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Article ; Online: CYCU-3: an Al(III)-based MOF for SO

Obeso, Juan L / López-Cervantes, Valeria B / Flores, Catalina V / Martínez, Ana / Amador-Sánchez, Yoarhy A / Portillo-Velez, N S / Lara-García, Hugo A / Leyva, Carolina / Solis-Ibarra, Diego / Peralta, Ricardo A

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 10, Page(s) 4790–4796

Abstract: The Al(III)-based MOF CYCU-3 exhibits a relevant ... ...

Abstract	The Al(III)-based MOF CYCU-3 exhibits a relevant SO
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt04073a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SU-101: a Bi(III)-based metal-organic framework as an efficient heterogeneous catalyst for the CO

Obeso, Juan L / Flores, J Gabriel / Flores, Catalina V / López-Cervantes, Valeria B / Martínez-Jiménez, V / de Los Reyes, José Antonio / Lima, Enrique / Solis-Ibarra, Diego / Ibarra, Ilich A / Leyva, Carolina / Peralta, Ricardo A

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 35, Page(s) 12490–12495

Abstract: A non-porous version of SU-101 (herein n-SU-101) was evaluated for the ... ...

Abstract	A non-porous version of SU-101 (herein n-SU-101) was evaluated for the CO
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt01743e
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Article ; Online: The landscape of the immunoglobulin repertoire in endemic pemphigus foliaceus.

Calonga-Solís, Verónica / Olbrich, Michael / Ott, Fabian / Adelman Cipolla, Gabriel / Malheiros, Danielle / Künstner, Axel / Farias, Ticiana D J / Camargo, Carolina M / Petzl-Erler, Maria Luiza / Busch, Hauke / Fähnrich, Anke / Augusto, Danillo G

Frontiers in immunology

2023 Volume 14, Page(s) 1189251

Abstract: ... patients in remission without treatment (n=6); and two control groups iv) from the endemic (n=6) and v) non ...

Abstract	Introduction: Primarily driven by autoreactive B cells, pemphigus foliaceus (PF) is an uncommon autoimmune blistering skin disease of sporadic occurrence worldwide. However, PF reaches a prevalence of 3% in the endemic areas of Brazil, the highest ever registered for any autoimmune disease, which indicates environmental factors influencing the immune response in susceptible individuals. We aimed to provide insights into the immune repertoire of patients with PF living in the endemic region of the disease, compared to healthy individuals from the endemic region and a non-endemic area. Methods: We characterized the B-cell repertoire in i) nontreated patients (n=5); ii) patients under immunosuppressive treatment (n=5); iii) patients in remission without treatment (n=6); and two control groups iv) from the endemic (n=6) and v) non-endemic areas in Brazil (n=4). We used total RNA extracted from peripheral blood mononuclear cells and performed a comprehensive characterization of the variable region of immunoglobulin heavy chain (IGH) in IgG and IgM using next-generation sequencing. Results: Compared to individuals from a different area, we observed remarkably lower clonotype diversity in the B-cell immune repertoire of patients and controls from the endemic area ( Discussion: Our results indicate that environmental factors, in addition to disease state, impact the characteristics of the repertoire. Our findings can be applied to further investigation of the environmental factors that trigger pemphigus and expand the knowledge for identifying new targeted and more effective therapies.
MeSH term(s)	Humans ; Pemphigus ; Leukocytes, Mononuclear ; Blister ; Immunoglobulins
Chemical Substances	Immunoglobulins
Language	English
Publishing date	2023-07-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1189251
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Article ; Online: Evaluation of the catalytic activity of Zn-MOF-74 for the alcoholysis of cyclohexene oxide.

Flores, J Gabriel / Obeso, Juan L / Martínez-Jiménez, V / Martín-Guaregua, Nancy / Islas-Jácome, Alejandro / González-Zamora, Eduardo / Serrano-Espejel, Héctor / Mondragón-Rodríguez, Britney / Leyva, Carolina / Solís-Casados, D A / Ibarra, Ilich A / Peralta, Ricardo A / Aguilar-Pliego, Julia / Antonio de Los Reyes, José

RSC advances

2023 Volume 13, Issue 39, Page(s) 27174–27179

Abstract: In the present work, nanocrystalline Zn-MOF-74 is shown to be a heterogeneous catalyst for the acid-catalyzed ring-opening alcoholysis of cyclohexene oxide. The results corroborated that accessible open metal sites within the material are critical ... ...

Abstract	In the present work, nanocrystalline Zn-MOF-74 is shown to be a heterogeneous catalyst for the acid-catalyzed ring-opening alcoholysis of cyclohexene oxide. The results corroborated that accessible open metal sites within the material are critical conditions (Zn(ii) Lewis acid sites) for this reaction. Zn-MOF-74 was tested at three different temperatures (30, 40, and 50 °C) for the alcoholysis reaction. Furthermore, the cyclohexene oxide conversion was 94% in less than two days. A comparison of the catalytic activity with different crystal sizes of Zn-MOF-74 and the homogenous phase, zinc acetate, was conducted. Zn-MOF-74 exhibited excellent catalytic cyclability for three cycles without losing its activity. The material showed chemical stability by retaining its crystalline structure after the reaction and cyclability process.
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra03122e
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Article: Optimizing perinatal wellbeing in pregnancy with obesity: a clinical trial with a multi-component nutrition intervention for prevention of gestational diabetes and infant growth and neurodevelopment impairment.

Perichart-Perera, Otilia / Reyes-Muñoz, Enrique / Borboa-Olivares, Hector / Rodríguez-Cano, Ameyalli M / Solis Paredes, Juan Mario / Hernández-Hernández, Larissa / Rodríguez-Hernández, Carolina / González-Ludlow, Isabel / Suárez-Rico, Blanca V / Sánchez-Martínez, Maribel / Torres-Herrera, Ursula / Canul-Euan, Arturo Alejandro / Tolentino-Dolores, Maricruz / Espejel-Nuñez, Aurora / Estrada-Gutierrez, Guadalupe

Frontiers in medicine

2024 Volume 11, Page(s) 1339428

Abstract: Pregnancy complicated by obesity represents an increased risk of unfavorable perinatal outcomes such as gestational diabetes mellitus (GDM), hypertensive disorders in pregnancy, preterm birth, and impaired fetal growth, among others. Obesity is ... ...

Abstract	Pregnancy complicated by obesity represents an increased risk of unfavorable perinatal outcomes such as gestational diabetes mellitus (GDM), hypertensive disorders in pregnancy, preterm birth, and impaired fetal growth, among others. Obesity is associated with deficiencies of micronutrients, and pregnant women with obesity may have higher needs. The intrauterine environment in pregnancies complicated with obesity is characterized by inflammation and oxidative stress, where maternal nutrition and metabolic status have significant influence and are critical in maternal health and in fetal programming of health in the offspring later in life. Comprehensive lifestyle interventions, including intensive nutrition care, are associated with a lower risk of adverse perinatal outcomes. Routine supplementation during pregnancy includes folic acid and iron; other nutrient supplementation is recommended for high-risk women or women in low-middle income countries. This study is an open label randomized clinical trial of parallel groups (UMIN Clinical Trials Registry: UMIN000052753, https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000060194) to evaluate the effect of an intensive nutrition therapy and nutrient supplementation intervention (folic acid, iron, vitamin D, omega 3 fatty acids, myo-inositol and micronutrients) in pregnant women with obesity on the prevention of GDM, other perinatal outcomes, maternal and newborn nutritional status, and infant growth, adiposity, and neurodevelopment compared to usual care. Given the absence of established nutritional guidelines for managing obesity during pregnancy, there is a pressing need to develop and implement new nutritional programs to enhance perinatal outcomes.
Language	English
Publishing date	2024-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1339428
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Article ; Online: Inherited human ezrin deficiency impairs adaptive immunity.

García-Solís, Blanca / Van Den Rym, Ana / Martinez-Martínez, Laura / Franco, Teresa / Pérez-Caraballo, Jareb J / Markle, Janet / Cubillos-Zapata, Carolina / Marín, Ana V / Recio, María J / Regueiro, José R / Navarro-Zapata, Alfonso / Mestre-Durán, Carmen / Ferreras, Cristina / Martín Cotázar, Carla / Mena, Roció / de la Calle-Fabregat, Carlos / López-Lera, Alberto / Fernández Arquero, Miguel / Pérez-Martínez, Antonio /

López-Collazo, Eduardo / Sánchez-Ramón, Silvia / Casanova, Jean-Laurent / Martínez-Barricarte, Rubén / de la Calle-Martín, Oscar / Pérez de Diego, Rebeca

The Journal of allergy and clinical immunology

2023 Volume 152, Issue 4, Page(s) 997–1009.e11

Abstract: Background: Inborn errors of immunity (IEI) are a group of monogenic diseases that confer susceptibility to infection, autoimmunity, and cancer. Despite the life-threatening consequences of some IEI, their genetic cause remains unknown in many patients.! ...

Abstract	Background: Inborn errors of immunity (IEI) are a group of monogenic diseases that confer susceptibility to infection, autoimmunity, and cancer. Despite the life-threatening consequences of some IEI, their genetic cause remains unknown in many patients. Objective: We investigated a patient with an IEI of unknown genetic etiology. Methods: Whole-exome sequencing identified a homozygous missense mutation of the gene encoding ezrin (EZR), substituting a threonine for an alanine at position 129. Results: Ezrin is one of the subunits of the ezrin, radixin, and moesin (ERM) complex. The ERM complex links the plasma membrane to the cytoskeleton and is crucial for the assembly of an efficient immune response. The A129T mutation abolishes basal phosphorylation and decreases calcium signaling, leading to complete loss of function. Consistent with the pleiotropic function of ezrin in myriad immune cells, multidimensional immunophenotyping by mass and flow cytometry revealed that in addition to hypogammaglobulinemia, the patient had low frequencies of switched memory B cells, CD4 Conclusions: Autosomal-recessive human ezrin deficiency is a newly recognized genetic cause of B-cell deficiency affecting cellular and humoral immunity.
MeSH term(s)	Humans ; CD8-Positive T-Lymphocytes ; Cytoskeleton/metabolism ; Cell Membrane/metabolism ; Immunity, Humoral
Chemical Substances	ezrin
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2023.05.022
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Article: Cancer Cachexia Affects Patients with Head and Neck Cancer in All Stages of Disease: A Prospective Cross-Sectional Study

Solís-Martínez, Obed / Álvarez-Altamirano, Karolina / Cardenas, Diana / Trujillo-Cabrera, Yanelly / Fuchs-Tarlovsky, Vanessa

Nutrition and cancer. 2022 Jan. 2, v. 74, no. 1

2022

Abstract: The aim of the study was to determine the prevalence of cancer cachexia according to the clinical stage and determine differences in body composition, usual energy intake, and pro-inflammatory profile between cachectic and non-cachectic patients newly ... ...

Abstract	The aim of the study was to determine the prevalence of cancer cachexia according to the clinical stage and determine differences in body composition, usual energy intake, and pro-inflammatory profile between cachectic and non-cachectic patients newly diagnosed with head and neck squamous cell carcinoma (HNSCC). A cross-sectional study was conducted in adult patients diagnosed with HNSCC admitted to the oncology unit before starting cancer treatment. Cancer cachexia was assessed according to Fearon criteria, and patients were divided into two groups: cachectic and non-cachectic patients. Body composition measured by bioelectrical impedance, energy intake, and biochemical and inflammatory markers were assessed. Comparative analyses were performed Student’s-T test, using one-way ANOVA, chi-square and Mann Whitney-U test. Of the 79 consecutive patients included in the analysis, 72% (n = 57; 61 ± 15 years) were classified as cachectic and 28% (n = 22;59 ± 10 years) as non-cachectic. According to clinical stage, the prevalence of cachexia was stage I = 8.8%, stage II = 15.8%, stage III = 33.3% and stage IV = 42.1% (P = 0.564) and phase angle showed to be different between these groups (P < 0.05). Body composition showed that fat-free mass and total body water were significantly lower in patients with cachexia (p < 0.05). No differences were observed in phase angle, food intake or inflammatory markers between cachectic and non-cachectic patients. Cancer-cachexia is prevalent in all clinical stages in newly diagnosed patients with HNSCC. Early identification of cancer cachexia will allow initiate specialized nutrition support in a timely manner.
Keywords	adults ; bioelectrical impedance ; body water ; cachexia ; cancer therapy ; cross-sectional studies ; energy intake ; food intake ; head and neck squamous cell carcinoma ; lean body mass
Language	English
Dates of publication	2022-0102
Size	p. 82-89.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2020.1869792
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Mixed Particulate Emulsifiers on Spray-Dried Avocado Oil-in-Water Pickering Emulsions.

Espinosa-Solis, Vicente / García-Tejeda, Yunia Verónica / Portilla-Rivera, Oscar Manuel / Chávez-Murillo, Carolina Estefania / Barrera-Figueroa, Víctor

Polymers

2022 Volume 14, Issue 15

Abstract: Avocado oil is a very valuable agro-industrial product which can be perishable in a short time if it is not stored in the right conditions. The encapsulation of the oils through the spray drying technique protects them from oxidation and facilitates ... ...

Abstract	Avocado oil is a very valuable agro-industrial product which can be perishable in a short time if it is not stored in the right conditions. The encapsulation of the oils through the spray drying technique protects them from oxidation and facilitates their incorporation into different pharmaceutical products and food matrices; however, the selection of environmentally friendly emulsifiers is a great challenge. Four formulations of the following solid particles: Gum Arabic, HI-CAP
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14153064
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Article ; Online: Central venous access by trainees: a systematic review and meta-analysis of the use of simulation to improve success rate on patients.

Madenci, Arin L / Solis, Carolina V / de Moya, Marc A

Simulation in healthcare : journal of the Society for Simulation in Healthcare

2014 Volume 9, Issue 1, Page(s) 7–14

Abstract: Introduction: Simulation training for invasive procedures may improve patient safety by enabling efficient training. This study is a meta-analysis with rigorous inclusion and exclusion criteria designed to assess the real patient procedural success of ... ...

Abstract	Introduction: Simulation training for invasive procedures may improve patient safety by enabling efficient training. This study is a meta-analysis with rigorous inclusion and exclusion criteria designed to assess the real patient procedural success of simulation training for central venous access. Methods: Published randomized controlled trials and prospective 2-group cohort studies that used simulation for the training of procedures involving central venous access were identified. The quality of each study was assessed. The primary outcome was the proportion of trainees who demonstrated the ability to successfully complete the procedure. Secondary outcomes included the mean number of attempts to procedural success and periprocedural adverse events. Proportions were compared between groups using risk ratios (RRs), whereas continuous variables were compared using weighted mean differences. Random-effects analysis was used to determine pooled effect sizes. Results: We identified 550 studies, of which 5 (3 randomized controlled trials, 2 prospective 2-group cohort studies) studies of central venous catheter (CVC) insertion were included in the meta-analysis, composed of 407 medical trainees. The simulation group had a significantly larger proportion of trainees who successfully placed CVCs (RR, 1.09; 95% confidence interval [CI], 1.03-1.16, P<0.01). In addition, the simulation group had significantly fewer mean attempts to CVC insertion (weighted mean difference, -1.42; 95% CI, -2.34 to -0.49, P<0.01). There was no significant difference in the rate of adverse events between the groups (RR, 0.50; 95% CI, 0.19-1.29; P=0.15). Conclusions: Training programs should consider adopting simulation training for CVC insertion to improve the real patient procedural success of trainees.
MeSH term(s)	Catheterization, Central Venous/standards ; Clinical Competence/standards ; Humans ; Inservice Training/methods ; Patient Simulation ; Students, Medical
Language	English
Publishing date	2014-02
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	2223429-9
ISSN	1559-713X ; 1559-2332
ISSN (online)	1559-713X
ISSN	1559-2332
DOI	10.1097/SIH.0b013e3182a3df26
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Article ; Online: Cohort profile: evaluation of immune response and household transmission of SARS-CoV-2 in Costa Rica: the RESPIRA study.

Loria, Viviana / Aparicio, Amada / Hildesheim, Allan / Cortés, Bernal / Barrientos, Gloriana / Retana, Daniela / Sun, Kaiyuan / Ocampo, Rebeca / Prevots, D Rebecca / Zúñiga, Michael / Waterboer, Tim / Wong-McClure, Roy / Morera, Melvin / Butt, Julia / Binder, Marco / Abdelnour, Arturo / Calderón, Alejandro / Gail, Mitchell H / Pfeiffer, Ruth M /

Solís, Cristina Barboza / Fantin, Romain / Vanegas, Juan Carlos / Mercado, Rachel / Ávila, Carlos / Porras, Carolina / Herrero, Rolando

BMJ open

2023 Volume 13, Issue 12, Page(s) e071284

Abstract: Purpose: The RESPIRA cohort aims to describe the nature, magnitude, time course and efficacy of the immune response to SARS-CoV-2 infection and vaccination, population prevalence, and household transmission of COVID-19.: Participants: From November ... ...

Abstract	Purpose: The RESPIRA cohort aims to describe the nature, magnitude, time course and efficacy of the immune response to SARS-CoV-2 infection and vaccination, population prevalence, and household transmission of COVID-19. Participants: From November 2020, we selected age-stratified random samples of COVID-19 cases from Costa Rica confirmed by PCR. For each case, two population-based controls, matched on age, sex and census tract were recruited, supplemented with hospitalised cases and household contacts. Participants were interviewed and blood and saliva collected for antibodies and PCR tests. Participants will be followed for 2 years to assess antibody response and infection incidence. Findings to date: Recruitment included 3860 individuals: 1150 COVID-19 cases, 1999 population controls and 719 household contacts from 304 index cases. The age and regional distribution of cases was as planned, including four age strata, 30% rural and 70% urban. The control cohort had similar sex, age and regional distribution as the cases according to the study design. Among the 1999 controls recruited, 6.8% reported at enrolment having had COVID-19 and an additional 12.5% had antibodies against SARS-CoV-2. Compliance with visits and specimens has been close to 70% during the first 18 months of follow-up. During the study, national vaccination was implemented and nearly 90% of our cohort participants were vaccinated during follow-up. Future plans: RESPIRA will enable multiple analyses, including population prevalence of infection, clinical, behavioural, immunological and genetic risk factors for SARS-CoV-2 acquisition and severity, and determinants of household transmission. We are conducting retrospective and prospective assessment of antibody levels, their determinants and their protective efficacy after infection and vaccination, the impact of long-COVID and a series of ancillary studies. Follow-up continues with bimonthly saliva collection for PCR testing and biannual blood collection for immune response analyses. Follow-up will be completed in early 2024. Trial registration number: NCT04537338.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Post-Acute COVID-19 Syndrome ; Costa Rica/epidemiology ; Prospective Studies ; Retrospective Studies ; Antibodies ; Double-Blind Method ; Immunity
Chemical Substances	Antibodies
Language	English
Publishing date	2023-12-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-071284
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