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  1. Article: [In memoram of Professor Hisashi Saito].

    Yamamoto, Y

    Nihon Kyosei Shika Gakkai zasshi = The journal of Japan Orthodontic Society

    1966  Volume 25, Issue 2, Page(s) 301

    MeSH term(s) History of Medicine ; Japan ; Orthodontics
    Language Japanese
    Publishing date 1966
    Publishing country Japan
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 604099-8
    ISSN 0021-454X
    ISSN 0021-454X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Pollen and spores record, and paleotemperature reconstructions for mid-Holocene sediments of the Northwest Pacific, supplementary data to: Kawahata, Hodaka; Yamamoto, Hisashi; Ohkushi, Ken?ichi; Yokoyama, Yusuke; Kimoto, Katsunori; Ohshima, Hideki; Matsuzaki, Hiroyuki (2009): Changes of environments and human activity at the Sannai-Maruyama ruins in Japan during the mid-Holocene Hypsithermal climatic interval. Quaternary Science Reviews, 28(9-10), 964-974

    Kawahata, Hodaka / Kimoto, Katsunori / Matsuzaki, Hiroyuki / Ohkushi, Ken?ichi / Ohshima, Hideki / Yamamoto, Hisashi / Yokoyama, Yusuke

    2009  

    Abstract: Sannai-Maruyama is one of the most famous and best-researched mid-Holocene (mid-Jomon) archaeological sites in Japan, because of a large community of people for a long period. Archaeological studies have shown that the Jomon people inhabited the Sannai- ... ...

    Abstract Sannai-Maruyama is one of the most famous and best-researched mid-Holocene (mid-Jomon) archaeological sites in Japan, because of a large community of people for a long period. Archaeological studies have shown that the Jomon people inhabited the Sannai-Maruyama site from 5.9-4.2 +/- 0.1 cal. kyr B.P. However, a continuous record of the terrestrial and marine environments around the site has not been available. Core KT05-7 PC-02, was recovered from Mutsu Bay, only 20 km from the site, for the reconstruction of high-resolution time series of environmental records, including sea surface temperature (SST). C37 alkenone SSTs showed clear fluctuations, with four periods of high (8.4-7.9, 7.0-5.9, 5.1-4.1, and 2.3-1.4 cal. kyr B.P.) and four of low (-8.4, 7.9-7.0, 5.9-5.1, and 4.1-2.3 cal. kyr B.P.) SST. Thus, each SST cycle lasted 1.0-2.0 kyr, and the amplitude of fluctuation was about 1.5-2.0 ?C. Total organic carbon (TOC) and C37 alkenone contents, and the TOC/total nitrogen ratio indicate that marine biogenic production was low before 7.0 cal. kyr B.P., but was clearly increased between 5.9 and 4.0 cal. kyr B.P., because of stronger vertical mixing. During the period when the community at the site prospered (between 5.9 and 4.2 +/- 0.1 cal. kyr B.P.), the terrestrial climate was relatively warm. The high relative abundance of pollen of both Castanea and Quercus subgen. Cyclobalanopsis supports the interpretation that the local climate was optimal for human habitation. Between 5.9 and 5.1 cal. kyr B.P., in spite of warm terrestrial climates, the C37 alkenone SST was low; this apparent discrepancy may be attributed to the water column structure in the Tsugaru Strait, which differed from the modern condition. The evidence suggests that at about 5.9 cal. kyr B.P, high productivity of marine resources such as fish and shellfish and a warm terrestrial climate led to the establishment of a human community at the Sannai-Maruyama site. Then, at about 4.1 +/- 0.1 cal. kyr B.P., abrupt marine and terrestrial cooling, indicated by a decrease of about 2 ?C in the C37 alkenone SST and an increase in pollen of taxa of cooler climates, led to a reduced terrestrial food supply, causing the people to abandon the site. The timing of the abandonment is consistent with the timing (around 4.0-4.3 cal. kyr B.P.) of the decline of civilizations in north Mesopotamia and along the Yangtze River. These findings suggest that a temperature rise of ~2 ?C in this century as a result of global warming could have a great impact on the human community and especially on agriculture, despite the advances of contemporary society.?
    Language English
    Dates of publication 2009-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/j.quascirev.2008.12.009
    DOI 10.1594/PANGAEA.705423
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article: Trimethylaluminum-mediated one-pot peptide elongation.

    Hattori, Tomohiro / Yamamoto, Hisashi

    Chemical science

    2023  Volume 14, Issue 21, Page(s) 5795–5801

    Abstract: Efficient and straightforward peptide bond formation of N-, and C-terminal unprotected amino acids was successfully achieved by using trimethylaluminum. The coupling reaction was accomplished by pre-reaction of N-, and C-terminal unprotected amino acids ... ...

    Abstract Efficient and straightforward peptide bond formation of N-, and C-terminal unprotected amino acids was successfully achieved by using trimethylaluminum. The coupling reaction was accomplished by pre-reaction of N-, and C-terminal unprotected amino acids and trimethylaluminum to form a five-membered ring that smoothly reacted with nucleophilic amino acid esters. This simple and highly efficient reaction system allows one-pot tripeptide synthesis without the need for expensive coupling reagents. Furthermore, peptide bond formation can be effectively achieved even for amino acids with bulky substituents at the side chain to afford the corresponding tripeptides in high yields in a one-pot manner. In addition, the reaction can be applied for further peptide elongation by the subsequent addition of amino acids and trimethylaluminum. We anticipate that this cost-effective, straightforward, and efficient protocol will be useful for the synthesis of a wide variety of peptides.
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc00208j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: An economical approach for peptide synthesis

    Muramatsu, Wataru / Yamamoto, Hisashi

    Chemical science

    2022  Volume 13, Issue 21, Page(s) 6309–6315

    Abstract: An economical, solvent-free, and metal-free method for peptide ... ...

    Abstract An economical, solvent-free, and metal-free method for peptide synthesis
    Language English
    Publishing date 2022-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc01466a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Super silyl-based stable protecting groups for both the C- and N-terminals of peptides: applied as effective hydrophobic tags in liquid-phase peptide synthesis.

    Wu, An / Yamamoto, Hisashi

    Chemical science

    2023  Volume 14, Issue 19, Page(s) 5051–5061

    Abstract: Tag-assisted liquid-phase peptide synthesis (LPPS) is one of the important processes in peptide synthesis in pharmaceutical discovery. Simple silyl groups have positive effects when incorporated in the tags due to their hydrophobic properties. Super ... ...

    Abstract Tag-assisted liquid-phase peptide synthesis (LPPS) is one of the important processes in peptide synthesis in pharmaceutical discovery. Simple silyl groups have positive effects when incorporated in the tags due to their hydrophobic properties. Super silyl groups contain several simple silyl groups and play an important role in modern aldol reactions. In view of the unique structural architecture and hydrophobic properties of the super silyl groups, herein, two new types of stable super silyl-based groups (tris(trihexylsilyl)silyl group and propargyl super silyl group) were developed as hydrophobic tags to increase the solubility in organic solvents and the reactivity of peptides during LPPS. The tris(trihexylsilyl)silyl group can be installed at the C-terminal of the peptides in ester form and N-terminal in carbamate form for peptide synthesis and it is compatible with hydrogenation conditions (Cbz chemistry) and Fmoc-deprotection conditions (Fmoc chemistry). The propargyl super silyl group is acid-resistant, which is compatible with Boc chemistry. Both tags are complementary to each other. The preparation of these tags requires less steps than previously reported tags. Nelipepimut-S was synthesized successfully with different strategies using these two types of super silyl tags.
    Language English
    Publishing date 2023-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc01239e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Purple haze: a useful sign for detecting gastric intestinal metaplasia.

    Yamamoto, Shunsuke / Ishida, Hisashi / Mita, Eiji

    Gastrointestinal endoscopy

    2023  Volume 97, Issue 5, Page(s) 987–989

    MeSH term(s) Humans ; Stomach Diseases ; Gastric Mucosa ; Metaplasia ; Stomach Neoplasms/diagnostic imaging ; Precancerous Conditions/diagnosis ; Helicobacter Infections
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.01.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Case of C3 Nephritis With a Rare Variant of the CFHR5 Gene.

    Kamido, Hisashi / Yamamoto, Shinya / Yokoi, Hideki / Mizuno, Masashi / Yanagita, Motoko

    Cureus

    2024  Volume 16, Issue 2, Page(s) e55102

    Abstract: C3 nephropathy is a renal disease caused by the aberrant activation of the alternative complement pathway. The long-term renal prognosis of C3 nephropathy is generally poor, and elucidation of its pathogenesis is clinically important. Genetic ... ...

    Abstract C3 nephropathy is a renal disease caused by the aberrant activation of the alternative complement pathway. The long-term renal prognosis of C3 nephropathy is generally poor, and elucidation of its pathogenesis is clinically important. Genetic abnormalities within complement genes, encompassing autoantibodies targeting complement components and complement factor H-related proteins (CFHRs), can lead to abnormal complement activation.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Single cord blood transplantation in Japan; expanding the possibilities of CBT.

    Yamamoto, Hisashi

    International journal of hematology

    2019  Volume 110, Issue 1, Page(s) 39–49

    Abstract: Cord blood (CB) has been an alternative stem cell source for patients with a wide variety of hematological diseases. Cord blood confers the advantages of rapid availability and higher tolerance to two HLA antigen mismatches compared with unrelated donors, ...

    Abstract Cord blood (CB) has been an alternative stem cell source for patients with a wide variety of hematological diseases. Cord blood confers the advantages of rapid availability and higher tolerance to two HLA antigen mismatches compared with unrelated donors, and this has increased opportunities for patients who do not have suitable donors or require urgent transplantation. Although the higher rate of engraftment failure remains a serious concern after cord blood transplantation (CBT), the mechanisms underlying this risk have gradually been clarified, which has helped to improve engraftment. Recent studies of CBT and other alternatives have reported comparable outcomes. Moreover, CBT shows promise even when patients are in a non-remission status, which may reflect the potent graft-versus-leukemia effect of CB. Here we compare the most recent outcomes of CBT with those of other stem cell sources and discuss the potential of CB and several outstanding issues that require resolution.
    MeSH term(s) Cord Blood Stem Cell Transplantation/methods ; Cord Blood Stem Cell Transplantation/standards ; Cord Blood Stem Cell Transplantation/trends ; Graft vs Leukemia Effect ; Hematologic Diseases/therapy ; Histocompatibility ; Humans ; Japan
    Language English
    Publishing date 2019-05-31
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-019-02672-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N- and C-Termini of Dipeptide.

    Hattori, Tomohiro / Yamamoto, Hisashi

    Journal of the American Chemical Society

    2022  Volume 144, Issue 4, Page(s) 1758–1765

    Abstract: A new type of peptide bond formation utilizing silacyclic amino acids or peptides is described. This work has the following advantages: (1) imidazolylsilane is a highly fascinating coupling reagent for dipeptide synthesis from N-,C-terminal unprotected ... ...

    Abstract A new type of peptide bond formation utilizing silacyclic amino acids or peptides is described. This work has the following advantages: (1) imidazolylsilane is a highly fascinating coupling reagent for dipeptide synthesis from N-,C-terminal unprotected amino acids with amino acid
    MeSH term(s) Carbon/chemistry ; Cyclization ; Dipeptides/chemistry ; Nitrogen/chemistry ; Peptides, Cyclic/chemical synthesis ; Peptides, Cyclic/chemistry ; Silanes/chemistry
    Chemical Substances Dipeptides ; Peptides, Cyclic ; Silanes ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c11260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Organocatalytic Activation of Inert Hydrosilane for Peptide Bond Formation.

    Muramatsu, Wataru / Yamamoto, Hisashi

    Organic letters

    2022  Volume 24, Issue 39, Page(s) 7194–7199

    Abstract: We describe the development of a reliable catalytic protocol for peptide bond formation that is generally applicable to natural and unnatural α-amino acids, β-amino acids, and peptides bearing various functional groups. A 10 mol % loading of HSi[OCH(CF< ... ...

    Abstract We describe the development of a reliable catalytic protocol for peptide bond formation that is generally applicable to natural and unnatural α-amino acids, β-amino acids, and peptides bearing various functional groups. A 10 mol % loading of HSi[OCH(CF<sub>3</sub>)<sub>2</sub>]<sub>3</sub> as a catalyst was sufficient to guarantee a consistently high yield of the resulting peptide. This method facilitates the sustainable utilization of natural resources by using a catalyst and an auxiliary based on earth-abundant silicon.
    MeSH term(s) Amines ; Amino Acids/chemistry ; Catalysis ; Peptides/chemistry ; Silicon
    Chemical Substances Amines ; Amino Acids ; Peptides ; Silicon (Z4152N8IUI)
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c02947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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