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  1. Article ; Online: Creating an explosion: Form and function in explosive fruit.

    Cullen, Erin / Hay, Angela

    Current opinion in plant biology

    2024  Volume 79, Page(s) 102543

    Abstract: Adaptations for seed dispersal are found everywhere in nature. However, only a fraction of this diversity is accessible through the study of model organisms. For example, Arabidopsis seeds are released by dehiscent fruit; and although many genes required ...

    Abstract Adaptations for seed dispersal are found everywhere in nature. However, only a fraction of this diversity is accessible through the study of model organisms. For example, Arabidopsis seeds are released by dehiscent fruit; and although many genes required for dehiscence have been identified, the genetic basis for the vast majority of seed dispersal strategies remains understudied. Explosive fruit generate mechanical forces to launch seeds over a wide area. Recent work indicates that key innovations required for explosive dispersal lie in localised lignin deposition and precise patterns of microtubule-dependent growth in the fruit valves, rather than dehiscence zone structure. These insights come from comparative approaches, which extend the reach of developmental genetics by developing experimental tools in less well-studied species, such as the Arabidopsis relative, Cardamine hirsuta.
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2024.102543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2005/717: Show issues

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  2. Book ; Online: Fit for Job

    Hay, Angela

    thüringer Studie zu multifaktoriellen Belastungen beim Heben und Tragen ; Kooperationsprojekt von Institutionen des Arbeits- und Gesundheitsschutzes in Thüringen ; Teilprojekt "arbeitsmedizinische Aspekte"

    (INQA-Bericht ; 15)

    2005  

    Author's details Angela Hay
    Series title INQA-Bericht ; 15
    Collection
    Subject code 613.62
    Language German
    Edition 1. Aufl.
    Publisher Initiative Neue Qualität der Arbeit c/o Bundesanst. für Arbeitsschutz und Arbeitsmedizin
    Publishing place Dortmund
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT016435853
    ISBN 3-86509-423-6 ; 978-3-86509-423-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Building the future workforce through indirect supervision.

    Knight, Kate H / Simpson, Angela / Hay, Jonathon

    British journal of nursing (Mark Allen Publishing)

    2024  Volume 33, Issue 3, Page(s) 98

    MeSH term(s) Humans ; Workforce ; Capacity Building
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2024.33.3.98
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3449: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Development and diversity of lignin patterns.

    Emonet, Aurélia / Hay, Angela

    Plant physiology

    2022  Volume 190, Issue 1, Page(s) 31–43

    Abstract: Different patterns of lignified cell walls are associated with diverse functions in a variety of plant tissues. These functions rely on the stiffness and hydrophobicity that lignin polymers impart to the cell wall. The precise pattern of subcellular ... ...

    Abstract Different patterns of lignified cell walls are associated with diverse functions in a variety of plant tissues. These functions rely on the stiffness and hydrophobicity that lignin polymers impart to the cell wall. The precise pattern of subcellular lignin deposition is critical for the structure-function relationship in each lignified cell type. Here, we describe the role of xylem vessels as water pipes, Casparian strips as apoplastic barriers, and the role of asymmetrically lignified endocarp b cells in exploding seed pods. We highlight similarities and differences in the genetic mechanisms underpinning local lignin deposition in these diverse cell types. By bringing together examples from different developmental contexts and different plant species, we propose that comparative approaches can benefit our understanding of lignin patterning mechanisms.
    MeSH term(s) Cell Wall/metabolism ; Lignin/metabolism ; Plants/metabolism ; Xylem/metabolism
    Chemical Substances Lignin (9005-53-2)
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiac261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  5. Article ; Online: Schooling PhD students in plant development.

    Pérez-Antón, Miguel / Hay, Angela

    The New phytologist

    2020  Volume 226, Issue 6, Page(s) 1544–1547

    MeSH term(s) Biological Evolution ; Developmental Biology ; Humans ; Plant Development ; Students
    Language English
    Publishing date 2020-05-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.16509
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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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  6. Article ; Online: Floral organ development goes live.

    Rambaud-Lavigne, Léa / Hay, Angela

    Journal of experimental botany

    2020  Volume 71, Issue 9, Page(s) 2472–2478

    Abstract: The chance to watch floral organs develop live is not to be missed! Here, we outline reasons why quantitative, live-cell imaging is an important approach to study floral morphogenesis, and provide a basic workflow of how to get started. We highlight key ... ...

    Abstract The chance to watch floral organs develop live is not to be missed! Here, we outline reasons why quantitative, live-cell imaging is an important approach to study floral morphogenesis, and provide a basic workflow of how to get started. We highlight key advances in morphodynamics of lateral organ development, and discuss recent work that uses live confocal imaging to address the regulation of floral organ number, its robustness, and patterning mechanisms that exploit stochasticity.
    MeSH term(s) Arabidopsis ; Flowers ; Gene Expression Regulation, Plant ; Morphogenesis
    Language English
    Publishing date 2020-01-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/eraa038
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    Z 55/29: Show issues

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  7. Article ; Online: Growth and tension in explosive fruit.

    Mosca, Gabriella / Eng, Ryan C / Adibi, Milad / Yoshida, Saiko / Lane, Brendan / Bergheim, Leona / Weber, Gaby / Smith, Richard S / Hay, Angela

    Current biology : CB

    2024  Volume 34, Issue 5, Page(s) 1010–1022.e4

    Abstract: Exploding seed pods of the common weed Cardamine hirsuta have the remarkable ability to launch seeds far from the plant. The energy for this explosion comes from tension that builds up in the fruit valves. Above a critical threshold, the fruit fractures ... ...

    Abstract Exploding seed pods of the common weed Cardamine hirsuta have the remarkable ability to launch seeds far from the plant. The energy for this explosion comes from tension that builds up in the fruit valves. Above a critical threshold, the fruit fractures along its dehiscence zone and the two valves coil explosively, ejecting the seeds. A common mechanism to generate tension is drying, causing tissues to shrink. However, this does not happen in C. hirsuta fruit. Instead, tension is produced by active contraction of growing exocarp cells in the outer layer of the fruit valves. Exactly how growth causes the exocarp tissue to contract and generate pulling force is unknown. Here we show that the reorientation of microtubules in the exocarp cell cortex changes the orientation of cellulose microfibrils in the cell wall and the consequent cellular growth pattern. We used mechanical modeling to show how tension emerges through growth due to the highly anisotropic orientation of load-bearing cellulose microfibrils and their effect on cell shape. By explicitly defining the cell wall as multi-layered in our model, we discovered that a cross-lamellate pattern of cellulose microfibrils further enhances the developing tension in growing cells. Therefore, the interplay of cell wall properties with turgor-driven growth enables the fruit exocarp to generate sufficient tension to power explosive seed dispersal.
    MeSH term(s) Fruit ; Seeds ; Microtubules ; Cell Wall ; Cellulose
    Chemical Substances Cellulose (9004-34-6)
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2024.01.059
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Age-dependent ventilator-induced lung injury: Mathematical modeling, experimental data, and statistical analysis.

    Hay, Quintessa / Grubb, Christopher / Minucci, Sarah / Valentine, Michael S / Van Mullekom, Jennifer / Heise, Rebecca L / Reynolds, Angela M

    PLoS computational biology

    2024  Volume 20, Issue 2, Page(s) e1011113

    Abstract: A variety of pulmonary insults can prompt the need for life-saving mechanical ventilation; however, misuse, prolonged use, or an excessive inflammatory response, can result in ventilator-induced lung injury. Past research has observed an increased ... ...

    Abstract A variety of pulmonary insults can prompt the need for life-saving mechanical ventilation; however, misuse, prolonged use, or an excessive inflammatory response, can result in ventilator-induced lung injury. Past research has observed an increased instance of respiratory distress in older patients and differences in the inflammatory response. To address this, we performed high pressure ventilation on young (2-3 months) and old (20-25 months) mice for 2 hours and collected data for macrophage phenotypes and lung tissue integrity. Large differences in macrophage activation at baseline and airspace enlargement after ventilation were observed in the old mice. The experimental data was used to determine plausible trajectories for a mathematical model of the inflammatory response to lung injury which includes variables for the innate inflammatory cells and mediators, epithelial cells in varying states, and repair mediators. Classification methods were used to identify influential parameters separating the parameter sets associated with the young or old data and separating the response to ventilation, which was measured by changes in the epithelial state variables. Classification methods ranked parameters involved in repair and damage to the epithelial cells and those associated with classically activated macrophages to be influential. Sensitivity results were used to determine candidate in-silico interventions and these interventions were most impact for transients associated with the old data, specifically those with poorer lung health prior to ventilation. Model results identified dynamics involved in M1 macrophages as a focus for further research, potentially driving the age-dependent differences in all macrophage phenotypes. The model also supported the pro-inflammatory response as a potential indicator of age-dependent differences in response to ventilation. This mathematical model can serve as a baseline model for incorporating other pulmonary injuries.
    MeSH term(s) Humans ; Mice ; Animals ; Aged ; Lung ; Ventilator-Induced Lung Injury ; Respiration, Artificial/adverse effects ; Macrophages ; Models, Theoretical
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011113
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  9. Article ; Online: A practical approach to the genomics of kidney disorders.

    Hay, Eleanor / Cullup, Thomas / Barnicoat, Angela

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 37, Issue 1, Page(s) 21–35

    Abstract: Rapid technological advances in genomic testing continue to increase our understanding of the genetic basis of a wide range of kidney disorders. Establishing a molecular diagnosis benefits the individual by bringing an end to what is often a protracted ... ...

    Abstract Rapid technological advances in genomic testing continue to increase our understanding of the genetic basis of a wide range of kidney disorders. Establishing a molecular diagnosis benefits the individual by bringing an end to what is often a protracted diagnostic odyssey, facilitates accurate reproductive counselling for families and, in the future, is likely to lead to the delivery of more targeted management and surveillance regimens. The selection of the most appropriate testing modality requires an understanding both of the technologies available and of the genetic architecture and heterogeneity of kidney disease. Whilst we are witnessing a far greater diagnostic yield with broader genetic testing, such approaches invariably generate variants of uncertain significance and secondary incidental findings, which are not only difficult to interpret but present ethical challenges with reporting and feeding back to patients and their families. Here, we review the spectrum of nephrogenetic disorders, consider the optimal approach to genetic testing, explore the clinical utility of obtaining a molecular diagnosis, reflect on the challenges of variant interpretation and look to the future of this dynamic field.
    MeSH term(s) Genetic Testing ; Genomics ; Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/genetics
    Language English
    Publishing date 2021-03-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-04995-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Seed coat development in explosively dispersed seeds of Cardamine hirsuta.

    Neumann, Ulla / Hay, Angela

    Annals of botany

    2019  Volume 126, Issue 1, Page(s) 39–59

    Abstract: Background and aims: Seeds are dispersed by explosive coiling of the fruit valves in Cardamine hirsuta. This rapid coiling launches the small seeds on ballistic trajectories to spread over a 2 m radius around the parent plant. The seed surface interacts ...

    Abstract Background and aims: Seeds are dispersed by explosive coiling of the fruit valves in Cardamine hirsuta. This rapid coiling launches the small seeds on ballistic trajectories to spread over a 2 m radius around the parent plant. The seed surface interacts with both the coiling fruit valve during launch and subsequently with the air during flight. We aim to identify features of the seed surface that may contribute to these interactions by characterizing seed coat differentiation.
    Methods: Differentiation of the outermost seed coat layers from the outer integuments of the ovule involves dramatic cellular changes that we characterize in detail at the light and electron microscopical level including immunofluorescence and immunogold labelling.
    Key results: We found that the two outer integument (oi) layers of the seed coat contributed differently to the topography of the seed surface in the explosively dispersed seeds of C. hirsuta vs. the related species Arabidopsis thaliana where seed dispersal is non-explosive. The surface of A. thaliana seeds is shaped by the columella and the anticlinal cell walls of the epidermal oi2 layer. In contrast, the surface of C. hirsuta seeds is shaped by a network of prominent ridges formed by the anticlinal walls of asymmetrically thickened cells of the sub-epidermal oi1 layer, especially at the seed margin. Both the oi2 and oi1 cell layers in C. hirsuta seeds are characterized by specialized, pectin-rich cell walls that are deposited asymmetrically in the cell.
    Conclusions: The two outermost seed coat layers in C. hirsuta have distinct properties: the sub-epidermal oi1 layer determines the topography of the seed surface, while the epidermal oi2 layer accumulates mucilage. These properties are influenced by polar deposition of distinct pectin polysaccharides in the cell wall. Although the ridged seed surface formed by oi1 cell walls is associated with ballistic dispersal in C. hirsuta, it is not restricted to explosively dispersed seeds in the Brassicaceae.
    MeSH term(s) Arabidopsis ; Arabidopsis Proteins ; Cardamine ; Cell Wall ; Seeds
    Chemical Substances Arabidopsis Proteins
    Language English
    Publishing date 2019-11-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1461328-1
    ISSN 1095-8290 ; 0305-7364
    ISSN (online) 1095-8290
    ISSN 0305-7364
    DOI 10.1093/aob/mcz190
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