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  1. Article: Free and perfectly safe but only partially effective vaccines can harm everyone.

    Talamàs, Eduard / Vohra, Rakesh

    Games and economic behavior

    2020  Volume 122, Page(s) 277–289

    Abstract: Risk compensation can undermine the ability ... ...

    Abstract Risk compensation can undermine the ability of
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1467668-0
    ISSN 1090-2473 ; 0899-8256 ; 0899-8256
    ISSN (online) 1090-2473 ; 0899-8256
    ISSN 0899-8256
    DOI 10.1016/j.geb.2020.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model.

    Vargas-Pozada, Eduardo E / Ramos-Tovar, Erika / Rodriguez-Callejas, Juan D / Cardoso-Lezama, Irina / Galindo-Gómez, Silvia / Talamás-Lara, Daniel / Vásquez-Garzón, Verónica Rocío / Arellanes-Robledo, Jaime / Tsutsumi, Víctor / Villa-Treviño, Saúl / Muriel, Pablo

    International journal of molecular sciences

    2022  Volume 23, Issue 17

    Abstract: Caffeine elicits protective effects against liver diseases, such as NASH; however, its mechanism of action involving the pyrin domain-containing-3 (NLRP3) inflammasome signaling pathway remains to be elucidated. This study aimed to evaluate the effect of ...

    Abstract Caffeine elicits protective effects against liver diseases, such as NASH; however, its mechanism of action involving the pyrin domain-containing-3 (NLRP3) inflammasome signaling pathway remains to be elucidated. This study aimed to evaluate the effect of caffeine on the NLRP3 inflammasome signaling pathway in a rat model of NASH. NASH was induced by feeding rats a high-fat, -sucrose, and -cholesterol diet (HFSCD) for 15 weeks along with a weekly low dose (400 mg/kg, i.p.) of CCl
    MeSH term(s) Animals ; Caffeine/pharmacology ; Caffeine/therapeutic use ; Inflammasomes/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Rats ; Signal Transduction ; Toll-Like Receptor 4/metabolism
    Chemical Substances Inflammasomes ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat ; Tlr4 protein, rat ; Toll-Like Receptor 4 ; Caffeine (3G6A5W338E) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2022-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23179954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model

    Eduardo E. Vargas-Pozada / Erika Ramos-Tovar / Juan D. Rodriguez-Callejas / Irina Cardoso-Lezama / Silvia Galindo-Gómez / Daniel Talamás-Lara / Verónica Rocío Vásquez-Garzón / Jaime Arellanes-Robledo / Víctor Tsutsumi / Saúl Villa-Treviño / Pablo Muriel

    International Journal of Molecular Sciences, Vol 23, Iss 9954, p

    2022  Volume 9954

    Abstract: Caffeine elicits protective effects against liver diseases, such as NASH; however, its mechanism of action involving the pyrin domain-containing-3 (NLRP3) inflammasome signaling pathway remains to be elucidated. This study aimed to evaluate the effect of ...

    Abstract Caffeine elicits protective effects against liver diseases, such as NASH; however, its mechanism of action involving the pyrin domain-containing-3 (NLRP3) inflammasome signaling pathway remains to be elucidated. This study aimed to evaluate the effect of caffeine on the NLRP3 inflammasome signaling pathway in a rat model of NASH. NASH was induced by feeding rats a high-fat, -sucrose, and -cholesterol diet (HFSCD) for 15 weeks along with a weekly low dose (400 mg/kg, i.p.) of CCl 4 . Caffeine was administered at 50 mg/kg p.o. The effects of HFSCD+CCl 4 and caffeine on the liver were evaluated using biochemical, ultrastructural, histological, and molecular biological approaches. The HFSCD+CCl 4 -treated rats showed fat accumulation in the liver, elevated levels of inflammatory mediators, NLRP3 inflammasome activation, antioxidant dysregulation, and liver fibrosis. Caffeine reduced necrosis, cholestasis, oxidative stress, and fibrosis. Caffeine exhibited anti-inflammatory effects by attenuating NLRP3 inflammasome activation. Moreover, caffeine prevented increases in toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB) protein levels and mitigated the phosphorylation of mitogen-activated protein kinase (MAPK). Importantly, caffeine prevented the activation of hepatic stellate cells. This study is the first to report that caffeine ameliorates NASH by inhibiting NLRP3 inflammasome activation through the suppression of the TLR4/MAPK/NF-κB signaling pathway.
    Keywords caffeine ; non-alcoholic steatohepatitis ; nucleotide-binding domain ; leucine-rich-containing family ; pyrin domain-containing-3 inflammasome ; toll-like receptor 4 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: CTCF

    Del Campo, Eduardo Portillo / Márquez, José Jorge Talamás / Reyes-Vargas, Francianella / Intriago-Ortega, María Del Pilar / Quintanar-Escorza, Martha Angélica / Burciaga-Nava, Jorge Alberto / Sifuentes-Alvarez, Antonio / Reyes-Romero, Miguel

    Biomedical reports

    2013  Volume 2, Issue 1, Page(s) 101–104

    Abstract: Estrogens play a key role in breast cancer, with 60-70% of the cases expressing estrogen receptors (ERs), which are encoded by ... ...

    Abstract Estrogens play a key role in breast cancer, with 60-70% of the cases expressing estrogen receptors (ERs), which are encoded by the
    Language English
    Publishing date 2013-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2013.200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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