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  1. Article ; Online: Reply to Juan Pablo Valdevenito, Marcio Augusto Averbeck, Sanjay Sinha, Enrico Finazzi-Agro, and Andrew Gammie's Letter to the Editor re: Karl H. Pang, Riccardo Campi, Salvador Arlandis, et al. Diagnostic Tests for Female Bladder Outlet Obstruction: A Systematic Review from the European Association of Urology Non-neurogenic Female LUTS Guidelines Panel. Eur Urol Focus 2022;8:1015-30.

    Pang, Karl H / Campi, Riccardo / Imran Omar, Muhammad / Harding, Christopher K

    European urology focus

    2023  Volume 9, Issue 4, Page(s) 629–630

    MeSH term(s) Humans ; Female ; Urology ; Urinary Bladder Neck Obstruction ; Urinary Bladder ; Diagnostic Tests, Routine
    Language English
    Publishing date 2023-02-01
    Publishing country Netherlands
    Document type Systematic Review ; Letter ; Comment
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2023.01.014
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  2. Article ; Online: Special clinical features with a novel mutation site of CHN1 gene in a Chinese family with Duane retraction syndrome.

    Wang, Minshu / Liu, Jing / Pang, Honglei / Bu, Juan

    Strabismus

    2024  , Page(s) 1–7

    Abstract: Purpose: This study is to describe the special clinical and genotypic features of a Chinese family with variant types of Duane retraction syndrome and to present our experience on managing these cases.: Methods: Four individuals from one family were ... ...

    Abstract Purpose: This study is to describe the special clinical and genotypic features of a Chinese family with variant types of Duane retraction syndrome and to present our experience on managing these cases.
    Methods: Four individuals from one family were reviewed by ophthalmologic examinations, in which two affected and two unaffected individuals were revealed. MRI scans were performed on the two patients. Relevant gene mutations were screened by the next-generation sequencing technology and confirmed by Sanger sequencing technology.
    Results: The six-year-old proband presented with special clinical features of severe horizontal gaze dysfunction, exotropia and mild scoliosis. His mother showed significantly limited binocular abductions, with retraction of eyeballs in adduction. From MRI scans, abducens nerves were not observed in both patients and the oculomotor nerve was slightly thin in the proband. The proband and his mother shared the same CHN1 gene mutation site (c. 62A>G; p.Y21C). Strabismus surgery was performed on the proband to correct the primary gaze exotropia.(NM_001822: exon3 or NM_001025201: exon4: c. 62A>G; p.Y21C).
    Conclusions: A novel CHN1 gene mutation was revealed from a Chinese family with Duane retraction syndrome. Remarkably, the proband and his mother presented different clinical features of ocular motility disorder. Strabismus correction surgery and amblyopia training helped to improve the appearance and visual function of the proband.
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1149100-0
    ISSN 1744-5132 ; 0927-3972
    ISSN (online) 1744-5132
    ISSN 0927-3972
    DOI 10.1080/09273972.2023.2299470
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    Zs.A 5485: Show issues Location:
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  3. Article: Multianticoagulant Pseudothrombocytopenia in a Patient with Primary Carcinoma of the Liver with Hypersplenism.

    Pang, Naiqi / Wang, Ying / Li, Peizhang / Li, Meiqing / Xie, Juan

    Clinical laboratory

    2024  Volume 70, Issue 3

    Abstract: Background: Pseudothrombocytopenia (PTCP) is a relatively rare phenomenon in vitro, the mechanism is not completely clear, and there is no unified solution for it. How to identify and solve PTCP accurately is a challenge for laboratory personnel.: ... ...

    Abstract Background: Pseudothrombocytopenia (PTCP) is a relatively rare phenomenon in vitro, the mechanism is not completely clear, and there is no unified solution for it. How to identify and solve PTCP accurately is a challenge for laboratory personnel.
    Methods: According to the patient's clinical manifestations, thrombocytopenia caused by hypersplenism was excluded. PTCP was confirmed by platelet volume histograms, scattergrams and platelet clumps on the blood smears. Commonly used alternative anticoagulants such as sodium citrate or heparin were used for platelet counting. The corrective effect of the platelet count was not good, so non-anticoagulant blood was collected and tested immediately, and blood smears were used to count platelets manually.
    Results: The PTCP of the patient could not be solved using sodium citrate and heparin anticoagulation. By collecting non-anticoagulant blood and testing immediately, the platelet count returned to normal (180 x 109/L), which is consistent with the results of manual counting on the patient's blood smears (175 x 109/L).
    Conclusions: When PTCP is confirmed, commonly used alternative anticoagulants can be used. If these do not work, non-anticoagulant blood can be collected and tested immediately, and blood smears can be used to count platelets manually.
    MeSH term(s) Humans ; Sodium Citrate/pharmacology ; Edetic Acid/pharmacology ; Hypersplenism/diagnosis ; Platelet Aggregation ; Thrombocytopenia/diagnosis ; Thrombocytopenia/drug therapy ; Anticoagulants/therapeutic use ; Anticoagulants/pharmacology ; Heparin/therapeutic use ; Heparin/pharmacology ; Liver ; Carcinoma
    Chemical Substances Sodium Citrate (1Q73Q2JULR) ; Edetic Acid (9G34HU7RV0) ; Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2024-03-12
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2023.230905
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  4. Article: Single-cell and bulk RNA sequencing highlights the role of M1-like infiltrating macrophages in antibody-mediated rejection after kidney transplantation.

    Pang, Qidan / Chen, Liang / An, Changyong / Zhou, Juan / Xiao, Hanyu

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27865

    Abstract: Background: Antibody-mediated rejection (ABMR) significantly affects transplanted kidney survival, yet the macrophage phenotype, ontogeny, and mechanisms in ABMR remain unclear.: Method: We analyzed post-transplant sequencing and clinical data from ... ...

    Abstract Background: Antibody-mediated rejection (ABMR) significantly affects transplanted kidney survival, yet the macrophage phenotype, ontogeny, and mechanisms in ABMR remain unclear.
    Method: We analyzed post-transplant sequencing and clinical data from GEO and ArrayExpress. Using dimensionality reduction and clustering on scRNA-seq data, we identified macrophage subpopulations and compared their infiltration in ABMR and non-rejection cases. Cibersort quantified these subpopulations in bulk samples. Cellchat, SCENIC, monocle2, and monocle3 helped explore intercellular interactions, predict transcription factors, and simulate differentiation of cell subsets. The Scissor method linked macrophage subgroups with transplant prognosis. Furthermore, hdWGCNA, nichnet, and lasso regression identified key genes associated with core transcription factors in selected macrophages, validated by external datasets.
    Results: Six macrophage subgroups were identified in five post-transplant kidney biopsies. M1-like infiltrating macrophages, prevalent in ABMR, correlated with pathological injury severity. MIF acted as a primary intercellular signal in these macrophages. STAT1 regulated monocyte-to-M1-like phenotype transformation, impacting transplant prognosis via the IFNγ pathway. The prognostic models built on the upstream and downstream genes of STAT1 effectively predicted transplant survival. The TLR4-STAT1-PARP9 axis may regulate the pro-inflammatory phenotype of M1-like infiltrating macrophages, identifying PARP9 as a potential target for mitigating ABMR inflammation.
    Conclusion: Our study delineates the macrophage landscape in ABMR post-kidney transplantation, underscoring the detrimental impact of M1-like infiltrating macrophages on ABMR pathology and prognosis.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27865
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  5. Article: A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm with Orbital Tumor as the Initial Symptom.

    Li, Peizhang / Pang, Naiqi / Li, Meiqin / Xie, Juan / Wang, Ying

    Clinical laboratory

    2024  Volume 70, Issue 4

    Abstract: Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy arising from precursor dendritic cells. It is a rare and challenging clinical presentation. For decades, there has been no treatment course for managing ... ...

    Abstract Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy arising from precursor dendritic cells. It is a rare and challenging clinical presentation. For decades, there has been no treatment course for managing BPDCN and its overall prognosis is poor.
    Methods and results: We report a 27-year-old man who was admitted to the hospital due to an orbital tumor as the first symptom. Progressive enlargement of the orbital tumor was accompanied by multiple purple circular nodules on the body trunk. Pathological confirmation of BPDCN after resection of the orbital mass. Bone marrow smear and flow cytometry on examination indicate AML-M5. Performance of chemotherapy and peripheral blood autologous stem cell transplantation.
    Conclusions: The clinical manifestations of blastic plasmacytoid dendritic cell neoplasms are diverse. The diagnosis of BPDCN can be difficult due to overlapping morphologic, immunophenotypic, and clinical features of other hematologic AML. Relapsed and refractory BPDCN remains an elusive therapeutic challenge. The future of new targeted therapeutic drugs is expected.
    MeSH term(s) Male ; Humans ; Adult ; Hematopoietic Stem Cell Transplantation ; Orbital Neoplasms/diagnosis ; Orbital Neoplasms/complications ; Orbital Neoplasms/pathology ; Dendritic Cells ; Transplantation, Autologous ; Skin Neoplasms/pathology ; Hematologic Neoplasms/diagnosis ; Leukemia, Myeloid, Acute/complications
    Language English
    Publishing date 2024-04-16
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2023.231014
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  6. Article ; Online: Causal Association Between Sepsis and Neurodegenerative Diseases: A Bidirectional Two-Sample Mendelian Randomization Study.

    Zeng, Youjie / Cao, Si / Pang, Ke / Tang, Juan / Lin, Guoxin

    Journal of Alzheimer's disease : JAD

    2024  Volume 97, Issue 1, Page(s) 229–237

    Abstract: Background: Previous observational studies suggested an association between sepsis and neurodegenerative diseases, but causality remains unclear.: Objective: Determining the causal association between sepsis and four neurodegenerative diseases ( ... ...

    Abstract Background: Previous observational studies suggested an association between sepsis and neurodegenerative diseases, but causality remains unclear.
    Objective: Determining the causal association between sepsis and four neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Lewy body dementia) through bidirectional two-sample Mendelian randomization (MR) analysis.
    Methods: Genome-wide association study summary statistics for all traits were obtained from publicly available databases. Inverse variance weighted (IVW) was the primary method for evaluating causal associations. In addition, three additional MR methods (MR-Egger, weighted median, and maximum likelihood method) were employed to supplement IVW. Furthermore, various sensitivity tests were conducted to assess the reliability: 1) Cochrane's Q test for assessing heterogeneity; 2) MR-Egger intercept test and MR-PRESSO global test for evaluating horizontal pleiotropy; 3) leave-one-out sensitivity test for determining the stability.
    Results: The results of IVW indicated that sepsis significantly increased the risk of Alzheimer's disease (OR = 1.11, 95% CI: 1.01-1.21, p = 0.025). In addition, three additional MR methods suggested parallel results. However, no causal effect of sepsis on the three other neurodegenerative diseases was identified. Subsequently, reverse MR analysis indicated that the four neurodegenerative diseases do not causally affect sepsis. Furthermore, sensitivity tests demonstrated the reliability of the MR analyses, suggesting no heterogeneity or horizontal pleiotropy.
    Conclusions: The present study contributes to a deeper comprehension of the intricate interplay between sepsis and neurodegenerative disorders, thereby offering potential avenues for the development of therapeutic agents that can effectively mitigate the multifarious complications associated with sepsis.
    MeSH term(s) Humans ; Neurodegenerative Diseases/complications ; Neurodegenerative Diseases/epidemiology ; Neurodegenerative Diseases/genetics ; Alzheimer Disease/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Reproducibility of Results ; Sepsis/complications ; Sepsis/genetics
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230954
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    Zs.A 6084: Show issues Location:
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  7. Article: Commentary: Can FXR serve as a potential target for COVID-19 prevention?

    Pang, Juan / Feng, Jia Nuo / Ling, Wenhua / Jin, Tianru

    Acta pharmaceutica Sinica. B

    2023  Volume 13, Issue 4, Page(s) 1786–1788

    Language English
    Publishing date 2023-02-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.01.023
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  8. Article ; Online: A review on recent advances on nobiletin in central and peripheral nervous system diseases.

    Pang, Yueshan / Xiong, Juan / Wu, You / Ding, Weijun

    European journal of medical research

    2023  Volume 28, Issue 1, Page(s) 485

    Abstract: In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited. Nobiletin, as a compound with high fat solubility, high bioavailability and low ... ...

    Abstract In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited. Nobiletin, as a compound with high fat solubility, high bioavailability and low toxicity, has been extensively studied. Accumulating scientific evidence has shown that nobiletin has a variety of biological functions in the nervous system, such as inhibiting the expression of inflammatory factors, reducing the neurotoxic response, improving the antioxidant capacity, promoting the survival of nerve cells, promoting axon growth, reducing blood‒brain barrier permeability, reducing brain oedema, promoting cAMP response element binding protein expression, improving memory, and promoting mild depolarization of nerve cell mitochondria to improve antioxidative stress capacity. Accumulating studies have shown that nobiletin also protects enteric nervous system, spinal cord and sciatic nerve. To explore the new therapeutic potential of nobiletin in the nervous system, recent and relevant research progress is reviewed in this article. This will provide a new research idea for nobiletin in the nervous system.
    MeSH term(s) Humans ; Flavones/chemistry ; Flavones/pharmacology ; Antioxidants ; Oxidative Stress ; Peripheral Nervous System Diseases
    Chemical Substances nobiletin (D65ILJ7WLY) ; Flavones ; Antioxidants
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-023-01450-7
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  9. Article: Reticular synthesis of 8-connected carboxyl hydrogen-bonded organic frameworks for white-light-emission.

    Xi, Xiao-Juan / Li, Yang / Lang, Feifan / Pang, Jiandong / Bu, Xian-He

    Chemical science

    2024  Volume 15, Issue 12, Page(s) 4529–4537

    Abstract: The rational design and construction of hydrogen-bonded organic frameworks (HOFs) are crucial for enabling their practical applications, but controlling their structure and preparation as intended remains challenging. Inspired by reticular chemistry, two ...

    Abstract The rational design and construction of hydrogen-bonded organic frameworks (HOFs) are crucial for enabling their practical applications, but controlling their structure and preparation as intended remains challenging. Inspired by reticular chemistry, two novel blue-emitting NKM-HOF-1 and NKM-HOF-2 were successfully constructed based on two judiciously designed peripherally extended pentiptycene carboxylic acids, namely H
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc06410g
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  10. Article ; Online: Pocket lab for the rapid detection of monkeypox virus.

    Wei, Jia / Meng, Xianying / Li, Juan / Pang, Bo

    Travel medicine and infectious disease

    2022  Volume 50, Page(s) 102478

    MeSH term(s) Humans ; Monkeypox virus
    Language English
    Publishing date 2022-10-17
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2022.102478
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