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Article ; Online: Genetic Susceptibility for Anthracycline-Induced Cardiomyopathy: Novel Insights by Combining SNPs.

Leerink, J M Jan / Feijen, E A M Lieke / Kremer, L C M Leontien

JACC. CardioOncology

2023 Volume 5, Issue 6, Page(s) 819–820

Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Editorial
ISSN	2666-0873
ISSN (online)	2666-0873
DOI	10.1016/j.jaccao.2023.08.002
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Article ; Online: Risk Prediction Models for Myocardial Dysfunction and Heart Failure in Patients with Current or Prior Cancer.

van Dalen, E C / Leerink, J M / Kremer, L C M / Feijen, E A M

Current oncology reports

2023 Volume 25, Issue 4, Page(s) 353–367

Abstract: Purpose of review: Cancer patients are at risk for treatment-related myocardial dysfunction and heart failure during or after treatment. Risk prediction models have the potential to play an important role in identifying patients at high or low risk in ... ...

Abstract	Purpose of review: Cancer patients are at risk for treatment-related myocardial dysfunction and heart failure during or after treatment. Risk prediction models have the potential to play an important role in identifying patients at high or low risk in order to take appropriate measures. Here, we review their current role. Recent findings: More and more risk prediction models are currently being developed. Unfortunately, they vary widely in their ability to identify patients and survivors at risk for myocardial dysfunction or heart failure, from very poor to strong. Part of this variation might be explained by methodological limitations of the models, but due to a lack of reporting it is not possible to completely assess this. There lies great potential in the improvement of the quality and the use of risk prediction models to inform patients and clinicians on the absolute risk of cardiac events in order to guide care.
MeSH term(s)	Humans ; Heart Failure/complications ; Survivors ; Neoplasms/complications
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057359-5
ISSN	1534-6269 ; 1523-3790
ISSN (online)	1534-6269
ISSN	1523-3790
DOI	10.1007/s11912-023-01368-7
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Article ; Online: Comment on: Cardiotoxicity in children with cancer treated with anthracyclines: A position statement on dexrazoxane.

Mavinkurve-Groothuis, Annelies M C / de Baat, Esmee C / Feijen, Elizabeth A M / Kremer, Leontien C M / Armenian, Saro H / Mulder, Renee L / van Dalen, Elvira C

Pediatric blood & cancer

2023 Volume 70, Issue 10, Page(s) e30604

MeSH term(s)	Child ; Humans ; Cardiotoxicity/etiology ; Cardiotoxicity/prevention & control ; Dexrazoxane/therapeutic use ; Anthracyclines/adverse effects ; Neoplasms/drug therapy ; Antibiotics, Antineoplastic/therapeutic use ; Polyketides/therapeutic use ; Razoxane/therapeutic use ; Cardiotonic Agents/therapeutic use
Chemical Substances	Dexrazoxane (048L81261F) ; Anthracyclines ; Antibiotics, Antineoplastic ; Polyketides ; Razoxane (5AR83PR647) ; Cardiotonic Agents
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30604
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Article ; Online: Improvement and implementation of a national individual care plan in paediatric palliative care: a study protocol.

Joren, Chantal Y / Kars, Marijke C / Kremer, Leontien C M / Rippen, Hester / Verhagen, A A Eduard / Aris-Meijer, Judith L

BMJ paediatrics open

2023 Volume 7, Issue 1

Abstract: Introduction: Paediatric palliative care (PPC) is care for children with life-threatening or life-limiting conditions, and can involve complex high-tech care, which can last for months or years. In 2015, the National Individual Care Plan (ICP) for PPC ... ...

Abstract	Introduction: Paediatric palliative care (PPC) is care for children with life-threatening or life-limiting conditions, and can involve complex high-tech care, which can last for months or years. In 2015, the National Individual Care Plan (ICP) for PPC was developed and has shown to be successful. The ICP can be seen as an instrument to facilitate coordination, quality and continuity of PPC. However, in practice, an ICP is often completed too late and for too few children. We aim to improve the coordination, quality and continuity of care for every child with a life-threatening or life-limiting condition and his/her family by further developing and implementing the ICP in the Netherlands. Methods and analysis: To evaluate the original ICP, ICP 1.0, interviews and questionnaires will be held among parents of children who have or have had an ICP 1.0 and healthcare professionals (HCPs) who used ICP 1.0. Based on the results, ICP 1.0 will be further developed. An implementation strategy will be written and the renewed ICP, ICP 2.0, will be nationally tested in an implementation period of approximately 7 months. During the implementation period, ICP 2.0 will be used for all children who are registered with Children's Palliative Care teams. After the implementation period, ICP 2.0 will be evaluated using interviews and questionnaires among parents of children who received ICP 2.0 and HPCs who worked with ICP 2.0. Based on these results, ICP 2.0 will be further optimised into the final version: ICP 3.0. Ethics and dissemination: This study received ethical approval. The ICP 3.0 will be disseminated through the Dutch Centre of Expertise in Children's Palliative Care, to ensure wide availability for the general public and HCPs within PPC. Additionally, we aim to publish study results in open-access, peer-reviewed journals and to present results at national and international scientific meetings.
MeSH term(s)	Humans ; Child ; Male ; Female ; Palliative Care/methods ; Hospice and Palliative Care Nursing ; Parents ; Health Personnel ; Netherlands
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-9772
ISSN (online)	2399-9772
DOI	10.1136/bmjpo-2022-001677
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Article ; Online: Assessment of fatigue and its impact in chronic liver disease.

Younossi, Zobair M / Kremer, Andreas E / Swain, Mark G / Jones, David / Bowlus, Christopher / Trauner, Michael / Henry, Linda / Gerber, Lynn

Journal of hepatology

2024

Abstract: ... stages of CLD such as primary biliary cholangitis (PBC), chronic hepatitis C viral infection (HCV) and ...

Abstract	Patient reported outcomes (PROs) such as health related quality of life (HRQL) are important outcome measures for patients with chronic liver diseases (CLDs). Presence of cirrhosis and advanced liver disease have been associated with worsened HRQL and fatigue. On the other hand, some patients with earlier stages of CLD such as primary biliary cholangitis (PBC), chronic hepatitis C viral infection (HCV) and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), also experience fatigue causing PRO impairment. Treatment for some CLDs may improve HRQL and, sometimes, levels of fatigue. We aimed to provide an in-depth expert review of concepts related to fatigue and HRQL in patients with PBC, HCV and MASLD. As such, a panel of experts in fatigue and CLD reviewed and discussed the literature and collaborated to provide this expert review of fatigue in CLD. Herein, we review and report on the complexity of fatigue highlighting that fatigue is comprised of peripheral (neuromuscular failure, often in conjunction with sub-maximal cardiorespiratory function) and central (central nervous system dysfunction) causes. Fatigue and HRQL are measured using validated self-report instruments. Additionally, fatigue can be measured through objective tests (e.g. grip strength). Fatigue has deleterious effects on HRQL and one's ability to be physically active and socially engaged but does not always correlate with CLD severity. Treatments for HCV and MASLD can improve levels of fatigue and HRQL, but current treatments for PBC do not seem to affect levels of fatigue. We conclude that obtaining PRO data to include HRQL and fatigue are essential for determining the comprehensive burden of CLD and its potential treatments. IMPACT AND IMPLICATIONS: Fatigue is a complex phenomenon associated with both a peripheral cause (neuromuscular failure and sub-maximal cardiorespiratory function) and a central cause (central nervous system dysfunction). Although fatigue is common among patients with CLD, it does not always correlate with the severity of the liver disease, but fatigue is related with significant decreases in patients' health related quality of life (HRQL). Appreciating the impact of fatigue using validated self-report measurements is important to better understand the burden of CLD and the effectiveness of treatment.
Language	English
Publishing date	2024-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2024.04.008
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Article ; Online: Implementation of a standardized clinical test kit for diagnostics of periprosthetic infections in the clinical routine.

Gramlich, Y / Kremer, M / Brüning, C / Breuer, J / Hofmann, L / Klug, A / Hoffmann, R

Der Unfallchirurg

2021 Volume 124, Issue Suppl 1, Page(s) 247–254

Abstract: ... examined.: Results: The test kit was implemented using blood samples (leukocyte count; C‑reactive ...

Title translation	Implementierung eines standardisierten Test-Kits zur Diagnostik von periprothetischen Infektionen in der klinischen Routine.
Abstract	Background: The number of primary arthroplasties is increasing and the proportion of revision arthroplasties is becoming increasingly more important. The need for standardized and guideline-based diagnostics for the safe detection of a periprosthetic joint infection (PJI) is becoming apparent. In the past 10 years various organizations have published definitions and diagnostic guidelines. The implementation of an inhouse standard test kit could help to simplify the process and could improve the diagnostic quality. Method: In 2016 a test kit was compiled in a monocentric prospective study, taking the International Consensus Meeting (ICM) criteria 2014 and the Infectious Diseases Society of America (IDSA) criteria into account, which also fulfils the definitions of the ICM criteria 2018 and criteria of the European Bone and Joint Infection Society 2021. The test kit was implemented in the clinical setting of a special department for aseptic and septic revision arthroplasty. The usability and accuracy of the test kit were examined. Results: The test kit was implemented using blood samples (leukocyte count; C‑reactive protein, CRP), samples for examining the synovial fluid (white blood cell count, PMN cell differentiation, microbiological culture for incubation over 14 days, alpha-defensin enzyme-linked immunosorbent assay, ELISA, leukocyte esterase test strips) together with information and request forms. Between April 2016 and February 2020 a total of 405 patients were investigated. Within 3 calendar years, the use of the test kit increased from 59% initially to 86%, and finally to 96% of cases in the third calendar year. The leukocyte esterase test strip was reliable in only 72%, due to undifferentiated readability or blood contamination. The costs increased by the only commercially available alpha-defensin ELISA test by approx. 52€ per puncture. The best individual test showed a sensitivity/specificity of 92.8%/95.2% with alpha-defensin. It was calculated which combinations showed a similar test quality and different combinations, such as CRP+ cell count+ microbiology showed a sensitivity/specificity both of around 90%. Metallosis is a challenge for preoperative PJI diagnostics. Discussion: In a prospective study it was shown, that the implementation of the standardized test kit lead to a guideline based PJI diagnostic in all cases and thus to a significantly increase of the diagnostic quality. There is currently no single test that reliably excludes or proves an infection. The alpha-defensin laboratory ELISA test showed the best test accuracy, whereby the consideration of test combinations is obligatory and at the same time safe.
MeSH term(s)	Arthritis, Infectious ; Arthroplasty, Replacement, Hip ; Biomarkers ; Humans ; Prospective Studies ; Prosthesis-Related Infections/diagnosis ; Sensitivity and Specificity ; Synovial Fluid ; alpha-Defensins
Chemical Substances	Biomarkers ; alpha-Defensins
Language	English
Publishing date	2021-08-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	605965-x
ISSN	1433-044X ; 0177-5537
ISSN (online)	1433-044X
ISSN	0177-5537
DOI	10.1007/s00113-021-01016-4
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Article ; Online: Palliative care for children: methodology for the development of a national clinical practice guideline.

van Teunenbroek, Kim C / Kremer, Leontien C M / Verhagen, A A Eduard / Verheijden, Johannes M A / Rippen, Hester / Borggreve, Brigitt C M / Michiels, Erna M C / Mulder, Renée L

BMC palliative care

2023 Volume 22, Issue 1, Page(s) 193

Abstract: Background: Provision of paediatric palliative care for children with life-threatening or life-limiting conditions and their families is often complex. Guidelines can support professionals to deliver high quality care. Stakeholders expressed the need to ...

Abstract	Background: Provision of paediatric palliative care for children with life-threatening or life-limiting conditions and their families is often complex. Guidelines can support professionals to deliver high quality care. Stakeholders expressed the need to update the first Dutch paediatric palliative care guideline with new scientific literature and new topics. This paper provides an overview of the methodology that is used for the revision of the Dutch paediatric palliative care guideline and a brief presentation of the identified evidence. Methods: The revised paediatric palliative care guideline was developed with a multidisciplinary guideline panel of 72 experts in paediatric palliative care and nine (bereaved) parents of children with life-threatening or life-limiting conditions. The guideline covered multiple topics related to (refractory) symptom treatment, advance care planning and shared-decision making, organisation of care, psychosocial care, and loss and bereavement. We established six main working groups that formulated 38 clinical questions for which we identified evidence by updating two existing systematic literature searches. The GRADE (CERQual) methodology was used for appraisal of evidence. Furthermore, we searched for additional literature such as existing guidelines and textbooks to deal with lack of evidence. Results: The two systematic literature searches yielded a total of 29 RCTs or systematic reviews of RCTs on paediatric palliative care interventions and 22 qualitative studies on barriers and facilitators of advance care planning and shared decision-making. We identified evidence for 14 out of 38 clinical questions. Furthermore, we were able to select additional literature (29 guidelines, two textbooks, and 10 systematic reviews) to deal with lack of evidence. Conclusions: The revised Dutch paediatric palliative care guideline addresses many topics. However, there is limited evidence to base recommendations upon. Our methodology will combine the existing evidence in scientific literature, additional literature, expert knowledge, and perspectives of patients and their families to provide recommendations.
MeSH term(s)	Child ; Humans ; Advance Care Planning ; Decision Making, Shared ; Palliative Care/methods ; Parents/psychology ; Practice Guidelines as Topic
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2091556-1
ISSN	1472-684X ; 1472-684X
ISSN (online)	1472-684X
ISSN	1472-684X
DOI	10.1186/s12904-023-01293-3
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Article: Efficacy of dalfampridine in neuromyelitis optica spectrum disorder: A pilot study.

de Seze, Jérôme / Clerc, Christine / Béreau, Matthieu / Bourre, Bertrand / Zephir, Hélène / Collongues, Nicolas / Kremer, Laurent / Vermersch, Patrick / Bigaut, Kevin

Multiple sclerosis journal - experimental, translational and clinical

2024 Volume 10, Issue 1, Page(s) 20552173241233952

Abstract: Objective: To assess the efficacy of dalfampridine in patients with neuromyelitis optica spectrum disorder.: Methods: We included 15 consecutive patients, who were started on a treatment of dalfampridine 10 mg twice daily for 2 weeks. Efficacy ... ...

Abstract	Objective: To assess the efficacy of dalfampridine in patients with neuromyelitis optica spectrum disorder. Methods: We included 15 consecutive patients, who were started on a treatment of dalfampridine 10 mg twice daily for 2 weeks. Efficacy assessment was based on walking ability improvement using Timed-25-Foot Walk and 12-item Multiple Sclerosis Walking Scale tests. Results: The mean Timed-25-Foot Walk score was reduced from 14.8 (±2.4) to 11.3 (±1.9) seconds ( Conclusion: Dalfampridine seems to be useful for symptomatic treatment of walking impairment in neuromyelitis optica spectrum disorder.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2841884-0
ISSN	2055-2173 ; 2055-2173
ISSN (online)	2055-2173
ISSN	2055-2173
DOI	10.1177/20552173241233952
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Article ; Online: In Vitro

Roquet-Banères, Françoise / Alcaraz, Matthéo / Hamela, Claire / Abendroth, Jan / Edwards, Thomas E / Kremer, Laurent

Antimicrobial agents and chemotherapy

2023 Volume 67, Issue 4, Page(s) e0160722

Abstract: ... in Mycobacterium tuberculosis. We found that this compound displayed very low MIC values against a panel of M. fortuitum ... clinical strains and exerted potent antimicrobial activity against M. fortuitum in macrophages. Remarkably ... sufficient to significantly protect the infected larvae from M. fortuitum-induced killing, which correlated ...

Abstract	Mycobacterium fortuitum represents one of the most clinically relevant rapid-growing mycobacterial species. Treatments are complex due to antibiotic resistance and to severe side effects of effective drugs, prolonged time of treatment, and co-infection with other pathogens. Herein, we explored the activity of NITD-916, a direct inhibitor of the enoyl-ACP reductase InhA of the type II fatty acid synthase in Mycobacterium tuberculosis. We found that this compound displayed very low MIC values against a panel of M. fortuitum clinical strains and exerted potent antimicrobial activity against M. fortuitum in macrophages. Remarkably, the compound was also highly efficacious in a zebrafish model of infection. Short duration treatments were sufficient to significantly protect the infected larvae from M. fortuitum-induced killing, which correlated with reduced bacterial burdens and abscesses. Biochemical analyses demonstrated an inhibition of
MeSH term(s)	Animals ; Mycobacterium fortuitum ; Zebrafish ; Mycobacterium tuberculosis ; Mycolic Acids/pharmacology ; Oxidoreductases
Chemical Substances	Mycolic Acids ; Oxidoreductases (EC 1.-)
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.01607-22
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Article ; Online: Evaluation and activity of new porphyrin-peptide cage-type conjugates for the photoinactivation of

Alcaraz, Matthéo / Lyonnais, Sébastien / Ghosh, Chandramouli / Aguilera-Correa, John Jairo / Richeter, Sébastien / Ulrich, Sébastien / Kremer, Laurent

Microbiology spectrum

2024 Volume 12, Issue 5, Page(s) e0000624

Abstract: Mycobacterium ... ...

Abstract	Mycobacterium abscessus
MeSH term(s)	Mycobacterium abscessus/drug effects ; Porphyrins/pharmacology ; Porphyrins/chemistry ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Biofilms/drug effects ; Humans ; Mycobacterium Infections, Nontuberculous/microbiology ; Mycobacterium Infections, Nontuberculous/drug therapy ; Microbial Sensitivity Tests ; Peptides/pharmacology ; Peptides/chemistry ; Photochemotherapy/methods ; Light
Chemical Substances	Porphyrins ; Photosensitizing Agents ; Anti-Bacterial Agents ; Peptides
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00006-24
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