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Article ; Online: Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and the possible negative influence of a peer presence.

Vignal, Lucie / Vielle, Cassandre / Williams, Maya / Maurice, Nicolas / Degoulet, Mickael / Baunez, Christelle

2024

Abstract: Rationale: The immediate social context significantly influences alcohol consumption in humans. Recent studies have revealed that peer presence could modulate drugs use in rats. The most efficient condition to reduce cocaine intake is the presence of a ... ...

Abstract	Rationale: The immediate social context significantly influences alcohol consumption in humans. Recent studies have revealed that peer presence could modulate drugs use in rats. The most efficient condition to reduce cocaine intake is the presence of a stranger peer, naive to drugs. Deep brain stimulation (DBS) of the Subthalamic Nucleus (STN), which was shown to have beneficial effects on addiction to cocaine or alcohol, also modulates the protective influence of peer's presence on cocaine use. Objectives: This study aimed to: 1) explore how the presence of an alcohol-naive stranger peer affects recreational and escalated alcohol intake, and 2) assess the involvement of STN on alcohol use and in the modulation induced by the presence of an alcohol-naïve stranger peer. Methods: Rats with STN DBS and control animals self-administered 10% (v/v) ethanol in presence, or absence, of an alcohol-naive stranger peer, before and after escalation of ethanol intake (observed after intermittent alcohol (20% (v/v) ethanol) access). Results: Neither STN DBS nor the presence of an alcohol-naive stranger peer modulated significantly recreational alcohol intake. After the escalation procedure, STN DBS reduced ethanol consumption. The presence of an alcohol-naive stranger peer increased consumption only in low drinkers, which effect was suppressed by STN DBS. Conclusions: These results highlight the influence of a peer's presence on escalated alcohol intake, and confirm the role of STN in addiction-like alcohol intake and in the social influence on drug consumption.
Language	English
Publishing date	2024-02-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-024-06532-w
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Article ; Online: Neurons in the Monkey's Subthalamic Nucleus Differentially Encode Motivation and Effort.

Nougaret, Simon / Baunez, Christelle / Ravel, Sabrina

The Journal of neuroscience : the official journal of the Society for Neuroscience

2022 Volume 42, Issue 12, Page(s) 2539–2551

Abstract: The understanding of the electrophysiological properties of the subthalamic nucleus (STN) neurons is crucial since it represents the main target of deep brain stimulation for the treatment of Parkinson's disease and obsessive-compulsive disorders. The ... ...

Abstract	The understanding of the electrophysiological properties of the subthalamic nucleus (STN) neurons is crucial since it represents the main target of deep brain stimulation for the treatment of Parkinson's disease and obsessive-compulsive disorders. The study of its nonmotor properties could shed light on the cognitive and motivational alterations possibly encountered after stimulation. In this study, we recorded the activity of STN neurons in two male behaving monkeys (
MeSH term(s)	Animals ; Macaca mulatta ; Male ; Motivation ; Neurons/physiology ; Reward ; Subthalamic Nucleus/physiology
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0281-21.2021
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Article ; Online: Correcting the reproduction number for time-varying tests: A proposal and an application to COVID-19 in France.

Baunez, Christelle / Degoulet, Mickaël / Luchini, Stéphane / Pintus, Matteo L / Pintus, Patrick A / Teschl, Miriam

PloS one

2023 Volume 18, Issue 2, Page(s) e0281943

Abstract: ... of tests, using the acceleration index (Baunez et al., 2021) as a simple measure of viral spread dynamics ...

Abstract	We provide a novel way to correct the effective reproduction number for the time-varying amount of tests, using the acceleration index (Baunez et al., 2021) as a simple measure of viral spread dynamics. Not correcting results in the reproduction number being a biased estimate of viral acceleration and we provide a formal decomposition of the resulting bias, involving the useful notions of test and infectivity intensities. When applied to French data for the COVID-19 pandemic (May 13, 2020-October 26, 2022), our decomposition shows that the reproduction number, when considered alone, characteristically underestimates the resurgence of the pandemic, compared to the acceleration index which accounts for the time-varying volume of tests. Because the acceleration index aggregates all relevant information and captures in real time the sizable time variation featured by viral circulation, it is a more parsimonious indicator to track the dynamics of an infectious disease outbreak in real time, compared to the equivalent alternative which would combine the reproduction number with the test and infectivity intensities.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Pandemics ; France/epidemiology ; Acceleration ; Reproduction
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281943
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Article ; Online: Evidence for a vocal signature in the rat and its reinforcing effects: a key role for the subthalamic nucleus.

Vielle, Cassandre / Montanari, Christian / Pelloux, Yann / Baunez, Christelle

Proceedings. Biological sciences

2021 Volume 288, Issue 1965, Page(s) 20212260

Abstract: Although rodents have a well-structured vocal form of communication, like humans and non-human primates, there is, to date, no evidence for a vocal signature in the well-known 50- and 22-kHz ultrasonic vocalizations (USVs) emitted by rats. Here, we show ... ...

Abstract	Although rodents have a well-structured vocal form of communication, like humans and non-human primates, there is, to date, no evidence for a vocal signature in the well-known 50- and 22-kHz ultrasonic vocalizations (USVs) emitted by rats. Here, we show that rats can recognize the identity of the USV emitter since they choose to preferentially self-administer playback of 50-kHz USVs emitted by a stranger rat over those of their cagemate. In a second experiment, we show that only stranger, but not familiar, 50-kHz USVs reduce cocaine self-administration. Finally, to study the neurobiological substrate of these processes, we have shown that subthalamic nucleus (STN)-lesioned rats did not lever press much for any USV playback, whatever their emotional valence, nor did they seem able to differentiate familiar from stranger peer. Advocating for the existence of a vocal signature in rats, these results highlight the importance of ultrasonic communication in the socio-affective influence of behaviour, such as the influence of proximal social factors on drug consumption and confirm the role of the STN on this influence.
MeSH term(s)	Animals ; Emotions ; Rats ; Subthalamic Nucleus ; Ultrasonics ; Vocalization, Animal
Language	English
Publishing date	2021-12-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2021.2260
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Article ; Online: Correcting the reproduction number for time-varying tests

Christelle Baunez / Mickaël Degoulet / Stéphane Luchini / Matteo L Pintus / Patrick A Pintus / Miriam Teschl

PLoS ONE, Vol 18, Iss 2, p e

A proposal and an application to COVID-19 in France.

2023 Volume 0281943

Abstract: ... of tests, using the acceleration index (Baunez et al., 2021) as a simple measure of viral spread dynamics ...

Abstract	We provide a novel way to correct the effective reproduction number for the time-varying amount of tests, using the acceleration index (Baunez et al., 2021) as a simple measure of viral spread dynamics. Not correcting results in the reproduction number being a biased estimate of viral acceleration and we provide a formal decomposition of the resulting bias, involving the useful notions of test and infectivity intensities. When applied to French data for the COVID-19 pandemic (May 13, 2020-October 26, 2022), our decomposition shows that the reproduction number, when considered alone, characteristically underestimates the resurgence of the pandemic, compared to the acceleration index which accounts for the time-varying volume of tests. Because the acceleration index aggregates all relevant information and captures in real time the sizable time variation featured by viral circulation, it is a more parsimonious indicator to track the dynamics of an infectious disease outbreak in real time, compared to the equivalent alternative which would combine the reproduction number with the test and infectivity intensities.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A few examples of the contribution of animal research in rodents for clinical application of deep brain stimulation.

Baunez, Christelle

Progress in brain research

2011 Volume 194, Page(s) 105–116

Abstract: In the late 1980s, deep brain stimulation has regained interest for the treatment of neurological disorders. The first spectacular application has been developed for the treatment of Parkinson's disease. This development has been the result of ... ...

Abstract	In the late 1980s, deep brain stimulation has regained interest for the treatment of neurological disorders. The first spectacular application has been developed for the treatment of Parkinson's disease. This development has been the result of interactions between clinical observations and studies carried out in animal models. Further investigations in animal models have lead to consider not only possible side effects of DBS on nonmotor functions in parkinsonian patients but also DBS as a possible strategy for other diseases, including psychiatric disorders such as obsessive compulsive disorder or addiction.
MeSH term(s)	Animal Experimentation ; Animals ; Behavior, Animal/physiology ; Deep Brain Stimulation/methods ; Humans ; Mental Disorders/pathology ; Mental Disorders/physiopathology ; Mental Disorders/therapy ; Models, Animal ; Nervous System Diseases/pathology ; Nervous System Diseases/physiopathology ; Nervous System Diseases/therapy ; Reaction Time ; Rodentia ; Subthalamic Nucleus/pathology ; Subthalamic Nucleus/physiology ; Subthalamic Nucleus/physiopathology
Language	English
Publishing date	2011
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1875-7855 ; 0079-6123
ISSN (online)	1875-7855
ISSN	0079-6123
DOI	10.1016/B978-0-444-53815-4.00013-3
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Article ; Online: Targeting the subthalamic nucleus in a preclinical model of alcohol use disorder.

Pelloux, Yann / Baunez, Christelle

Psychopharmacology

2017 Volume 234, Issue 14, Page(s) 2127–2137

Abstract: Background: The subthalamic nucleus (STN) has only recently been considered to have a role in reward processing. In rats, inactivation of the STN by lesion or high-frequency stimulation (HFS) decreases motivation for cocaine but increases motivation for ...

Abstract	Background: The subthalamic nucleus (STN) has only recently been considered to have a role in reward processing. In rats, inactivation of the STN by lesion or high-frequency stimulation (HFS) decreases motivation for cocaine but increases motivation for sucrose. For ethanol, the effect of STN lesion depends on the individual's baseline intake; decreasing motivation for ethanol in rats with lower ethanol intake, while increasing motivation for ethanol in rats with higher-but still limited-ethanol intake. However, the involvement of the STN in behaviour more closely resembling some aspects of alcohol use disorder has not been assessed. This study aimed to determine the effect of STN lesions on the escalation of ethanol intake, subsequent increases in the motivation to "work" for ethanol and the choice of ethanol over a non-drug alternative. Results: We found that STN lesion prevented increases in ethanol intake observed during intermittent ethanol access and after a long period of ethanol privation. STN lesion also decreased the motivation to work for ethanol after escalated intake. Surprisingly, STN lesion increased the choice of alcohol over saccharin. This was associated with a blunting of the hedonic responses to the taste of the reinforcement alternatives. Conclusion: These results evidence the involvement of the STN in different ethanol-motivated behaviours and therefore position the STN as an interesting target for the treatment of alcohol use disorders.
Language	English
Publishing date	2017-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-017-4618-5
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Article ; Online: Correction to: Peer presence and familiarity as key factors to reduce cocaine intake in both rats and humans: an effect mediated by the subthalamic nucleus.

Giorla, Elodie / Nordmann, Sandra / Vielle, Cassandre / Pelloux, Yann / Roux, Perrine / Protopopescu, Camelia / Manrique, Christine / Davranche, Karen / Montanari, Christian / Giorgi, Lisa / Vilotitch, Antoine / Huguet, Pascal / Carrieri, Patrizia / Baunez, Christelle

Psychopharmacology

2023 Volume 240, Issue 6, Page(s) 1389

Language	English
Publishing date	2023-04-07
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-023-06364-0
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Article ; Online: Social modulation of drug use and drug addiction.

Pelloux, Yann / Giorla, Elodie / Montanari, Christian / Baunez, Christelle

Neuropharmacology

2019 Volume 159, Page(s) 107545

Abstract: This review aims to demonstrate how social science and behavioral neurosciences have highlighted the influence of social interactions on drug use in animal models. In neurosciences, the effect of global social context that are distal from drug use has ... ...

Abstract	This review aims to demonstrate how social science and behavioral neurosciences have highlighted the influence of social interactions on drug use in animal models. In neurosciences, the effect of global social context that are distal from drug use has been widely studied. For human and other social animals such as monkeys and rodents, positive social interactions are rewarding, can overcome drug reward and, in all, protect from drug use. In contrast, as other types of stress, negative social experiences facilitate the development and maintenance of drug abuse. However, interest recently emerged in the effect of so-called "proximal" social factors, that is, social interactions during drug-taking. These recent studies have characterized the role of the drug considered, the sharing of drug experience and the familiarity of the peer which interaction are made with. We also examine the few studies regarding the sensorial mediator of social behaviors and critically review the neural mediation of social factors on drug use. However, despite considerable characterization of the factors modulating distal influences, the mechanisms for proximal influences on drug use remain largely unknown. This article is part of the Special Issue entitled 'The neuropharmacology of social behavior: from bench to bedside'.
MeSH term(s)	Analgesics, Opioid/administration & dosage ; Animals ; Cocaine/administration & dosage ; Conditioning, Operant/drug effects ; Conditioning, Operant/physiology ; Disease Models, Animal ; Drug-Seeking Behavior/drug effects ; Drug-Seeking Behavior/physiology ; Drug-Seeking Behavior/trends ; Humans ; Self Administration ; Social Behavior ; Substance-Related Disorders/physiopathology ; Substance-Related Disorders/psychology
Chemical Substances	Analgesics, Opioid ; Cocaine (I5Y540LHVR)
Language	English
Publishing date	2019-02-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2019.02.027
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Article ; Online: Tracking the dynamics and allocating tests for COVID-19 in real-time: An acceleration index with an application to French age groups and départements.

Baunez, Christelle / Degoulet, Mickael / Luchini, Stéphane / Pintus, Patrick A / Teschl, Miriam

PloS one

2021 Volume 16, Issue 6, Page(s) e0252443

Abstract: An acceleration index is proposed as a novel indicator to track the dynamics of COVID-19 in real-time. Using data on cases and tests in France for the period between the first and second lock-downs-May 13 to October 25, 2020-our acceleration index shows ... ...

Abstract	An acceleration index is proposed as a novel indicator to track the dynamics of COVID-19 in real-time. Using data on cases and tests in France for the period between the first and second lock-downs-May 13 to October 25, 2020-our acceleration index shows that the pandemic resurgence can be dated to begin around July 7. It uncovers that the pandemic acceleration was stronger than national average for the [59-68] and especially the 69 and older age groups since early September, the latter being associated with the strongest acceleration index, as of October 25. In contrast, acceleration among the [19-28] age group was the lowest and is about half that of the [69-78]. In addition, we propose an algorithm to allocate tests among French "départements" (roughly counties), based on both the acceleration index and the feedback effect of testing. Our acceleration-based allocation differs from the actual distribution over French territories, which is population-based. We argue that both our acceleration index and our allocation algorithm are useful tools to guide public health policies as France might possibly enter a third lock-down period with indeterminate duration.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/transmission ; COVID-19 Testing/methods ; Child ; Child, Preschool ; Female ; France/epidemiology ; Health Policy/legislation & jurisprudence ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Models, Statistical ; Pandemics ; Physical Distancing ; SARS-CoV-2/pathogenicity
Language	English
Publishing date	2021-06-01
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0252443
Database	MEDical Literature Analysis and Retrieval System OnLINE

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