnostic and early r/r CHL samples, whereas TME patterns were more divergent in pairs of diagnostic and late relapse samples. Integrated analysis of IMC and single-cell RNA sequencing data identified unique architecture defined by CXCR5 Conclusion: We identified the interaction of CXCR5+ HRS cells with ligand-expressing CXCL13+ macrophages as a prominent crosstalk axis in relapsed CHL. Harnessing this TME biology, we developed a novel prognostic model applicable to r/r CHL biopsies, RHL4S, opening new avenues for spatial biomarker development.
MeSH term(s)	Humans ; Hodgkin Disease/drug therapy ; Tumor Microenvironment ; Ecosystem ; Neoplasm Recurrence, Local ; Treatment Outcome ; Recurrence
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.23.01115
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