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  1. Article: Terne, Christopher

    Moore, Norman / Bevan, Michael

    Oxford dictionary of national biography v.54

    2004  

    Author's details Norman Moore, rev. Michael Bevan
    MeSH term(s) Physicians ; History, 17th Century ; History of Medicine
    Keywords England
    Language English
    Size p. 155.
    Publisher Oxford University Press
    Publishing place Oxford ; New York
    Document type Article
    ISBN 019861411X ; 9780198614111
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Article: Nugent, Christopher

    Moore, Norman / Bevan, Michael

    Oxford dictionary of national biography v.41

    2004  

    Author's details Norman Moore and Michael Bevan
    MeSH term(s) Physicians ; History, 18th Century ; History of Medicine
    Keywords England
    Language English
    Size p. 253-254.
    Publisher Oxford University Press
    Publishing place Oxford ; New York
    Document type Article
    ISBN 019861411X ; 9780198614111
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article: Langton, Christopher

    Moore, Norman / Bakewell, Sarah

    Oxford dictionary of national biography v.32

    2004  

    Author's details Norman Moore, rev. Sarah Bakewell
    MeSH term(s) Physicians ; History, 16th Century ; History of Medicine
    Keywords England
    Language English
    Size p. 511.
    Publisher Oxford University Press
    Publishing place Oxford ; New York
    Document type Article
    ISBN 019861411X ; 9780198614111
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article: Pemberton, Christopher Robert

    Moore, Norman / Bevan, Michael

    Oxford dictionary of national biography v.43

    2004  

    Author's details Norman Moore, rev. Michael Bevan
    MeSH term(s) Physicians ; History, 18th Century ; History, 19th Century ; History of Medicine
    Keywords England
    Language English
    Size p. 503.
    Publisher Oxford University Press
    Publishing place Oxford ; New York
    Document type Article
    ISBN 019861411X ; 9780198614111
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article ; Online: Quantification of Methylation and Phosphorylation Stoichiometry.

    Ayoub, Christopher A / Moore, Khadijah I / Kuret, Jeff

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2754, Page(s) 221–235

    Abstract: Tauopathies including Alzheimer's disease (AD) are neurodegenerative disorders accompanied by the conversion of functional forms of the microtubule associated protein Tau into non-functional aggregates. A variety of post-translational modifications (PTMs) ...

    Abstract Tauopathies including Alzheimer's disease (AD) are neurodegenerative disorders accompanied by the conversion of functional forms of the microtubule associated protein Tau into non-functional aggregates. A variety of post-translational modifications (PTMs) on Tau precede or accompany the conversion, placing them in position to modulate Tau function as well as its propensity to aggregate. Although Tau PTMs can be characterized by their sites of modification, their total stoichiometry when summed over all sites also is an important metric of their potential impact on function. Here we provide a protocol for rapidly producing recombinant Tau with enzyme-specific PTMs at high stoichiometry in vitro and demonstrate its utility in the context of hyperphosphorylation. Additionally, protocols for estimating phosphorylation and methylation stoichiometry on Tau proteins isolated from any source are presented. Together these methods support experimentation on Tau PTM function over a wide range of experimental conditions.
    MeSH term(s) Humans ; Phosphorylation ; Protein Processing, Post-Translational ; tau Proteins/genetics ; tau Proteins/metabolism ; Alzheimer Disease/metabolism ; Tauopathies/metabolism ; Methylation
    Chemical Substances tau Proteins
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3629-9_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pregnant Woman With Abdominal Pain.

    Boivin, Zachary / Barber, Douglas / Agaraj, Irini / Moore, Christopher L

    Annals of emergency medicine

    2024  Volume 83, Issue 4, Page(s) 403–404

    MeSH term(s) Pregnancy ; Female ; Humans ; Pregnant Women ; Abdominal Pain/diagnostic imaging ; Abdominal Pain/etiology ; Pregnancy Complications/diagnostic imaging
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2023.09.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Maximizing the Utility and Comparability of Accelerometer Data from Large-Scale Epidemiologic Studies.

    Lee, I-Min / Moore, Christopher C / Evenson, Kelly R

    Journal for the measurement of physical behaviour

    2023  Volume 6, Issue 1, Page(s) 6–12

    Abstract: There is much evidence showing that physical activity is related to optimal health, including physical and mental function, and quality of life. Additionally, data are accumulating with regards to the detrimental health impacts of sedentary behavior. ... ...

    Abstract There is much evidence showing that physical activity is related to optimal health, including physical and mental function, and quality of life. Additionally, data are accumulating with regards to the detrimental health impacts of sedentary behavior. Much of the evidence related to long-term health outcomes, such as cardiovascular disease and cancer - the two leading causes of death in the United States and worldwide, comes from observational epidemiologic studies and, in particular, prospective cohort studies. Few data on these outcomes are derived from randomized controlled trials, conventionally regarded as the "gold standard" of research designs. Why is there a paucity of data from randomized trials on physical activity or sedentary behavior and long-term health outcomes? A further issue to consider is that prospective cohort studies investigating these outcomes can take a long time to accrue sufficient numbers of endpoints for robust and meaningful findings. This contrasts with the rapid pace at which technology advances. Thus, while the use of devices for measuring physical behaviors has been an important development in large-scale epidemiologic studies over the past decade, cohorts that are now publishing results on health outcomes related to accelerometer-assessed physical activity and sedentary behavior may have been initiated years ago, using "dated" technology. This paper, based on a keynote presentation at ICAMPAM 2022, discusses the issues of study design and slow pace of discovery in prospective cohort studies and suggests some possible ways to maximize the utility and comparability of "dated" device data from prospective cohort studies for research investigations, using the Women's Health Study as an example.
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 2575-6613
    ISSN (online) 2575-6613
    DOI 10.1123/jmpb.2022-0035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: BL-OG: BioLuminescent-OptoGenetics.

    Moore, Christopher I / Berglund, Ken

    Journal of neuroscience research

    2019  Volume 98, Issue 3, Page(s) 469–470

    Language English
    Publishing date 2019-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.24575
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1232: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants.

    Voigts, Jakob / Deister, Christopher A / Moore, Christopher I

    eLife

    2020  Volume 9

    Abstract: Predictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosensory ...

    Abstract Predictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosensory neocortex. We found that deviant stimuli enhanced tactile detection and were encoded in L2/3 neural tuning. To test the contribution of L6, we applied weak optogenetic drive that changed which L6 neurons were sensory responsive, without affecting overall firing rates in L6 or L2/3. This stimulation selectively suppressed behavioral sensitivity to deviant stimuli, without impacting baseline performance. This stimulation also eliminated deviance encoding in L2/3 but did not impair basic stimulus responses across layers. In contrast, stronger L6 drive inhibited firing and suppressed overall sensory function. These findings indicate that, despite their sparse activity, specific ensembles of stimulus-driven L6 neurons are required to form neocortical predictions, and to realize their behavioral benefit.
    MeSH term(s) Animals ; Female ; Male ; Mice ; Neocortex/physiology ; Sensation/physiology ; Somatosensory Cortex/physiology
    Language English
    Publishing date 2020-12-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.48957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants

    Jakob Voigts / Christopher A Deister / Christopher I Moore

    eLife, Vol

    2020  Volume 9

    Abstract: Predictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosensory ...

    Abstract Predictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosensory neocortex. We found that deviant stimuli enhanced tactile detection and were encoded in L2/3 neural tuning. To test the contribution of L6, we applied weak optogenetic drive that changed which L6 neurons were sensory responsive, without affecting overall firing rates in L6 or L2/3. This stimulation selectively suppressed behavioral sensitivity to deviant stimuli, without impacting baseline performance. This stimulation also eliminated deviance encoding in L2/3 but did not impair basic stimulus responses across layers. In contrast, stronger L6 drive inhibited firing and suppressed overall sensory function. These findings indicate that, despite their sparse activity, specific ensembles of stimulus-driven L6 neurons are required to form neocortical predictions, and to realize their behavioral benefit.
    Keywords cortex ; oddball ; deviant ; vibrissa ; prediction ; layer 6 ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 150
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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