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  1. Article ; Online: Ling Zhi-8, a fungal immunomodulatory protein in

    Li, Ju-Pi / Chu, Ching-Liang / Chao, Wan-Ru / Yeh, Cheng-Siang / Lee, Yi-Ju / Chen, Dz-Chi / Yang, Shun-Fa / Chao, Yu-Hua

    Aging

    2023  Volume 15, Issue 9, Page(s) 3621–3634

    Abstract: ... for its clinical utility. Ling Zhi-8 (LZ-8), a fungal immunomodulatory protein in ...

    Abstract CPT-11 (Irinotecan) remains an important chemotherapeutic agent against various solid tumors nowadays. Potential adverse effects, especially gastrointestinal toxicities, are the main limiting factor for its clinical utility. Ling Zhi-8 (LZ-8), a fungal immunomodulatory protein in
    MeSH term(s) Mice ; Animals ; Reishi ; Irinotecan ; Claudin-1/genetics
    Chemical Substances Irinotecan (7673326042) ; Claudin-1
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Zhi

    Fan, Ye / Li, Xian / Sima, Biao / Liu, Zhao

    1

    (Hou han shu : 後漢書 ; / Fan ye zhuan; li xian deng zhu ; 11)

    1982  

    Institution 中華書局 / 编辑部
    Series title Hou han shu : 後漢書
    / Fan ye zhuan; li xian deng zhu ; 11
    Language Chinese
    Size S. 2999-3383
    Edition Di 1 ban, di 3 ci yin shua
    Publisher Zhong hua shu ju
    Publishing place Bei jing
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book: Zhi

    Fan, Ye / Li, Xian / Sima, Biao / Liu, Zhao

    2

    (Hou han shu : 後漢書 ; / Fan ye zhuan; li xian deng zhu ; 12)

    1982  

    Institution 中華書局 / 编辑部
    Series title Hou han shu : 後漢書
    / Fan ye zhuan; li xian deng zhu ; 12
    Language Chinese
    Size S. 3385-3684, 2, 2 S.
    Edition Di 1 ban, di 3 ci yin shua
    Publisher Zhong hua shu ju
    Publishing place Bei jing
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article ; Online: The Therapeutic Effect and Potential Pharmacological Mechanisms of Ding-Zhi-Xiao-Wan on Depression were Investigated by Meta-analysis, Network Pharmacology and Molecular Docking.

    Lin, Li-Li / Wu, Han-Biao / Qiu, Zhi-Kun

    Current computer-aided drug design

    2023  Volume 20, Issue 1, Page(s) 16–32

    Abstract: Introduction: Ding-Zhi-Xiao-Wan (DZXW) produces potential antidepressant-like effects ...

    Abstract Introduction: Ding-Zhi-Xiao-Wan (DZXW) produces potential antidepressant-like effects. However, its antidepressant mechanisms are still unclear.
    Objective: To analyze the antidepressant effects and the pharmacological mechanisms of DZXW, meta-analysis, network pharmacology, and molecular docking were selected in this study.
    Methods: The compounds of DZXW and genes associated with compounds or depression were obtained from databases. The genes overlapping between DZXW compounds and depression were compared by Venn diagram. A network of medicine-ingredients-targets-disease was constructed, visualized, and analyzed. Protein-protein interaction, gene ontology, pathway enrichment, and molecular docking were performed to evaluate the potential mechanisms of DZXW for the treatment of depression.
    Results: Meta-analysis showed that the antidepressant-like effects were produced by DZXW. The network pharmacology analysis showed that a total of 74 compound-related genes and 12607 PTSD-related genes were identified in the databases with 65 overlapping genes. The active ingredients derived from DZXW (i.e Beta-sitosterol, Stigmasterol, Fumarine, Hederagenin) elicited the antidepressant-like effects by targets, such as ACHE, HTR2A, and CHRM1. Moreover, the signaling pathways, like neuroactive ligand-receptor interaction, pathways in cancer, and cholinergic synapse, might play important roles in the treatment of depression by DZXW.
    Conclusion: This study provides studies analysis and molecular evidence with the beneficial effects of DZXW for the treatment of depression.
    Language English
    Publishing date 2023-04-19
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6697
    ISSN (online) 1875-6697
    DOI 10.2174/1573409919666230417103355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid classification and identification of chemical compositions of Pu-zhi-hui-ling decoction by UHPLC-Q-Orbitrap HRMS.

    Shao, Jia / Zheng, Yanxue / Wang, Yuanyuan / Li, Guohui / Wei, Jinxia / Cheng, Wenbo / Li, Yubo

    Natural product research

    2024  , Page(s) 1–10

    Abstract: Pu-zhi-hui-ling decoction (PZHLD) is a traditional Chinese medicine (TCM) formula for the treatment ...

    Abstract Pu-zhi-hui-ling decoction (PZHLD) is a traditional Chinese medicine (TCM) formula for the treatment of Alzheimer's disease (AD), but its chemical composition has not been reported. In this study, we aimed to establish a mass spectrometry (MS) analysis method for rapid classification and identification of the chemical constituents in PZHLD. The sample was analysed by ultrahigh-performance liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS). The chemical constituents of PZHLD were identified based on accurate MS data, fragmentation characteristics of MS/MS, and reference information described in the literature. A total of 123 chemical constituents were identified. In addition, we summarised the fragmentation pathways of the chemical constituents in PZHLD. Our finding might lay the foundation for the further pharmacodynamic study and clinical application of PZHLD.
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2299302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Si-Zhi Wan regulates osteoclast autophagy in osteoporosis through the AMPK signaling pathway to attenuate osteoclastogenesis.

    Huang, Yucheng / Yao, Huan / Tjahjono, Adi Wirawan / Xiang, Li / Li, Ke / Tang, Jiahe / Gao, Yongxiang

    The Journal of pharmacy and pharmacology

    2024  Volume 76, Issue 3, Page(s) 236–244

    Abstract: Objectives: The mechanisms underlying the therapeutic effects of Si-Zhi Wan (SZW ...

    Abstract Objectives: The mechanisms underlying the therapeutic effects of Si-Zhi Wan (SZW), a traditional Chinese medicine used to treat osteoporosis (OP), remain unknown. This study investigated the therapeutic effects of SZW on mice that underwent ovariectomy (OVX) and underlying mechanisms thereof.
    Methods: We established an in vivo model of OP by performing OVX in mice. Microcomputed tomography (Micro-CT) was used to assess changes in bone characteristics of mice following SZW administration for 4 weeks. H&E staining revealed alterations in bone tissues of mice. Osteoclastogenesis in mouse bone tissue was observed using tartrate-resistant acid phosphatase staining and western blotting. Furthermore, we examined the impact of SZW on osteoclastogenesis in vitro using receptor activator of nuclear factor kappa-B ligand (RANKL). Finally, we explored the regulatory effects of SZW on osteoclast autophagy and the AMPK pathway.
    Key findings: The results demonstrated that high-dose SZW reversed changes in bone density parameters caused by OVX, including bone volume (BV), BV/total volume, trabecular number, and trabecular spacing (P = 0.0007, 0.0035, 0.0114, and 0.0182, respectively), and stimulated the formation of bone trabeculae in mice (P < 0.0001). Furthermore, SZW suppressed osteoclast formation in mice with OVX and inhibited osteoclast formation induced by RANKL. Mechanistically, SZW inhibited osteoclast precursor cell autophagy through the AMPK pathway.
    Conclusions: SZW effectively inhibited the autophagy of osteoclast precursors by regulating the AMPK pathway, thereby exerting anti-osteoclastogenic effects and serving as an alternative therapy for OP.
    MeSH term(s) Female ; Mice ; Animals ; Humans ; Osteoclasts/metabolism ; Osteogenesis ; AMP-Activated Protein Kinases/metabolism ; X-Ray Microtomography ; Osteoporosis/drug therapy ; Osteoporosis/metabolism ; Signal Transduction ; Autophagy ; RANK Ligand/metabolism ; RANK Ligand/pharmacology ; RANK Ligand/therapeutic use ; Ovariectomy ; Cell Differentiation
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; RANK Ligand
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 3107-0
    ISSN 2042-7158 ; 0022-3573 ; 0373-1022
    ISSN (online) 2042-7158
    ISSN 0022-3573 ; 0373-1022
    DOI 10.1093/jpp/rgad126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.149: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Zhi

    Fan, Ye / Li, Xian

    (Hou han shu : 後漢書 ; / Fan ye zhuan; li xian deng zhu ; 6)

    1973  

    Series title Hou han shu : 後漢書
    / Fan ye zhuan; li xian deng zhu ; 6
    Language Chinese
    Size S. 2999-3684, 2, 2, S
    Edition Di 1 ban, shang hai di 2 ci yin shua
    Publisher Zhong hua shu ju
    Publishing place Bei jing
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: Sisheng zhi yu

    Li, Jianmin

    Zhou Qin Han maixue zhi yuanliu

    (Zhongyang yanjiuyuan lishiyuyanyanjiusuo zhuankan ; 101)

    2000  

    Author's details Li Jianmin
    Series title Zhongyang yanjiuyuan lishiyuyanyanjiusuo zhuankan ; 101
    Zhong yang yan jiu yuan li shi yu yan yan jiu suo zhuan kan
    Collection Zhong yang yan jiu yuan li shi yu yan yan jiu suo zhuan kan
    Language Chinese
    Size IV, 435 S. : Ill.
    Publisher Zhongyanjiushiyusuo
    Publishing place Taibei
    Publishing country Taiwan
    Document type Book
    HBZ-ID TT002248783
    ISBN 957-671-704-3 ; 957-671-703-5 ; 978-957-671-704-8 ; 978-957-671-703-1
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 4722 order for loan Magazin

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  9. Article ; Online: Optimization of the proportions of advantageous components in the hypolipidemic "bioequivalent substance system" of Jiang-Zhi-Ning and its mechanism of action.

    Li, Yumiao / Zhang, Yan / Zhang, Yu / Lin, Tianfeng / Gao, Yanyan / Cai, Yuan / Zhou, Chang / Yang, Leyi / Liu, Bin / Dong, Shifen / Jiang, Yanyan

    Pharmaceutical biology

    2023  Volume 61, Issue 1, Page(s) 1374–1386

    Abstract: Context: Jiang-Zhi-Ning (JZN), a traditional Chinese medicinal formula, is used to treat ...

    Abstract Context: Jiang-Zhi-Ning (JZN), a traditional Chinese medicinal formula, is used to treat hyperlipidemia in clinics.
    Objective: To screen the hypolipidemic "bioequivalent substance system (BSS)" of JZN and elucidate the potential hypolipidemic mechanism.
    Materials and methods: In vitro
    Results: In vitro
    Discussion and conclusions: These findings provided new feasible ideas and methods for the elucidation of the pharmacodynamic material basis.
    MeSH term(s) Male ; Animals ; Mice ; Mice, Inbred ICR ; Cholesterol, LDL ; Administration, Oral ; Gene Expression Profiling
    Chemical Substances Jiang-Zhi-Ning ; Cholesterol, LDL
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2023.2243999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1300: Show issues Location:
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  10. Article ; Online: Qing-Zhi-Tiao-Gan-Tang (QZTGT) prevents nonalcoholic steatohepatitis (NASH) by expression pattern correction.

    Chu, Hang / Zhang, Weitao / Tan, Yan / Diao, Zhipeng / Li, Peng / Wu, Yapeng / Xie, Like / Sun, Jianguo / Yang, Ke / Li, Pingping / Xie, Cen / Li, Ping / Hua, Qian / Xu, Xiaojun

    Journal of ethnopharmacology

    2023  Volume 317, Page(s) 116665

    Abstract: Ethnopharmacological relevance: Qing-Zhi-Tiao-Gan-Tang or Qing-Zhi-Tiao-Gan Decoction (QZTGT) is ...

    Abstract Ethnopharmacological relevance: Qing-Zhi-Tiao-Gan-Tang or Qing-Zhi-Tiao-Gan Decoction (QZTGT) is based on the compatibility theory of traditional Chinese medicine (TCM), that is a combination of three classical formulae for the treatment of nonalcoholic fatty liver disease (NAFLD). Its pharmacodynamic material basis is made up of quinones, flavanones, and terpenoids.
    Aim of the study: This study aimed to look for a promising recipe for treating nonalcoholic steatohepatitis (NASH), a more advanced form of NAFLD, and to use a transcriptome-based multi-scale network pharmacological platform (TMNP) to find its therapy targets.
    Materials and methods: A classical dietary model of NASH was established using MCD (Methionine- and choline-deficient) diet-fed mice. Liver coefficients like ALT, AST, serum TC, and TG levels were tested following QZTGT administration. A transcriptome-based multi-scale network pharmacological platform (TMNP) was used to further analyze the liver gene expression profile.
    Results: The composition of QZTGT was analyzed by HPLC-Q-TOF/MS, a total of 89 compounds were separated and detected and 31 of them were found in rat plasma. QZTGT improved liver morphology, inflammation and fibrosis in a classical NASH model. Transcriptomic analysis of liver samples from NASH animal model revealed that QZTGT was able to correct gene expression. We used transcriptome-based multi-scale network pharmacological platform (TMNP) to predicted molecular pathways regulated by QZTGT to improve NASH. Further validation indicated that "fatty acid degradation", "bile secretion" and "steroid biosynthesis" pathways were involved in the improvement of NASH phenotype by QZTGT.
    Conclusions: Using HPLC-Q-TOF/MS, the compound composition of QZTGT, a Traditional Chinese prescription, was separated, analyzed and identified systematically. QZTGT mitigated NASH symptoms in a classical dietary model of NASH. Transcriptomic and network pharmacology analysis predicted the potential QZTGT regulated pathways. These pathways could be used as therapeutic targets for NASH.
    MeSH term(s) Rats ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/metabolism ; Liver Cirrhosis/drug therapy ; Choline ; Diet ; Mice, Inbred C57BL ; Disease Models, Animal
    Chemical Substances Choline (N91BDP6H0X)
    Language English
    Publishing date 2023-06-04
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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