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Article ; Online: Glucose-Responsive Chitosan Nanoparticle/Poly(vinyl alcohol) Hydrogels for Sustained Insulin Release

Ali, Akbar / Saroj, Saroj / Saha, Sunita / Gupta, Sanjay Kumar / Rakshit, Tatini / Pal, Suchetan

ACS applied materials & interfaces

2023 Volume 15, Issue 27, Page(s) 32240–32250

Abstract: Stimuli-responsive hydrogels (HGs) with a controlled drug release profile are the current challenge for advanced therapeutic applications. Specifically, antidiabetic drug-loaded glucose-responsive HGs are being investigated for closed-loop insulin ... ...

Abstract	Stimuli-responsive hydrogels (HGs) with a controlled drug release profile are the current challenge for advanced therapeutic applications. Specifically, antidiabetic drug-loaded glucose-responsive HGs are being investigated for closed-loop insulin delivery in insulin-dependent diabetes patients. In this direction, new design principles must be exploited to create inexpensive, naturally occurring, biocompatible glucose-responsive HG materials for the future. In this work, we developed chitosan nanoparticle/poly(vinyl alcohol) (PVA) hybrid HGs (CPHGs) for controlled insulin delivery for diabetes management. In this design, PVA and chitosan nanoparticles (CNPs) are cross-linked with a glucose-responsive formylphenylboronic acid (FPBA)-based cross-linker
MeSH term(s)	Rats ; Animals ; Polyvinyl Alcohol/chemistry ; Insulin ; Chitosan/chemistry ; Glucose ; Blood Glucose ; Diabetes Mellitus, Type 1 ; Insulin Infusion Systems ; Hydrogels/chemistry ; Nanoparticles ; Biocompatible Materials ; Hydrogen-Ion Concentration
Chemical Substances	polyvinyl alcohol hydrogel ; Polyvinyl Alcohol (9002-89-5) ; Insulin ; Chitosan (9012-76-4) ; Glucose (IY9XDZ35W2) ; Blood Glucose ; Hydrogels ; Biocompatible Materials
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c05031
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Article: Existence and pattern of sleep-related breathing disorders in patients diagnosed with bronchial asthma.

Meena, Saroj Kumari / Gupta, Rajnish / Puri, Manmohan

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2024

Abstract: Asthma and obstructive sleep apnea (OSA) are commonly prevalent diseases, and both can co-exist to result in an alternate overlap syndrome, where a bidirectional relationship can adversely affect each other. This study aimed to determine the existence ... ...

Abstract	Asthma and obstructive sleep apnea (OSA) are commonly prevalent diseases, and both can co-exist to result in an alternate overlap syndrome, where a bidirectional relationship can adversely affect each other. This study aimed to determine the existence and pattern of sleep-related breathing disorders in subjects with bronchial asthma. It was prospectively conducted at the National Institute of Tuberculosis and Respiratory Diseases, New Delhi, in diagnosed cases of bronchial asthma. A subjective assessment of sleepiness was done using the Epworth sleepiness scale (ESS). All subjects underwent overnight polysomnography (PSG) in the Sleep Laboratory of the Institute. A total of 70 subjects were screened, and among them, finally, 30 were enrolled. The mean age of the subjects was 37.53±11.21 years, the mean body mass index (BMI) was 26.4±5.58 kg/m2, the mean ESS score was 3.1, and 80% of the subjects were male. After PSG, OSA (apnea hypopnea index >5/hour) was found in 63% (19/30) of the patients, of whom 43% had mild OSA, 10% had moderate OSA, and 10% had severe OSA. 10% (3/30) had nocturnal oxygen desaturation, while none had sleep hypoventilation. Patients with OSA compared to those without OSA had a higher BMI, more co-morbid allergic rhinitis, severe bronchial asthma, and a worse percentage of predicted forced expiratory volume in the first second. The study showed high detection rates of OSA in bronchial asthma patients. Hence, asthma patients should be evaluated for OSA.
Language	English
Publishing date	2024-04-23
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2024.2855
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Article ; Online: Post-farmgate food businesses of India

Gupta, Manavi / Kishore, Avinash / Roy, Devesh / Saroj, Sunil

Global Food Security 36(March 2023): 100665

The enterprises, the entrepreneurs, and the employees

2023

Abstract: PR ... IFPRI3; CRP4; 3 Building Inclusive and Efficient Markets, Trade Systems, and Food Industry; ISI ... Development Strategies and Governance (DSG); Transformation Strategies; SAR; A4NH ...

Abstract	PR IFPRI3; CRP4; 3 Building Inclusive and Efficient Markets, Trade Systems, and Food Industry; ISI Development Strategies and Governance (DSG); Transformation Strategies; SAR; A4NH CGIAR Research Program on Agriculture for Nutrition and Health (A4NH)
Keywords	INDIA ; SOUTH ASIA ; ASIA ; agrifood sector ; enterprises ; entrepreneurs ; farmgate ; employees
Language	English
Publisher	Elsevier
Publishing country	us
Document type	Article ; Online
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Article ; Online: Design and Fabrication of Broad-Spectrum Antimicrobial Porous Metallo-Polymeric Microsphere for Water Disinfection.

Gupta, Anil R / Rank, Monika / Singh, Aneesha / Sharma, Saroj

Macromolecular bioscience

2024 , Page(s) e2400004

Abstract: An expedient and efficient approach is used to synthesize a new class of metallo-polymeric microspheres (MPMs) as antimicrobials to succumb the wide range of bacteria from water. Three types of MPMs, that is, poly[Silver (I)-methacrylate-co- ... ...

Abstract	An expedient and efficient approach is used to synthesize a new class of metallo-polymeric microspheres (MPMs) as antimicrobials to succumb the wide range of bacteria from water. Three types of MPMs, that is, poly[Silver (I)-methacrylate-co-methylmethacrylate] (pAgMA), poly[Copper (II)-methacrylate-co-methyl methacrylate] (pCuMA), and poly[Nickel (II)-methacrylate-co-methylmethacrylate] (pNiMA), are prepared via radical suspension polymerization technique in 3D shape with porous texture. The structural and morphological characterization of the prepared microspheres are examined by analytical techniques. The antimicrobial potentialities of prepared MPMs are investigated at the laboratory scale study, revealing that the MPMs exhibit strong antibacterial activity (≈99.9% killing) against Gram-negative and Gram-positive bacteria [Enterobacter hormaechei (EH), Bacillus megatarium (BM), and Bacillus bataviensis (BB)]. The MacConkey agar medium test reveals that MPMs have substantial biocidal efficacy against broad-spectrum Gram-negative bacteria present in tap water. The MPMs exhibit significant antimicrobial efficacy via contact killing owe to the presence of integrated biocidal metal moiety, which represents that the MPMs are safe for water disinfection.
Language	English
Publishing date	2024-03-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2039130-4
ISSN	1616-5195 ; 1616-5187
ISSN (online)	1616-5195
ISSN	1616-5187
DOI	10.1002/mabi.202400004
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Article: Anterior Chamber Biometric Parameters Associated With Intraocular Pressure Reduction After Phacoemulsification in Non-Glaucomatous Eyes With Open Angles.

Sarkar, Deepayan / Anshukita, Anshukita / Karkhur, Samendra / Sharma, Bhavana / Gupta, Saroj

Cureus

2024 Volume 16, Issue 1, Page(s) e51500

Abstract: Background: Decreased intra-ocular pressure after cataract surgery has been reported in eyes with and without glaucoma with variable magnitude. It is influenced by the anatomical structure of the anterior chamber. Preoperative evaluation of anterior ... ...

Abstract	Background: Decreased intra-ocular pressure after cataract surgery has been reported in eyes with and without glaucoma with variable magnitude. It is influenced by the anatomical structure of the anterior chamber. Preoperative evaluation of anterior chamber parameters can help to predict the change in intra-ocular pressure postoperatively. Objective: The objective of the study is to evaluate intraocular pressure (IOP) change after uneventful phacoemulsification in non-glaucomatous eyes with open angles and its correlation with preoperative anterior chamber parameters measured by anterior segment optical coherence tomography (AS-OCT). Methods: In this hospital-based prospective observational study, we included consecutive patients without glaucoma and open angles on gonioscopy who had undergone uncomplicated phacoemulsification with intraocular lens implantation (IOL). IOP and anterior chamber biometric parameters were measured preoperatively and compared with parameters obtained three months post-operatively by AS-OCT. The change in IOP and its relation to the parameters, including anterior chamber angle (ACA), anterior chamber depth (ACD), angle opening distance 500 μm anterior to the scleral spur (AOD500), anterior chamber width (ACW), lens vault (LV), and trabecular iris space area (TISA500) were evaluated. The main outcome measure was a change in IOP after phacoemulsification in normal eyes. Results: Sixty-four eyes of 64 patients were enrolled. The mean patient age was 58.5 ± 9.4 years. The average IOP reduction was 2.43±1.64 mm of Hg from a preoperative mean of 16.77±2.54 mmHg three months after phacoemulsification surgery. The mean AOD500 increased significantly (0.440 ± 0.07 to 0.522 ±0.092) from preoperatively to three months postoperatively (p < 0.001). Preoperative lens vault and preoperative IOP had a strong positive correlation with the change in IOP at three months (r-value = 0.606; p-value <0.001) and (r-value = 0.73; p-value <0.001). There was a significant negative correlation between pre-operative TISA and AOD with change in IOP at three months (r-value = -0.545; p-value <0.001) and (r-value = -0.69; p-value <0.01). Conclusion: Phacoemulsification surgery results in IOP reduction in non-glaucomatous eyes. Pre-operative IOP, lens vault, AOD, and TISA were significant predictors for IOP reduction.
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.51500
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Article ; Online: Conjunctival "Melanoma-

Choudhary, Sanjiv / Srivastava, Ankita / Gupta, Saroj / Joshi, Deepti

Skinmed

2023 Volume 21, Issue 2, Page(s) 114–115

Abstract: A 16-year-old girl born from a nonconsanguineous marriage presented to the dermatology out-patient department with innumerable hyperpigmented macules predominantly over the photoexposed parts of her body involving the face, neck, chest, back, of forearms, ...

Abstract	A 16-year-old girl born from a nonconsanguineous marriage presented to the dermatology out-patient department with innumerable hyperpigmented macules predominantly over the photoexposed parts of her body involving the face, neck, chest, back, of forearms, hands, and legs with a history of photosensitivity and photophobia (Figure 1). These were interspersed with multiple depigmented macules over her arms and legs since, she was three years old. She also had a small pigmented mass involving the left eye present for the last 3 months. She had a family history of similar cutaneous lesions in her elder sister. There was no history of hearing loss, seizures, spasticity, or cognitive impairment.
MeSH term(s)	Female ; Humans ; Aged ; Adolescent ; Child, Preschool ; Xeroderma Pigmentosum/complications ; Xeroderma Pigmentosum/diagnosis ; Xeroderma Pigmentosum/pathology ; Nevus, Pigmented ; Skin Neoplasms/diagnosis ; Melanoma/pathology
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2171125-2
ISSN	1751-7125 ; 1540-9740
ISSN (online)	1751-7125
ISSN	1540-9740
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Article ; Online: Genome based safety assessment for Bacillus coagulans strain LBSC (DSM 17654) for probiotic application.

Saroj, Dina B / Gupta, Anil K

International journal of food microbiology

2020 Volume 318, Page(s) 108523

Abstract: The present study on Bacillus coagulans strain LBSC (DSM 17654) describes the use of whole genome sequencing, in correlation with the phenotypic properties to assess the safety of the strain. Analysis of the 16S rRNA sequence of the B. coagulans strain ... ...

Abstract	The present study on Bacillus coagulans strain LBSC (DSM 17654) describes the use of whole genome sequencing, in correlation with the phenotypic properties to assess the safety of the strain. Analysis of the 16S rRNA sequence of the B. coagulans strain LBSC (DSM 17654), showed 100% homology with 99% coverage with B. coagulans strain HM-08. BLAT (BLAST Like Analysis Tool) analysis for whole genome comparison with B. coagulans ATCC 7050, B. coagulans HM-08 and B. coagulans Slac showed 96%, 99% and 99% sequence identity respectively. Whole genome sequencing results demonstrated a single scaffold of 36,35,902 bp and 3331 coding sequences. Gene ontology segregated the proteins as those with molecular function, cellular component and biological process of the predicted genes from assembled genome. Risk associated sequences like antibiotic resistance genes, biogenic amine producing genes, virulence factor genes and other safety related genes were identified with focus on horizontal gene transfer and its non-functionality. The absence of mobile elements in the vicinity of the genes, render it non-transferable and non-toxic phenotypic properties confirm the non-functionality of the genes. Absence of functional genes of concern and confirmation of absence of mobile elements in the vicinity of other non-clinically significant genes indicated no safety concern. The absence of complete and functional prophage sequences which are deleterious for the genome stability and presence of CRISPR system which are advantageous for genome stability by acting as a barrier to entry of foreign DNA elements indicated the stability of the genome. The molecular approach used in this study satisfies the requirements for the safety assessment of the probiotic strain which could indicate it to be potentially safe.
MeSH term(s)	Bacillus coagulans/genetics ; Bacterial Proteins/genetics ; Base Sequence ; Consumer Product Safety ; DNA, Bacterial/genetics ; Genome, Bacterial/genetics ; Genomic Instability ; Probiotics ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA
Chemical Substances	Bacterial Proteins ; DNA, Bacterial ; RNA, Ribosomal, 16S
Language	English
Publishing date	2020-01-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2020.108523
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Article ; Online: Comment on: Correlation between choroidal thickness and intraocular pressure control in primary angle-closure glaucoma.

Anshukita / Khurum, Fazil / Karkhur, Samendra / Gupta, Saroj

Indian journal of ophthalmology

2022 Volume 70, Issue 8, Page(s) 3160–3161

MeSH term(s)	Choroid ; Glaucoma, Angle-Closure/diagnosis ; Humans ; Intraocular Pressure ; Tomography, Optical Coherence ; Tonometry, Ocular
Language	English
Publishing date	2022-07-30
Publishing country	India
Document type	Letter ; Comment
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_839_22
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Article ; Online: Post-farmgate food businesses of India

Gupta, Manavi / Kishore, Avinash / Roy, Devesh / Saroj, Sunil

Global Food Security

The enterprises, the entrepreneurs, and the employees

2023

Abstract: In 2015–16, 21 million small and medium enterprises engaged in the business of manufacturing, trading, retailing, and serving food linked India's 146 million farmers to its nearly 1.3 billion consumers. These food enterprises employed 25 million men and ... ...

Abstract	In 2015–16, 21 million small and medium enterprises engaged in the business of manufacturing, trading, retailing, and serving food linked India's 146 million farmers to its nearly 1.3 billion consumers. These food enterprises employed 25 million men and 10 million women and had an annual turnover of $ 227 billion. Between 2010–11 and 2015–16, the gross value added (GVA) by the post-farmgate food businesses (PFFBs) increased by $16.3 billion (from $ 22.9 billion to $ 39.2 billion) which is comparable to the growth of $19.5 billion in the GVA by the primary food production (or the farm) sector which is nearly 10 times larger in size. Despite their growing contribution to the overall food economy, PFFBs are ignored in research and policy discussions on food systems. This paper tries to fill this gap by using two large nationally representative datasets from India—the Enterprise Survey and the Periodic Labor Force Survey (PLFS)—to assess the key characteristics of PFFBs and the entrepreneurs and employees who work in them. We show that despite rapid economic growth in the country, micro-enterprises with less than 5 employees continue to dominate India's food economy. Most of these firms are informal, rely purely on spot exchanges with their sellers and buyers, and do not borrow money from formal financial institutions. We find a strong positive association between the formal status and the productivity and profitability of PFFBs.
Keywords	food systems ; enterprises ; entrepreneurs
Language	English
Publishing date	2023-04-27T22:40:09Z
Publisher	Elsevier
Publishing country	fr
Document type	Article ; Online
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Article ; Online: Can Duvelisib and Eganelisib work for both cancer and COVID-19? Molecular-level insights from MD simulations and enhanced samplings.

Panda, Saroj Kumar / Karmakar, Shaswata / Sen Gupta, Parth Sarthi / Rana, Malay Kumar

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 14, Page(s) 10961–10973

Abstract: SARS-CoV-2 has caused severe illness and anxiety worldwide, evolving into more dreadful variants capable of evading the host's immunity. Cytokine storms, led by PI3Kγ, are common in cancer and SARS-CoV-2. Naturally, there is a yearning to see whether any ...

Abstract	SARS-CoV-2 has caused severe illness and anxiety worldwide, evolving into more dreadful variants capable of evading the host's immunity. Cytokine storms, led by PI3Kγ, are common in cancer and SARS-CoV-2. Naturally, there is a yearning to see whether any drugs could alleviate cytokine storms for both. Upon investigation, we identified two anticancer drugs, Duvelisib and Eganelisib, that could also work against SARS-CoV-2. This report is the first to decipher their synergic therapeutic effectiveness against COVID-19 and cancer with molecular insights from atomistic simulations. In addition to PI3Kγ, these drugs exhibit specificity for the main protease among all SARS-CoV-2 targets, with significant negative binding free energies and small time-dependent conformational changes of the complexes. Complexation makes active sites and secondary structures highly mechanically stiff, with barely any deformation. Replica simulations estimated large pulling forces in enhanced sampling to dissociate the drugs from Mpro's active site. Furthermore, the radial distribution function (RDF) demonstrated that the therapeutic molecules were closest to the His41 and Cys145 catalytic dyad residues. Finally, analyses implied Duvelisib and Eganelisib as promising dual-purposed anti-COVID and anticancer drugs, potentially targeting Mpro and PI3Kγ to stop virus replication and cytokine storms concomitantly. We also distinguished hotspot residues imparting significant interactions.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Cytokine Release Syndrome ; Neoplasms/drug therapy ; Protein Kinase Inhibitors ; Antineoplastic Agents/pharmacology ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Isoquinolines ; Purines
Chemical Substances	duvelisib (610V23S0JI) ; Protein Kinase Inhibitors ; Antineoplastic Agents ; Isoquinolines ; Purines
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp05934k
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