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  1. Article: Early work on the ubiquitin proteasome system, an interview with Avram Hershko. Interview by CDD.

    Hershko, Avram

    Cell death and differentiation

    2005  Volume 12, Issue 9, Page(s) 1158–1161

    MeSH term(s) Animals ; Biochemistry/history ; Cysteine Endopeptidases/physiology ; History, 20th Century ; Humans ; Israel ; Nobel Prize ; Proteins/chemistry ; Proteins/history ; Ubiquitin/physiology ; Ubiquitins/chemistry ; Ubiquitins/history ; United States
    Chemical Substances Proteins ; Ubiquitin ; Ubiquitins ; Cysteine Endopeptidases (EC 3.4.22.-)
    Language English
    Publishing date 2005-09
    Publishing country England
    Document type Historical Article ; Interview ; Portraits
    ZDB-ID 1225672-9
    ISSN 1350-9047
    ISSN 1350-9047
    DOI 10.1038/sj.cdd.4401709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4230: Show issues Location:
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    Zs.MG 80: Show issues

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  2. Article: Science as an adventure - lessons for the young scientist.

    Hershko, Avram

    Rambam Maimonides medical journal

    2010  Volume 1, Issue 1, Page(s) e0001

    Language English
    Publishing date 2010-07-02
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2573657-7
    ISSN 2076-9172
    ISSN 2076-9172
    DOI 10.5041/RMMJ.10001
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  3. Article ; Online: Role of phosphorylation of Cdc20 in the regulation of the action of APC/C in mitosis.

    Shevah-Sitry, Danielle / Miniowitz-Shemtov, Shirly / Teichner, Adar / Kaisari, Sharon / Hershko, Avram

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 35, Page(s) e2210367119

    Abstract: The ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) is essential for the control of mitosis, and its activity is subject to tight regulation. In early mitosis, APC/C is inhibited by the mitotic checkpoint system, but subsequently it regains ...

    Abstract The ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) is essential for the control of mitosis, and its activity is subject to tight regulation. In early mitosis, APC/C is inhibited by the mitotic checkpoint system, but subsequently it regains activity and promotes metaphase-anaphase transition by targeting cyclin B and securin for degradation. The phosphorylation of APC/C by the mitotic protein kinase Cdk1-cyclin B facilitates its interaction with its coactivator Cdc20, while the phosphorylation of Cdc20 inhibits its binding to APC/C. This raises the question of how Cdc20 binds to APC/C under conditions of high Cdk1 activity. It seemed possible that the opposing action of protein phosphatases produces a fraction of unphosphorylated Cdc20 that binds to APC/C. We found, however, that while inhibitors of protein phosphatases PP2A and PP1 increased the overall phosphorylation of Cdc20 in anaphase extracts from
    MeSH term(s) Anaphase-Promoting Complex-Cyclosome/genetics ; Anaphase-Promoting Complex-Cyclosome/metabolism ; Animals ; Cdc20 Proteins/metabolism ; Humans ; Mitosis/genetics ; Phosphoprotein Phosphatases/metabolism ; Phosphorylation ; Xenopus
    Chemical Substances Cdc20 Proteins ; CDC20 protein, human (156288-95-8) ; Anaphase-Promoting Complex-Cyclosome (EC 2.3.2.27) ; Phosphoprotein Phosphatases (EC 3.1.3.16)
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2210367119
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    Zs.A 1148: Show issues Location:
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  4. Article ; Online: From rabbit reticulocytes to clam oocytes: in search of the system that targets mitotic cyclins for degradation.

    Hershko, Avram

    Molecular biology of the cell

    2010  Volume 21, Issue 10, Page(s) 1645–1647

    Abstract: By the late 1980s, the basic biochemistry of ubiquitin-mediated protein degradation had already been elucidated by studies that used reticulocyte lysates. However, the scope and biological functions of this system remained largely obscure. Therefore, I ... ...

    Abstract By the late 1980s, the basic biochemistry of ubiquitin-mediated protein degradation had already been elucidated by studies that used reticulocyte lysates. However, the scope and biological functions of this system remained largely obscure. Therefore, I became interested at that time in the mechanisms by which mitotic cyclins are degraded in exit from mitosis. Using a cell-free system from clam oocytes that faithfully reproduced cell cycle stage-specific degradation of cyclins, we identified in 1995 a large ubiquitin ligase complex that targets mitotic cyclins for degradation. Subsequent studies in many laboratories showed that this ubiquitin ligase, now called the anaphase-promoting complex/cyclosome, has centrally important roles in many aspects of cell cycle control.
    MeSH term(s) Anaphase-Promoting Complex-Cyclosome ; Animals ; Bivalvia/metabolism ; Cell Cycle ; Cell-Free System/metabolism ; Cyclins/history ; Cyclins/metabolism ; Female ; History, 20th Century ; History, 21st Century ; Israel ; Ligases/history ; Ligases/metabolism ; Mitosis ; Oocytes/cytology ; Oocytes/metabolism ; Rabbits ; Reticulocytes/metabolism ; Ubiquitin/history ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligase Complexes
    Chemical Substances Cyclins ; Ubiquitin ; Ubiquitin-Protein Ligase Complexes (EC 2.3.2.23) ; Anaphase-Promoting Complex-Cyclosome (EC 2.3.2.27) ; Ligases (EC 6.-)
    Language English
    Publishing date 2010-03-24
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Review
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E09-07-0583
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    Zs.A 2853: Show issues Location:
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    Zs.MO 410: Show issues

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  5. Article: Some lessons from my work on the biochemistry of the ubiquitin system.

    Hershko, Avram

    The Journal of biological chemistry

    2008  Volume 284, Issue 16, Page(s) 10291–10295

    MeSH term(s) Biochemistry ; Education, Graduate ; Humans ; Research ; Ubiquitin/metabolism
    Chemical Substances Ubiquitin
    Language English
    Publishing date 2008-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.X800016200
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    Uc I Zs.108: Show issues Location:
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  6. Article ; Online: Irwin Allan Rose (1926-2015).

    Wilkinson, Keith / Hershko, Avram

    Nature

    2015  Volume 523, Issue 7562, Page(s) 532

    MeSH term(s) Biochemistry/history ; Enzymes/history ; Enzymes/metabolism ; Glycolysis ; History, 20th Century ; History, 21st Century ; Nobel Prize ; Ubiquitin/history ; Ubiquitin/metabolism ; United States
    Chemical Substances Enzymes ; Ubiquitin
    Language English
    Publishing date 2015-07-30
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/523532a
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    Zs.A 26: Show issues Location:
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    Zs.MO 244: Show issues

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  7. Article ; Online: Science as an Adventure - Lessons for the Young Scientist

    Avram Hershko

    Rambam Maimonides Medical Journal, Vol 1, Iss 1, p e

    2010  Volume 0001

    Abstract: I graduated as MD in 1965, after gaining substantial exposure to basic science in the course of my medical studies. I obtained my PhD degree in 1969, and thus, in essence, I have been actively engaged in conducting research for over half a century. It ... ...

    Abstract I graduated as MD in 1965, after gaining substantial exposure to basic science in the course of my medical studies. I obtained my PhD degree in 1969, and thus, in essence, I have been actively engaged in conducting research for over half a century. It goes without saying, that to be successful in any field one has to love what one does. This is most important in experimental science, since experiments do not always work and at times the results disprove what you had been hoping for. Moments when everything comes together and you can shout “Eureka” are few and far between, and the outcomes attained might not exactly fit the starting hypothesis. However, such unexpected results can turn out to be of greatest importance. In one of my first experiments during my postdoctorate period, I observed quite by accident that the enzyme involved in the degradation of the protein tyrosine aminotransferase required energy. I wondered why would the degradation of an intracellular protein require energy, whereas to our knowledge protein degradation outside of cells – e.g. the digestion of food – does not. This “accidental” observation led me to assume the existence of some kind of novel, unknown energy-dependent mechanism that governs highly selective protein degradation within cells. I was very impressed by this finding, and all my subsequent work was influenced by this one experiment. Although it had been reached fortuitously, I considered the observation to be important. It might have been mere luck that I chose to do this type of experiment early on in my career, but luck by itself would not have steered me toward further achievements. I had to embark on serious scientific work to pursue this unique finding – and I have been pursuing it ever since.
    Keywords Nobel Laureate ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 190
    Publishing date 2010-07-01T00:00:00Z
    Publisher Rambam Health Care Campus
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes.

    Kaisari, Sharon / Miniowitz-Shemtov, Shirly / Sitry-Shevah, Danielle / Shomer, Pnina / Kozlov, Guennadi / Gehring, Kalle / Hershko, Avram

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 9

    Abstract: The mitotic (or spindle assembly) checkpoint system ensures accurate chromosome segregation in mitosis by preventing the onset of anaphase until correct bipolar attachment of sister chromosomes to the mitotic spindle is attained. It acts by promoting the ...

    Abstract The mitotic (or spindle assembly) checkpoint system ensures accurate chromosome segregation in mitosis by preventing the onset of anaphase until correct bipolar attachment of sister chromosomes to the mitotic spindle is attained. It acts by promoting the assembly of a mitotic checkpoint complex (MCC), composed of mitotic checkpoint proteins BubR1, Bub3, Mad2, and Cdc20. MCC binds to and inhibits the action of ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome), which targets for degradation regulators of anaphase initiation. When the checkpoint system is satisfied, MCCs are disassembled, allowing the recovery of APC/C activity and initiation of anaphase. Many of the pathways of the disassembly of the different MCCs have been elucidated, but the mode of their regulation remained unknown. We find that UBR5 (ubiquitin-protein ligase
    MeSH term(s) Cell Cycle Proteins/metabolism ; Humans ; M Phase Cell Cycle Checkpoints ; Mitosis ; Poly-ADP-Ribose Binding Proteins/metabolism ; Protein Binding ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
    Chemical Substances BUB3 protein, human ; Cell Cycle Proteins ; Poly-ADP-Ribose Binding Proteins ; UBR5 protein, human (EC 2.3.2.26) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2121478119
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  9. Article: The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture).

    Hershko, Avram

    Angewandte Chemie (International ed. in English)

    2005  Volume 44, Issue 37, Page(s) 5932–5943

    MeSH term(s) Cell Division/physiology ; Hydrolysis ; Proteins/metabolism ; Ubiquitin/metabolism ; Ubiquitin/physiology
    Chemical Substances Proteins ; Ubiquitin
    Language English
    Publishing date 2005-09-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.200501724
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  10. Article: Some Lessons from My Work on the Biochemistry of the Ubiquitin System

    Hershko, Avram

    Journal of biological chemistry. 2009 Apr. 17, v. 284, no. 16

    2009  

    Language English
    Dates of publication 2009-0417
    Size p. 10291-10295.
    Publishing place American Society for Biochemistry and Molecular Biology
    Document type Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    Database NAL-Catalogue (AGRICOLA)

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