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Article ; Online: Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents.

Khalil, Ahmed F / El-Moselhy, Tarek F / El-Bastawissy, Eman A / Abdelhady, Rasha / Younis, Nancy S / El-Hamamsy, Mervat H

Journal of enzyme inhibition and medicinal chemistry

2023 Volume 38, Issue 1, Page(s) 2157411

Abstract: Mutant isocitrate dehydrogenase (IDH) 2 "IDH2m" acquires a neo-enzymatic activity reducing α-ketoglutarate to an oncometabolite, D-2-hydroxyglutarate (2-HG). ... ...

Abstract	Mutant isocitrate dehydrogenase (IDH) 2 "IDH2m" acquires a neo-enzymatic activity reducing α-ketoglutarate to an oncometabolite, D-2-hydroxyglutarate (2-HG). Three
MeSH term(s)	Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Mutation ; Antineoplastic Agents/pharmacology ; Triazines/pharmacology ; Triazines/chemistry
Chemical Substances	enasidenib (3T1SS4E7AG) ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; Enzyme Inhibitors ; Antineoplastic Agents ; Triazines
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2082578-X
ISSN	1475-6374 ; 1475-6366
ISSN (online)	1475-6374
ISSN	1475-6366
DOI	10.1080/14756366.2022.2157411
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Article ; Online: Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX.

Zain-Alabdeen, Abdelrahman I / El-Moselhy, Tarek F / Sharafeldin, Nabaweya / Angeli, Andrea / Supuran, Claudiu T / El-Hamamsy, Mervat H

Scientific reports

2022 Volume 12, Issue 1, Page(s) 16756

Abstract: Limited presence of hCA IX in normal physiological tissues and their overexpression only in solid hypoxic tumors made this isoform excellent possible target for developing new anticancer agents. We reported designing and synthesis of two novel series of ... ...

Abstract	Limited presence of hCA IX in normal physiological tissues and their overexpression only in solid hypoxic tumors made this isoform excellent possible target for developing new anticancer agents. We reported designing and synthesis of two novel series of benzenesulfonamides derivatives as hCA IX inhibitors bearing rigid cyclic linkers (1,3,5-dihydrotriazine in series A and 1,3,5-triazine in series B) in replace of traditional linear linkers. Also, novel cyanoethenyl spacer was assembled next to the 1,3,5-triazine linker in series B. Target compounds of series (A) and (B) were screened against four hCA isoforms. Human CA IX efficiently inhibited in series (A) by compound 5a (K
MeSH term(s)	Antigens, Neoplasm/metabolism ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/drug therapy ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/pharmacology ; Caspases/metabolism ; Female ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Sulfonamides ; Triazines/pharmacology ; Benzenesulfonamides
Chemical Substances	Antigens, Neoplasm ; Antineoplastic Agents ; Carbonic Anhydrase Inhibitors ; Sulfonamides ; Triazines ; Caspases (EC 3.4.22.-) ; Carbonic Anhydrase IX (EC 4.2.1.1)
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-21024-7
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Article ; Online: Corrigendum to "Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors" [Bioorg. Med. Chem. 27 (2019) 115126].

Tawfik, Haytham O / El-Moselhy, Tarek F / El-Din, Nabaweya S / El-Hamamsy, Mervat H

Bioorganic & medicinal chemistry

2020 Volume 28, Issue 19, Page(s) 115687

Language	English
Publishing date	2020-08-18
Publishing country	England
Document type	Published Erratum
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2020.115687
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Article ; Online: Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFR

Abo Al-Hamd, Mahmoud G / Tawfik, Haytham O / Abdullah, Omeima / Yamaguchi, Koki / Sugiura, Masaharu / Mehany, Ahmed B M / El-Hamamsy, Mervat H / El-Moselhy, Tarek F

Journal of enzyme inhibition and medicinal chemistry

2023 Volume 38, Issue 1, Page(s) 2241674

Abstract: Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showed ... ...

Abstract	Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showed moderate to good activity against NCI 60 cancer cell lines, with GI % mean up to 74% for
MeSH term(s)	Humans ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; ErbB Receptors/metabolism ; Erlotinib Hydrochloride/pharmacology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Molecular Docking Simulation ; Mutation ; Protein Kinase Inhibitors/chemistry ; Quinolines/chemistry
Chemical Substances	Antineoplastic Agents ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Erlotinib Hydrochloride (DA87705X9K) ; Protein Kinase Inhibitors ; Quinolines
Language	English
Publishing date	2023-08-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2082578-X
ISSN	1475-6374 ; 1475-6366
ISSN (online)	1475-6374
ISSN	1475-6366
DOI	10.1080/14756366.2023.2241674
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Article ; Online: Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors.

El-Hamamsy, Mervat H / Sharafeldin, Nabaweya A / El-Moselhy, Tarek F / Tawfik, Haytham O

Archiv der Pharmazie

2020 Volume 353, Issue 8, Page(s) e2000060

Abstract: Lung, colorectal, and breast cancers are the top three types of cancer by incidence and are responsible for one-third of the cancer incidence and mortality. A series of 18 3,4-dihydropyrimidine analogues bearing a 1,2-methylenedioxybenzene component at ... ...

Abstract	Lung, colorectal, and breast cancers are the top three types of cancer by incidence and are responsible for one-third of the cancer incidence and mortality. A series of 18 3,4-dihydropyrimidine analogues bearing a 1,2-methylenedioxybenzene component at position 4 with diverse side chains at positions 5 and 6 was designed and synthesized as inhibitors of the Eg5 kinesin enzyme. Target compounds were screened for their anticancer activity according to the NCI-USA protocol toward a panel of 60 cancer cell lines. Compounds 12a and 12b displayed the best antiproliferation activity against many cell lines. Interestingly, compound 12a displayed lethal effects against non-small-cell lung cancer NCI-H522 cells (-42.26%) and MDA-MB-468 breast cancer cells (-1.10%) at a single-dose assay concentration of 10
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Kinesin/antagonists & inhibitors ; Kinesin/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Structure-Activity Relationship ; Thiones/chemical synthesis ; Thiones/chemistry ; Thiones/pharmacology
Chemical Substances	Antineoplastic Agents ; Enzyme Inhibitors ; KIF11 protein, human ; Pyrimidines ; Thiones ; monastrol (6BSM97YZ8G) ; Kinesin (EC 3.6.4.4)
Language	English
Publishing date	2020-05-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202000060
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Article ; Online: Corrigendum to "Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors" [Bioorg. Med. Chem. 27 (2019) 115126].

Tawfik, Haytham O / El-Moselhy, Tarek F / El-Din, Nabaweya S / El-Hamamsy, Mervat H

Bioorganic & medicinal chemistry

2019 Volume 28, Issue 2, Page(s) 115255

Language	English
Publishing date	2019-12-17
Publishing country	England
Document type	Published Erratum
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2019.115255
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Article ; Online: Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis,

Saad, Mohamed H / El-Moselhy, Tarek F / S El-Din, Nabaweya / Mehany, Ahmed B M / Belal, Amany / Abourehab, Mohammed A S / Tawfik, Haytham O / El-Hamamsy, Mervat H

Journal of enzyme inhibition and medicinal chemistry

2022 Volume 37, Issue 1, Page(s) 2489–2511

Abstract: Two new series of symmetric ( ...

Abstract	Two new series of symmetric (
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B/metabolism ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Dihydropyridines ; Humans ; Molecular Docking Simulation ; Nitriles ; Structure-Activity Relationship
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B ; Antineoplastic Agents ; Dihydropyridines ; Nitriles ; 1,4-dihydropyridine (7M8K3P6I89)
Language	English
Publishing date	2022-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2082578-X
ISSN	1475-6374 ; 1475-6366
ISSN (online)	1475-6374
ISSN	1475-6366
DOI	10.1080/14756366.2022.2120478
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Article ; Online: Corrigendum to "Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats" [Life Sci. 313 (2022) 121285].

Ahmed, Al-Shaimaa F / Sharkawi, Sara S / AbdelHameed, Sara S / Bayoumi, Asmaa M / Moussa, Rabab S / Alhakamy, Nabil A / Al Sadoun, Hadeel / Mansouri, Rasha A / El-Moselhy, Mohamed A / El-Daly, Mahmoud / Anter, Aliaa F

Life sciences

2023 Volume 326, Page(s) 121829

Language	English
Publishing date	2023-06-02
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2023.121829
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Article ; Online: Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.

Tawfik, Haytham O / El-Moselhy, Tarek F / El-Din, Nabaweya S / El-Hamamsy, Mervat H

Bioorganic & medicinal chemistry

2019 Volume 27, Issue 23, Page(s) 115126

Abstract: A series of twenty-one 3,4-dihydropyrimidine derivatives bearing the heterocyclic 1,3-benzodioxole at position 4 in addition to different substituents at positions 2, 3 and 5 were designed and synthesized as monastrol analogs. The novel synthesized ... ...

Abstract	A series of twenty-one 3,4-dihydropyrimidine derivatives bearing the heterocyclic 1,3-benzodioxole at position 4 in addition to different substituents at positions 2, 3 and 5 were designed and synthesized as monastrol analogs. The novel synthesized compounds were screened for their cytotoxic activity towards 60 cancer cell lines according to NCI (USA) protocol. Compounds 10b and 15 showed the best antitumor activity against most cell lines. Compound 15 was subsequently tested in 5-doses mode and displayed high selectivity towards CNS, prostate and leukemia subpanel with selectivity ratios of 22.30, 15.38 and 12.56, respectively at GI
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Drug Design ; Drug Screening Assays, Antitumor ; HEK293 Cells ; Humans ; Kinesin/antagonists & inhibitors ; Kinesin/metabolism ; Molecular Docking Simulation ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Pyrimidines/chemistry ; Pyrimidines/pharmacology
Chemical Substances	1,4-dihydropyrimidine ; Antineoplastic Agents ; KIF11 protein, human ; Pyrimidines ; Kinesin (EC 3.6.4.4)
Language	English
Publishing date	2019-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2019.115126
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Article ; Online: Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats.

Life sciences

2022 Volume 313, Page(s) 121285

Abstract: Objective: Polycystic ovaries (PCO) is a hormonal disorder that is a leading cause of infertility. The formation of multiple persistent cysts and hormonal imbalance are hallmarks of PCO. Recent clinical studies reported a beneficial effect of the ... ...

Abstract	Objective: Polycystic ovaries (PCO) is a hormonal disorder that is a leading cause of infertility. The formation of multiple persistent cysts and hormonal imbalance are hallmarks of PCO. Recent clinical studies reported a beneficial effect of the ketogenic diet (KD; high-fat, low-carbohydrate) on PCO. The aim of this study was to investigate the effect of the KD alone and in combination with metformin on letrozole-induced PCO in female rats. Methods: Female rats were grouped into control and PCO (letrozole; 1 mg/kg for 21 days). The PCO group was subdivided into PCO (non-treated), PCO-metformin (300 mg/kg), PCO rats fed with KD only, and PCO rats treated with metformin and fed with KD. All groups continued to receive letrozole during the 21-day treatment period. At the end of the experiment, serum and ovaries were collected for further analysis. Results: The untreated-PCO rats showed increased testosterone, LH/FSH ratio, and ovary weights. Disturbed apoptosis and proliferation balance were evident as a low caspase-3 activation and proliferating cell nuclear antigen expression and increased TGF-β expression. The KD improved the letrozole-induced effects, which was comparable to the effect of metformin. Combining the KD with metformin treatment additively enhanced the metformin effect. Conclusion: Our results indicate that the KD has a protective role against PCO in rats, especially when combined with metformin. This study reveals a potential therapeutic role of the KD in PCO, which could prompt valuable future clinical applications.
MeSH term(s)	Humans ; Rats ; Female ; Animals ; Letrozole/adverse effects ; Metformin/pharmacology ; Metformin/therapeutic use ; Diet, Ketogenic ; Polycystic Ovary Syndrome/chemically induced ; Polycystic Ovary Syndrome/drug therapy
Chemical Substances	Letrozole (7LKK855W8I) ; Metformin (9100L32L2N)
Language	English
Publishing date	2022-12-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2022.121285
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