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Article ; Online: C-C bond formation

Velasco-Rubio, Álvaro / Martínez-Balart, Pol / Álvarez-Constantino, Andrés M / Fañanás-Mastral, Martín

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 62, Page(s) 9424–9444

Abstract: ... to develop more atom-efficient and clean C-C bond forming reactions. These processes, however, are hampered ... by the low reactivity of the aliphatic C-H bonds. Photocatalytic processes based on hydrogen atom transfer C ... compounds. In this article, we summarize the main achievements in this field applied to the development of C ...

Abstract	The direct functionalization of alkanes represents a very important challenge in the goal to develop more atom-efficient and clean C-C bond forming reactions. These processes, however, are hampered by the low reactivity of the aliphatic C-H bonds. Photocatalytic processes based on hydrogen atom transfer C-H bond activation strategies have become a useful tool to activate and functionalize these inert compounds. In this article, we summarize the main achievements in this field applied to the development of C-C bond forming reactions, and we discuss the key mechanistic features that enable these transformations.
Language	English
Publishing date	2023-08-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc02790b
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Article ; Online: Pd-Catalyzed allylic C-H activation to seven-membered

Velasco-Rubio, Álvaro / Varela, Jesús A / Saá, Carlos

Chemical communications (Cambridge, England)

2021 Volume 57, Issue 83, Page(s) 10915–10918

Abstract: Pd-catalyzed allylic C-H activation of simple olefins allows an easy entry to seven-membered ...

Abstract	Pd-catalyzed allylic C-H activation of simple olefins allows an easy entry to seven-membered
Language	English
Publishing date	2021-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d1cc04056a
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Article ; Online: Implications of the prevalence of Ascaris sp. in the funerary context of a Late Antique population (5th-7th c.) in Granada (Spain).

López-Gijón, Ramón / Camarós, Edgard / Rubio-Salvador, Ángel / Duras, Salvatore / Botella-López, Miguel C / Alemán-Aguilera, Inmaculada / Rodríguez-Aguilera, Ángel / Bustamante-Álvarez, Macarena / Sánchez-Barba, Lydia P / Dufour, Benjamin / Le Bailly, Matthieu

International journal of paleopathology

2023 Volume 43, Page(s) 45–50

Abstract: ... Antiquity (5th - 7th c.) Granada (Spain).: Materials: The study included pelvic and cranial control ...

Abstract	Objective: To evaluate the prevalence of gastro-intestinal parasites in human remains from Late Antiquity (5th - 7th c.) Granada (Spain). Materials: The study included pelvic and cranial control samples from 17 skeletons from the archaeological sites of Los Mondragones (n = 13) and Rafael Guillén (n = 4). Methods: In the paleoparasitological study, soil samples from pelvic area and cranium were analyzed using the rehydration, homogenization, and micro-sieving method and visualization under brightfield microscopy. Results: Ascaris sp. eggs were detected in pelvic samples from seven individuals. Conclusions: These findings may indicate that this parasite was endemic. Its detection frequency is one of the highest reported at group level in an osteological series from Late Antiquity. Significance: The prevalence of Ascaris sp. associated with skeletal remains has implications for assessing the lifestyle and health of populations in southern Spain during the Late Antique period. Limitations: The number of individuals is small and taphonomic processes could have limited paleoparasitological findings SUGGESTIONS FOR FURTHER RESEARCH: Future interdisciplinary studies of this type are warranted in larger osteological series to improve knowledge of parasitosis in the past.
MeSH term(s)	Animals ; Humans ; Ascaris ; Spain/epidemiology ; Prevalence ; Intestinal Diseases, Parasitic/epidemiology ; Intestinal Diseases, Parasitic/parasitology ; Archaeology
Language	English
Publishing date	2023-09-20
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2606330-X
ISSN	1879-9825 ; 1879-9817
ISSN (online)	1879-9825
ISSN	1879-9817
DOI	10.1016/j.ijpp.2023.09.002
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Article ; Online: C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein.

Gargantilla, Marta / Francés, Clara / Adhav, Anmol / Forcada-Nadal, Alicia / Martínez-Gualda, Belén / Martí-Marí, Olaia / López-Redondo, María Luisa / Melero, Roberto / Marco-Marín, Clara / Gougeard, Nadine / Espinosa, Carolina / Rubio-Del-Campo, Antonio / Ruiz-Partida, Rafael / Hernández-Sierra, María Del Pilar / Villamayor-Belinchón, Laura / Bravo, Jerónimo / Llacer, José-Luis / Marina, Alberto / Rubio, Vicente /

San-Félix, Ana / Geller, Ron / Pérez-Pérez, María-Jesús

Journal of medicinal chemistry

2023 Volume 66, Issue 15, Page(s) 10432–10457

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, by infecting cells via the interaction of its spike protein (S) with the primary cell receptor angiotensin-converting enzyme (ACE2). To search for inhibitors of this key step ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, by infecting cells via the interaction of its spike protein (S) with the primary cell receptor angiotensin-converting enzyme (ACE2). To search for inhibitors of this key step in viral infection, we screened an in-house library of multivalent tryptophan derivatives. Using VSV-S pseudoparticles, we identified compound
MeSH term(s)	Humans ; SARS-CoV-2/metabolism ; COVID-19 ; Tryptophan/pharmacology ; Tryptophan/metabolism ; Angiotensin-Converting Enzyme 2/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Cryoelectron Microscopy ; Protein Binding
Chemical Substances	Tryptophan (8DUH1N11BX) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c00576
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Article ; Online: Faecal Microbiota Transplantation is a simple, effective and safe treatment in the management of C. difficile infection in daily clinical practice.

Ferre Aracil, Carlos / El Hajra Martínez, Ismael / Vera Mendoza, MaríaI Sabel / Ramos Martínez, Antonio / Muñez Rubio, Elena / Fernández-Cruz, Ana / Matallana Royo, Virginia / García-Maseda, Sarela / Sánchez Romero, Isabel / Martínez Ruiz, Rocío / Calleja Panero, José Luis

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 41, Issue 4, Page(s) 206–210

Abstract: Introduction: Faecal microbiota transplantation (FMT) is a treatment supported by wide scientific evidence and proved to be very effective in the management of Clostridioides difficile infection (CDI). The objective of this study is to analyze its ... ...

Abstract	Introduction: Faecal microbiota transplantation (FMT) is a treatment supported by wide scientific evidence and proved to be very effective in the management of Clostridioides difficile infection (CDI). The objective of this study is to analyze its effectiveness and safety in a real clinical practice setting. Methods: Retrospective, single-center and descriptive observational study in which all FMT performed between May 2016 and December 2020 were included. Technical success was defined as the successful administration of the faecal preparation in the patient's gastrointestinal tract and clinical success the disappearance of diarrhoea in the first 72 h after the procedure with no relapse within the following 8 weeks after the therapy was started. Results: 15 FMT were performed in 13 patients. Median age was 79 years (range: 40-98 years); being 60% women and 33.3% depedent persons. The indication for FMT was recurrent CDI in 84.6%. All FMTs were performed by colonoscopy and from related donors. With a first procedure, the FMT was effective in 11 of 13 patients (84.61%; 95% CI; 54.55-98.07). Time until resolution of symptoms was less than 48 h in all cases. Post-transplant follow-up was 25.66 ± 17.5 months. No significant short or long-term complications were recorded at follow-up. Conclusion: TMF is a simple, effective and safe procedure in CD infection, even in elderly patients or those with great comorbidities.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Fecal Microbiota Transplantation/methods ; Clostridioides difficile ; Retrospective Studies ; Treatment Outcome ; Feces ; Clostridium Infections
Language	English
Publishing date	2023-01-19
Publishing country	Spain
Document type	Observational Study ; Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.01.004
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Article ; Online: Textbook outcome in urgent early cholecystectomy for acute calculous cholecystitis: results post hoc of the S.P.Ri.M.A.C.C study.

Fugazzola, Paola / Carbonell-Morote, Silvia / Cobianchi, Lorenzo / Coccolini, Federico / Rubio-García, Juan Jesús / Sartelli, Massimo / Biffl, Walter / Catena, Fausto / Ansaloni, Luca / Ramia, Jose Manuel

World journal of emergency surgery : WJES

2024 Volume 19, Issue 1, Page(s) 12

Abstract: Introduction: A textbook outcome patient is one in which the operative course passes uneventful, without complications, readmission or mortality. There is a lack of publications in terms of TO on acute cholecystitis.: Objetive: The objective of this ... ...

Abstract	Introduction: A textbook outcome patient is one in which the operative course passes uneventful, without complications, readmission or mortality. There is a lack of publications in terms of TO on acute cholecystitis. Objetive: The objective of this study is to analyze the achievement of TO in patients with urgent early cholecystectomy (UEC) for Acute Cholecystitis. and to identify which factors are related to achieving TO. Materials and methods: This is a post hoc study of the SPRiMACC study. It´s a prospective multicenter observational study run by WSES. The criteria to define TO in urgent early cholecystectomy (TOUEC) were no 30-day mortality, no 30-day postoperative complications, no readmission within 30 days, and hospital stay ≤ 7 days (75th percentile), and full laparoscopic surgery. Patients who met all these conditions were taken as presenting a TOUEC. Outcomes: 1246 urgent early cholecystectomies for ACC were included. In all, 789 patients (63.3%) achieved all TOUEC parameters, while 457 (36.6%) failed to achieve one or more parameters and were considered non-TOUEC. The patients who achieved TOUEC were younger had significantly lower scores on all the risk scales analyzed. In the serological tests, TOUEC patients had lower values for in a lot of variables than non-TOUEC patients. The TOUEC group had lower rates of complicated cholecystitis. Considering operative time, a shorter duration was also associated with a higher probability of reaching TOUEC. Conclusion: Knowledge of the factors that influence the TOUEC can allow us to improve our results in terms of textbook outcome.
MeSH term(s)	Humans ; Cholecystectomy, Laparoscopic/methods ; Prospective Studies ; Cholecystectomy ; Cholecystitis, Acute/surgery ; Cholecystitis/surgery
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2233734-9
ISSN	1749-7922 ; 1749-7922
ISSN (online)	1749-7922
ISSN	1749-7922
DOI	10.1186/s13017-024-00539-6
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Article ; Online: Oral Presentation Award Winner: LDL-C Reduction in Diabetic Patients after Percutaneous Coronary Intervention: Is There any Difference with Non-diabetic?

Mallofré, N / Torres, G / Roca, C / Rojas, P / Sutil, M / Casanovas, N / Lloreda, M / Castaldo, F / Bosch, E / Martínez-Rubio, A

European cardiology

2023 Volume 18, Page(s) e19

Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article ; Review
ISSN	1758-3764
ISSN (online)	1758-3764
DOI	10.15420/ecr.2023.18.PO2
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Article ; Online: Catalytic Lewis Base Additive Enables Selective Copper-Catalyzed Borylative α-C-H Allylation of Alicyclic Amines.

Pérez-Saavedra, Borja / Velasco-Rubio, Álvaro / Rivera-Chao, Eva / Varela, Jesús A / Saá, Carlos / Fañanás-Mastral, Martín

Journal of the American Chemical Society

2022 Volume 144, Issue 35, Page(s) 16206–16216

Abstract: Functionalized alicyclic amines are important building blocks for the synthesis of bioactive natural compounds and drugs. Existing methods of functionalization are typically limited to the synthesis of protected amines or the use of highly basic ... ...

Abstract	Functionalized alicyclic amines are important building blocks for the synthesis of bioactive natural compounds and drugs. Existing methods of functionalization are typically limited to the synthesis of protected amines or the use of highly basic organometallic reagents that can compromise functional group tolerance. Here, we report a novel approach that enables the transformation of
MeSH term(s)	Amines/chemistry ; Catalysis ; Copper/chemistry ; Imines ; Lewis Bases
Chemical Substances	Amines ; Imines ; Lewis Bases ; Copper (789U1901C5)
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c07969
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Article ; Online: The photosynthetic cytochrome c

Bernal-Bayard, Pilar / Puerto-Galán, Leonor / Yruela, Inmaculada / García-Rubio, Inés / Castell, Carmen / Ortega, José M / Alonso, Pablo J / Roncel, Mercedes / Martínez, Jesús I / Hervás, Manuel / Navarro, José A

Photosynthesis research

2016 Volume 133, Issue 1-3, Page(s) 273–287

Abstract: The photosynthetic cytochrome c ...

Abstract	The photosynthetic cytochrome c
MeSH term(s)	Amino Acid Sequence ; Cytochrome c Group/chemistry ; Cytochrome c Group/isolation & purification ; Cytochrome c Group/metabolism ; Diatoms/metabolism ; Electron Spin Resonance Spectroscopy ; Models, Molecular ; Molecular Weight ; Photosynthesis ; Photosystem II Protein Complex/metabolism ; Static Electricity
Chemical Substances	Cytochrome c Group ; Photosystem II Protein Complex ; cytochrome C-550 (9064-80-6)
Language	English
Publishing date	2016-12-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1475688-2
ISSN	1573-5079 ; 0166-8595
ISSN (online)	1573-5079
ISSN	0166-8595
DOI	10.1007/s11120-016-0327-x
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Article ; Online: Comparison of plasma inflammatory biomarkers between MIS-C and potentially serious infections in pediatric patients.

Visa-Reñé, Núria / Rubio-Páez, Adriana / Mitjans-Rubies, Núria / Paredes-Carmona, Fernando

Reumatologia clinica

2024 Volume 20, Issue 2, Page(s) 84–91

Abstract: ... of multisystemic inflammatory syndrome in children (MIS-C). We aimed to compare the clinical and laboratory ... findings of MIS-C cases versus other febrile cases cataloged as potentially suspected bacterial infection ... non-MIS-C).: Methods: Unicentric ambispective observational cohort study (June 2020-February 2022 ...

Abstract	Background: Inflammatory biomarkers have been used for the diagnosis and management of multisystemic inflammatory syndrome in children (MIS-C). We aimed to compare the clinical and laboratory findings of MIS-C cases versus other febrile cases cataloged as potentially suspected bacterial infection (non-MIS-C). Methods: Unicentric ambispective observational cohort study (June 2020-February 2022). We analyzed demographics, clinical symptoms and laboratory findings in MIS-C cases and in non-MIS-C cases with febrile processes of patients under 15 years of age admitted to hospital. Results: We enrolled 54 patients with potential suspected bacterial infection and 20 patients with MIS-C for analysis. Fever (100%), gastrointestinal (80%) and mucocutaneous findings (35%) were common in MIS-C patients, also hypotension (36.8%) and tachycardia (55%). Laboratory findings showed significantly elevated proBNP (70%), ferritin (35%), D-dimer (80%) and lymphopenia (55%) and thrombocytopenia (27.8%) in MIS-C cases. IL-6 values were high in non-MIS-C patients (92.6%). Conclusions: In the management of MIS-C patients, the dynamic monitoring of proBNP, ferritin, D-dimer, lymphocytes and platelets could be helpful to pediatricians to effectively evaluate the progress of MIS-C in the early phases, not IL-6 values. The applicability of the IL-6 level as a prognostic biomarker in MIS-C patients may require closer discussion. In addition, the optimal laboratory markers, as stated in our study, can help establish a biomarkers model to early distinguish the MIS-C versus non-MIS-C in patients who are admitted to febrile syndrome.
MeSH term(s)	Child ; Humans ; COVID-19 ; SARS-CoV-2 ; Interleukin-6 ; Fever/etiology ; Biomarkers ; Bacterial Infections ; Ferritins
Chemical Substances	Interleukin-6 ; Biomarkers ; Ferritins (9007-73-2)
Language	English
Publishing date	2024-02-10
Publishing country	Spain
Document type	Observational Study ; Journal Article
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reumae.2024.01.005
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