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  1. Article: [The effect of Ba Duan Jin on the balance of community-dwelling older adults: a cluster randomized control trial].

    Duan, L L / Zhao, Y B / Er, Y L / Ye, P P / Wang, W / Gao, X / Deng, X / Jin, Y / Wang, Y / Ji, C R / Ma, X Y / Gao, C / Zhao, Y H / Zhu, S Q / Su, S Z / Guo, X E / Peng, J J / Yu, Y / Yang, C /
    Su, Y Y / Zhao, M / Guo, L H / Wu, Y P / Luo, Y N / Meng, R L / Xu, H F / Liu, H Z / Ruan, H H / Xie, B / Zhang, H M / Liao, Y H / Chen, Y / Wang, L H

    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

    2024  Volume 45, Issue 2, Page(s) 250–256

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Male ; Humans ; Female ; Aged ; Independent Living ; Exercise ; Health Education ; China
    Language Chinese
    Publishing date 2024-02-26
    Publishing country China
    Document type Randomized Controlled Trial ; English Abstract ; Journal Article
    ZDB-ID 645026-x
    ISSN 0254-6450
    ISSN 0254-6450
    DOI 10.3760/cma.j.cn112338-20230506-00283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Complete Genome Sequence of Glutamicibacter mysorens NBNZ-009, Isolated from Jin Lake Sediment.

    Wang, Yueying / Su, Xin / Liu, Jie / Fang, Wei / Zhu, Lei

    Microbiology resource announcements

    2022  Volume 11, Issue 10, Page(s) e0076222

    Abstract: Members of the ... ...

    Abstract Members of the genus
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00762-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Clinical course of patients with severe SARS-CoV-2 infection co-treatment with Jin Si Herbal Tea in Eastern Taiwan: A retrospective cohort study.

    Li, Pei-Chen / Wang, Hui-Sheng / Shibu, Marthandam Asokan / Wang, Jhen / Huang, Shiau-Huei / Wang, Jeng-Hung / Wang, Ji-Hung / Huang, Chih-Yang / Chiang, Chien-Yi / Lin, Yu-Jung / Ho, Tsung-Jung / Lin, Shinn-Zong / Chung, Hui-Chun / Yu, Hsin-Yuan / Su, San-Hua / Chou, Ying-Fang / Tai, Chia-Hui / Ding, Dah-Ching / Shih, Cheng Yen

    Journal of herbal medicine

    2022  Volume 36, Page(s) 100610

    Abstract: ... beneficial for COVID-19 treatment. An herbal preparation Jin Si Herbal Tea (JS) was formulated with herbal ...

    Abstract Introduction: Coronavirus disease-2019 (COVID-19) has affected more than 608 million people and has killed 6.5 million people in the world. A few studies showed traditional Chinese medicine can be beneficial for COVID-19 treatment. An herbal preparation Jin Si Herbal Tea (JS) was formulated with herbal extracts known for their potential to decrease spike protein and ACE2 interaction, 3CL, and TRPMSS2 protease activity, and thus aimed to evaluate the clinical course of JS co-treatment along with the usual treatment schedule given for severe COVID-19 patients.
    Methods: This retrospective cohort study included patients with severe COVID-19 admitted to Hualien Tzu Chi Hospital between June and July 2021. All the patients were co-treated with JS and the primary outcome was death. The secondary outcomes included laboratory exam, Ct value, clinical course, and hospital stays. There were 10 patients recruited in this study and divided into < 70 years and ≧ 70 years groups (n = 5 in each group).
    Results: Older patients (≧70 years) had a higher Charlson Comorbidity Index, VACO index, and lower hemoglobin levels than < 70 years patients. The trend of lymphocyte count, LDH, D-dimer, and Ct value of non-survivors was not consistent with previous studies. The death rate was 20% and the recovery rate to mild illness in 14 days was 40%.
    Conclusion: In conclusion, this is the first clinical study of JS co-treatment in severe COVID-19 patients. JS co-treatment might reduce death rate and recovery time. Further large-scale clinical trials would be expected.
    Language English
    Publishing date 2022-10-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-8033
    ISSN 2210-8033
    DOI 10.1016/j.hermed.2022.100610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Chinese patent medicine, Jin-tang-ning, ameliorates hyperglycemia through improving β cell function in pre-diabetic KKAy mice.

    Liu, Shuai-Nan / Liu, Quan / Lei, Lei / Sun, Su-Juan / Li, Cai-Na / Huan, Yi / Hou, Shao-Cong / Shen, Zhu-Fang

    Chinese journal of natural medicines

    2020  Volume 18, Issue 11, Page(s) 827–836

    Abstract: Jin-tang-ning (JTN), a Chinese patent medicine, mainly comprised of Bombyx moriL., has been proved ...

    Abstract Jin-tang-ning (JTN), a Chinese patent medicine, mainly comprised of Bombyx moriL., has been proved to show α-glucosidase inhibitory efficacy and clinically effective for the treatment of type 2 diabetes (T2DM). Recently, we have reported that JTN could ameliorate postprandial hyperglycemia and improved β cell function in monosodium glutamate (MSG)-induced obese mice, suggesting that JTN might play a potential role in preventing the conversion of impaired glucose tolerance (IGT) to T2DM. In this study, we evaluated the effect of JTN on the progression of T2DM in the pre-diabetic KKAy mice. During the 10 weeks of treatment, blood biochemical analysis and oral glucose tolerance tests were performed to evaluate glucose and lipid profiles. The β cell function was quantified using hyperglycemic clamp at the end of the study. JTN-treated groups exhibited slowly raised fasting and postprandial blood glucose levels, and also ameliorated lipid profile. JTN improved glucose intolerance after 8 weeks of treatment. Meanwhile, JTN restored glucose-stimulated first-phase of insulin secretion and induced higher maximum insulin levels in the hyperglycemic clamp. Thus, to investigate the underlying mechanisms of JTN in protecting β cell function, the morphologic changes of the pancreatic islets were observed by optical microscope and immunofluorescence of hormones (insulin and glucagon). Pancreatic protein expression levels of key factors involving in insulin secretion-related pathway and ER stress were also detected by Western blot. Pre-diabetic KKAy mice exhibited a compensatory augment in β cell mass and abnormal α cell distribution. Long-term treatment of JTN recovered islet morphology accompanied by reducing α cell area in KKAy mice. JTN upregulated expression levels of glucokinase (GCK), pyruvate carboxylase (PCB) and pancreas duodenum homeobox-1 (PDX-1), while down-regulating C/EBP homologous protein (Chop) expression in pancreas of the hyperglycemic clamp, which indicated the improvement of mitochondrial metabolism and relief of endoplasmic reticulum (ER) stress of β cells after JTN treatment. These results will provide a new insight into exploring a novel strategy of JTN for protecting β cell function and preventing the onset of pre-diabetes to T2DM.
    MeSH term(s) Animals ; Biological Products/pharmacology ; Bombyx ; Endoplasmic Reticulum Stress ; Female ; Glucokinase ; Glucose Tolerance Test ; Homeodomain Proteins ; Hyperglycemia/drug therapy ; Insulin Secretion ; Insulin-Secreting Cells/drug effects ; Islets of Langerhans/drug effects ; Medicine, Chinese Traditional ; Mice ; Mice, Inbred C57BL ; Nonprescription Drugs/pharmacology ; Prediabetic State ; Pyruvate Carboxylase ; Trans-Activators ; Transcription Factor CHOP
    Chemical Substances Biological Products ; Ddit3 protein, mouse ; Homeodomain Proteins ; Nonprescription Drugs ; Trans-Activators ; pancreatic and duodenal homeobox 1 protein ; Transcription Factor CHOP (147336-12-7) ; Glucokinase (EC 2.7.1.2) ; Pyruvate Carboxylase (EC 6.4.1.1)
    Language English
    Publishing date 2020-12-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 2192577-X
    ISSN 1875-5364 ; 2095-6975 ; 1672-3651
    ISSN (online) 1875-5364
    ISSN 2095-6975 ; 1672-3651
    DOI 10.1016/S1875-5364(20)60023-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Chinese patent medicine, Jin-tang-ning, ameliorates hyperglycemia through improving β cell function in pre-diabetic KKAy mice

    LIU, Shuai-Nan / LIU, Quan / LEI, Lei / SUN, Su-Juan / LI, Cai-Na / HUAN, Yi / HOU, Shao-Cong / SHEN, Zhu-Fang

    Chinese journal of natural medicines. 2020 Nov., v. 18, no. 11

    2020  

    Abstract: Jin-tang-ning (JTN), a Chinese patent medicine, mainly comprised of Bombyx moriL., has been proved ...

    Abstract Jin-tang-ning (JTN), a Chinese patent medicine, mainly comprised of Bombyx moriL., has been proved to show α-glucosidase inhibitory efficacy and clinically effective for the treatment of type 2 diabetes (T2DM). Recently, we have reported that JTN could ameliorate postprandial hyperglycemia and improved β cell function in monosodium glutamate (MSG)-induced obese mice, suggesting that JTN might play a potential role in preventing the conversion of impaired glucose tolerance (IGT) to T2DM. In this study, we evaluated the effect of JTN on the progression of T2DM in the pre-diabetic KKAy mice. During the 10 weeks of treatment, blood biochemical analysis and oral glucose tolerance tests were performed to evaluate glucose and lipid profiles. The β cell function was quantified using hyperglycemic clamp at the end of the study. JTN-treated groups exhibited slowly raised fasting and postprandial blood glucose levels, and also ameliorated lipid profile. JTN improved glucose intolerance after 8 weeks of treatment. Meanwhile, JTN restored glucose-stimulated first-phase of insulin secretion and induced higher maximum insulin levels in the hyperglycemic clamp. Thus, to investigate the underlying mechanisms of JTN in protecting β cell function, the morphologic changes of the pancreatic islets were observed by optical microscope and immunofluorescence of hormones (insulin and glucagon). Pancreatic protein expression levels of key factors involving in insulin secretion-related pathway and ER stress were also detected by Western blot. Pre-diabetic KKAy mice exhibited a compensatory augment in β cell mass and abnormal α cell distribution. Long-term treatment of JTN recovered islet morphology accompanied by reducing α cell area in KKAy mice. JTN upregulated expression levels of glucokinase (GCK), pyruvate carboxylase (PCB) and pancreas duodenum homeobox-1 (PDX-1), while down-regulating C/EBP homologous protein (Chop) expression in pancreas of the hyperglycemic clamp, which indicated the improvement of mitochondrial metabolism and relief of endoplasmic reticulum (ER) stress of β cells after JTN treatment. These results will provide a new insight into exploring a novel strategy of JTN for protecting β cell function and preventing the onset of pre-diabetes to T2DM.
    Keywords Bombyx ; Western blotting ; area ; blood ; blood glucose ; duodenum ; endoplasmic reticulum ; fluorescent antibody technique ; glucagon ; glucokinase ; glucose ; glucose tolerance ; hyperglycemia ; insulin ; insulin secretion ; islets of Langerhans ; lipid composition ; mass ; medicine ; mice ; mitochondria ; monosodium glutamate ; noninsulin-dependent diabetes mellitus ; protein synthesis ; pyruvate carboxylase
    Language English
    Dates of publication 2020-11
    Size p. 827-836.
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 2192577-X
    ISSN 1875-5364 ; 2095-6975 ; 1672-3651
    ISSN (online) 1875-5364
    ISSN 2095-6975 ; 1672-3651
    DOI 10.1016/S1875-5364(20)60023-1
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Estimation of Urbanization Impacts on Local Weather: A Case Study in Northern China (Jing-Jin-Ji District)

    Su, Hui-Dong / Cao, Xuejian / Jia, Yang-Wen / Ni, Guangheng / Niu, Cunwen / Wang, Da-Cheng / Wang, Junhua / Zhang, Mingxi

    Water. 2019 Apr. 17, v. 11, no. 4

    2019  

    Abstract: With the past rapid economic development and large population growth, Jing-Jin-Ji District has been ... of past urbanization and potential future urbanization on the regional weather in the center of Jing-Jin ... the influence of urbanization on local weather in the Jing-Jin-Ji District at regional scales using a single ...

    Abstract With the past rapid economic development and large population growth, Jing-Jin-Ji District has been undergoing rapid urbanization, which has caused considerable regional weather changes in local regions. In this paper, we used the Weather Research and Forecasting (WRF) model to quantitatively analyze the effects of past urbanization and potential future urbanization on the regional weather in the center of Jing-Jin-Ji District. The hydrometeorological data from two weeks in July 2019 were used to simulate the influence of urbanization on local weather in the Jing-Jin-Ji District at regional scales using a single-layer canopy parameterization scheme. To better quantify the differences in temperature and precipitation induced by urbanization, three simulation scenarios were designed, which were no urban cover (NU), current urbanization cover (CU), and full urban land cover (FU), respectively. The results showed that: (1) Urbanization progress (from NU to CU and from CU to FU) in Jing-Jin-Ji District increased the daytime temperature, night temperature, and temperature difference between day and night, while decreasing the total rainfall and peak rainfall. (2) Compared with NU, the mean temperature of the CU and FU increased 0.3 K and 0.6 K, respectively, and the mean precipitation of CU and FU decreased by approximately 6% and 8.4%, respectively. (3) The main influence of urbanization on weather was reflected by the maximum temperature and peak rainfall, while the other impacts were relatively insignificant. (4) Compared with NU, the maximum temperature of CU and FU increased 0.82 K and 1.35 K, respectively, and the peak rainfall of NU and FU decreased by approximately 9.5% and 19.0%, respectively; The results of this study bring to light the urban management strategies for policy makers.
    Keywords canopy ; case studies ; hydrometeorology ; issues and policy ; land cover ; models ; night temperature ; population growth ; rain ; urbanization ; China
    Language English
    Dates of publication 2019-0417
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2521238-2
    ISSN 2073-4441
    ISSN 2073-4441
    DOI 10.3390/w11040797
    Database NAL-Catalogue (AGRICOLA)

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  7. Book: Shanghai jin du shi

    Su, Zhiliang

    The history of narcotics control in Shanghai

    2009  

    Title variant History of narcotics control in Shanghai
    Author's details Zhiliang Su ... [deng] zhu
    MeSH term(s) Drug and Narcotic Control/history ; Opium/adverse effects ; History, 19th Century ; History, 20th Century
    Keywords China
    Language Chinese ; English
    Size 2, 10, 335 p. ;, 24 cm.
    Edition Di 1 ban.
    Publisher Shanghai san lian shu dian
    Publishing place Shanghai
    Document type Book
    Note Table of contents also in English.
    ISBN 9787542629975 ; 7542629972
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: Exploration of anti-cancer effects and mechanisms of Zuo-Jin-Wan and its alkaloid components in vitro and in orthotopic HepG2 xenograft immunocompetent mice.

    Chou, Shun-Ting / Hsiang, Chien-Yun / Lo, Hsin-Yi / Huang, Hui-Fen / Lai, Ming-Tsung / Hsieh, Ching-Liang / Chiang, Su-Yin / Ho, Tin-Yun

    BMC complementary and alternative medicine

    2017  Volume 17, Issue 1, Page(s) 121

    Abstract: Background: Zuo-Jin-Wan (ZJW), a two-herb formula consisting of Coptis chinensis (CC) and ...

    Abstract Background: Zuo-Jin-Wan (ZJW), a two-herb formula consisting of Coptis chinensis (CC) and Evodia rutaecarpa (ER), is commonly used in traditional Chinese medicine for the treatment of cancers. However, the efficacies and mechanisms of ZJW and its alkaloid components on cancers are still unclear.
    Methods: Here we investigated the anti-cancer effects and mechanisms of ZJW, CC, ER, berberine, and evodiamine in cells and in intrahepatic xenograft mice.
    Results: Treatment of HepG2 cells with ZJW, CC, ER, berberine, and evodiamine significantly displayed cytotoxic effects in a dose- and time-dependent manner. Hierarchical cluster analysis of gene expression profiles showed that CC and ZJW shared a similar mechanism for the cytotoxic effects, suggesting that CC was the active ingredient of ZJW for anti-cancer activity. Network analysis further showed that c-myc was the likely key molecule involved in the regulation of ZJW-affected gene expression. A human hepatoma xenograft model was established by intrahepatic injection of HepG2 cells containing nuclear factor-κB-driven luciferase genes in immunocompetent mice. In vivo bioluminescence imaging showed that cells had been successfully transplanted in mouse liver. Oral administration of ZJW for 28 consecutive days led to a significant decrease in the accumulation of ascites, the ratio of tumor-to-liver, and the number of transplanted cells in livers.
    Conclusions: In conclusion, our findings suggested for the first time that ZJW significantly suppressed human cancer cell growth in orthotopic HepG2 xenograft-bearing immunocompetent mice. Moreover, c-myc might play a potent role in the cytotoxic mechanisms of ZJW, CC, ER, berberine, and evodiamine.
    MeSH term(s) Alkaloids/pharmacology ; Alkaloids/therapeutic use ; Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Berberine/pharmacology ; Berberine/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Coptis/chemistry ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Evodia/chemistry ; Female ; Hep G2 Cells ; Heterografts ; Humans ; Medicine, Chinese Traditional ; Mice, Inbred ICR ; Phytotherapy ; Quinazolines/pharmacology ; Quinazolines/therapeutic use
    Chemical Substances Alkaloids ; Antineoplastic Agents, Phytogenic ; Drugs, Chinese Herbal ; Quinazolines ; Zuo-Jin-Wan ; Berberine (0I8Y3P32UF) ; evodiamine (C01825BVNL)
    Language English
    Publishing date 2017-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050429-9
    ISSN 1472-6882 ; 1472-6882
    ISSN (online) 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-017-1586-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Establishment of an Experimental Breast Cancer ZHENG Model and Curative Effect Evaluation of Zuo-Jin Wan.

    Du, Jia / Sun, Yang / Wang, Xiu-Feng / Lu, Yi-Yu / Zhou, Qian-Mei / Su, Shi-Bing

    Evidence-based complementary and alternative medicine : eCAM

    2013  Volume 2013, Page(s) 324732

    Abstract: ... Jin Wan (ZJW). Our results showed that 4T1 LFISS mice have the features of LFISS including ...

    Abstract Herbal formulas based on the traditional Chinese medicine (TCM) syndrome (ZHENG) have been used as alternative treatments for breast cancer. However, there is a lack of the experimental animal ZHENG model for the evaluation of the herbal formulas. In this study, we have established 4T1 mouse breast cancer with Liver Fire Invading Stomach Syndrome model (4T1 LFISS mice) and investigated the effects of the herbal formula, Zuo-Jin Wan (ZJW). Our results showed that 4T1 LFISS mice have the features of LFISS including irritability, loss of appetite, yellow urine, chow, and a tail hot. Compared to untreated 4T1 LFISS mice, ZJW significantly reduced tumor weight and volume (P < 0.05), although it was weaker than Cisplatin. However, ZJW significantly increased the body weight and food intake of 4T1 LFISS mice and decreased serum ALT, AST, Cr, and BUN levels and ZHENG score (P < 0.05), while Cisplatin reduced the food intake, and body weight and increased serum ALT, AST, Cr, and BUN levels in 4T1 LFISS mice. Our study has provided a mouse breast cancer ZHENG model and showed that ZJW suppresses tumor growth and improves LFISS and kidney and liver functions in the 4T1 LFISS mice.
    Language English
    Publishing date 2013-11-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2013/324732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Conference proceedings: Quan qiu jin du de kai duan

    Su, Zhiliang

    1909 nian Shanghai wan guo jin yan hui = The beginning of global drug control : the 1909 Shanghai International Opium Conference

    2009  

    Title variant 1909 nian Shanghai wan guo jin yan hui ; Beginning of global drug control :
    Event/congress International Opium Conference (1909, ShanghaiChina)
    Author's details Su Zhiliang, Liu Xiaohong zhu
    MeSH term(s) Drug and Narcotic Control/history ; Opium/history ; History, 20th Century
    Language Chinese ; English
    Size [2], 5, 257 p. :, ill., maps, ports. ;, 24 cm.
    Edition Di 1 ban.
    Publisher Shanghai san lian shu dian
    Publishing place Shanghai Shi
    Document type Book ; Conference proceedings
    Note In Chinese; preface and table of contents also in English.
    ISBN 9787542629470 ; 7542629476
    Database Catalogue of the US National Library of Medicine (NLM)

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