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Article ; Online: Pembelajaran Angklung untuk SLB Bagian B Tuna Rungu Menggunakan Colouring Score Berbasis Multimedia

Diana Effendi

Dinamisia, Vol 3, Iss 2, Pp 205-

2020 Volume 213

Abstract: The introduction of angklung music especially for deaf students is done by replacing numeric notes with various hand movements by the teacher. It takes two teachers to produce harmonious music with one teacher focusing on melody and the other teacher ... ...

Abstract	The introduction of angklung music especially for deaf students is done by replacing numeric notes with various hand movements by the teacher. It takes two teachers to produce harmonious music with one teacher focusing on melody and the other teacher focusing on chords. However, hand movements are still limited to ordinary notes. The teacher's hand movements do not yet include the crescendo and decrescence notes. In addition, if one of the teachers is unable to attend, it cannot produce a harmonious music. To overcome this, multimedia-based angklung learning aids and android-based applications are made, where multimedia allows an angklung game to be carried out without the help of a trainer. So that it can replace the score that is usually designated by a trainer, it can be replaced with an animated color change (colouring score) when the angklung tone is played. In this study using the Development Research method, the procedures in this study are (1) determining the concept (concept), (2) Media Design (Design), (3) Material Collection (Material Collecting), (4) Manufacturing Process (Assembly) , and (5) (Testing) .In this study identified the needs of users (trainers and angklung players), designing application story boards that are used as a reference at the implementation stage.This learning activity does not replace the role of the trainer, but only as a media alternative in carrying out angklung training activities.
Keywords	angklung ; score ; colourings core method ; multimedia ; Technology (General) ; T1-995 ; Social Sciences ; H ; Social sciences (General) ; H1-99
Subject code	780
Language	Indonesian
Publishing date	2020-01-01T00:00:00Z
Publisher	Universitas Lancang Kuning
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effectiveness of COVID-19 Vaccines against SARS-CoV-2 Omicron Variant (B.1.1.529): A Systematic Review with Meta-Analysis and Meta-Regression.

Pratama, Nando Reza / Wafa, Ifan Ali / Budi, David Setyo / Sutanto, Henry / Asmarawati, Tri Pudy / Barlian Effendi, Gema / Wungu, Citrawati Dyah Kencono

Vaccines

2022 Volume 10, Issue 12

Abstract: Vaccine effectiveness (VE) and the urgency of booster vaccination against SARS-CoV-2 Omicron variant need evaluation. A systematic search was conducted from 1−6 April, 2022. VE difference (VED) estimates were assessed using random-effects and meta- ... ...

Abstract	Vaccine effectiveness (VE) and the urgency of booster vaccination against SARS-CoV-2 Omicron variant need evaluation. A systematic search was conducted from 1−6 April, 2022. VE difference (VED) estimates were assessed using random-effects and meta-regression analyses were performed for evaluating VE over time. Compared to full dose, booster dose of overall vaccines provided better protection against any and severe Omicron infections within 3 months (p < 0.001), and within 3 months or more in any, severe, and symptomatic infections (p < 0.001). From meta-regression analysis of overall vaccines, the full-dose VE against any and symptomatic Omicron infections reduced per month by 2.45% and 5.5%, respectively; whereas booster dose effectiveness against any and symptomatic Omicron infections reduced per month by 1.79% and 1.14%, respectively. The VE estimates of booster dose provide excellent protection against symptomatic infection compared to full dose. The VE estimates of Ad26.COV2.S, BNT162b2, ChAdOx1 nCov-19, and mRNA-1273 against Omicron infection are generally moderate, despite the VE estimates declining over time.
Language	English
Publishing date	2022-12-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10122180
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Article ; Online: AUXIN-BINDING-PROTEIN1 (ABP1) in phytochrome-B-controlled responses.

Effendi, Yunus / Jones, Alan M / Scherer, Günther F E

Journal of experimental botany

2013 Volume 64, Issue 16, Page(s) 5065–5074

Abstract: The auxin receptor ABP1 directly regulates plasma membrane activities including the number of PIN-formed (PIN) proteins and auxin efflux transport. Red light (R) mediated by phytochromes regulates the steady-state level of ABP1 and auxin-inducible growth ...

Abstract	The auxin receptor ABP1 directly regulates plasma membrane activities including the number of PIN-formed (PIN) proteins and auxin efflux transport. Red light (R) mediated by phytochromes regulates the steady-state level of ABP1 and auxin-inducible growth capacity in etiolated tissues but, until now, there has been no genetic proof that ABP1 and phytochrome regulation of elongation share a common mechanism for organ elongation. In far red (FR)-enriched light, hypocotyl lengths were larger in the abp1-5 and abp1/ABP1 mutants, but not in tir1-1, a null mutant of the TRANSPORT-INHIBITOR-RESPONSE1 auxin receptor. The polar auxin transport inhibitor naphthylphthalamic acid (NPA) decreased elongation in the low R:FR light-enriched white light (WL) condition more strongly than in the high red:FR light-enriched condition WL suggesting that auxin transport is an important condition for FR-induced elongation. The addition of NPA to hypocotyls grown in R- and FR-enriched light inhibited hypocotyl gravitropism to a greater extent in both abp1 mutants and in phyB-9 and phyA-211 than the wild-type hypocotyl, arguing for decreased phytochrome action in conjunction with auxin transport in abp1 mutants. Transcription of FR-enriched light-induced genes, including several genes regulated by auxin and shade, was reduced 3-5-fold in abp1-5 compared with Col and was very low in abp1/ABP1. In the phyB-9 mutant the expression of these reporter genes was 5-15-fold lower than in Col. In tir1-1 and the phyA-211 mutants shade-induced gene expression was greatly attenuated. Thus, ABP1 directly or indirectly participates in auxin and light signalling.
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis/growth & development ; Arabidopsis/metabolism ; Arabidopsis/radiation effects ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Gene Expression Regulation, Plant ; Hypocotyl/genetics ; Hypocotyl/growth & development ; Hypocotyl/metabolism ; Hypocotyl/radiation effects ; Indoleacetic Acids/metabolism ; Light ; Phytochrome A/genetics ; Phytochrome A/metabolism ; Phytochrome B/genetics ; Phytochrome B/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Seedlings/genetics ; Seedlings/growth & development ; Seedlings/metabolism ; Seedlings/radiation effects
Chemical Substances	Arabidopsis Proteins ; Indoleacetic Acids ; PHYA protein, Arabidopsis ; PHYB protein, Arabidopsis ; Phytochrome A ; Plant Proteins ; Receptors, Cell Surface ; auxin-binding protein 1 ; Phytochrome B (136250-22-1)
Language	English
Publishing date	2013-09-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/ert294
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Article: Colonoscopy, Biomarkers, and Targeted Therapy in Colorectal Cancer.

Effendi-Ys, Rustam

Acta medica Indonesiana

2022 Volume 54, Issue 3, Page(s) 476–486

Abstract: This review highlights the most versatile diagnostic test of colonoscopy for CRC. It remains the gold standard diagnostic tools for CRC, and to prevent CRC by screening and removing the polyp or premalignant lesions. This work also provides the most ... ...

Abstract	This review highlights the most versatile diagnostic test of colonoscopy for CRC. It remains the gold standard diagnostic tools for CRC, and to prevent CRC by screening and removing the polyp or premalignant lesions. This work also provides the most promising biomarkers, which highlights the application of the novel biomarkers in conjunction with clinical and pathologic features have allowed for more individualized approaches and targeted therapy to patients with CRC.CRC is the third most common cancer diagnosed, and the second leading cause of cancer-related deaths worldwide. With a population totaling 273,523,621 people, Indonesia has an estimated of 396,914 new cases of all cancers and 234,511 cancer-related deaths. Among those cancer cases, an estimated of 34,189 new CRC cases and 17,786 CRC deaths occurred in 2020. Most of CRC cases were located in the rectum compared to those in the distal colon or proximal colon. Clinical signs, symptoms and therapeutic approaches vary, depending on the stage and the location of CRC. Those cancer locations are different in terms of their associated molecular alterations.Biomarker tests of tumor tissue from colonoscopy biopsy can help doctors to select a specific CRC treatment, and the tests can be used to determine prognostic value, predictive factors and the targeted therapy. Targeted therapies are recommended for advanced or mCRC patients with KRAS/NRAS/BRAF mutated or wild-type tumors, HER2-amplified tumors, and NTRK gene fusion-positive, while immunotherapy is only offered for tumor with MSI-High (dMMR) status. The biomarkers and targeting approaches against colorectal CSCs are being developed and will be quite challenging.
MeSH term(s)	Biomarkers, Tumor/genetics ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Humans ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras)/genetics
Chemical Substances	Biomarkers, Tumor ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2022-09-09
Publishing country	Indonesia
Document type	Journal Article ; Review
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
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Article: AUXIN-BINDING-PROTEIN1 (ABP1) in phytochrome-B-controlled responses

Effendi, Yunus / Jones, Alan M / Scherer, Günther F. E

Journal of experimental botany. 2013 Nov., v. 64, no. 16

2013

Abstract	The auxin receptor ABP1 directly regulates plasma membrane activities including the number of PIN-formed (PIN) proteins and auxin efflux transport. Red light (R) mediated by phytochromes regulates the steady-state level of ABP1 and auxin-inducible growth capacity in etiolated tissues but, until now, there has been no genetic proof that ABP1 and phytochrome regulation of elongation share a common mechanism for organ elongation. In far red (FR)-enriched light, hypocotyl lengths were larger in the abp1-5 and abp1/ABP1 mutants, but not in tir1-1, a null mutant of the TRANSPORT-INHIBITOR-RESPONSE1 auxin receptor. The polar auxin transport inhibitor naphthylphthalamic acid (NPA) decreased elongation in the low R:FR light-enriched white light (WL) condition more strongly than in the high red:FR light-enriched condition WL suggesting that auxin transport is an important condition for FR-induced elongation. The addition of NPA to hypocotyls grown in R- and FR-enriched light inhibited hypocotyl gravitropism to a greater extent in both abp1 mutants and in phyB-9 and phyA-211 than the wild-type hypocotyl, arguing for decreased phytochrome action in conjunction with auxin transport in abp1 mutants. Transcription of FR-enriched light-induced genes, including several genes regulated by auxin and shade, was reduced 3-5-fold in abp1-5 compared with Col and was very low in abp1/ABP1. In the phyB-9 mutant the expression of these reporter genes was 5–15-fold lower than in Col. In tir1-1 and the phyA-211 mutants shade-induced gene expression was greatly attenuated. Thus, ABP1 directly or indirectly participates in auxin and light signalling.
Keywords	auxins ; etiolation ; gene expression ; gravitropism ; hypocotyls ; mutants ; naphthylphthalamic acid ; phytochrome ; plasma membrane ; red light ; reporter genes ; white light
Language	English
Dates of publication	2013-11
Size	p. 5065-5074.
Publishing place	Oxford University Press [etc.]
Document type	Article
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/ert294
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Comparison of Serum Interleukin-8 Levels Based on Severity of Liver Cirrhosis.

Rey, Imelda / Effendi-Ys, Rustam / Sukatendel, Khairani

Medical archives (Sarajevo, Bosnia and Herzegovina)

2024 Volume 78, Issue 2, Page(s) 92–94

Abstract: ... with hepatitis B virus (HBV) infection, as well as in the development of liver cirrhosis and cancer.: Objective ... from which we identified 1 individual with child-pugh A, 28 individuals with child-pugh B, and 41 individuals with child ... B and C patients did not exhibit any noteworthy differences during our analysis (p = 0.109, p>0.05 ...

Abstract	Background: The molecule known as Interleukin-8 (IL-8), a chemotactic leukocyte, has been found to have a crucial role in the perpetuation of the inflammatory environment that is associated with hepatitis B virus (HBV) infection, as well as in the development of liver cirrhosis and cancer. Objective: The aim of this study was to carefully examine the role of IL-8 in the inflammatory reaction and to compare the levels based on the severity of liver cirrhosis. Methods: The study was conducted from February 2018 to September 2018 at the Gastroenterohepatology Division, Internal medicine Department, Faculty of Medicine, Universitas Sumatera Utara. The study was designed as an analytic comparative, cross-sectional study. The liver cirrhosis patients who participated in this study met the inclusion criteria and provided informed consent. Results: A total of 70 patients were included in the study, from which we identified 1 individual with child-pugh A, 28 individuals with child-pugh B, and 41 individuals with child-pugh C. The serum level of IL-8 was found to be 98 (11-320) (pg/ml). The IL-8 levels between child-pugh B and C patients did not exhibit any noteworthy differences during our analysis (p = 0.109, p>0.05). Conclusion: There is no notable inequality in the levels of IL-8 across different stages of liver cirrhosis.
MeSH term(s)	Humans ; Interleukin-8 ; Cross-Sectional Studies ; Liver Cirrhosis ; Hepatitis B/complications ; Hepatitis B virus
Chemical Substances	Interleukin-8
Language	English
Publishing date	2024-03-19
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ZDB-ID	128782-5
ISSN	1986-5961 ; 0025-8083 ; 0350-199X
ISSN (online)	1986-5961
ISSN	0025-8083 ; 0350-199X
DOI	10.5455/medarh.2024.78.92-94
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Article ; Online: Al-Harakaḧ al-Jawhariyaḧ as Perfecting of Existence and Its Relation With Natural Sciences and Humanities

Rahmat Effendi

Jurnal Ushuluddin, Vol 29, Iss 1, Pp 71-

2021 Volume 86

Abstract: Mullā Ṣadrā’s discourse in the discourse of Islamic philosophy is only limited to ontological and epistemological aspects. There has not been much further investigation into Ṣadrā’s philosophy. This causes Ṣadrā’s philosophy to dwell only in the ... ...

Abstract	Mullā Ṣadrā’s discourse in the discourse of Islamic philosophy is only limited to ontological and epistemological aspects. There has not been much further investigation into Ṣadrā’s philosophy. This causes Ṣadrā’s philosophy to dwell only in the theoreticalmetaphysical realm. If we look further, Ṣadrā’s philosophy also has a relationship with the natural sciences and the humanities. Through the concept of al-harakaḧ al-jawhariyaḧ Ṣadrā explains this. Al-Harakaḧ al-jawhariyaḧ as the embodiment of the principle of existence (aṣālaḧ al-wujūd) is not only Ṣadrā’s ontology but as Islamic original thought in solving ontological problems since ancient times. Al-Harakaḧ al-jawhariyaḧ or substance motion is an immaterial gradual motion in every existenceentity, both material and non-material existence. Each mawjūd entity is an existence that experiences motion to point to one point, namely perfection. This perfection is in an immaterial state in every hierarchical reality of existence. Every existence, both human and natural, will move towards this essential perfection. This article will reveal that alharakaḧ al-jawhariyaḧ is a motion in the context of improvement in terms of substance and accident. It is also through this concept that Ṣadrā shows his relation to the natural sciences and humanities. This relationship is in the form of proving the existence of God, the creation of nature, and the social relations of society. This research is based on library research with a descriptive analysis method and holistic approach. In the end, al-harakaḧ al-jawhariyaḧ has a broad relationship in existence and all existing entities
Keywords	al-harakaḧ aljawhariyaḧ ; existence ; perfection ; natural sciences ; humanities ; Philosophy. Psychology. Religion ; B ; Islam. Bahai Faith. Theosophy ; etc ; BP1-610
Subject code	100
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Universitas Islam Negeri Sultan Syarif Kasim Riau
Document type	Article ; Online
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Article ; Online: The Changes of Amino Terminal Pro B-type Natriuretic Peptide (NT-proBNP) Concentration and Left Ventricular Ejection Fraction on Doxorubicin Chemotherapy Patients

Telly Kamelia / Sarwono Waspadji / Lukman Hakim Makmun / Shufrie Effendi / Muchlis Ramli / Ina Susanti Timan

Jurnal Penyakit Dalam Indonesia, Vol 4, Iss 2, Pp 78-

2017 Volume 83

Abstract: Introduction. Cancer patients who received chemotherapy regimen containing doxorubicin has been known to have serious side effect in heart, called as cardiotoxicity. The measurement of NT-proBNP proposed to be used as a new parameter to identify and ... ...

Abstract	Introduction. Cancer patients who received chemotherapy regimen containing doxorubicin has been known to have serious side effect in heart, called as cardiotoxicity. The measurement of NT-proBNP proposed to be used as a new parameter to identify and evaluate cardiotoxicity in cancer patients earlier before it has been manifested, superior than measurement of left ventricle ejection fraction (LVEF). The aims of this study to examine the changes of NT-proBNP concentration and LVEF on patients with cancer who receive chemotherapy regimen containing doxorubicin. Methods. The study used pre and post test design to observe the changes of NT-proBNP concentration and LVEF on the patients who receive naïve doxorubicin chemotherapy and after chemotherapy-cycle I to cyce IV at the Ciptomangunkusumo hospital, Jakarta. Echocardiography and NT-proBNP were examined on naïve chemotherapy and after chemotherapy each cycle. Statistical analysis was performed by using two way Anova and Friedman nonparametric test. Results. During the period of October 2007 to June 2008, a total of 29 consecutive patiets receiving doxorubicin chemotherapy regimen CHOP (Cyclophosphamide, doxorubicin, Vincristine, Prednisone and FAC-5 Fluorouracil, doxorubicin, Cyclophosphamide) were collected. The increase of median NT-proBNP concentration between naïve chemotherapy and: post chemotherapy cycle I was 32 pg/mL (12,5-124,6 pg/mL), post chemotherapy cycle II was 135 pg/mL (44-275,2 pg/mL), post chemotherapy cycle III was 275,1 pg/mL (97,8-907,2 pg/mL), post chemotherapy cycle IV was 514,6 pg/mL (80,6-6458,2 pg/mL). With Friedman test, p< 0,000. With Anova two way test, it was found the difference between naïve LVEF and LVEF: post chemotherapy cycle I was 5,1% (p 0,000), post chemotherapy cycle II 8,9% (p 0,000), post chemotherapy cycle III 11,2% (p 0,000), post chemotherapy cycle IV 12,5% (p 0,000). Conclusions. Elevated NT-proBNP concentration and LVEF reduction had been observed in doxorubicin chemotherapy patients.
Keywords	cardiotoxicity ; chemotherapy ; doxorubicin ; LVEF ; NT-proBNP ; Internal medicine ; RC31-1245
Subject code	610
Language	Indonesian
Publishing date	2017-06-01T00:00:00Z
Publisher	Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital
Document type	Article ; Online
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Article: DNA detection using nanostructured SERS substrates with Rhodamine B as Raman label.

Fang, Cheng / Agarwal, Ajay / Buddharaju, Kavitha Devi / Khalid, Nizamudin Mohamed / Salim, Shaik Mohamed / Widjaja, Effendi / Garland, Marc V / Balasubramanian, Narayanan / Kwong, Dim-Lee

Biosensors & bioelectronics

2008 Volume 24, Issue 2, Page(s) 216–221

Abstract: ... PNA-DNA-Zr was incubated with a Raman label, Rhodamine B (RB). The carboxylic acid group in RB reacted ...

Abstract	A technique is demonstrated to detect DNA hybridization at low concentrations, based on Surface-Enhanced Raman Scattering (SERS) using silicon nanostructures coated with gold-silver as substrate. Standard silicon process technologies were employed to fabricate the SERS substrates featuring nanogaps with a characteristic distance of 15+/-10nm. Target DNA was hybridized with cysteine-modified Peptide Nucleic Acids (PNA), which was previously fixed into the nanogaps as the capture sites. After hybridization, the introduced phosphate groups from the backbone of the target DNA showed strong affinity to an inorganic linker, Zr(4+), so that resulting in the assembly substrate-PNA-DNA-Zr. Since PNA does not possess phosphate groups, the linker is avoided when there is no hybridization from the complimentary DNA. Subsequently, the assembly of substrate-PNA-DNA-Zr was incubated with a Raman label, Rhodamine B (RB). The carboxylic acid group in RB reacted with the linker Zr(4+) allowing this Raman Label to be attached to the assembly substrate-PNA-DNA-Zr. The Raman peaks corresponding to RB were selected to detect the target DNA, with a detection limit of 1 x 10(-12)M.
MeSH term(s)	Biosensing Techniques/instrumentation ; DNA/analysis ; DNA/chemistry ; DNA/genetics ; Equipment Design ; Equipment Failure Analysis ; Nanostructures/chemistry ; Nanostructures/ultrastructure ; Nanotechnology/instrumentation ; Reproducibility of Results ; Rhodamines/chemistry ; Sensitivity and Specificity ; Spectrum Analysis, Raman/instrumentation ; Staining and Labeling
Chemical Substances	Rhodamines ; DNA (9007-49-2) ; rhodamine B (K7G5SCF8IL)
Language	English
Publishing date	2008-10-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2008.03.032
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Article ; Online: DesC1 and DesC2, Δ9 Fatty Acid Desaturases of Filamentous Cyanobacteria: Essentiality and Complementarity.

Effendi, Devi B / Suzuki, Iwane / Murata, Norio / Awai, Koichiro

Plant & cell physiology

2023

Abstract: DesC1 and DesC2, which are fatty acid desaturases found in cyanobacteria, are responsible for introducing a double bond at the Δ9 position of fatty-acyl chains, which are subsequently esterified to the sn-1 and sn-2 positions of the glycerol moiety, ... ...

Abstract	DesC1 and DesC2, which are fatty acid desaturases found in cyanobacteria, are responsible for introducing a double bond at the Δ9 position of fatty-acyl chains, which are subsequently esterified to the sn-1 and sn-2 positions of the glycerol moiety, respectively. However, since the discovery of these two desaturases in the Antarctic cyanobacterium Nostoc sp. SO-36, no further research has been reported. This study presents a comprehensive characterization of DesC1 and DesC2 through targeted mutagenesis and transformation using two cyanobacteria strains: Anabaena sp. PCC 7120, comprising both desaturases, and Synechocystis sp. PCC 6803, containing a single Δ9 desaturase (hereafter referred to as DesCs) sharing similarity with DesC1 in amino acid sequence. The results suggested that both DesC1 and DesC2 were essential in Anabaena sp. PCC 7120 and that DesC1, but not DesC2, complemented DesCs in Synechocystis sp. PCC 6803. In addition, DesC2 from Anabaena sp. PCC 7120 desaturated fatty acids esterified to the sn-2 position of the glycerol moiety in Synechocystis sp. PCC 6803.
Language	English
Publishing date	2023-12-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	208907-5
ISSN	1471-9053 ; 0032-0781
ISSN (online)	1471-9053
ISSN	0032-0781
DOI	10.1093/pcp/pcad153
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