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Article: BMI Is Associated With Increased Plasma and Urine Appearance of Glucosinolate Metabolites After Consumption of Cooked Broccoli.

Charron, Craig S / Vinyard, Bryan T / Jeffery, Elizabeth H / Ross, Sharon A / Seifried, Harold E / Novotny, Janet A

2020 Volume 7, Page(s) 575092

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2020-09-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2020.575092
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Oxidative stress and antioxidants: a link to disease and prevention?

Seifried, Harold E

The Journal of nutritional biochemistry

2007 Volume 18, Issue 3, Page(s) 168–171

Abstract: The thrust of this presentation takes a more programmatic approach and gives an overview of the programs at the NIH and the NCI that have a broad nutritional and basic science undercurrent and outline. Also discussed briefly are some areas of general ... ...

Abstract	The thrust of this presentation takes a more programmatic approach and gives an overview of the programs at the NIH and the NCI that have a broad nutritional and basic science undercurrent and outline. Also discussed briefly are some areas of general concern that are under investigation in the nutrition group and are included in the group's outreach efforts among professional and academic organizations. The overarching focus of these efforts is to stress the importance of nutrition as a potential modulator of health/disease risks associated with genetic predisposition and environmentally induced disease from diet, lifestyle and exposure to pollutants.
MeSH term(s)	Animals ; Antioxidants/therapeutic use ; Genes/physiology ; Humans ; National Institutes of Health (U.S.) ; Neoplasms/etiology ; Neoplasms/prevention & control ; Oxidative Stress/physiology ; Polymorphism, Genetic ; United States
Chemical Substances	Antioxidants
Language	English
Publishing date	2007-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2006.12.003
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Article ; Online: Study on Human Urinary Metabolic Profiles after Consumption of Kale and Daikon Radish using a High-resolution Mass Spectrometry-Based Non-targeted and Targeted Metabolomic Approach.

Sun, Jianghao / Charron, Craig S / Liu, Zhihao / Novotny, Janet A / Harrington, Peter de B / Ross, Sharon A / Seifried, Harold E / Chen, Pei

Journal of agricultural and food chemistry

2020

Abstract: In the present study, urine samples were collected from healthy human volunteers to determine the metabolic fates of phenolic compounds and glucosinolates after a single meal of kale and daikon radish. The major glucosinolates and phenolic compounds in ... ...

Abstract	In the present study, urine samples were collected from healthy human volunteers to determine the metabolic fates of phenolic compounds and glucosinolates after a single meal of kale and daikon radish. The major glucosinolates and phenolic compounds in kale and daikon radish were measured. The urinary metabolome after feeding at different time periods was investigated. A targeted metabolite analysis method was developed based on the known metabolic pathways for glucosinolates and phenolic compounds. Using a targeted approach, a total of 18 metabolites were found in urine: 4 from phenolic compounds and 14 from glucosinolates. Among these metabolites, 4-methylsulfinyl-3-butenyl isothiocyanate, 4-methylsulfinyl-3-butenyl isothiocyanate-cysteine, and 4-methylsulfinyl-3-butenylglucosinolate-
Language	English
Publishing date	2020-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.0c05184
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Article: Consumption of baby kale increased cytochrome P450 1A2 (CYP1A2) activity and influenced bilirubin metabolism in a randomized clinical trial

Charron, Craig S / Jeffery, Elizabeth H / Kramer, Matthew / Novotny, Janet A / Ross, Sharon A / Seifried, Harold E

Journal of functional foods. 2020 Jan., v. 64

2020

Abstract: Brassica vegetables may modulate cancer risk by regulation of xenobiotic metabolizing enzymes (XMEs). In a randomized crossover study, the effect of kale consumption on CYP1A2, CYP2A6, XO, and NAT2 activity was determined by urinary caffeine metabolite ... ...

Abstract	Brassica vegetables may modulate cancer risk by regulation of xenobiotic metabolizing enzymes (XMEs). In a randomized crossover study, the effect of kale consumption on CYP1A2, CYP2A6, XO, and NAT2 activity was determined by urinary caffeine metabolite ratios, UGT1A1 activity by serum bilirubin concentrations, and GSTA protein and GST activity in blood by ELISA. Adults (n = 25) consumed a basal diet supplemented with kale and radish for 14 days or control vegetables. The kale diet increased CYP1A2 activity by 16.4% on day 8 and 15.2% on day 15 compared to control. Conjugated bilirubin was reduced by the kale diet, decreasing from 19.4 to 14.3 to 9.5% of total bilirubin on days 1, 8, and 15, respectively, which may be explained by induction of MRP2. Other XMEs were not affected by diet. The implications of these results for cancer risk will be clarified as the functions of these XMEs become better understood.
Keywords	adults ; bilirubin ; blood serum ; Brassica ; caffeine ; cross-over studies ; cytochrome P-450 ; diet ; enzyme-linked immunosorbent assay ; enzymes ; kale ; metabolism ; metabolites ; neoplasms ; radishes ; randomized clinical trials ; risk ; xenobiotics
Language	English
Dates of publication	2020-01
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2019.103624
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparison of Effects of Diet on Mammary Cancer: Efficacy of Various Preventive Agents and Metabolomic Changes of Different Diets and Agents.

Lubet, Ronald A / Beger, Richard D / Miller, Mark Steven / Luster, John / Seifried, Harold E / Grubbs, Clinton J

Cancer prevention research (Philadelphia, Pa.)

2018 Volume 11, Issue 12, Page(s) 831–840

Abstract: ... glycophospholipids (e.g., oleyl-linoleoyl-glycerophosphocholine) and decreased primary bile acids (e.g., taurocholate ...

Abstract	To determine the effects of diet, rats were placed on a standard diet (4% fat) or on a modified Western (high-fat diet, HFD) diet (21% fat) at 43 days of age (DOA) and administered methylnitrosourea (MNU) at 50 DOA. Rats were administered effective (tamoxifen, vorozole, and Targretin) or ineffective (metformin and Lipitor) chemopreventive agents either by daily gavage or in the diet beginning at 57 DOA and continuing until sacrifice (190 DOA). Latency period of the tumors was determined by palpation, and multiplicity and cancer weights per rat were determined at final sacrifice. Rats on the HFD versus standard diet had: (i) a 6% increase in final body weights; (ii) significant decreases in tumor latency; and (iii) significant increases in final tumor multiplicity and average tumor weight. Tamoxifen, vorozole, and Targretin were highly effective preventive agents, whereas Lipitor and metformin were ineffective in rats on either diet. Serum was collected at 78 DOA and at sacrifice (190 DOA), and metabolomics were determined to identify the metabolite changes due to diets and effective agents. Rats given the HFD had increased levels of saturated free fatty acids (including myristate) and decreased levels of 2-aminooctanoate. Furthermore, rats on the HFD diet had increased levels of 2-aminobutyrate and decreases in glycine markers previously identified as indicators of prediabetes. Targretin increased long-chain glycophospholipids (e.g., oleyl-linoleoyl-glycerophosphocholine) and decreased primary bile acids (e.g., taurocholate). Tamoxifen increased palmitoyl-linoleoyl-glycophosphocholine and decreased stearoyl-arachidonyl glycophosphocholine. Finally, increased levels of methylated nucleotides (5-methylcytidine) and decreased levels of urea cycle metabolites (N-acetylcitrulline) were associated with the presence of mammary cancers.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Diet, High-Fat/adverse effects ; Female ; Food-Drug Interactions ; Mammary Neoplasms, Experimental/chemically induced ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Metabolomics ; Methylnitrosourea/administration & dosage ; Methylnitrosourea/toxicity ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Methylnitrosourea (684-93-5)
Language	English
Publishing date	2018-11-20
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2434717-6
ISSN	1940-6215 ; 1940-6207
ISSN (online)	1940-6215
ISSN	1940-6207
DOI	10.1158/1940-6207.CAPR-18-0116
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Article ; Online: Absorption and metabolism of isothiocyanates formed from broccoli glucosinolates: effects of BMI and daily consumption in a randomised clinical trial.

Charron, Craig S / Vinyard, Bryan T / Ross, Sharon A / Seifried, Harold E / Jeffery, Elizabeth H / Novotny, Janet A

The British journal of nutrition

2018 Volume 120, Issue 12, Page(s) 1370–1379

Abstract: Sulphoraphane originates from glucoraphanin in broccoli and is associated with anti-cancer effects. A preclinical study suggested that daily consumption of broccoli may increase the production of sulphoraphane and sulphoraphane metabolites available for ... ...

Abstract	Sulphoraphane originates from glucoraphanin in broccoli and is associated with anti-cancer effects. A preclinical study suggested that daily consumption of broccoli may increase the production of sulphoraphane and sulphoraphane metabolites available for absorption. The objective of this study was to determine whether daily broccoli consumption alters the absorption and metabolism of isothiocyanates derived from broccoli glucosinolates. We conducted a randomised cross-over human study (n 18) balanced for BMI and glutathione S-transferase μ 1 (GSTM1) genotype in which subjects consumed a control diet with no broccoli (NB) for 16 d or the same diet with 200 g of cooked broccoli and 20 g of raw daikon radish daily for 15 d (daily broccoli, DB) and 100 g of broccoli and 10 g of daikon radish on day 16. On day 17, all subjects consumed a meal of 200 g of broccoli and 20 g of daikon radish. Plasma and urine were collected for 24 h and analysed for sulphoraphane and metabolites of sulphoraphane and erucin by triple quadrupole tandem MS. For subjects with BMI >26 kg/m2 (median), plasma AUC and urinary excretion rates of total metabolites were higher on the NB diet than on the DB diet, whereas for subjects with BMI <26 kg/m2, plasma AUC and urinary excretion rates were higher on the DB diet than on the NB diet. Daily consumption of broccoli interacted with BMI but not GSTM1 genotype to affect plasma concentrations and urinary excretion of glucosinolate-derived compounds believed to confer protection against cancer. This trial was registered as NCT02346812.
MeSH term(s)	Acetylcysteine/chemistry ; Adult ; Aged ; Anticarcinogenic Agents ; Area Under Curve ; Body Mass Index ; Brassica/chemistry ; Cooking ; Cross-Over Studies ; Diet ; Female ; Genotype ; Glucose/analogs & derivatives ; Glucose/chemistry ; Glucosinolates/chemistry ; Glutathione Transferase/metabolism ; Glycoside Hydrolases/metabolism ; Humans ; Imidoesters/chemistry ; Isothiocyanates/blood ; Isothiocyanates/chemistry ; Isothiocyanates/metabolism ; Isothiocyanates/urine ; Male ; Mannitol/chemistry ; Middle Aged ; Raphanus ; Sulfides/blood ; Sulfides/chemistry ; Sulfides/urine ; Tandem Mass Spectrometry ; Thiocyanates/blood ; Thiocyanates/chemistry ; Thiocyanates/urine
Chemical Substances	Anticarcinogenic Agents ; Glucosinolates ; Imidoesters ; Isothiocyanates ; Sulfides ; Thiocyanates ; glucoerucin (21973-56-8) ; Mannitol (3OWL53L36A) ; erucin (CTE370DL3U) ; Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18) ; Glycoside Hydrolases (EC 3.2.1.-) ; thioglucosidase (EC 3.2.1.147) ; sulforaphane (GA49J4310U) ; Glucose (IY9XDZ35W2) ; glucoraphanin (Q86A197713) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2018-11-14
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114518002921
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Article ; Online: Opportunities for small nutrition-related cancer research grants (R03) from the National Cancer Institute.

Nicastro, Holly L / Seifried, Harold E / Milner, John A

The Journal of nutrition

2011 Volume 141, Issue 10, Page(s) 1765–1768

Abstract: Small research grants, or R03 grants, provide limited, short-term support for individual research projects. R03s may be an excellent means of support for projects by nutrition scientists at all stages in their careers. The National Cancer Institute (NCI) ...

Abstract	Small research grants, or R03 grants, provide limited, short-term support for individual research projects. R03s may be an excellent means of support for projects by nutrition scientists at all stages in their careers. The National Cancer Institute (NCI) has awarded roughly one-half of all nutrition-related NIH R03 grants in the period from 2005 to 2010. A detailed review of the recent NCI grant portfolio identified potential strategies for successful applications. Projects that addressed important nutrition and cancer issues had feasible and appropriate specific aims, were innovative, and were based on sound concepts were most positively viewed by reviewers. Furthermore, applicants with suitable expertise, training, mentorship, and records of accomplishment who, when appropriate, collaborated with investigators with complementary knowledge and skills were more likely to receive higher priority scores.
MeSH term(s)	Animals ; Biomedical Research/economics ; Humans ; National Cancer Institute (U.S.) ; Nutritional Sciences/economics ; Peer Review, Research ; Research Personnel/education ; Research Support as Topic ; United States
Language	English
Publishing date	2011-08-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.3945/jn.111.144261
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Article: Absorption and metabolism of isothiocyanates formed from broccoli glucosinolates: effects of BMI and daily consumption in a randomised clinical trial

Charron, Craig S / Vinyard, Bryan T / Ross, Sharon A / Seifried, Harold E / Jeffery, Elizabeth H / Novotny, Janet A

British journal of nutrition. 2018 Dec. 28, v. 120, no. 12

2018

Abstract	Sulphoraphane originates from glucoraphanin in broccoli and is associated with anti-cancer effects. A preclinical study suggested that daily consumption of broccoli may increase the production of sulphoraphane and sulphoraphane metabolites available for absorption. The objective of this study was to determine whether daily broccoli consumption alters the absorption and metabolism of isothiocyanates derived from broccoli glucosinolates. We conducted a randomised cross-over human study (n 18) balanced for BMI and glutathione S-transferase μ 1 (GSTM1) genotype in which subjects consumed a control diet with no broccoli (NB) for 16 d or the same diet with 200 g of cooked broccoli and 20 g of raw daikon radish daily for 15 d (daily broccoli, DB) and 100 g of broccoli and 10 g of daikon radish on day 16. On day 17, all subjects consumed a meal of 200 g of broccoli and 20 g of daikon radish. Plasma and urine were collected for 24 h and analysed for sulphoraphane and metabolites of sulphoraphane and erucin by triple quadrupole tandem MS. For subjects with BMI >26 kg/m2 (median), plasma AUC and urinary excretion rates of total metabolites were higher on the NB diet than on the DB diet, whereas for subjects with BMI <26 kg/m2, plasma AUC and urinary excretion rates were higher on the DB diet than on the NB diet. Daily consumption of broccoli interacted with BMI but not GSTM1 genotype to affect plasma concentrations and urinary excretion of glucosinolate-derived compounds believed to confer protection against cancer. This trial was registered as NCT02346812.
Keywords	antineoplastic activity ; body mass index ; broccoli ; diet ; excretion ; genotype ; glucoraphanin ; glutathione transferase ; humans ; intestinal absorption ; isothiocyanates ; metabolism ; metabolites ; neoplasms ; radishes ; randomized clinical trials ; urine
Language	English
Dates of publication	2018-1228
Size	p. 1370-1379.
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114518002921
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Broccoli consumption affects the human gastrointestinal microbiota.

Kaczmarek, Jennifer L / Liu, Xiaoji / Charron, Craig S / Novotny, Janet A / Jeffery, Elizabeth H / Seifried, Harold E / Ross, Sharon A / Miller, Michael J / Swanson, Kelly S / Holscher, Hannah D

The Journal of nutritional biochemistry

2018 Volume 63, Page(s) 27–34

Abstract: The human gastrointestinal microbiota is increasingly linked to health outcomes; however, our understanding of how specific foods alter the microbiota is limited. Cruciferous vegetables such as broccoli are a good source of dietary fiber and ... ...

Abstract	The human gastrointestinal microbiota is increasingly linked to health outcomes; however, our understanding of how specific foods alter the microbiota is limited. Cruciferous vegetables such as broccoli are a good source of dietary fiber and phytonutrients, including glucosinolates, which can be metabolized by gastrointestinal microbes. This study aimed to determine the impact of broccoli consumption on the gastrointestinal microbiota of healthy adults. A controlled feeding, randomized, crossover study consisting of two 18-day treatment periods separated by a 24-day washout was conducted in healthy adults (n=18). Participants were fed at weight maintenance with the intervention period diet including 200 g of cooked broccoli and 20 g of raw daikon radish per day. Fecal samples were collected at baseline and at the end of each treatment period for microbial analysis. Beta diversity analysis indicated that bacterial communities were impacted by treatment (P=.03). Broccoli consumption decreased the relative abundance of Firmicutes by 9% compared to control (P=.05), increased the relative abundance of Bacteroidetes by 10% compared to control (P=.03) and increased Bacteroides by 8% relative to control (P=.02). Furthermore, the effects were strongest among participants with body mass index <26 kg/m
MeSH term(s)	Adult ; Aged ; Bacteroidetes ; Body Mass Index ; Brassica ; Feces/microbiology ; Female ; Gastrointestinal Microbiome/genetics ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2018-09-21
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2018.09.015
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Article ; Online: Dietary Selenium Levels Affect Selenoprotein Expression and Support the Interferon-γ and IL-6 Immune Response Pathways in Mice.

Tsuji, Petra A / Carlson, Bradley A / Anderson, Christine B / Seifried, Harold E / Hatfield, Dolph L / Howard, Michael T

Nutrients

2015 Volume 7, Issue 8, Page(s) 6529–6549

Abstract: Selenium is an essential element that is required to support a number of cellular functions and biochemical pathways. The objective of this study was to examine the effects of reduced dietary selenium levels on gene expression to assess changes in ... ...

Abstract	Selenium is an essential element that is required to support a number of cellular functions and biochemical pathways. The objective of this study was to examine the effects of reduced dietary selenium levels on gene expression to assess changes in expression of non-selenoprotein genes that may contribute to the physiological consequences of selenium deficiency. Mice were fed diets that were either deficient in selenium or supplemented with selenium in the form of sodium selenite for six weeks. Differences in liver mRNA expression and translation were measured using a combination of ribosome profiling, RNA-Seq, microarrays, and qPCR. Expression levels and translation of mRNAs encoding stress-related selenoproteins were shown to be up-regulated by increased selenium status, as were genes involved in inflammation and response to interferon-γ. Changes in serum cytokine levels were measured which confirmed that interferon-γ, as well as IL-6, were increased in selenium adequate mice. Finally, microarray and qPCR analysis of lung tissue demonstrated that the selenium effects on immune function are not limited to liver. These data are consistent with previous reports indicating that adequate selenium levels can support beneficial immune responses, and further identify the IL-6 and interferon-γ pathways as being responsive to dietary selenium intake.
MeSH term(s)	Animals ; Computational Biology ; Dietary Supplements ; Gene Expression ; Gene Expression Profiling ; Inflammation/immunology ; Interferon-gamma/blood ; Interferon-gamma/immunology ; Interleukin-6/blood ; Interleukin-6/immunology ; Mice ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Selenium/administration & dosage ; Selenium/blood ; Selenoproteins/genetics ; Selenoproteins/metabolism ; Sequence Analysis, RNA ; Sodium Selenite/metabolism ; Up-Regulation
Chemical Substances	Interleukin-6 ; RNA, Messenger ; Selenoproteins ; Interferon-gamma (82115-62-6) ; Selenium (H6241UJ22B) ; Sodium Selenite (HIW548RQ3W)
Language	English
Publishing date	2015-08-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu7085297
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