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  1. Article ; Online: Recurrent Miller Fisher syndrome: Case report.

    Peral Quirós, A / Acebrón, F / Del Carmen Blanco Valero, M / Labella Álvarez, F

    Neurologia (Barcelona, Spain)

    2021  Volume 36, Issue 7, Page(s) 561–562

    MeSH term(s) Gangliosides ; Humans ; Miller Fisher Syndrome/diagnosis ; Ophthalmoplegia
    Chemical Substances Gangliosides
    Language English
    Publishing date 2021-06-23
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 2654369-2
    ISSN 2173-5808 ; 2173-5808
    ISSN (online) 2173-5808
    ISSN 2173-5808
    DOI 10.1016/j.nrleng.2020.08.015
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  2. Article: El uso clínico de pruebas analíticas diagnósticas en las sepsis infantiles.

    Blanco Quirós, A

    Anales de pediatria (Barcelona, Spain : 2003)

    2007  Volume 67, Issue 6, Page(s) 527–529

    Title translation Clinical use of diagnostic laboratory tests in childhood sepsis.
    MeSH term(s) Child ; Hematologic Tests ; Humans ; Sepsis/blood ; Sepsis/diagnosis
    Language Spanish
    Publishing date 2007-09-14
    Publishing country Spain
    Document type Editorial ; Review
    ZDB-ID 2102669-5
    ISSN 1695-4033
    ISSN 1695-4033
    DOI 10.1016/s1695-4033(07)70798-1
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    Zs.B 1640: Show issues Location:
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  3. Article: Spatial and Temporal Distribution of

    Blanco Vázquez, Cristina / Barral, Thiago Doria / Romero, Beatriz / Queipo, Manuel / Merediz, Isabel / Quirós, Pablo / Armenteros, José Ángel / Juste, Ramón / Domínguez, Lucas / Domínguez, Mercedes / Casais, Rosa / Balseiro, Ana

    Animals : an open access journal from MDPI

    2021  Volume 11, Issue 5

    Abstract: The present work investigated the prevalence, spatial distribution, and temporal distribution of tuberculosis (TB) in free-ranging Eurasian badgers ( ...

    Abstract The present work investigated the prevalence, spatial distribution, and temporal distribution of tuberculosis (TB) in free-ranging Eurasian badgers (
    Language English
    Publishing date 2021-04-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani11051294
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  4. Article ; Online: Urinary Plasminogen Activator Inhibitor-1: A Biomarker of Acute Tubular Injury.

    Paniagua-Sancho, María / Quiros, Yaremi / Casanova, Alfredo G / Blanco-Gozalo, Víctor / Agüeros-Blanco, Consuelo / Benito-Hernández, Adalberto / Ramos-Barron, María A / Gómez-Alamillo, Carlos / Arias, Manuel / Sancho-Martínez, Sandra M / López-Hernández, Francisco J

    American journal of nephrology

    2021  Volume 52, Issue 9, Page(s) 714–724

    Abstract: Introduction: Acute kidney injury (AKI) is a threatening, multiaetiological syndrome encompassing a variety of forms and damage patterns. AKI lacks sufficiently specific diagnostic tools to evaluate the distinct combination of pathophysiological events ... ...

    Abstract Introduction: Acute kidney injury (AKI) is a threatening, multiaetiological syndrome encompassing a variety of forms and damage patterns. AKI lacks sufficiently specific diagnostic tools to evaluate the distinct combination of pathophysiological events underlying each case, which limits personalized and optimized handling. Therefore, a pathophysiological diagnosis based on new urinary biomarkers is sought for practical (readiness and noninvasiveness) and conceptual reasons, as the urine is a direct product of the kidneys. However, biomarkers found in the urine may also have extrarenal origin, thus conveying pathophysiological information from other organs or tissues. Urinary plasminogen activator inhibitor-1 (PAI-1) has been associated to AKI, although its origin and traffic to the urine are not known.
    Methods: Herein, we studied the blood or renal origin of urinary PAI-1 (uPAI-1) in experimental AKI in Wistar rats, by means of the in situ renal perfusion method. For this purpose, urine was collected while the kidneys of rats with AKI showing increased uPAI-1 excretion, and controls, were in situ perfused with a saline solution.
    Results: Our results show that during perfusion, PAI-1 remained in the urine of AKI rats, suggesting that renal cells shed this protein directly to the urine. PAI-1 is also significantly increased in the urine of AKI patients. Its low correlation with other urinary markers such as NGAL or NAG suggests that PAI-1 provides complementary and distinct phenotypical information.
    Conclusion: In conclusion, uPAI-1 is a biomarker produced by damaged kidneys following AKI, whose precise pathophysiological meaning in AKI needs to be further investigated.
    MeSH term(s) Acute Kidney Injury/urine ; Adult ; Aged ; Animals ; Biomarkers/urine ; Female ; Humans ; Kidney Tubules ; Male ; Middle Aged ; Plasminogen Activator Inhibitor 1/urine ; Rats ; Rats, Wistar
    Chemical Substances Biomarkers ; Plasminogen Activator Inhibitor 1 ; SERPINE1 protein, human
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000518455
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    Zs.A 1635: Show issues Location:
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  5. Article: Asma y virus respiratorio sincitial.

    Blanco Quirós, A

    Anales de pediatria (Barcelona, Spain : 2003)

    2003  Volume 58, Issue 1, Page(s) 86–7; author reply 87–8

    Title translation Asthma and respiratory syncytial virus.
    MeSH term(s) Asthma/virology ; Humans ; Infant ; Respiratory Syncytial Virus Infections/complications
    Language Spanish
    Publishing date 2003-01-28
    Publishing country Spain
    Document type Comment ; Letter
    ZDB-ID 2102669-5
    ISSN 1695-4033
    ISSN 1695-4033
    DOI 10.1016/s1695-4033(03)78006-0
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  6. Article ; Online: Sublingual immunotherapy is safe in children, but the challenge is how to increase its efficiency?

    Blanco Quirós, A / Arranz Sanz, E

    Allergologia et immunopathologia

    2011  Volume 39, Issue 3, Page(s) 119–121

    MeSH term(s) Animals ; Antigens, Dermatophagoides/administration & dosage ; Asthma/prevention & control ; Desensitization, Immunologic/methods ; Female ; Humans ; Hypersensitivity/prevention & control ; Male ; Pyroglyphidae/immunology ; Rhinitis, Allergic, Perennial/prevention & control
    Chemical Substances Antigens, Dermatophagoides
    Language English
    Publishing date 2011-05
    Publishing country Spain
    Document type Comment ; Editorial
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.1016/j.aller.2011.04.003
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    Zs.A 1165: Show issues Location:
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  7. Article ; Online: Prescripción pediátrica de fármacos antiasmáticos en atención primaria en Castilla y León. Variabilidad geográfica.

    Casares Alonso, I / Cano Garcinuño, A / Blanco Quirós, A / Pérez García, I

    Anales de pediatria (Barcelona, Spain : 2003)

    2015  Volume 83, Issue 3, Page(s) 191–200

    Abstract: Introduction and objectives: Asthma is one of the most prevalent chronic diseases with effective treatment in paediatrics. The aim of this study is to describe the paediatric prescribing of anti-asthmatics in Castilla-León, analyzing its geographic ... ...

    Title translation Paediatric prescribing of anti-asthmatics in primary care in Castilla-León. Geographical variability.
    Abstract Introduction and objectives: Asthma is one of the most prevalent chronic diseases with effective treatment in paediatrics. The aim of this study is to describe the paediatric prescribing of anti-asthmatics in Castilla-León, analyzing its geographic variability and temporal evolution.
    Material and methods: An analysis was made of prescriptions dispensed in pharmacies of R03 therapeutic subgroup (anti-asthmatic agents), and the active ingredients mepyramine and ketotifen, prescribed in children less than 14 years of age in the Castilla-León health service from 2005 to 2010 in Primary Care. Data is presented in prescribed daily doses per thousand inhabitants per day (PDHD) for each active ingredient being calculated raw rates and age-adjusted to the variables health area, type of health zone and year of study.
    Results: A total of 462,354 prescriptions of anti-asthmatic agents were dispensed to a population of 1,580,229 persons/year. There was wide variation between areas in the type and intensity of anti-asthmatic agents used, partly explained by differences in the prevalence of asthma. Montelukast predominated as controller drug in most of them (PDHD 3.1 to 7.7), being similar the consumption intensity in the three types of health zones (PDHD 4.7 to 4.8). The annual variability was low.
    Conclusions: The study describes the paediatric prescribing pattern of anti-asthmatic agents in Castilla-León between 2005-2010. It shows wide geographical variation, as well as inadequacies regarding current recommendations of asthma treatment.
    MeSH term(s) Adolescent ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Child ; Drug Prescriptions/statistics & numerical data ; Humans ; Primary Health Care ; Retrospective Studies ; Spain ; Spatio-Temporal Analysis
    Chemical Substances Anti-Asthmatic Agents
    Language Spanish
    Publishing date 2015-09
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ISSN 1695-9531
    ISSN (online) 1695-9531
    DOI 10.1016/j.anpedi.2014.09.014
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  8. Article ; Online: Anti-asthmatic prescription variability in children according to age.

    Casares-Alonso, I / Cano-Garcinuño, A / Blanco-Quirós, A / Pérez-García, I

    Allergologia et immunopathologia

    2015  Volume 43, Issue 4, Page(s) 383–391

    Abstract: Introduction: There is little research in the Spanish paediatric population about the consumption of anti-asthmatic agents. The aim of this study was to describe the current pattern of anti-asthmatic drug prescription in the paediatric population from a ...

    Abstract Introduction: There is little research in the Spanish paediatric population about the consumption of anti-asthmatic agents. The aim of this study was to describe the current pattern of anti-asthmatic drug prescription in the paediatric population from a region of Spain, using the prescribed daily dose as a unit of measurement.
    Methods: We analysed the requirements of R03 therapeutic subgroup (anti-asthmatic agents) in children less than 14 years of age in the Public Health System of Castilla y León from 2005 to 2010. Consumption data are presented in prescribed daily doses per thousand inhabitants per day (PDHD) and compared with defined daily doses per thousand inhabitants per day (DHD).
    Results: 394 876 prescriptions of anti-asthmatics were given to a population of 1 580 229 persons/year. Bronchodilators, leukotriene receptor antagonists, single inhaled corticosteroids (ICS) and long-acting β2-adrenergics associated with inhaled corticosteroids were the most commonly prescribed drugs: 7.5, 5.2, 4.9 and 2.2 PDHD, respectively. The maximum prescription of bronchodilators (15.9 PDHD/9.8 DHD) occurred in children under 12 months, with montelukast (8.9 PDHD/3.6 DHD) and single inhaled corticosteroids (7.9 PDHD/2.9 DHD) at one year of age.
    Conclusions: Between 2005 and 2010, children under four years received a high prescription of anti-asthmatic drugs. The use of maintenance therapy was poorly aligned with the recommendations of asthma guidelines. The PDHD was more accurate for measuring consumption than DHD, especially in younger children.
    MeSH term(s) Adolescent ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Practice Patterns, Physicians' ; Spain
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2015-07
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.1016/j.aller.2014.05.010
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  9. Article ; Online: Use of EHRs in a Tertiary Hospital During COVID-19 Pandemic: A Multi-Purpose Approach Based on Standards.

    Pedrera, Miguel / Garcia, Noelia / Blanco, Alvar / Terriza, Ana Isabel / Cruz, Jaime / Lopez, Elena Ana / Calvo, Fernando / Jimenez, María Jesús / Gonzalez, Patricia / Quiros, Víctor / Cruz, Juan Luis / Bernal, José Luis / Serrano, Pablo

    Studies in health technology and informatics

    2021  Volume 281, Page(s) 28–32

    Abstract: This work aims to describe how EHRs have been used to meet the needs of healthcare providers and researchers in a 1,300-beds tertiary Hospital during COVID-19 pandemic. For this purpose, essential clinical concepts were identified and standardized with ... ...

    Abstract This work aims to describe how EHRs have been used to meet the needs of healthcare providers and researchers in a 1,300-beds tertiary Hospital during COVID-19 pandemic. For this purpose, essential clinical concepts were identified and standardized with LOINC and SNOMED CT. After that, these concepts were implemented in EHR systems and based on them, data tools, such as clinical alerts, dynamic patient lists and a clinical follow-up dashboard, were developed for healthcare support. In addition, these data were incorporated into standardized repositories and COVID-19 databases to improve clinical research on this new disease. In conclusion, standardized EHRs allowed implementation of useful multi- purpose data resources in a major Hospital in the course of the pandemic.
    MeSH term(s) COVID-19 ; Electronic Health Records ; Humans ; Pandemics ; SARS-CoV-2 ; Tertiary Care Centers
    Language English
    Publishing date 2021-05-27
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI210114
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  10. Article ; Online: Comparative morphology, histology, and cytology of odontocete cetaceans prostates.

    Suárez-Santana, Cristian M / Fernández, Antonio / Sierra, Eva / Arbelo, Manuel / Bernaldo de Quirós, Yara / Andrada, Marisa / Mompeo, Blanca / Pérez, Lilian / Blanco, Alfonso / Méndez, Aniceto / Espinosa de Los Monteros, Antonio / Rivero, Miguel A

    Anatomical record (Hoboken, N.J. : 2007)

    2019  Volume 303, Issue 7, Page(s) 2036–2053

    Abstract: The prostate is the only male accessory gland in cetaceans. However, little is known about this organ in these species. Anatomical and histological characteristics of the prostate have been described in only a few cetacean species, further, one study ... ...

    Abstract The prostate is the only male accessory gland in cetaceans. However, little is known about this organ in these species. Anatomical and histological characteristics of the prostate have been described in only a few cetacean species, further, one study reported a high incidence of prostatic pathologies in cetaceans that may impair reproduction. The objective of this work was to describe and compare the morphological, histological, and cytological characteristics of the prostate in different odontocete cetaceans. To this end, the prostate glands of 47 animals from nine different species of cetaceans were macroscopically and microscopically studied. Members of the families Delphinidae, Ziphiidae, and Physeteridae were included. In general, the prostate appeared as a musculo-glandular organ with two distinct parts-the Corpus prostatae and the Pars disseminata prostatae. In the pygmy sperm whale (Kogia breviceps) and the Cuvier's beaked whale (Ziphius cavirostris), the prostate was a discrete gland with a small Corpus prostatae. Microscopically, the prostates of different delphinids species shared similarities; however, the prostate of the pygmy sperm whale revealed significant histological differences compared to those of the delphinids. Immunohistochemical analysis was performed using low- and high-molecular-weight cytokeratin, vimentin, and prostatic specific antigen commercial antibodies. Electron microscopy analysis was performed on the prostate of a bottlenose dolphin and the cytomorphological differences among the major epithelial components of the prostatic epithelium were described. Anat Rec, 2019. © 2019 American Association for Anatomy Anat Rec, 303:2036-2053, 2020. © 2019 American Association for Anatomy.
    MeSH term(s) Animals ; Cetacea/anatomy & histology ; Male ; Prostate/anatomy & histology ; Prostate/cytology
    Language English
    Publishing date 2019-10-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.24285
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