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Article ; Online: The genus Cryptotendipes Beck et Beck in Florida, with the description of a new species (Diptera: Chironomidae: Chironominae).

Epler, J H

Zootaxa

2018 Volume 4433, Issue 3, Page(s) 583–594

Abstract: ... for the state, C. pseudotener (Goetghebuer), is recorded and a new species, C. rutteri Epler, is described ...

Abstract	Species of the genus Cryptotendipes Beck et Beck in Florida are reviewed. Previous Florida records of C. casuarius (Townes) are shown to be misidentifications of C. emorsus (Townes). One species new for the state, C. pseudotener (Goetghebuer), is recorded and a new species, C. rutteri Epler, is described from pharate pupae and associated larval exuviae. Thus, a total of three species are known from the state. Keys are provided for adult males, pupae and larvae of these three species.
MeSH term(s)	Animals ; Chironomidae ; Florida ; Larva ; Male ; Pupa
Language	English
Publishing date	2018-06-13
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4433.3.12
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Article ; Online: A new species of <i>Dicrotendipes</i> (Diptera: Chironomidae) from Florida.

Epler, J H

Zootaxa

2016 Volume 4208, Issue 1, Page(s) zootaxa.4208.1.4

Abstract: ... Malloch) and D. tritomus (Kieffer); while the larvae are unique and were keyed by Epler (1992, 1995, 2001 ...

Abstract	A new species of Dicrotendipes is described in all life stages from Florida. Adults of this new species are nearly identical to D. modestus (Say); pupae are similar to D. modestus, D. neomodestus (Malloch) and D. tritomus (Kieffer); while the larvae are unique and were keyed by Epler (1992, 1995, 2001) as Dicrotendipes sp. A. The taxonomic status of D. modestus and D. pulsus (Walker) is discussed.
MeSH term(s)	Animals ; Chironomidae/anatomy & histology ; Chironomidae/classification ; Chironomidae/growth & development ; Female ; Florida ; Larva/anatomy & histology ; Male ; Pupa/anatomy & histology ; Species Specificity
Language	English
Publishing date	2016-12-14
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4208.1.4
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Article ; Online: Pica in Pregnancy: An Unusual Presentation.

Epler, Katharine E / Pierce, Arand / Rappaport, Valerie J

Obstetrics and gynecology

2017 Volume 130, Issue 6, Page(s) 1377–1379

Abstract: Background: Pica is common in pregnancy and is often felt to be benign. The following case of severe pica presenting without anemia is unusual in its presentation, laboratory findings, and treatment.: Case: A 31-year-old multiparous woman at 37 0/7 ... ...

Abstract	Background: Pica is common in pregnancy and is often felt to be benign. The following case of severe pica presenting without anemia is unusual in its presentation, laboratory findings, and treatment. Case: A 31-year-old multiparous woman at 37 0/7 weeks of gestation presented with esophagitis and gastritis secondary to laundry detergent consumption. She had borderline anemia (hemoglobin of 11 g/dL and hematocrit of 37%, mean corpuscular volume 80%) but was severely iron-deficient (serum ferritin 7 micrograms/dL). Parenteral iron infusion was associated with dramatic resolution of her cravings within 36 hours of treatment. Conclusion: Pica may be related to deficient iron stores in the absence of anemia and can result in serious morbidity. Parenteral iron may be associated with rapid pica resolution in symptomatic pregnant patients.
MeSH term(s)	Adult ; Anemia, Iron-Deficiency/diagnosis ; Anemia, Iron-Deficiency/physiopathology ; Anemia, Iron-Deficiency/therapy ; Chemically-Induced Disorders/diagnosis ; Chemically-Induced Disorders/etiology ; Chemically-Induced Disorders/physiopathology ; Chemically-Induced Disorders/therapy ; Detergents/toxicity ; Esophagitis/chemically induced ; Esophagitis/diagnosis ; Female ; Gastritis/chemically induced ; Gastritis/diagnosis ; Humans ; Iron/administration & dosage ; Iron/deficiency ; Noxae/toxicity ; Pica/diagnosis ; Pica/etiology ; Pica/physiopathology ; Pica/therapy ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/physiopathology ; Pregnancy Complications/therapy ; Trace Elements/administration & dosage ; Trace Elements/deficiency ; Treatment Outcome
Chemical Substances	Detergents ; Noxae ; Trace Elements ; Iron (E1UOL152H7)
Language	English
Publishing date	2017-09-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000002365
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Article: Strategies for Glycoengineering Therapeutic Proteins.

Dammen-Brower, Kris / Epler, Paige / Zhu, Stanley / Bernstein, Zachary J / Stabach, Paul R / Braddock, Demetrios T / Spangler, Jamie B / Yarema, Kevin J

Frontiers in chemistry

2022 Volume 10, Page(s) 863118

Abstract: Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a long-established, substantial role in the safety and pharmacokinetic properties of this dominant category of drugs. In the past few years and moving forward, ... ...

Abstract	Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a long-established, substantial role in the safety and pharmacokinetic properties of this dominant category of drugs. In the past few years and moving forward, glycosylation is increasingly being implicated in the pharmacodynamics and therapeutic efficacy of therapeutic proteins. This article provides illustrative examples of drugs that have already been improved through glycoengineering including cytokines exemplified by erythropoietin (EPO), enzymes (ectonucleotide pyrophosphatase 1, ENPP1), and IgG antibodies (e.g., afucosylated Gazyva
Language	English
Publishing date	2022-04-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2022.863118
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Article: New Records of Corixidae and Micronectidae (Insecta: Heteroptera: Corixoidea) from Florida, with a Checklist of All Species Known from the State

Epler, J. H / Denson D. R

Entomological news. 2017 Apr., v. 126, no. 5

2017

Abstract: Five new state records for Florida Corixidae are given. Two introduced species of Micronectidae are discussed. A checklist of all Florida Corixidae and Micronectidae is presented. ...

Abstract	Five new state records for Florida Corixidae are given. Two introduced species of Micronectidae are discussed. A checklist of all Florida Corixidae and Micronectidae is presented.
Keywords	Corixidae ; introduced species ; records ; Florida
Language	English
Dates of publication	2017-04
Size	p. 410-414.
Publishing place	American Entomological Society
Document type	Article
ZDB-ID	427420-9
ISSN	0013-872X
ISSN	0013-872X
DOI	10.3157%2F021.126.0510
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Balancing quality and quaternary care imperative using a high-risk case review committee in adults.

Ibrahim, Michael / Acker, Andrew / Weiss, Steve / Lawrence, Kendall / Ottemiller, Stephanie / McGarvey, Jeremy / Epler, Mark / Williams, Matthew / Szeto, Wilson Y / Acker, Michael

Interactive cardiovascular and thoracic surgery

2022 Volume 35, Issue 6

Abstract: Objectives: Quaternary care centres have an imperative to serve as hospitals of last resort and must also meet professional quality targets. We developed a high-risk committee (HRC) to evaluate cases meeting pre-defined predicted risk cut-offs as a part ...

Abstract	Objectives: Quaternary care centres have an imperative to serve as hospitals of last resort and must also meet professional quality targets. We developed a high-risk committee (HRC) to evaluate cases meeting pre-defined predicted risk cut-offs as a part of an overall quality improvement drive. Methods: We describe the structure, outcomes and effects of the Penn HRC. Using propensity-matching, we investigated whether the committee modifies or screens risk. We used multivariable analysis to examine the impact of unmeasured variables on clinical outcomes in this cohort. Results: Institutional predicted and observed mortality had already been in decline prior to HRC institution in 2017, due to a multi-faceted quality improvement initiative. Between 2017 and 2020, the HRC discussed 205 patients with a median predicted risk of mortality of 10.6% (range 0.4-66%). Coronary artery bypass grafting was the most commonly presented operation. A total of 155 patients underwent operation (risk 10.3%), 12 had surgery deferred for optimization (risk 6%), 50 had surgery declined (risk 11.7%) and 12 patients had a deferred decision for further investigation. Overall 30-day survival was 86% for the entire cohort and 89% for operated patients. A matched analysis of similar patients prior to and following the HRC showed that the HRC did not directly modify outcomes. Most patients had better than expected survival (observed:expected mortality < 1). Predicted risk did not predict 30-day mortality among this high-risk cohort. Conclusions: HRCs serve as an important element in quality improvement by encouraging a thoughtful approach and channelling the collective experience of a group of senior surgeons. It may improve patient selection by identifying a cohort with extremely poor survival, while allowing safe operation with acceptable outcomes among a group with very high operative risk.
MeSH term(s)	Adult ; Humans ; Advisory Committees ; Coronary Artery Bypass/adverse effects ; Quality Improvement ; Hospitals ; Surgeons ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2022-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivac268
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Article ; Online: Impact of mail-based continuous positive airway pressure initiation on treatment usage and effectiveness.

Donovan, Lucas M / Parsons, Elizabeth C / McCall, Catherine A / He, Ken / Sharma, Rahul / Gamache, Justina / Pannick, Anna P / McDowell, Jennifer A / Pai, James / Epler, Eric / Duan, Kevin I / Spece, Laura J / Feemster, Laura C / Kapur, Vishesh K / Au, David H / Palen, Brian N

Sleep & breathing = Schlaf & Atmung

2022 Volume 27, Issue 1, Page(s) 303–308

Abstract: Purpose: In-person visits with a trained therapist have been standard care for patients initiating continuous positive airway pressure (CPAP). These visits provide an opportunity for hands-on training and an in-person assessment of mask fit. However, to ...

Abstract	Purpose: In-person visits with a trained therapist have been standard care for patients initiating continuous positive airway pressure (CPAP). These visits provide an opportunity for hands-on training and an in-person assessment of mask fit. However, to improve access, many health systems are shifting to remote CPAP initiation with equipment mailed to patients. While there are potential benefits of a mailed approach, relative patient outcomes are unclear. Specifically, many have concerns that a lack of in-person training may contribute to reduced CPAP adherence. To inform this knowledge gap, we aimed to compare treatment usage after in-person or mailed CPAP initiation. Methods: Our medical center shifted from in-person to mailed CPAP dispensation in March 2020 during the COVID-19 pandemic. We assembled a cohort of patients with newly diagnosed obstructive sleep apnea (OSA) who initiated CPAP in the months before (n = 433) and after (n = 186) this shift. We compared 90-day adherence between groups. Results: Mean nightly PAP usage was modest in both groups (in-person 145.2, mailed 140.6 min/night). We did not detect between-group differences in either unadjusted or adjusted analyses (adjusted difference - 0.2 min/night, 95% - 27.0 to + 26.5). Conclusions: Mail-based systems of CPAP initiation may be able to improve access without reducing CPAP usage. Future work should consider the impact of mailed CPAP on patient-reported outcomes and the impact of different remote setup strategies.
MeSH term(s)	Humans ; Continuous Positive Airway Pressure ; Pandemics ; Postal Service ; COVID-19/therapy ; Cognition
Language	English
Publishing date	2022-03-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-022-02608-z
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Article ; Online: Analysis of the possibility of applying a condition-based maintenance model on an example of tank weapons

Igor J. Epler

Vojnotehnički Glasnik, Vol 61, Iss 4, Pp 121-

2013 Volume 137

Abstract: For any modern army it is very important to continuously maintain a high degree of operational (combat) readiness (availability) in order to maximize the effectiveness of the use of technical systems. Since determination and prediction of technical ... ...

Abstract	For any modern army it is very important to continuously maintain a high degree of operational (combat) readiness (availability) in order to maximize the effectiveness of the use of technical systems. Since determination and prediction of technical states and failures of technical systems in engineering, especially in armament, are difficult due to the impossibility of continuous condition monitoring with appropriate measuring equipment there is a need for a maintenance model that would be most helpful in taking timely action maintenance. In this paper, the subject of research is a model of maintenance of the M-84 tank weapoons systems. IntroductionThe M-84 tank is one of the most promising technical systems in the Serbian Army. Its use and modifications are foreseen in the next ten years. The M-84 is characterized by good tactical and technical characteristics. It has a powerful 125 mm cannon, coupled 7.62 mm machine gun and 12.7 mm anti-aircraft machine gun. The M-84 tank has an automatic battery charger and a fire control system. The fire control system enables fast target tracking and stabilization of the cannon barrel, which is a prerequisite for timely and favorable effect on the target. There are certain ambiguities in the existing model of maintenance of tank weapons. Technical diagnostics Technical diagnostics, as a part of the process of condition-based maintenance, should determine technical conditions of components or technical systems with certain accuracy at a point in time. Maintenance strategy A maintenance strategy can be defined as a variant of a maintenance system determined by a concept, organization and character of maintenance procedures, as well as the relationship between the various levels at which maintenance is performed. It is defined for technical system parts, individual technical systems and for system maintenance as a whole. The basic maintenance strategies implemented today are: - corrective maintenance, - preventive maintenance, - combined maintenance. Some developed ...
Keywords	tank weapons ; diagnostic ; component ; tehnical system ; condition based maintenance ; model ; Military Science ; U ; Engineering (General). Civil engineering (General) ; TA1-2040
Subject code	690
Language	English
Publishing date	2013-12-01T00:00:00Z
Publisher	University of Defence in Belgrade
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Proposal for a trial of early left ventricular venting during venoarterial extracorporeal membrane oxygenation for cardiogenic shock.

Ibrahim, Michael / Acker, Michael A / Szeto, Wilson / Gutsche, Jacob / Williams, Matthew / Atluri, Pavan / Woods, Matthew / Richards, Thomas / Gardner, Timothy J / McGarvey, Jeremy / Epler, Mark / Wald, Joyce / Rame, Eduardo / Birati, Edo / Bermudez, Christian

JTCVS open

2021 Volume 8, Page(s) 393–400

Abstract: Objective: Patients with profound cardiogenic shock may require venoarterial (VA) extracorporeal membrane oxygenation (ECMO) for circulatory support most commonly via the femoral vessels. The rate of cardiac recovery in this population remains low, ... ...

Abstract	Objective: Patients with profound cardiogenic shock may require venoarterial (VA) extracorporeal membrane oxygenation (ECMO) for circulatory support most commonly via the femoral vessels. The rate of cardiac recovery in this population remains low, possibly because peripheral VA-ECMO increases ventricular afterload. Whether direct ventricular unloading in peripheral VA-ECMO enhances cardiac recovery is unknown, but is being more frequently utilized. A randomized trial is warranted to evaluate the clinical effectiveness of percutaneous left ventricle venting to enhance cardiac recovery in the setting of VA-ECMO. Methods: We describe the rationale, design, and initial testing of a randomized controlled trial of VA-ECMO with and without percutaneous left ventricle venting using a percutaneous micro-axial ventricular assist device. Results: This is an ongoing prospective randomized controlled trial in adult patients with primary cardiac failure presenting in cardiogenic shock requiring peripheral VA-ECMO, designed to test the safety and effectiveness of percutaneous left ventricle venting in improving the rate of cardiac recovery. Conclusions: The results of this nonindustry-sponsored trial will provide critical information on whether left ventricle unloading in peripheral VA-ECMO is safe and effective.
Language	English
Publishing date	2021-07-30
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-2736
ISSN (online)	2666-2736
DOI	10.1016/j.xjon.2021.07.024
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Article ; Online: Health System Approach to Improve Chronic Obstructive Pulmonary Disease Care after Hospital Discharge: Stepped-Wedge Clinical Trial.

Au, David H / Collins, Margaret P / Berger, Douglas B / Carvalho, Paula G / Nelson, Karin M / Reinke, Lynn F / Goodman, Richard B / Adamson, Rosemary / Woo, Deborah M / Rise, Peter J / Coggeshall, Scott S / Plumley, Robert B / Epler, Eric M / Moss, Brianna R / McDowell, Jennifer A / Weppner, William G

American journal of respiratory and critical care medicine

2022 Volume 205, Issue 11, Page(s) 1281–1289

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Hospitals ; Humans ; Patient Discharge ; Patient Readmission ; Pulmonary Disease, Chronic Obstructive ; Quality of Life
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202107-1707OC
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