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  1. Article ; Online: From skin infection to invasive diseases

    Ikrame ZEOUK

    Notulae Scientia Biologicae, Vol 15, Iss

    A descriptive review of Staphylococcus aureus, focusing on Panton-Valentine leucocidin and methicillin-resistant strains

    2023  Volume 1

    Abstract: Despite advances in scientific research, Staphylococccus aureus remains a pyogenic and toxigenic bacterium involved in different infections, it endowed with the capacity to infect several biotopes and cause a wide range of infections ranging from skin ... ...

    Abstract Despite advances in scientific research, Staphylococccus aureus remains a pyogenic and toxigenic bacterium involved in different infections, it endowed with the capacity to infect several biotopes and cause a wide range of infections ranging from skin diseases to other serious pathologies such as pneumonia, meningitis, sepsis, osteomyelitis and infectious endocarditis. Moreover, the emergence of resistant strains constitutes a serious public health problem. Thus, the development of new active compounds from natural sources such as medicinal plants is urgently needed. To this end, the aim of our review was to describe the state of art of infections caused by S. aureus, its pathogenesis, treatment and to provide a synthesis about studies reporting a bio guided isolation of most promising compounds selected for their anti-staphylococcal activity.
    Keywords bio guided fractionation ; natural products ; resistance ; Staphylococcus aureus ; Agriculture (General) ; S1-972 ; Science (General) ; Q1-390
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Society of Land Measurements and Cadastre from Transylvania (SMTCT)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: From Wuhan to COVID-19 Pandemic: An Up-to-Date Review of Its Pathogenesis, Potential Therapeutics, and Recent Advances.

    Zeouk, Ikrame / Bekhti, Khadija / Lorenzo-Morales, Jacob

    Microorganisms

    2020  Volume 8, Issue 6

    Abstract: The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. To date, there are no specific antiviral agents available for this disease, currently ... ...

    Abstract The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. To date, there are no specific antiviral agents available for this disease, currently known as COVID-19. Therefore, genomic sequencing and therapeutic clinical trials are being conducted to develop effective antiviral agents. Several reports have investigated FDA-approved drugs as well as in silico virtual screening approaches such as molecular docking and modeling to find novel antiviral agents. Until now, antiparasitic drugs such as chloroquine have shown the most relevant results. Furthermore, there is an urgent need to understand the pathogenesis of this novel coronavirus, its transmission routes, surface survival and evolution in the environment. So far, the scientific community has indicated a possible transmission of COVID-19 via blood transfusion which is challenging in the case of asymptomatic individuals. Protocols for pathogen inactivation are also needed. In this paper, we reviewed recent findings about this life-threatening pandemic.
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8060850
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  3. Article: Antistaphylococcal Activity and Phytochemical Analysis of Crude Extracts of Five Medicinal Plants Used in the Center of Morocco against Dermatitis.

    Zeouk, Ikrame / Balouiri, Mounyr / Bekhti, Khadija

    International journal of microbiology

    2019  Volume 2019, Page(s) 1803102

    Abstract: Novel drugs for methicillin- ... ...

    Abstract Novel drugs for methicillin-resistant
    Language English
    Publishing date 2019-11-04
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2467270-1
    ISSN 1687-9198 ; 1687-918X
    ISSN (online) 1687-9198
    ISSN 1687-918X
    DOI 10.1155/2019/1803102
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  4. Article: From Wuhan to COVID-19 Pandemic: An Up-to-Date Review of Its Pathogenesis, Potential Therapeutics, and Recent Advances

    Zeouk, Ikrame / Bekhti, Khadija / Lorenzo-Morales, Jacob

    Microorganisms. 2020 June 04, v. 8, no. 6

    2020  

    Abstract: The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. To date, there are no specific antiviral agents available for this disease, currently ... ...

    Abstract The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. To date, there are no specific antiviral agents available for this disease, currently known as COVID-19. Therefore, genomic sequencing and therapeutic clinical trials are being conducted to develop effective antiviral agents. Several reports have investigated FDA-approved drugs as well as in silico virtual screening approaches such as molecular docking and modeling to find novel antiviral agents. Until now, antiparasitic drugs such as chloroquine have shown the most relevant results. Furthermore, there is an urgent need to understand the pathogenesis of this novel coronavirus, its transmission routes, surface survival and evolution in the environment. So far, the scientific community has indicated a possible transmission of COVID-19 via blood transfusion which is challenging in the case of asymptomatic individuals. Protocols for pathogen inactivation are also needed. In this paper, we reviewed recent findings about this life-threatening pandemic.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; blood transfusion ; chloroquine ; computer simulation ; evolution ; genomics ; humans ; pandemic ; pathogenesis ; pathogens ; public health ; respiratory system
    Language English
    Dates of publication 2020-0604
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8060850
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: From Wuhan to COVID-19 Pandemic

    Ikrame Zeouk / Khadija Bekhti / Jacob Lorenzo-Morales

    Microorganisms, Vol 8, Iss 850, p

    An Up-to-Date Review of Its Pathogenesis, Potential Therapeutics, and Recent Advances

    2020  Volume 850

    Abstract: The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. To date, there are no specific antiviral agents available for this disease, currently ... ...

    Abstract The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. To date, there are no specific antiviral agents available for this disease, currently known as COVID-19. Therefore, genomic sequencing and therapeutic clinical trials are being conducted to develop effective antiviral agents. Several reports have investigated FDA-approved drugs as well as in silico virtual screening approaches such as molecular docking and modeling to find novel antiviral agents. Until now, antiparasitic drugs such as chloroquine have shown the most relevant results. Furthermore, there is an urgent need to understand the pathogenesis of this novel coronavirus, its transmission routes, surface survival and evolution in the environment. So far, the scientific community has indicated a possible transmission of COVID-19 via blood transfusion which is challenging in the case of asymptomatic individuals. Protocols for pathogen inactivation are also needed. In this paper, we reviewed recent findings about this life-threatening pandemic.
    Keywords COVID-19 ; SARS-CoV-2 ; pathogenicity ; therapeutic advances ; prevention ; Biology (General) ; QH301-705.5 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Inhibition of Acanthamoeba polyphaga by chlorhexidine-mediated oxidative stress response.

    Sifaoui, Ines / Zeouk, Ikrame / Reyes-Batlle, María / Lopez-Arencibia, Atteneri / Piñero, José E / Lorenzo-Morales, Jacob

    Journal of global antimicrobial resistance

    2022  Volume 30, Page(s) 468–473

    Abstract: Objectives: Acanthamoeba keratitis is a severe corneal infection caused by a ubiquitous opportunistic protozoan pathogen known as acanthamoeba. For the last decade, the approach to treating this infection typically includes the use of polyhexamethylene ... ...

    Abstract Objectives: Acanthamoeba keratitis is a severe corneal infection caused by a ubiquitous opportunistic protozoan pathogen known as acanthamoeba. For the last decade, the approach to treating this infection typically includes the use of polyhexamethylene biguanide (0.02%) and/or chlorhexidine (Chx) (0.02%). Although chlorhexidine is reportedly effective, its mode of action towards this type of cell is not clear. The aim of this work was to study the effect of chlorhexidine on the oxidative status of Acanthamoeba polyphaga.
    Methods: The effect of chlorhexidine (Chx) on the oxidative state of Acanthamoeba polyphaga was studied using different antiradical methods including ABTS, DPPH and FRAP and measuring the activity of a couple of antioxidant enzyme namely SOD, NADH-FRD and SDH.
    Results: The chlorhexidine was able to induce oxidative imbalance in cells by over expression of reactive oxygen species and/or inhibiting the antioxidant enzymes. In addition to enhancing the antiradical activity in response to oxidative stress, the present drug was able to reduce the activity of two antioxidant enzymes, superoxide dismutase (SOD) and reduced flavin adenine dinucleotide-fumarate reductase (NADH-FRD), to 30% and 40%, respectively.
    Conclusions: We could observe an increase of the antiradical capacity of cell's lysate supernatant, to cope with the overproduction of ROS. The imbalance state The inhibition of both SOD and NADH-FRD activities could have a major role in cell oxidative imbalance.
    MeSH term(s) Acanthamoeba ; Antioxidants/pharmacology ; Chlorhexidine/pharmacology ; NAD/pharmacology ; Oxidative Stress ; Superoxide Dismutase/pharmacology
    Chemical Substances Antioxidants ; NAD (0U46U6E8UK) ; Superoxide Dismutase (EC 1.15.1.1) ; Chlorhexidine (R4KO0DY52L)
    Language English
    Publishing date 2022-05-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2022.05.018
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  7. Article ; Online: Susceptibility patterns of bacteria isolated from the hospital environment towards disinfectants commonly used for surfaces and medical devices

    Jaouhar Samira / El Ouali Lalami Abdelhakim / Bouzid Jawad / Zeouk Ikrame / Bekhti Khadija

    E3S Web of Conferences, Vol 319, p

    2021  Volume 01081

    Abstract: This study aimed to evaluate the bactericidal activity of common disinfectants used for surfaces and medical devices. Sodium hypochlorite (D1), disinfectant (D2) composed of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine, chloride de ... ...

    Abstract This study aimed to evaluate the bactericidal activity of common disinfectants used for surfaces and medical devices. Sodium hypochlorite (D1), disinfectant (D2) composed of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine, chloride de didecyldimethylammonium, and disinfectant (D3) composed of Didecyldimethylammonium chloride and Polyhexamethylene biguanide hydrochloride, were tested against 15 strains isolated from the hospital environment and four reference bacteria. The microdilution method was performed to assess antimicrobial activity. The susceptibility was evaluated by comparing the minimum inhibitory dilution with the dilution of disinfectant recommended by the manufacture. D1 and D2 were active against Staphylococcus epidermidis, Staphylococcus saprophyticus, Enterobacter cloacae, Escherichia coli, Pseudomonas fluorescens, Methicillin-resistant Staphylococcus aureus, Bacillus spp, Corynebacterium spp, Gram-positive bacillus, Escherichia coli ATCC 25922, Bacillus subtilis ATCC 3366, and Pseudomonas aeruginosa ATCC 27853 strains but not active against Micrococcus spp, and Staphylococcus aureus ATCC 29213. D3 was ineffective against Micrococcus spp, Bacillus Gram Positive, Staphylococcus epidermidis, and Escherichia coli ATCC 25922. Therefore, D1 and D2 can eliminate most pathogenic bacteria in hospitals, in comparison to D3. It is necessary to monitor the antibacterial activity of disinfectants against reference strains but also against those usually present on surfaces. The obtained results could have promising applications in controlling the emergence of nosocomial infections.
    Keywords Environmental sciences ; GE1-350
    Subject code 630
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: From wuhan to COVID-19 pandemic: An up-to-date review of its pathogenesis, potential therapeutics, and recent advances

    Zeouk, Ikrame / Bekhti, Khadija / Lorenzo-morales, Jacob

    Microorg.

    Abstract: The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. To date, there are no specific antiviral agents available for this disease, currently ... ...

    Abstract The emergence of a novel human coronavirus (SARS-CoV-2) causing severe contagious respiratory tract infections presents a serious threat to public health worldwide. To date, there are no specific antiviral agents available for this disease, currently known as COVID-19. Therefore, genomic sequencing and therapeutic clinical trials are being conducted to develop effective antiviral agents. Several reports have investigated FDA-approved drugs as well as in silico virtual screening approaches such as molecular docking and modeling to find novel antiviral agents. Until now, antiparasitic drugs such as chloroquine have shown the most relevant results. Furthermore, there is an urgent need to understand the pathogenesis of this novel coronavirus, its transmission routes, surface survival and evolution in the environment. So far, the scientific community has indicated a possible transmission of COVID-19 via blood transfusion which is challenging in the case of asymptomatic individuals. Protocols for pathogen inactivation are also needed. In this paper, we reviewed recent findings about this life-threatening pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #592873
    Database COVID19

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  9. Article ; Online: Bioguided Isolation of Active Compounds from

    Zeouk, Ikrame / Ouedrhiri, Wessal / Sifaoui, Ines / Bazzocchi, Isabel L / Piñero, José E / Jiménez, Ignacio A / Lorenzo-Morales, Jacob / Bekhti, Khadija

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 14

    Abstract: Despite intensified efforts to develop an effective antibiotic, ...

    Abstract Despite intensified efforts to develop an effective antibiotic,
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Bacterial Toxins ; Exotoxins ; Leukocidins ; Methicillin-Resistant Staphylococcus aureus/growth & development ; Phytochemicals/chemistry ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Rhamnus/chemistry
    Chemical Substances Anti-Bacterial Agents ; Bacterial Toxins ; Exotoxins ; Leukocidins ; Panton-Valentine leukocidin ; Phytochemicals
    Language English
    Publishing date 2021-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26144352
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  10. Article ; Online: Biological and Pharmacological Properties of Myrtenol: A Review.

    Mrabti, Hanae Naceiri / Jaouadi, Imane / Zeouk, Ikrame / Ghchime, Rokia / El Menyiy, Naoual / Omari, Nasreddine El / Balahbib, Abdelaali / Al-Mijalli, Samiah H / Abdallah, Emad M / El-Shazly, Mohamed / Zengin, Gokhan / Bouyahya, Abdelhakim

    Current pharmaceutical design

    2022  Volume 29, Issue 6, Page(s) 407–414

    Abstract: Myrtenol ( ... ...

    Abstract Myrtenol (C
    MeSH term(s) Humans ; Plant Extracts/pharmacology ; Oils, Volatile/pharmacology ; Monoterpenes/pharmacology ; Antioxidants/pharmacology
    Chemical Substances myrtenol (S1B8392IQY) ; Plant Extracts ; Oils, Volatile ; Monoterpenes ; Antioxidants
    Language English
    Publishing date 2022-12-24
    Publishing country United Arab Emirates
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612829666221222121041
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