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  1. Article: "Fuzziness" in the celular interactome: a historical perspective.

    Welch, G Rickey

    Advances in experimental medicine and biology

    2012  Volume 725, Page(s) 184–190

    Abstract: Some historical background is given for appreciating the impact of the empirical construct known as the cellular protein-protein interactome, which is a seemingly de novo entity that has arisen of late within the context of postgenomic systems biology. ... ...

    Abstract Some historical background is given for appreciating the impact of the empirical construct known as the cellular protein-protein interactome, which is a seemingly de novo entity that has arisen of late within the context of postgenomic systems biology. The approach here builds on a generalized principle of "fuzziness" in protein behavior, proposed by Tompa and Fuxreiter.(1) Recent controversies in the analysis and interpretation of the interactome studies are rationalized historically under the auspices of this concept. There is an extensive literature on protein-protein interactions, dating to the mid-1900s, which may help clarify the "fuzziness" in the interactome picture and, also, provide a basis for understanding the physiological importance of protein-protein interactions in vivo.
    MeSH term(s) Animals ; History, 20th Century ; History, 21st Century ; Humans ; Protein Binding ; Protein Interaction Mapping/history ; Proteins/chemistry ; Proteins/metabolism ; Systems Biology
    Chemical Substances Proteins
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Historical Article ; Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-1-4614-0659-4_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The 'fuzzy' interactome.

    Welch, G Rickey

    Trends in biochemical sciences

    2009  Volume 34, Issue 1, Page(s) 1–2; author reply 3

    MeSH term(s) Biology/methods ; Biology/trends ; Databases, Protein ; Models, Biological ; Models, Theoretical ; Protein Binding ; Protein Interaction Mapping ; Proteins/metabolism ; Reproducibility of Results
    Chemical Substances Proteins
    Language English
    Publishing date 2009-01
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2008.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Physiology, physiomics, and biophysics: a matter of words.

    Welch, G Rickey

    Progress in biophysics and molecular biology

    2009  Volume 100, Issue 1-3, Page(s) 4–17

    Abstract: The historical inter-relationship of physiology, physiomics, and biophysics is investigated from the perspective of an etymological exposition. Deriving from the fundamental Greek root physis, commonality in the original meaning of the word-forms is ... ...

    Abstract The historical inter-relationship of physiology, physiomics, and biophysics is investigated from the perspective of an etymological exposition. Deriving from the fundamental Greek root physis, commonality in the original meaning of the word-forms is examined, and factors guiding the terminological evolution are described. An intimate connection between physiology and systems biology throughout history is revealed, and parallels to the modern-day directive influence of information technology in scientific advancement are seen at critical times in the past. While supporting the conceptual unity of the physiome notion, an etymological study of the expression "physiology" also yields semantic import for the understanding of systems biology epistemology today.
    MeSH term(s) Biophysics ; Humans ; Physiology ; Systems Biology ; Terminology as Topic
    Language English
    Publishing date 2009-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 209302-9
    ISSN 1873-1732 ; 0079-6107
    ISSN (online) 1873-1732
    ISSN 0079-6107
    DOI 10.1016/j.pbiomolbio.2009.08.001
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  4. Article ; Online: Cell versus protoplasm: revisionist history.

    Welch, G Rickey / Clegg, James S

    Cell biology international

    2012  Volume 36, Issue 7, Page(s) 643–647

    Abstract: Recent investigations give reason to question anew the historical status of the 'cell theory' as the ultimate driving force in the development of our understanding of life's processes at the most fundamental level. A revisitation of critical research ... ...

    Abstract Recent investigations give reason to question anew the historical status of the 'cell theory' as the ultimate driving force in the development of our understanding of life's processes at the most fundamental level. A revisitation of critical research papers and commentaries from the 19th Century shows that the disregarded (and historically maligned) 'protoplasmic theory of life' played a more deterministic role in the early advancement of knowledge on cell structure and function.
    MeSH term(s) Cell Biology/history ; Cytoplasm/chemistry ; History, 19th Century ; Models, Molecular
    Language English
    Publishing date 2012-07
    Publishing country England
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1143453-3
    ISSN 1095-8355 ; 1065-6995
    ISSN (online) 1095-8355
    ISSN 1065-6995
    DOI 10.1042/CBI20120128
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    Zs.A 1451: Show issues Location:
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  5. Article ; Online: From protoplasmic theory to cellular systems biology: a 150-year reflection.

    Welch, G Rickey / Clegg, James S

    American journal of physiology. Cell physiology

    2010  Volume 298, Issue 6, Page(s) C1280–90

    Abstract: Present-day cellular systems biology is producing data on an unprecedented scale. This field has generated a renewed interest in the holistic, "system" character of cell structure-and-function. Underlying the data deluge, however, there is a clear and ... ...

    Abstract Present-day cellular systems biology is producing data on an unprecedented scale. This field has generated a renewed interest in the holistic, "system" character of cell structure-and-function. Underlying the data deluge, however, there is a clear and present need for a historical foundation. The origin of the "system" view of the cell dates to the birth of the protoplasm concept. The 150-year history of the role of "protoplasm" in cell biology is traced. It is found that the "protoplasmic theory," not the "cell theory," was the key 19th-century construct that drove the study of the structure-and-function of living cells and set the course for the development of modern cell biology. The evolution of the "protoplasm" picture into the 20th century is examined by looking at controversial issues along the way and culminating in the current views on the role of cytological organization in cellular activities. The relevance of the "protoplasmic theory" to 21st-century cellular systems biology is considered.
    MeSH term(s) Animals ; Biomedical Research/history ; Cell Physiological Phenomena ; Cytoplasm/physiology ; Cytoskeleton/physiology ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Models, Biological ; Systems Biology/history ; Terminology as Topic ; Water/metabolism
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2010-03-03
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00016.2010
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  6. Article ; Online: Sex differences in paediatric airway anatomy.

    Ripoll, Juan G / Guo, Winston / Andersen, Kylie J / Baker, Sarah E / Wiggins, Chad C / Shepherd, John R A / Carter, Rickey E / Welch, Brian T / Joyner, Michael J / Dominelli, Paolo B

    Experimental physiology

    2020  Volume 105, Issue 4, Page(s) 721–731

    Abstract: New findings: What is the central question of this study? Are sex difference in the central airways present in healthy paediatric patients? What is the main finding and its importance? In patients ≤12 years we found no sex differences in central airway ... ...

    Abstract New findings: What is the central question of this study? Are sex difference in the central airways present in healthy paediatric patients? What is the main finding and its importance? In patients ≤12 years we found no sex differences in central airway luminal area. After 14 years, the males had significantly larger central airway luminal areas than the females. The sex differences were minimized, but preserved when correcting for height. Luminal area is the main determinant of airway resistance and our finding could help explain sex differences in pulmonary system limitations to exercise in paediatric patients.
    Abstract: Cross-sectional airway area is the main determinant of resistance to airflow in the respiratory system. In paediatric patients (<18 years), previous evidence for sex differences in cross-sectional airway area was limited to patients with history of pulmonary disease or cadaveric studies with small numbers of subjects. These studies either only report tracheal data and do not include a range of ages or correct for height. Therefore, we sought to assess sex differences in airway luminal area utilizing paediatric patients of varying ages and no history of respiratory disease. Using three-dimensional reconstructions from high-resolution computed tomography scans, we retrospectively assessed the cross-sectional airway area in healthy paediatric females (n = 97) and males (n = 128) over a range of ages (1-17 years). The areas of the trachea, left main bronchus, left upper lobe, left lower lobe, right main bronchus, intermediate bronchus and right upper lobe were measured at three discrete points by a blinded investigator. No differences between the sexes were noted in the cross-sectional areas of the youngest (ages 1-12 years) patients (P > 0.05). However, in patients ≥14 years the cross-sectional areas were larger in the males compared to females in most airway sites. For instance, the cross-sectional size of the trachea was 25% (218 ± 44 vs. 163 ± 24 mm
    MeSH term(s) Airway Resistance/physiology ; Bronchi/anatomy & histology ; Child ; Child, Preschool ; Female ; Humans ; Inhalation/physiology ; Lung/anatomy & histology ; Male ; Retrospective Studies ; Sex Characteristics ; Tomography, X-Ray Computed/methods ; Trachea/anatomy & histology
    Language English
    Publishing date 2020-03-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP088370
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  7. Book: Organized multienzyme systems

    Welch, G. Rickey

    catalytic properties

    (Biotechnology and applied biochemistry series)

    1985  

    Author's details edited by G. Rickey Welch
    Series title Biotechnology and applied biochemistry series
    MeSH term(s) Catalysis ; Membrane Proteins ; Multienzyme Complexes
    Language English
    Size xiii, 458 p. :, ill.
    Publisher Academic Press
    Publishing place Orlando
    Document type Book
    ISBN 9780127440408 ; 0127440402
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Book: The Fluctuating enzyme

    Welch, G. Rickey

    (Nonequilibrium problems in the physical sciences and biology, ; v. 5)

    1986  

    Author's details edited by G. Rickey Welch
    Series title Nonequilibrium problems in the physical sciences and biology, ; v. 5
    MeSH term(s) Binding Sites ; Catalysis ; Enzymes ; Kinetics ; Macromolecular Substances ; Protein Conformation
    Language English
    Size xiii, 496 p. :, ill.
    Publisher Wiley
    Publishing place New York
    Document type Book
    Note "A Wiley-Interscience publication."
    ISBN 9780471888703 ; 0471888702
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Book: The fluctuating enzyme

    Welch, G. Rickey

    (Nonequilibrium problems in the physical sciences and biology ; 5)

    1986  

    Author's details ed.: G. Rickey Welch
    Series title Nonequilibrium problems in the physical sciences and biology ; 5
    Keywords Enzymes ; Molecular dynamics ; Stereochemistry ; Structure-activity relationships (Biochemistry)
    Language English
    Size XIII, 496 S., graph. Darst.
    Publisher Wiley
    Publishing place New York, N.Y. u.a.
    Document type Book
    Note Literaturangaben
    ISBN 0471888702 ; 9780471888703
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book ; Conference proceedings: The organization of cell metabolism

    Welch, G. Rickey

    [proceedings of a NATO Advanced Research Workshop on the Organization of Cell Metabolizm, Aug. 31 - Sept. 4, 1985, Hanstholm, Denmark]

    (NATO ASI series : Series A, Life sciences ; 127)

    1986  

    Institution Advanced Research Workshop on the Organization of Cell Metabolism
    Event/congress NATO advanced research workshop on the organization of cell metabolism (1985.08.31-09.04, HanstholmDänemark)
    Author's details ed. by G. Rickey Welch
    Series title NATO ASI series : Series A, Life sciences ; 127
    Language English
    Size XIII, 389 S, Ill., graph. Darst, 26 cm
    Document type Book ; Conference proceedings
    ISBN 0306425548 ; 9780306425547
    Database Leibniz Institute of Plant Biochemistry

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