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  1. Book ; Online ; E-Book: Neuropsychiatric disorders and epigenetics

    Peedicayil, Jacob / Grayson, Dennis R.

    (Translational epigenetics series)

    2024  

    Abstract: Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to ... ...

    Author's details edited by Jacob Peedicayil, Dennis R. Grayson
    Series title Translational epigenetics series
    Abstract Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy
    Keywords Neurobehavioral disorders/Genetic aspects ; Epigenetics ; Troubles neurocognitifs - Aspect génétique ; Épigénétique
    Subject code 616.80442
    Language English
    Size 1 Online-Ressource (xvii, 398 Seiten), Illustrationen
    Edition Second edition
    Publisher Elsevier Academic Press
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Note Previous edition: 2017 ; Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030732224
    ISBN 0-443-18517-4 ; 978-0-443-18517-5 ; 0443185166 ; 9780443185168
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Epigenetics in psychiatry

    Peedicayil, Jacob / Grayson, Dennis R. / Avramopoulos, Dimitri

    2021  

    Author's details edited by Jacob Peedicayil, Dennis R. Grayson, Dimitri Avramopoulos
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxix, 816 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021073521
    ISBN 978-0-12-823578-2 ; 9780128235775 ; 0-12-823578-0 ; 0128235772
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Epigenetics and psychiatric disease

    Grayson, Dennis R.

    (Progress in molecular biology and translational science ; volume 157)

    2018  

    Author's details edited by Dennis R. Grayson
    Series title Progress in molecular biology and translational science ; volume 157
    Collection
    Language English
    Size xvi, 433 Seiten, Illustrationen
    Edition First edition
    Publisher Academic Press, an imprint of Elsevier
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT019820355
    ISBN 978-0-12-813565-5 ; 0-12-813565-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 357 -157- verfügbar in Königswinter Königswinter

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  4. Book ; Online ; E-Book: Neuropsychiatric disorders and epigenetics

    Yasui, Dag H. / Peedicayil, Jacob / Grayson, Dennis R.

    (Translational epigenetics series)

    2017  

    Author's details edited by Dag H. Yasui, Jacob Peedicayil, Dennis R. Grayson
    Series title Translational epigenetics series
    Keywords Neurobehavioral disorders/Genetic aspects ; Epigenetics
    Subject code 616.80442
    Language English
    Size 1 Online-Ressource (xix, 423 Seiten), Illustrationen
    Publisher Elsevier AP
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019363466
    ISBN 978-0-12-800527-9 ; 9780128002261 ; 0-12-800527-0 ; 0128002263
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  5. Book ; Audio / Video: Epigenetics in psychiatry

    Peedicayil, Jacob / Grayson, Dennis R. / Avramopoulos, Dimitri

    2014  

    Author's details ed. by Jacob Peedicayil ; Dennis R. Grayson ; Dimitri Avramopoulos
    Keywords Mental illness/Genetic aspects ; Nervous system/Diseases/Genetic aspects
    Subject code 616.80442
    Language English
    Size XXVIII, 635 S. : Ill., graph. Darst.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Audio / Video
    HBZ-ID HT018392505
    ISBN 978-0-12-417114-5 ; 0-12-417114-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 3547 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Behavioral and Molecular Characterization of Prenatal Stress Effects on the C57BL/6J Genetic Background for the Study of Autism Spectrum Disorder.

    Dunn, Jeffrey T / Guidotti, Alessandro / Grayson, Dennis R

    eNeuro

    2024  Volume 11, Issue 2

    Abstract: Stress-inducing events during pregnancy are associated with aberrant neurodevelopment resulting in adverse psychiatric outcomes, including autism spectrum disorder (ASD). While numerous preclinical models for the study of ASD are frequently generated ... ...

    Abstract Stress-inducing events during pregnancy are associated with aberrant neurodevelopment resulting in adverse psychiatric outcomes, including autism spectrum disorder (ASD). While numerous preclinical models for the study of ASD are frequently generated using C57BL/6J mice, few studies have investigated the effects of prenatal stress on this genetic background. In the current manuscript, we stressed C57BL/6 dams during gestation and examined numerous behavioral and molecular endophenotypes in the adult male and female offspring to characterize the resultant phenotype as compared with offspring born from nonstressed (NS) dams. Adult mice born from prenatal restraint stressed (PRS) dams demonstrated reduced sociability and reciprocal social interaction along with increased marble burying behaviors relative to mice born from nonstressed control dams. Differential expression of genes related to excitatory and inhibitory neurotransmission was evaluated in the medial prefrontal cortex, amygdala, hippocampus, nucleus accumbens and caudate putamen via qRT-PCR. The male PRS mouse behavioral phenotype coincided with aberrant expression of glutamate and GABA marker genes (e.g., Grin1, Grin2b, Gls, Gat1, Reln) in neural substrates of social behavior. Rescue of the male PRS sociability deficit by a known antipsychotic with epigenetic properties (i.e., clozapine (5 mg/kg) + 18 hr washout) indicated possible epigenetic regulation of genes that govern sociability. Clozapine treatment increased the expression levels of genes involved in DNA methylation, histone methylation, and histone acetylation in the nucleus accumbens. Identification of etiology-specific mechanisms underlying clinically relevant behavioral phenotypes may ultimately provide novel therapeutic interventions for the treatment of psychiatric disorders including ASD.
    MeSH term(s) Humans ; Pregnancy ; Male ; Female ; Animals ; Mice ; Clozapine/pharmacology ; Histones/metabolism ; Autism Spectrum Disorder/genetics ; Epigenesis, Genetic ; Prenatal Exposure Delayed Effects/genetics ; Mice, Inbred C57BL ; Behavior, Animal/physiology ; Disease Models, Animal
    Chemical Substances Clozapine (J60AR2IKIC) ; Histones
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0186-23.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Special Issue Introduction: Role of Epigenetic Gene Regulation in Brain Function.

    Grayson, Dennis R

    Genes

    2017  Volume 8, Issue 7

    Abstract: In 1957, Conrad H. Waddington published a paper in which he demonstrated the inheritance of an acquired characteristic in a population in response to an environmental stimulus [1].[ ... ]. ...

    Abstract In 1957, Conrad H. Waddington published a paper in which he demonstrated the inheritance of an acquired characteristic in a population in response to an environmental stimulus [1].[...].
    Language English
    Publishing date 2017-07-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes8070181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Methylation and expression of glucocorticoid receptor exon-1 variants and FKBP5 in teenage suicide-completers.

    Rizavi, Hooriyah S / Khan, Omar S / Zhang, Hui / Bhaumik, Runa / Grayson, Dennis R / Pandey, Ghanshyam N

    Translational psychiatry

    2023  Volume 13, Issue 1, Page(s) 53

    Abstract: A dysregulated hypothalamic-pituitary-adrenal (HPA) axis has repeatedly been demonstrated to play a fundamental role in psychiatric disorders and suicide, yet the mechanisms underlying this dysregulation are not clear. Decreased expression of the ... ...

    Abstract A dysregulated hypothalamic-pituitary-adrenal (HPA) axis has repeatedly been demonstrated to play a fundamental role in psychiatric disorders and suicide, yet the mechanisms underlying this dysregulation are not clear. Decreased expression of the glucocorticoid receptor (GR) gene, which is also susceptible to epigenetic modulation, is a strong indicator of impaired HPA axis control. In the context of teenage suicide-completers, we have systematically analyzed the 5'UTR of the GR gene to determine the expression levels of all GR exon-1 transcript variants and their epigenetic state. We also measured the expression and the epigenetic state of the FK506-binding protein 51 (FKBP5/FKBP51), an important modulator of GR activity. Furthermore, steady-state DNA methylation levels depend upon the interplay between enzymes that promote DNA methylation and demethylation activities, thus we analyzed DNA methyltransferases (DNMTs), ten-eleven translocation enzymes (TETs), and growth arrest- and DNA-damage-inducible proteins (GADD45). Focusing on both the prefrontal cortex (PFC) and hippocampus, our results show decreased expression in specific GR exon-1 variants and a strong correlation of DNA methylation changes with gene expression in the PFC. FKBP5 expression is also increased in both areas suggesting a decreased GR sensitivity to cortisol binding. We also identified aberrant expression of DNA methylating and demethylating enzymes in both brain regions. These findings enhance our understanding of the complex transcriptional regulation of GR, providing evidence of epigenetically mediated reprogramming of the GR gene, which could lead to possible epigenetic influences that result in lasting modifications underlying an individual's overall HPA axis response and resilience to stress.
    MeSH term(s) Adolescent ; Humans ; DNA Methylation ; Exons ; Glucocorticoids/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Pituitary-Adrenal System/metabolism ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Tacrolimus Binding Proteins/genetics ; Tacrolimus Binding Proteins/metabolism ; Suicide, Completed
    Chemical Substances Glucocorticoids ; Receptors, Glucocorticoid ; Tacrolimus Binding Proteins (EC 5.2.1.-) ; tacrolimus binding protein 5 (EC 5.2.1.8)
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-023-02345-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Altered Expression and

    Matrisciano, Francesco / Locci, Valentina / Dong, Erbo / Nicoletti, Ferdinando / Guidotti, Alessandro / Grayson, Dennis R

    Current neuropharmacology

    2023  Volume 20, Issue 12, Page(s) 2354–2368

    Abstract: Background: mGlu5 metabotropic glutamate receptors are considered as candidate drug targets in the treatment of "monogenic" forms of autism spectrum disorders (ASD), such as Fragile- X syndrome (FXS). However, despite promising preclinical data, ... ...

    Abstract Background: mGlu5 metabotropic glutamate receptors are considered as candidate drug targets in the treatment of "monogenic" forms of autism spectrum disorders (ASD), such as Fragile- X syndrome (FXS). However, despite promising preclinical data, clinical trials using mGlu5 receptor antagonists to treat FXS showed no beneficial effects.
    Objective: Here, we studied the expression and function of mGlu5 receptors in the striatum of adult BTBR mice, which model idiopathic forms of ASD, and behavioral phenotype.
    Methods: Behavioral tests were associated with biochemistry analysis including qPCR and western blot for mRNA and protein expression. In vivo analysis of polyphosphoinositides hydrolysis was performed to study the mGlu5-mediated intracellular signaling in the striatum of adult BTBR mice under basal conditions and after MTEP exposure.
    Results: Expression of mGlu5 receptors and mGlu5 receptor-mediated polyphosphoinositides hydrolysis were considerably high in the striatum of BTBR mice, sensitive to MTEP treatment. Changes in the expression of genes encoding for proteins involved in excitatory and inhibitory neurotransmission and synaptic plasticity, including Fmr1, Dlg4, Shank3, Brd4, bdnf-exon IX, Mef2c, and Arc, GriA2, Glun1, Nr2A, and Grm1, Grm2, GriA1, and Gad1 were also found. Behaviorally, BTBR mice showed high repetitive stereotypical behaviors, including self-grooming and deficits in social interactions. Acute or repeated injections with MTEP reversed the stereotyped behavior and the social interaction deficit. Similar effects were observed with the NMDA receptor blockers MK-801 or ketamine.
    Conclusion: These findings support a pivotal role of mGlu5 receptor abnormal expression and function in idiopathic ASD adult forms and unveil novel potential targets for therapy.
    MeSH term(s) Mice ; Animals ; Autism Spectrum Disorder/drug therapy ; Autism Spectrum Disorder/genetics ; Nuclear Proteins/metabolism ; Nuclear Proteins/pharmacology ; Nuclear Proteins/therapeutic use ; Transcription Factors/metabolism ; Mice, Inbred Strains ; Corpus Striatum/metabolism ; Disease Models, Animal ; Microfilament Proteins/metabolism ; Microfilament Proteins/pharmacology ; Microfilament Proteins/therapeutic use ; Nerve Tissue Proteins ; Fragile X Mental Retardation Protein/genetics ; Fragile X Mental Retardation Protein/metabolism ; Fragile X Mental Retardation Protein/therapeutic use
    Chemical Substances Nuclear Proteins ; Transcription Factors ; Shank3 protein, mouse ; Microfilament Proteins ; Nerve Tissue Proteins ; Fmr1 protein, mouse ; Fragile X Mental Retardation Protein (139135-51-6)
    Language English
    Publishing date 2023-10-05
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1567202619999220209112609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: An epigenetic basis for an omnigenic model of psychiatric disorders.

    Peedicayil, Jacob / Grayson, Dennis R

    Journal of theoretical biology

    2018  Volume 443, Page(s) 52–55

    MeSH term(s) DNA Methylation ; Epigenesis, Genetic ; Humans ; Mental Disorders/genetics ; Mental Disorders/metabolism ; Models, Genetic ; Models, Neurological ; Mutation
    Language English
    Publishing date 2018-01-31
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2972-5
    ISSN 1095-8541 ; 0022-5193
    ISSN (online) 1095-8541
    ISSN 0022-5193
    DOI 10.1016/j.jtbi.2018.01.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 923: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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