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  1. Article ; Online: Comment on Kutz et al. Comparative Cardiovascular Effectiveness and Safety of SGLT-2 Inhibitors, GLP-1 Receptor Agonists, and DPP-4 Inhibitors According to Frailty in Type 2 Diabetes. Diabetes Care 2023;46:2004-2014.

    Maltese, Giuseppe / Sinclair, Alan J

    Diabetes care

    2024  Volume 47, Issue 4, Page(s) e32–e33

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/drug therapy ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Glucagon-Like Peptide-1 Receptor Agonists ; Frailty ; Hypoglycemic Agents/adverse effects
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Dipeptidyl-Peptidase IV Inhibitors ; Glucagon-Like Peptide-1 Receptor Agonists ; Hypoglycemic Agents
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc23-2420
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    Zs.MO 365: Show issues

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  2. Article ; Online: Legends of allergy and immunology: Sergio Bonini.

    Maltese, Giuseppe / Rasi, Guido

    Allergy

    2021  Volume 76, Issue 10, Page(s) 3227–3229

    MeSH term(s) Allergy and Immunology ; Humans ; Hypersensitivity
    Language English
    Publishing date 2021-05-21
    Publishing country Denmark
    Document type News
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14847
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  3. Article ; Online: Mediterranean diet, type 2 diabetes prevention and healthy ageing: Do we need more evidence?

    Maltese, Giuseppe / Koufakis, Theocharis / Kotsa, Kalliopi / Basile, Giorgio / Siow, Richard

    Diabetes research and clinical practice

    2023  Volume 205, Page(s) 110928

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/prevention & control ; Diet, Mediterranean ; Healthy Aging ; Cardiovascular Diseases/prevention & control
    Language English
    Publishing date 2023-09-29
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2023.110928
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    Zs.A 2047: Show issues Location:
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  4. Article ; Online: Antiatherosclerotic Effects of Sodium-Glucose Cotransporter 2 Inhibitors: An Underrecognized Piece of the Big Puzzle?

    Koufakis, Theocharis / Vas, Prashanth / Maltese, Giuseppe / Kotsa, Kalliopi

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 10, Page(s) e4244–e4245

    MeSH term(s) Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Atherosclerosis/prevention & control
    Chemical Substances Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac116
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  5. Article ; Online: Toward a new model for the management of type 2 diabetes: The mountain is there and there is no other option than to climb it.

    Koufakis, Theocharis / Maltese, Giuseppe / Kotsa, Kalliopi

    Pharmacological research

    2022  Volume 184, Page(s) 106443

    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide-1 Receptor ; Humans ; Hypoglycemic Agents/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2022-09-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2022.106443
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  6. Article ; Online: Can sodium-glucose cotransporter 2 inhibitors 'spin the thread of life'?

    Maltese, Giuseppe / Koufakis, Theocharis / Kotsa, Kalliopi / Karalliedde, Janaka

    Trends in endocrinology and metabolism: TEM

    2022  Volume 34, Issue 1, Page(s) 1–4

    Abstract: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) were first used as antidiabetic agents that lower the blood glucose levels by promoting glycosuria. In recent years, randomised clinical trials have demonstrated that SGLT2i reduce cardiovascular-renal ... ...

    Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT2i) were first used as antidiabetic agents that lower the blood glucose levels by promoting glycosuria. In recent years, randomised clinical trials have demonstrated that SGLT2i reduce cardiovascular-renal events and all-cause mortality in people with and without diabetes. The cardio-renal benefits observed are independent of glucose lowering effect and multiple mechanisms have been proposed for these results. SGLT2i can exert anti-ageing effects on the vasculature and other body organs through several signalling pathways including the activation of the nuclear factor erythroid-2-related factor 2 and the induction of antioxidant enzymes. We speculate that the pro-longevity effects of the SGLT2i are mediated by soluble Klotho, an anti-ageing kidney-derived hormone and an emerging therapeutic target for cardio-renal diseases.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Glucose ; Sodium/therapeutic use
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2022.10.002
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    Zs.A 2999: Show issues Location:
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  7. Article ; Online: Interdisciplinary assessment and diagnostic algorithm: The role of the cardiologist.

    Rosano, Giuseppe M C / Vitale, Cristiana / Maltese, Giuseppe

    Diabetes research and clinical practice

    2021  Volume 176, Page(s) 108851

    Abstract: Patients with diabetes have an increased risk of developing heart failure and those with heart failure are at higher risk of developing diabetes. In patients with diabetes antidiabetic medications and the metabolic alterations of diabetes increase the ... ...

    Abstract Patients with diabetes have an increased risk of developing heart failure and those with heart failure are at higher risk of developing diabetes. In patients with diabetes antidiabetic medications and the metabolic alterations of diabetes increase the risk of developing heart failure. In diabetic patients with heart failure and in those with an increased likelihood of developing the disease a stepwise approach based on the use of natriuretic peptides and echocardiography to rule out the presence of heart failure should be used. Once the diagnosis of heart failure is established it will be important to define the phenotype according to the left ventricular function and, where appropriate, use additional tests to identify possible additional underlying causes of heart failure like coronary artery disease. A multidisciplinary heart failure management programs is recommended in all patients with diabetes mellitus and heart failure to enable appropriate investigations, accurate diagnosis, and appropriate agreed evidence-based therapy and care plan. The implementation of a multidisciplinary heart failure management program requires a multidisciplinary team that will have to follow the patients throughout the whole heart failure trajectory and that should consider a holistic approach to the diabetic patient with heart failure rather than focussing merely on either heart failure or diabetes.
    MeSH term(s) Algorithms ; Cardiologists ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/drug therapy ; Diabetic Angiopathies/physiopathology ; Diagnostic Techniques, Cardiovascular ; Diagnostic Techniques, Endocrine ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/etiology ; Heart Failure/physiopathology ; Humans ; Hypoglycemic Agents/therapeutic use ; Patient Care Team ; Physician's Role ; Prognosis ; Ventricular Function, Left/physiology
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2021-05-04
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2021.108851
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  8. Article ; Online: The importance of sleep quality, quantity, and chronotype in the management of diabetes: Is it time to wake up?

    Koufakis, Theocharis / Maltese, Giuseppe / Popovic, Djordje S / Kotsa, Kalliopi

    Journal of diabetes

    2022  Volume 14, Issue 9, Page(s) 633–634

    MeSH term(s) Circadian Rhythm ; Diabetes Mellitus/therapy ; Humans ; Sleep ; Sleep Quality ; Sleep Wake Disorders ; Surveys and Questionnaires
    Language English
    Publishing date 2022-09-09
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 2503337-2
    ISSN 1753-0407 ; 1753-0393
    ISSN (online) 1753-0407
    ISSN 1753-0393
    DOI 10.1111/1753-0407.13313
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  9. Article ; Online: COVID-19 Clinical trials: Quality matters more than quantity.

    Bonini, Sergio / Maltese, Giuseppe

    Allergy

    2020  Volume 75, Issue 10, Page(s) 2542–2547

    Abstract: Despite the ferment aroused in the scientific community by the COVID-19 outbreak and the over 11,000 papers listed in PubMed, published evidence on safe and effective drugs has not progressed yet at the same speed of the pandemic. However, clinical ... ...

    Abstract Despite the ferment aroused in the scientific community by the COVID-19 outbreak and the over 11,000 papers listed in PubMed, published evidence on safe and effective drugs has not progressed yet at the same speed of the pandemic. However, clinical research is rapidly progressing, as shown by the hundreds of registered clinical trials on candidate drugs for COVID-19. Unfortunately, information on protocols of individual studies differs from registry to registry. Furthermore, study designs, criteria for stratification of patients and choice of outcomes are quite heterogeneous. All this makes data sharing and secondary analysis difficult. At last, small single centre studies and the use of drugs on a compassionate basis should be replaced by highly powered, multi-centre, multi-arm clinical trials, in order to provide the required evidence of safety and efficacy of novel or repurposed candidate drugs. Hopefully, the efforts of clinical researchers in the fight against the SARS Cov-2 will result into the identification of effective treatments. To make this possible, clinical research should be oriented by guidelines for more harmonized high-quality studies and by a united commitment of the scientific community to share personal knowledge and data. Allergists and clinical immunologists should have a leading role in this unprecedent challenge.
    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Research Design ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14409
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  10. Article ; Online: Sodium-glucose cotransporter 2 inhibitors in frail, older people with type 2 diabetes and heart failure: do we have enough evidence to confidently support the use?

    Koufakis, Theocharis / Doumas, Michael N / Bargiota, Alexandra / Kotsa, Kalliopi / Maltese, Giuseppe

    Expert review of clinical pharmacology

    2023  Volume 16, Issue 9, Page(s) 771–774

    MeSH term(s) Humans ; Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Frail Elderly ; Heart Failure/drug therapy ; Sodium ; Glucose
    Chemical Substances Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-08-18
    Publishing country England
    Document type Editorial ; Comment
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2023.2247977
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