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  1. Article ; Online: From Birth to "Immunohealth," Allergies and Enterocolitis.

    Houghteling, Pearl D / Walker, W Allan

    Journal of clinical gastroenterology

    2015  Volume 49 Suppl 1, Page(s) S7–S12

    Abstract: Microbial signals stimulate development and maintenance of the neonatal immune system. The process begins in utero, with limited exposure to microbes in the intrauterine environment, as well as maternal immune signals priming the developing immune system. ...

    Abstract Microbial signals stimulate development and maintenance of the neonatal immune system. The process begins in utero, with limited exposure to microbes in the intrauterine environment, as well as maternal immune signals priming the developing immune system. After birth and initial colonization, the immune system must be able to activate against pathogens, but also achieve oral tolerance of food and resident gut microbes. Through microbial signals and appropriate nutrition, the immune system is able to achieve homeostasis. Major challenges to successful colonization and immune system regulation include abnormal microbial inoculi (cesarean section, hygiene) and antibiotics. When normal colonization is interrupted, dysbiosis occurs. This imbalance of microbes and subsequently of the immune system can result in allergic diseases, asthma, or necrotizing enterocolitis. Probiotics and probiotic-derived therapies represent an exciting avenue to replete the population of commensal microbes and to prevent the immune-mediated sequelae of dysbiosis.
    MeSH term(s) Asthma/microbiology ; Dysbiosis/complications ; Dysbiosis/immunology ; Enterocolitis, Necrotizing/microbiology ; Female ; Fetal Development/immunology ; Gastrointestinal Microbiome/immunology ; Humans ; Hypersensitivity/microbiology ; Immune System/growth & development ; Immune System/microbiology ; Immunity, Innate ; Infant, Newborn ; Pregnancy ; Probiotics
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000000355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1523: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Why is initial bacterial colonization of the intestine important to infants' and children's health?

    Houghteling, Pearl D / Walker, W Allan

    Journal of pediatric gastroenterology and nutrition

    2014  Volume 60, Issue 3, Page(s) 294–307

    Abstract: Microbial colonization of the infant occurs during a critical time window for immune and gastrointestinal development. Infant colonization sets the stage for the adult microbiome. This review is a broad survey of the factors affecting infant colonization ...

    Abstract Microbial colonization of the infant occurs during a critical time window for immune and gastrointestinal development. Infant colonization sets the stage for the adult microbiome. This review is a broad survey of the factors affecting infant colonization and the downstream effects on gastrointestinal health and disease. Major topics affecting colonization include initial inoculation dependent on birth mode, the impact of breast-feeding, and inside-out modulation of the developing microbiome by the immune system. Major outcomes of colonization include the timing-dependent education of the neonatal immune system, which is interconnected with barrier function and metabolism. These all engage in further continuing cross-talk with the microbiome, genetics, and nutrition. This review also briefly examines mechanisms of disease resulting from disrupted colonization as well as nutritional and microbial therapies.
    MeSH term(s) Adaptive Immunity ; Animals ; Breast Feeding ; Child ; Child Development ; Child Nutritional Physiological Phenomena ; Child, Preschool ; Delivery, Obstetric ; Female ; Humans ; Immunity, Innate ; Infant ; Infant Nutritional Physiological Phenomena ; Intestinal Mucosa/growth & development ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Intestines/growth & development ; Intestines/immunology ; Intestines/microbiology ; Male ; Microbiota
    Language English
    Publishing date 2014-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000000597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1728: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Single-Cell Analysis of the Neonatal Immune System Across the Gestational Age Continuum.

    Peterson, Laura S / Hedou, Julien / Ganio, Edward A / Stelzer, Ina A / Feyaerts, Dorien / Harbert, Eliza / Adusumelli, Yamini / Ando, Kazuo / Tsai, Eileen S / Tsai, Amy S / Han, Xiaoyuan / Ringle, Megan / Houghteling, Pearl / Reiss, Jonathan D / Lewis, David B / Winn, Virginia D / Angst, Martin S / Aghaeepour, Nima / Stevenson, David K /
    Gaudilliere, Brice

    Frontiers in immunology

    2021  Volume 12, Page(s) 714090

    Abstract: Although most causes of death and morbidity in premature infants are related to immune maladaptation, the premature immune system remains poorly understood. We provide a comprehensive single-cell depiction of the neonatal immune system at birth across ... ...

    Abstract Although most causes of death and morbidity in premature infants are related to immune maladaptation, the premature immune system remains poorly understood. We provide a comprehensive single-cell depiction of the neonatal immune system at birth across the spectrum of viable gestational age (GA), ranging from 25 weeks to term. A mass cytometry immunoassay interrogated all major immune cell subsets, including signaling activity and responsiveness to stimulation. An elastic net model described the relationship between GA and immunome (R=0.85, p=8.75e-14), and unsupervised clustering highlighted previously unrecognized GA-dependent immune dynamics, including decreasing basal MAP-kinase/NFκB signaling in antigen presenting cells; increasing responsiveness of cytotoxic lymphocytes to interferon-α; and decreasing frequency of regulatory and invariant T cells, including NKT-like cells and CD8
    MeSH term(s) Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/metabolism ; Biomarkers ; Cell Communication ; Disease Susceptibility/immunology ; Embryonic Development/immunology ; Gene Expression Regulation ; Gestational Age ; Humans ; Immune System Phenomena ; Immunomodulation ; Infant, Newborn ; Premature Birth ; Signal Transduction ; Single-Cell Analysis/methods ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-08-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.714090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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