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  1. Article: Frontiers in Chronobiology: Endogenous Clocks at the Core of Signaling Pathways in Physiology.

    Costa, Rodolfo

    Frontiers in physiology

    2021  Volume 12, Page(s) 684745

    Language English
    Publishing date 2021-05-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.684745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Entrainment of Biological Rhythms.

    Costa, Rodolfo / Kyriacou, Charalambos

    Frontiers in physiology

    2021  Volume 12, Page(s) 757000

    Language English
    Publishing date 2021-09-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.757000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Natural alleles of the clock gene

    Andreatta, Gabriele / Montagnese, Sara / Costa, Rodolfo

    Frontiers in physiology

    2023  Volume 13, Page(s) 1092951

    Abstract: Circadian clocks orchestrate a variety of physiological and behavioural functions within the 24-h day. These timekeeping systems have also been implicated in developmental and reproductive processes that span more (or less) than 24 h. Whether natural ... ...

    Abstract Circadian clocks orchestrate a variety of physiological and behavioural functions within the 24-h day. These timekeeping systems have also been implicated in developmental and reproductive processes that span more (or less) than 24 h. Whether natural alleles of cardinal clock genes affect entire sets of life-history traits (i.e., reproductive arrest, developmental time, fecundity), thus providing a wider substrate for seasonal adaptation, remains unclear. Here we show that natural alleles of the
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.1092951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Gold standard motion analysis system for evaluating jumping performance in rhythmic gymnastics

    Silvia Coppola / Claudia Costa / Rodolfo Vastola

    Journal of Human Sport and Exercise, Vol 18, Iss

    2023  Volume 3

    Abstract: The aim of this study is to investigate the effectiveness, not yet described in the literature, of the gold standard system for motion analysis, to analyse the kinematic and dynamic aspects of the split leap in rhythmic gymnastics performed with and ... ...

    Abstract The aim of this study is to investigate the effectiveness, not yet described in the literature, of the gold standard system for motion analysis, to analyse the kinematic and dynamic aspects of the split leap in rhythmic gymnastics performed with and without the ribbon. The sample consists of six top level gymnasts aged between 13 and 16 (mean 15.1 ± 0.94). The acquisitions were carried out with the integrated multifactorial optoelectronic system BTS Bioengineering. Fifteen passive markers, six BTS Smart-DX cameras, two cameras for video support and seven BTS-6000 force platforms were used. After the acquisition of the gymnasts' anthropometric measurements, a standardized and specific neuromuscular activation was carried out. The software SMART tracker and SMART analyser were used to process and analyse the dynamics and kinematics data. A questionnaire was administered to the gymnasts to collect information regarding training. The results showed no major differences in force impulse, jump amplitude, elevation and flight time between the trials performed with and without ribbon. The experiment conducted demonstrates the effectiveness of using the integrated multifactor optoelectronic system to carry out the kinematic and dynamic analysis of a highly complex sports technique.
    Keywords Performance analysis of sport ; Gold standard system ; Sport performance ; Gymnasts ; Biomechanical evaluation ; Sports medicine ; RC1200-1245
    Subject code 796
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher University of Alicante
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The role of astrocytes in generating circadian rhythmicity in health and disease.

    Costa, Rodolfo / Montagnese, Sara

    Journal of neurochemistry

    2021  Volume 157, Issue 1, Page(s) 42–52

    Abstract: Evidence is accumulating that the mammalian circadian clock system is considerably more complex than previously believed, also in terms of the cell types that actually contribute to generating the oscillation within the master clock, in the ... ...

    Abstract Evidence is accumulating that the mammalian circadian clock system is considerably more complex than previously believed, also in terms of the cell types that actually contribute to generating the oscillation within the master clock, in the suprachiasmatic nuclei of the hypothalamus. Here we review the evidence that has lead to the identification of a bona fide astrocytic circadian clock, and that of the potential contribution of such clock to the generation of circadian and seasonal rhythmicity in health and in neurodegenerative disorders. Finally, we speculate on the role of the astrocytic clock in determining some of the clinical features of hepatic encephalopathy, a reversible neuropsychiatric syndrome associated with advanced liver disease, which is characterized by transient, profound morphological and functional astrocytic abnormalities, in the absence of significant, structural neuronal changes.
    MeSH term(s) Animals ; Astrocytes/metabolism ; Circadian Rhythm/physiology ; Humans ; Hypothalamus/metabolism ; Mammals ; Neurons/metabolism ; Suprachiasmatic Nucleus/metabolism
    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.15312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.170: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Driving fatigue increases after the Spring transition to Daylight Saving Time in young male drivers: A pilot study.

    Orsini, Federico / Giusti, Gianluca / Zarantonello, Lisa / Costa, Rodolfo / Montagnese, Sara / Rossi, Riccardo

    Transportation research. Part F, Traffic psychology and behaviour

    2024  Volume 99, Page(s) 83–97

    Abstract: The Spring transition to Daylight Saving Time (DST) has been associated with several health and road safety issues. Previous literature has focused primarily on the analysis of historical crash and hospitalization data, without investigating specific ... ...

    Abstract The Spring transition to Daylight Saving Time (DST) has been associated with several health and road safety issues. Previous literature has focused primarily on the analysis of historical crash and hospitalization data, without investigating specific crash contributing factors, such as driving fatigue. The present study aims to uncover the effects of DST-related circadian desynchrony and sleep deprivation on driving fatigue, by means of a driving simulator experiment. Eighteen participants (all males, age range 21-30 years, mean = 24.2, SD = 2.9) completed two 50-minute trials (at one week distance, same time and same day of the week) on a monotonous highway environment, the second one taking place in the week after the Spring transition to DST. Driving fatigue was evaluated by analysing several different variables (including driving-based, physiological and subjective indices) and by comparison with a historical cohort of pertinent, matched controls who had also undergone two trials, but in the absence of any time change in between. Results showed a considerable rise in fatigue levels throughout the driving task in both trials, but with significantly poorer performance in the post-DST trial, documented by a worsening in vehicle lateral control and an increase in eyelid closure. However, participants seemed unable to perceive this decrease in their alertness, which most likely prevented them from implementing fatigue-coping strategies. These findings indicate that DST has a detrimental effect on driving fatigue in young male drivers in the week after the Spring transition, and provide valuable insights into the complex relationship between DST and road safety.
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2019959-4
    ISSN 1873-5517 ; 1369-8478
    ISSN (online) 1873-5517
    ISSN 1369-8478
    DOI 10.1016/j.trf.2023.10.014
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  7. Article: New Promising Therapeutic Approach for Refractory Corneal Epithelial Defects.

    Vilares Morgado, Rodrigo / Moura, Rodolfo / Moreira, Raúl / Falcão-Reis, Fernando / Pinheiro-Costa, João

    Cureus

    2023  Volume 15, Issue 5, Page(s) e39324

    Abstract: The purpose of this case report is to describe a case of continuous wear of a gas-permeable mini-scleral contact lens with a fluid reservoir of autologous serum (AS) combined with AS drops as a successful empirical and accessible alternative therapeutic ... ...

    Abstract The purpose of this case report is to describe a case of continuous wear of a gas-permeable mini-scleral contact lens with a fluid reservoir of autologous serum (AS) combined with AS drops as a successful empirical and accessible alternative therapeutic option for refractory persistent epithelial defects in a patient with severe neurotrophic keratopathy (NK) due to severe dry eye disease and chronic contact lens wear. A 61-year-old Caucasian female with bilateral NK presented a history of multiple episodes of bilateral persistent epithelial defects, having already been submitted to three tectonic-penetrating keratoplasties in her left eye (OS). In May 2017, the patient developed
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.39324
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  8. Article ; Online: Circadian rhythms and the liver.

    Costa, Rodolfo / Mangini, Chiara / Domenie, Esther D / Zarantonello, Lisa / Montagnese, Sara

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 43, Issue 3, Page(s) 534–545

    Abstract: This narrative review briefly describes the mammalian circadian timing system, the specific features of the liver clock, also by comparison with other peripheral clocks, the role of the liver clock in the preparation of food intake, and its relationship ... ...

    Abstract This narrative review briefly describes the mammalian circadian timing system, the specific features of the liver clock, also by comparison with other peripheral clocks, the role of the liver clock in the preparation of food intake, and its relationship with energy metabolism. It then goes on to provide a chronobiological perspective of the pathophysiology and management of several types of liver disease, with a particular focus on metabolic-associated fatty liver disease (MAFLD), decompensated cirrhosis and liver transplantation. Finally, it provides some insight into the potential contribution of circadian principles and circadian hygiene practices in preventing MAFLD, improving the prognosis of advanced liver disease and modulating liver transplantation outcomes.
    MeSH term(s) Animals ; Humans ; Circadian Rhythm/physiology ; Liver/metabolism ; Liver Diseases/metabolism ; Mammals
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15501
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Personalising circadian hygiene educational initiatives aimed at university students-"He who has ears to hear, let him hear".

    Giusti, Gianluca / Domenie, Esther D / Zarantonello, Lisa / Mangini, Chiara / Ferrari, Paolo / Costa, Rodolfo / Montagnese, Sara

    Journal of sleep research

    2024  , Page(s) e14194

    Abstract: The aim of the present study was to characterise "early drop-outs" (n = 3185) out of a group of university students (n = 7766) engaged in an ongoing circadian education initiative, to evaluate its efficacy and direct its developments. The initiative is ... ...

    Abstract The aim of the present study was to characterise "early drop-outs" (n = 3185) out of a group of university students (n = 7766) engaged in an ongoing circadian education initiative, to evaluate its efficacy and direct its developments. The initiative is aimed at improving sleep timing/quality through one of two sets of circadian hygiene advice covering the timing of sleep, meals, exercise and light exposure, and it has already been shown to have a positive effect on sleep timing. This second, interim analysis confirmed the high prevalence of disturbed night sleep and social jetlag amongst students at Padova University. Three-thousand, one-hundred and eighty-five (41.0%) students were early drop-outs. These were more commonly males (46.4 versus 37.6%; χ
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1122722-9
    ISSN 1365-2869 ; 0962-1105
    ISSN (online) 1365-2869
    ISSN 0962-1105
    DOI 10.1111/jsr.14194
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3464: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 343: Show issues

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  10. Article ; Online: Small Extracellular Vesicles from Human Amniotic Fluid Samples as Promising Theranostics.

    Costa, Ambra / Quarto, Rodolfo / Bollini, Sveva

    International journal of molecular sciences

    2022  Volume 23, Issue 2

    Abstract: Since the first evidence that stem cells can provide pro-resolving effects via paracrine secretion of soluble factors, growing interest has been addressed to define the most ideal cell source for clinical translation. Leftover or clinical waste samples ... ...

    Abstract Since the first evidence that stem cells can provide pro-resolving effects via paracrine secretion of soluble factors, growing interest has been addressed to define the most ideal cell source for clinical translation. Leftover or clinical waste samples of human amniotic fluid obtained following prenatal screening, clinical intervention, or during scheduled caesarean section (C-section) delivery at term have been recently considered an appealing source of mesenchymal progenitors with peculiar regenerative capacity. Human amniotic fluid stem cells (hAFSC) have been demonstrated to support tissue recovery in several preclinical models of disease by exerting paracrine proliferative, anti-inflammatory and regenerative influence. Small extracellular vesicles (EVs) concentrated from the hAFSC secretome (the total soluble trophic factors secreted in the cell-conditioned medium, hAFSC-CM) recapitulate most of the beneficial cell effects. Independent studies in preclinical models of either adult disorders or severe diseases in newborns have suggested a regenerative role of hAFSC-EVs. EVs can be eventually concentrated from amniotic fluid (hAF) to offer useful prenatal information, as recently suggested. In this review, we focus on the most significant aspects of EVs obtained from either hAFSC and hAF and consider the current challenges for their clinical translation, including isolation, characterization and quantification methods.
    MeSH term(s) Amniotic Fluid ; Extracellular Vesicles ; Humans ; Precision Medicine ; Stem Cells
    Language English
    Publishing date 2022-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23020590
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